DRUG ADDICTION & ABUSE: IMMUNOPHARMACOTHERAPY
Lin M, Eubanks LM, Zhou B, Janda KD. Evaluation of a Hapten Conjugate Vaccine against the "zombie Drug" Xylazine. Chem. Commun. 2024;60(35):4711-4714. DOI: 10.1039/D4CC00883A. PMID: 38596865.
Eubanks LM, Pholcharee T, Oyen D, Natori Y, Zhou B, Wilson IA, Janda KD. An Engineered Human-Antibody Fragment with Fentanyl Pan-Specificity That Reverses Carfentanil-Induced Respiratory Depression. ACS Chem Neurosci. 2023;14(16):2849-56. PMID: 37534714.
Lin M, Eubanks LM, Karadkhelkar NM, Blake S, Janda KD. Catalytic Antibody Blunts Carfentanil-Induced Respiratory Depression. ACS Pharmacol Transl Sci. 2023;6(5):802-11. PMID: 37200811.
Park H, Lin M, Zhou J, Eubanks LM, Zhou B, Janda KD. Development of a Vaccine against the Synthetic Opioid U-47700. Front Pharmacol. 2023;14:1219985. PMID: 37492086.
Richardson RS, Sulima A, Rice KC, Kucharczk JA, Janda KD, Nisbett KE, Koob GF, Vendruscolo LF, Leggio L. Pharmacological GHSR (ghrelin receptor) blockade reduces alcohol binge-like drinking in male and female mice. Neuropharmacology. 2023;238:109643. PMID: 37369277.
Lee JC, Eubanks LM, Zhou B, Janda KD. Development of an effective monoclonal antibody against heroin and its metabolites reveals therapies have mistargeted 6-monoacetylmorphine and morphine over heroin. ACS Cent Sci. 2022;8(10):1464-70. PMID: 36313156.
Lee JC, Park H, Eubanks LM, Ellis B, Zhou B, Janda KD. A vaccine against benzimidazole-derived new psychoactive substances that are more potent than fentanyl. J Med Chem. 2022;65(3):2522-31. PMID: 34994550.
Lee JC, Janda KD. Development of effective therapeutics for polysubstance use disorders. Curr Opin Chem Biol. 2022;66:102105. PMID: 34936944.
Lin M, Marin A, Ellis B, Eubanks LM, Andrianov AK, Janda KD. Polyphosphazene: A new adjuvant platform for cocaine vaccine development. Mol Pharm. 2022;19(9):3358-66. PMID: 35984034.
Belz TF, Lin M, Eubanks LM, Ellis B, Janda KD. Vaccine design through transition state mimicry of heroin hydrolysis. Tetrahedron Lett. 2021;71:153045.
Blake S, Bremer PT, Zhou B, Petrovsky N, Smith LC, Hwang CS, Janda KD. Developing translational vaccines against heroin and fentanyl through investigation of adjuvants and stability. Mol Pharm. 2021;18(1):228-35. PMID: 33301675.
Eubanks LM, Blake S, Natori Y, Ellis B, Bremer PT, Janda KD. A highly efficacious carfentanil vaccine that blunts opioid-induced antinociception and respiratory depression. ACS Chem Biol. 2021;16(2):277-82. PMID: 33533592.
Lee JC, Janda KD. Immunopharmacotherapeutic advancements in addressing methamphetamine abuse. RSC Chem Biol. 2021;2(1):77-93. PMID: 34458776.
Lin M, Lee JC, Blake S, Ellis B, Eubanks LM, Janda KD. Broadly neutralizing synthetic cannabinoid vaccines. JACS Au. 2021;1(1):31-40. PMID: 34467269.
Lin M, Ellis B, Eubanks LM, Janda KD. Pharmacokinetic approach to combat the synthetic cannabinoid PB-22. ACS Chem Neurosci. 2021;12(14):2573-9. PMID: 34254505.
Park H, Lee JC, Eubanks LM, Ellis B, Zhou B, Janda KD. Improvements on a chemically contiguous hapten for a vaccine to address fentanyl-contaminated heroin. Bioorg Med Chem. 2021;41:116225. PMID: 34034147.
Staples MC, Herman MA, Lockner JW, Avchalumov Y, Kharidia KM, Janda KD, Roberto M, Mandyam CD. Isoxazole-9 reduces enhanced fear responses and retrieval in ethanol-dependent male rats. J Neurosci Res. 2021;99(11):3047-65. PMID: 34496069.
Townsend EA, Bremer PT, Jacob NT, Negus SS, Janda KD, Banks ML. A synthetic opioid vaccine attenuates fentanyl-vs-food choice in male and female rhesus monkeys. Drug Alcohol Depend. 2021;218:108348. PMID: 33268227.
Belz TF, Bremer PT, Zhou B, Ellis B, Eubanks LM, Janda KD. Enhancement of a heroin vaccine through hapten deuteration. J Am Chem Soc. 2020;142(31):13294-8. PMID: 32700530.
Belz TF, Bremer PT, Zhou B, Blake S, Ellis B, Eubanks LM, Janda KD. Sulfonate-isosteric replacement examined within heroin-hapten vaccine design. Bioorg Med Chem Lett. 2020;30(17):127388. PMID: 32738981.
Natori Y, Kim D J. Synthesis of drug vaccine against heroin contaminated with fentanyl and their biological evaluation. J Synth Org Chem Jpn. 2020;78(9):875-85.
Townsend EA, Bremer PT, Faunce KE, Negus SS, Jaster AM, Robinson HL, Janda KD, Banks ML. Evaluation of a dual fentanyl/heroin vaccine on the antinociceptive and reinforcing effects of a fentanyl/heroin mixture in male and female rats. ACS Chem Neurosci. 2020;11(9):1300-10. PMID: 32271538.
Wang J, Ellis B, Zhou B, Eubanks LM, Blake S, Janda KD. A fentanyl vaccine constructed upon opsonizing antibodies specific for the Galalpha1-3Gal epitope. Chem Commun (Camb). 2020;56(48):6551-4. PMID: 32396160.
Hwang CS, Ellis B, Zhou B, Janda KD. Heat shock proteins: A dual carrier-adjuvant for an anti-drug vaccine against heroin. Bioorg Med Chem. 2019;27(1):125-32. PMID: 30497790.
Hwang CS, Smith LC, Wenthur CJ, Ellis B, Zhou B, Janda KD. Heroin vaccine: Using titer, affinity, and antinociception as metrics when examining sex and strain differences. Vaccine. 2019;37(30):4155-63. PMID: 31176539.
Natori Y, Hwang CS, Lin L, Smith LC, Zhou B, Janda KD. A chemically contiguous hapten approach for a heroin-fentanyl vaccine. Beilstein J Org Chem. 2019;15:1020-31. PMID: 31164940.
Nguyen JD, Grant Y, Creehan KM, Hwang CS, Vandewater SA, Janda KD, Cole M, Taffe MA. △9-tetrahydrocannabinol attenuates oxycodone self-administration under extended access conditions. Neuropharmacology. 2019;151:127-35. PMID: 30980837.
Olson ME, Sugane T, Zhou B, Janda KD. Consequence of hapten stereochemistry: An efficacious methamphetamine vaccine. J Am Chem Soc. 2019;141(36):14089-92. PMID: 31479256.
Olson ME, Eubanks LM, Janda KD. Chemical interventions for the opioid crisis: Key advances and remaining challenges. J Am Chem Soc. 2019;141(5):1798-806. PMID: 30532973.
Smith LC, Bremer PT, Hwang CS, Zhou B, Ellis B, Hixon MS, Janda KD. Monoclonal antibodies for combating synthetic opioid intoxication. J Am Chem Soc. 2019;141(26):10489-503. PMID: 31187995.
Smith LC, Lin L, Hwang CS, Zhou B, Kubitz DM, Wang H, Janda KD. Lateral flow assessment and unanticipated toxicity of Kratom. Chem Res Toxicol. 2019;32(1):113-21. PMID: 30380840.
Tenney RD, Blake S, Bremer PT, Zhou B, Hwang CS, Poklis JL, Janda KD, Banks ML. Vaccine blunts fentanyl potency in male rhesus monkeys. Neuropharmacology. 2019;158:107730. PMID: 31369740.
Townsend EA, Blake S, Faunce KE, Hwang CS, Natori Y, Zhou B, Bremer PT, Janda KD, Banks ML. Conjugate vaccine produces long-lasting attenuation of fentanyl vs. food choice and blocks expression of opioid withdrawal-induced increases in fentanyl choice in rats. Neuropsychopharmacology. 2019;44(10):1681-9. PMID: 31043682.
Banks ML, Olson ME, Janda KD. Immunopharmacotherapies for treating opioid use disorder. Trends Pharmacol Sci. 2018;39(11):908-11. PMID: 30343725.
Galinato MH, Lockner JW, Fannon-Pavlich MJ, Sobieraj JC, Staples MC, Somkuwar SS, Ghofranian A, Chaing S, Navarro AI, Joea A, Luikart BW, Janda KD, Heyser C, Koob GF, Mandyam CD. A synthetic small-molecule Isoxazole-9 protects against methamphetamine relapse. Mol Psychiatry. 2018;23(3):629-38. PMID: 28348387.
Hwang CS, Bremer PT, Wenthur CJ, Ho SO, Chiang S, Ellis B, Zhou B, Fujii G, Janda KD. Enhancing efficacy and stability of an antiheroin vaccine: Examination of antinociception, opioid binding profile, and lethality. Mol Pharm. 2018;15(3):1062-72. PMID: 29420901.
Hwang CS, Smith LC, Natori Y, Ellis B, Zhou B, Janda KD. Efficacious vaccine against heroin contaminated with fentanyl. ACS Chem Neurosci. 2018;9(6):1269-75. PMID: 29558798.
Hwang CS, Smith LC, Natori Y, Ellis B, Zhou B, Janda KD. Improved admixture vaccine of fentanyl and heroin hapten immunoconjugates: Antinociceptive evaluation of fentanyl-contaminated heroin. ACS Omega. 2018;3(9):11537-43. PMID: 30288464.
Kallupi M, Xue S, Zhou B, Janda KD, George O. An enzymatic approach reverses nicotine dependence, decreases compulsive-like intake, and prevents relapse. Sci Adv. 2018;4(10):eaat4751. PMID: 30345354.
Kimishima A, Olson ME, Natori Y, Janda KD. Efficient syntheses of cocaine vaccines and their in vivo evaluation. ACS Med Chem Lett. 2018;9(5):411-6. PMID: 29795751.
Kimishima A, Olson ME, Janda KD. Investigations into the efficacy of multi-component cocaine vaccines. Bioorg Med Chem Lett. 2018;28(16):2779-83. PMID: 29317163.
Nguyen JD, Hwang CS, Grant Y, Janda KD, Taffe MA. Prophylactic vaccination protects against the development of oxycodone self-administration. Neuropharmacology. 2018;138:292-303. PMID: 29936242.
Olson ME, Janda KD. Vaccines to combat the opioid crisis: Vaccines that prevent opioids and other substances of abuse from entering the brain could effectively treat addiction and abuse. EMBO Rep. 2018;19(1):5-9. PMID: 29237715.
Tararina MA, Xue S, Smith LC, Muellers SN, Miranda PO, Janda KD, Allen KN. Crystallography coupled with kinetic analysis provides mechanistic underpinnings of a nicotine-degrading enzyme. Biochemistry. 2018;57(26):3741-51. PMID: 29812904.
Xue S, Kallupi M, Zhou B, Smith LC, Miranda PO, George O, Janda KD. An enzymatic advance in nicotine cessation therapy. Chem Commun (Camb). 2018;54(14):1686-9. PMID: 29308799.
Bremer PT, Janda KD. Conjugate vaccine immunotherapy for substance use disorder. Pharmacol Rev. 2017;69(3):298-315. PMID: 28634286.
Bremer PT, Schlosburg JE, Banks ML, Steele FF, Zhou B, Poklis JL, Janda KD. Development of a clinically viable heroin vaccine. J Am Chem Soc. 2017;139(25):8601-11. PMID: 28574716.
Gooyit M, Miranda PO, Wenthur CJ, Ducime A, Janda KD. Influencing antibody-mediated attenuation of methamphetamine CNS distribution through vaccine linker design. ACS Chem Neurosci. 2017;8(3):468-72. PMID: 27958709.
Hwang CS, Janda KD. A vision for vaccines: Combating the opioid epidemic. Biochemistry. 2017;56(42):5625-7. PMID: 28994583.
Jacob NT, Anraku K, Kimishima A, Zhou B, Collins KC, Lockner JW, Ellis BA, Janda KD. A bioconjugate leveraging xenoreactive antibodies to alleviate cocaine-induced behavior. Chem Commun (Camb). 2017;53(58):8156-9. PMID: 28677711.
Kimishima A, Wenthur CJ, Zhou B, Janda KD. An advance in prescription opioid vaccines: Overdose mortality reduction and extraordinary alteration of drug half-life. ACS Chem Biol. 2017;12(1):36-40. PMID: 28103678.
Nguyen JD, Bremer PT, Ducime A, Creehan KM, Kisby BR, Taffe MA, Janda KD. Active vaccination attenuates the psychostimulant effects of α-PVP and MDPV in rats. Neuropharmacology. 2017;116:1-8. PMID: 27956054.
Nguyen JD, Bremer PT, Hwang CS, Vandewater SA, Collins KC, Creehan KM, Janda KD, Taffe MA. Effective active vaccination against methamphetamine in female rats. Drug Alcohol Depend. 2017;175:179-86. PMID: 28437722.
Wenthur CJ, Cai X, Ellis BA, Janda KD. Augmenting the efficacy of anti-cocaine catalytic antibodies through chimeric hapten design and combinatorial vaccination. Bioorg Med Chem Lett. 2017;27(16):3666-8. PMID: 28709828.
Wenthur CJ, Zhou B, Janda KD. Vaccine-driven pharmacodynamic dissection and mitigation of fenethylline psychoactivity. Nature. 2017;548(7668):476-9. PMID: 28813419.
Bremer PT, Kimishima A, Schlosburg JE, Zhou B, Collins KC, Janda KD. Combatting synthetic designer opioids: A conjugate vaccine ablates lethal doses of fentanyl class drugs. Angew Chem Int Ed Engl. 2016;55(11):3772-5. PMID: 26879590.
Collins KC, Schlosburg JE, Bremer PT, Janda KD. Methamphetamine vaccines: Improvement through hapten design. J Med Chem. 2016;59(8):3878-85. PMID: 27054372.
Evans SM, Foltin RW, Hicks MJ, Rosenberg JB, De BP, Janda KD, Kaminsky SM, Crystal RG. Efficacy of an adenovirus-based anti-cocaine vaccine to reduce cocaine self-administration and reacqusition using a choice procedure in rhesus macaques. Pharmacol Biochem Behav. 2016;150-151:76-86. PMID: 27697554.
Jacob NT, Lockner JW, Schlosburg JE, Ellis BA, Eubanks LM, Janda KD. Investigations of enantiopure nicotine haptens using an adjuvanting carrier in anti-nicotine vaccine development. J Med Chem. 2016;59(6):2523-9. PMID: 26918428.
Kimishima A, Wenthur CJ, Eubanks LM, Sato S, Janda KD. Cocaine vaccine development: Evaluation of carrier and adjuvant combinations that activate multiple Toll-like receptors. Mol Pharm. 2016;13(11):3884-90. PMID: 27717287.
Zhou B, Eubanks LM, Jacob NT, Ellis B, Roberts AJ, Janda KD. Studies towards the improvement of an anti-cocaine monoclonal antibody for treatment of acute overdose. Bioorg Med Chem Lett. 2016;26(20):5078-81. PMID: 27599743.
Collins KC, Janda KD. Hapten design for anti-addiction vaccine development. In: Montoya ID, editor. Biologics to Treat Substance Abuse Disorders: Vaccines, Monoclonal Antibodies, and Enzymes: Springer; 2015. p. 327-65.
Lockner JW, Lively JM, Collins KC, Vendruscolo JC, Azar MR, Janda KD. A conjugate vaccine using enantiopure hapten imparts superior nicotine-binding capacity. J Med Chem. 2015;58(2):1005-11. PMID: 25493909.
Lockner JW, Eubanks LM, Choi JL, Lively JM, Schlosburg JE, Collins KC, Globisch D, Rosenfeld-Gunn RJ, Wilson IA, Janda KD. Flagellin as carrier and adjuvant in cocaine vaccine development. Mol Pharm. 2015;12(2):653-62. PMID: 25531528.
Miller ML, Aarde SM, Moreno AY, Creehan KM, Janda KD, Taffe MA. Effects of active anti-methamphetamine vaccination on intravenous self-administration in rats. Drug Alcohol Depend. 2015;153:29-36. PMID: 26118833.
Xue S, Schlosburg JE, Janda KD. A new strategy for smoking cessation: Characterization of a bacterial enzyme for the degradation of nicotine. J Am Chem Soc. 2015;137(32):10136-9. PMID: 26237398.
Bremer PT, Schlosburg JE, Lively JM, Janda KD. Injection route and TLR9 agonist addition significantly impact heroin vaccine efficacy. Mol Pharm. 2014;11(3):1075-80. PMID: 24517171.
Collins KC, Schlosburg JE, Lockner JW, Bremer PT, Ellis BA, Janda KD. Lipid tucaresol as an adjuvant for methamphetamine vaccine development. Chem Commun (Camb). 2014;50(31):4079-81. PMID: 24615284.
Collins KC, Janda KD. Investigating hapten clustering as a strategy to enhance vaccines against drugs of abuse. Bioconjug Chem. 2014;25(3):593-600. PMID: 24521489.
Eubanks LM, Ellis BA, Cai X, Schlosburg JE, Janda KD. A human recombinant monoclonal antibody to cocaine: Preparation, characterization and behavioral studies. Bioorg Med Chem Lett. 2014;24(19):4664-6. PMID: 25205191.
Hicks MJ, Kaminsky SM, De BP, Rosenberg JB, Evans SM, Foltin RW, Andrenyak DM, Moody DE, Koob GF, Janda KD, Ricart Arbona RJ, Lepherd ML, Crystal RG. Fate of systemically administered cocaine in nonhuman primates treated with the dAd5GNE anticocaine vaccine. Hum Gene Ther Clin Dev. 2014;25(1):40-9. PMID: 24649839.
Seki H, Pellett S, Silhar P, Stowe GN, Blanco B, Lardy MA, Johnson EA, Janda KD. Synthesis/biological evaluation of hydroxamic acids and their prodrugs as inhibitors for Botulinum neurotoxin A light chain. Bioorg Med Chem. 2014;22(3):1208-17. PMID: 24360826.
Cai X, Tsuchikama K, Janda KD. Modulating cocaine vaccine potency through hapten fluorination. J Am Chem Soc. 2013;135(8):2971-4. PMID: 23398531.
Cai X, Whitfield T, Hixon MS, Grant Y, Koob GF, Janda KD. Probing active cocaine vaccination performance through catalytic and noncatalytic hapten design. J Med Chem. 2013;56(9):3701-9. PMID: 23627877.
Cai X, Whitfield T, Moreno AY, Grant Y, Hixon MS, Koob GF, Janda KD. Probing the effects of hapten stability on cocaine vaccine immunogenicity. Mol Pharm. 2013;10(11):4176-84. PMID: 23927436.
De BP, Pagovich OE, Hicks MJ, Rosenberg JB, Moreno AY, Janda KD, Koob GF, Worgall S, Kaminsky SM, Sondhi D, Crystal RG. Disrupted adenovirus-based vaccines against small addictive molecules circumvent anti-adenovirus immunity. Hum Gene Ther. 2013;24(1):58-66. PMID: 23140508.
Lockner JW, Ho SO, McCague KC, Chiang SM, Do TQ, Fujii G, Janda KD. Enhancing nicotine vaccine immunogenicity with liposomes. Bioorg Med Chem Lett. 2013;23(4):975-8. PMID: 23313243.
Maoz A, Hicks MJ, Vallabhjosula S, Synan M, Kothari PJ, Dyke JP, Ballon DJ, Kaminsky SM, De BP, Rosenberg JB, Martinez D, Koob GF, Janda KD, Crystal RG. Adenovirus capsid-based anti-cocaine vaccine prevents cocaine from binding to the nonhuman primate CNS dopamine transporter. Neuropsychopharmacology. 2013;38(11):2170-8. PMID: 23660705.
Matyas GR, Mayorov AV, Rice KC, Jacobson AE, Cheng K, Iyer MR, Li F, Beck Z, Janda KD, Alving CR. Liposomes containing monophosphoryl lipid A: A potent adjuvant system for inducing antibodies to heroin hapten analogs. Vaccine. 2013;31(26):2804-10. PMID: 23624097.
Miller ML, Moreno AY, Aarde SM, Creehan KM, Vandewater SA, Vaillancourt BD, Wright MJ, Jr., Janda KD, Taffe MA. A methamphetamine vaccine attenuates methamphetamine-induced disruptions in thermoregulation and activity in rats. Biol Psychiatry. 2013;73(8):721-8. PMID: 23098894.
Rosenberg JB, De BP, Hicks MJ, Janda KD, Kaminsky SM, Worgall S, Crystal RG. Suppression of nicotine-induced pathophysiology by an adenovirus hexon-based antinicotine vaccine. Hum Gene Ther. 2013;24(6):595-603. PMID: 23611296.
Schlosburg JE, Vendruscolo LF, Bremer PT, Lockner JW, Wade CL, Nunes AA, Stowe GN, Edwards S, Janda KD, Koob GF. Dynamic vaccine blocks relapse to compulsive intake of heroin. Proc Natl Acad Sci U S A. 2013;110(22):9036-41. PMID: 23650354.
Bremer PT, Janda KD. Investigating the effects of a hydrolytically stable hapten and a Th1 adjuvant on heroin vaccine performance. J Med Chem. 2012;55(23):10776-80. PMID: 23134263.
Hicks MJ, Rosenberg JB, De BP, Pagovich OE, Young CN, Qiu JP, Kaminsky SM, Hackett NR, Worgall S, Janda KD, Davisson RL, Crystal RG. AAV-directed persistent expression of a gene encoding anti-nicotine antibody for smoking cessation. Sci Transl Med. 2012;4(140):140ra87. PMID: 22745437.
Moreno AY, Azar MR, Koob GF, Janda KD. Probing the protective effects of a conformationally constrained nicotine vaccine. Vaccine. 2012;30(47):6665-70. PMID: 22963803.
Rosenberg JB, Hicks MJ, De BP, Pagovich O, Frenk E, Janda KD, Wee S, Koob GF, Hackett NR, Kaminsky SM, Worgall S, Tignor N, Mezey JG, Crystal RG. AAVrh.10-mediated expression of an anti-cocaine antibody mediates persistent passive immunization that suppresses cocaine-induced behavior. Hum Gene Ther. 2012;23(5):451-9. PMID: 22486244.
Treweek JB, Janda KD. An antidote for acute cocaine toxicity. Mol Pharm. 2012;9(4):969-78. PMID: 22380623.
Wee S, Hicks MJ, De BP, Rosenberg JB, Moreno AY, Kaminsky SM, Janda KD, Crystal RG, Koob GF. Novel cocaine vaccine linked to a disrupted adenovirus gene transfer vector blocks cocaine psychostimulant and reinforcing effects. Neuropsychopharmacology. 2012;37(5):1083-91. PMID: 21918504.
Hicks MJ, De BP, Rosenberg JB, Davidson JT, Moreno AY, Janda KD, Wee S, Koob GF, Hackett NR, Kaminsky SM, Worgall S, Toth M, Mezey JG, Crystal RG. Cocaine analog coupled to disrupted adenovirus: A vaccine strategy to evoke high-titer immunity against addictive drugs. Mol Ther. 2011;19(3):612-9. PMID: 21206484.
Janda KD, Treweek JB. Vaccines targeting drugs of abuse: Is the glass half-empty or half-full? Nat Rev Immunol. 2011;12(1):67-72. PMID: 22173478.
Koob G, Hicks MJ, Wee S, Rosenberg JB, De BP, Kaminsky SM, Moreno A, Janda KD, Crystal RG. Anti-cocaine vaccine based on coupling a cocaine analog to a disrupted adenovirus. CNS Neurol Disord Drug Targets. 2011;10(8):899-904. PMID: 22229312.
Moreno AY, Mayorov AV, Janda KD. Impact of distinct chemical structures for the development of a methamphetamine vaccine. J Am Chem Soc. 2011;133(17):6587-95. PMID: 21473576.
Moreno AY, Janda KD. Current challenges for the creation of effective vaccines against drugs of abuse. Expert Rev Vaccines. 2011;10(12):1637-9. PMID: 22085165.
Stowe GN, Schlosburg JE, Vendruscolo LF, Edwards S, Misra KK, Schulteis G, Zakhari JS, Koob GF, Janda KD. Developing a vaccine against multiple psychoactive targets: A case study of heroin. CNS Neurol Disord Drug Targets. 2011;10(8):865-75. PMID: 22229311.
Stowe GN, Vendruscolo LF, Edwards S, Schlosburg JE, Misra KK, Schulteis G, Mayorov AV, Zakhari JS, Koob GF, Janda KD. A vaccine strategy that induces protective immunity against heroin. J Med Chem. 2011;54(14):5195-204. PMID: 21692508.
Treweek JB, Roberts AJ, Janda KD. Immunopharmacotherapeutic manifolds and modulation of cocaine overdose. Pharmacol Biochem Behav. 2011;98(3):474-84. PMID: 21356233.
Moreno AY, Azar MR, Warren NA, Dickerson TJ, Koob GF, Janda KD. A critical evaluation of a nicotine vaccine within a self-administration behavioral model. Mol Pharm. 2010;7(2):431-41. PMID: 20104903.
Treweek JB, Roberts AJ, Janda KD. Superadditive effects of ethanol and flunitrazepam: Implications of using immunopharmacotherapy as a therapeutic. Mol Pharm. 2010;7(6):2056-68. PMID: 20849117.
Moreno AY, Janda KD. Immunopharmacotherapy: Vaccination strategies as a treatment for drug abuse and dependence. Pharmacol Biochem Behav. 2009;92(2):199-205. PMID: 19350728.
Treweek JB, Sun C, Mayorov AV, Qi L, Levy CL, Roberts AJ, Dickerson TJ, Janda KD. Prevention of drug-induced memory impairment by immunopharmacotherapy. J Med Chem. 2008;51(21):6866-75. PMID: 18921991.
Brogan AP, Eubanks LM, Koob GF, Dickerson TJ, Janda KD. Antibody-catalyzed oxidation of △(9)-tetrahydrocannabinol. J Am Chem Soc. 2007;129(12):3698-702. PMID: 17335216.
Ino A, Dickerson TJ, Janda KD. Positional linker effects in haptens for cocaine immunopharmacotherapy. Bioorg Med Chem Lett. 2007;17(15):4280-3. PMID: 17531484.
McKenzie KM, Mee JM, Rogers CJ, Hixon MS, Kaufmann GF, Janda KD. Identification and characterization of single chain anti-cocaine catalytic antibodies. J Mol Biol. 2007;365(3):722-31. PMID: 17084858.
Xu Y, Hixon MS, Dawson PE, Janda KD. Development of a FRET assay for monitoring of HIV gp41 core disruption. J Org Chem. 2007;72(18):6700-7. PMID: 17685571.
Dickerson TJ, Janda KD. The use of small molecules to investigate molecular mechanisms and therapeutic targets for treatment of botulinum neurotoxin A intoxication. ACS Chem Biol. 2006;1(6):359-69. PMID: 17163773.
Eubanks LM, Rogers CJ, Beuscher AEt, Koob GF, Olson AJ, Dickerson TJ, Janda KD. A molecular link between the active component of marijuana and Alzheimer's disease pathology. Mol Pharm. 2006;3(6):773-7. PMID: 17140265.
Rogers CJ, Eubanks LM, Dickerson TJ, Janda KD. Unexpected acetylcholinesterase activity of cocaine esterases. J Am Chem Soc. 2006;128(48):15364-5. PMID: 17131989.
Zhu X, Dickerson TJ, Rogers CJ, Kaufmann GF, Mee JM, McKenzie KM, Janda KD, Wilson IA. Complete reaction cycle of a cocaine catalytic antibody at atomic resolution. Structure. 2006;14(2):205-16. PMID: 16472740.
Carrera MR, Trigo JM, Wirsching P, Roberts AJ, Janda KD. Evaluation of the anticocaine monoclonal antibody GNC92H2 as an immunotherapy for cocaine overdose. Pharmacol Biochem Behav. 2005;81(4):709-14. PMID: 16005948.
Dickerson TJ, Kaufmann GF, Janda KD. Bacteriophage-mediated protein delivery into the central nervous system and its application in immunopharmacotherapy. Expert Opin Biol Ther. 2005;5(6):773-81. PMID: 15952908.
Meijler MM, Kaufmann GF, Qi L, Mee JM, Coyle AR, Moss JA, Wirsching P, Matsushita M, Janda KD. Fluorescent cocaine probes: A tool for the selection and engineering of therapeutic antibodies. J Am Chem Soc. 2005;127(8):2477-84. PMID: 15725002.
Qi L, Yamamoto N, Meijler MM, Altobell LJ, 3rd, Koob GF, Wirsching P, Janda KD. △9-tetrahydrocannabinol immunochemical studies: Haptens, monoclonal antibodies, and a convenient synthesis of radiolabeled △9-tetrahydrocannabinol. J Med Chem. 2005;48(23):7389-99. PMID: 16279798.
Rogers CJ, Mee JM, Kaufmann GF, Dickerson TJ, Janda KD. Toward cocaine esterase therapeutics. J Am Chem Soc. 2005;127(28):10016-7. PMID: 16011362.
Carrera MR, Ashley JA, Hoffman TZ, Isomura S, Wirsching P, Koob GF, Janda KD. Investigations using immunization to attenuate the psychoactive effects of nicotine. Bioorg Med Chem. 2004;12(3):563-70. PMID: 14738965.
Carrera MR, Meijler MM, Janda KD. Cocaine pharmacology and current pharmacotherapies for its abuse. Bioorg Med Chem. 2004;12(19):5019-30. PMID: 15351386.
Carrera MR, Kaufmann GF, Mee JM, Meijler MM, Koob GF, Janda KD. Treating cocaine addiction with viruses. Proc Natl Acad Sci U S A. 2004;101(28):10416-21. PMID: 15226496.
Dickerson TJ, Yamamoto N, Janda KD. Antibody-catalyzed oxidative degradation of nicotine using riboflavin. Bioorg Med Chem. 2004;12(18):4981-7. PMID: 15336277.
Meijler MM, Matsushita M, Wirsching P, Janda KD. Development of immunopharmacotherapy against drugs of abuse. Curr Drug Discov Technol. 2004;1(1):77-89. PMID: 16472221.
Meijler MM, Matsushita M, Altobell LJ, 3rd, Wirsching P, Janda KD. A new strategy for improved nicotine vaccines using conformationally constrained haptens. J Am Chem Soc. 2003;125(24):7164-5. PMID: 12797775.
Moss JA, Coyle AR, Ahn JM, Meijler MM, Offer J, Janda KD. Tandem IMAC-HPLC purification of a cocaine-binding scFv antibody. J Immunol Methods. 2003;281(1-2):143-8. PMID: 14580888.
Redwan el RM, Larsen NA, Zhou B, Wirsching P, Janda KD, Wilson IA. Expression and characterization of a humanized cocaine-binding antibody. Biotechnol Bioeng. 2003;82(5):612-8. PMID: 12652485.
Dickerson TJ, Janda KD. Aqueous aldol catalysis by a nicotine metabolite. J Am Chem Soc. 2002;124(13):3220-1. PMID: 11916401.
Isomura S, Hoffman TZ, Wirsching P, Janda KD. Synthesis, properties, and reactivity of cocaine benzoylthio ester possessing the cocaine absolute configuration. J Am Chem Soc. 2002;124(14):3661-8. PMID: 11929256.
Carrera MR, Ashley JA, Wirsching P, Koob GF, Janda KD. A second-generation vaccine protects against the psychoactive effects of cocaine. Proc Natl Acad Sci U S A. 2001;98(4):1988-92. PMID: 11172063.
Isomura S, Wirsching P, Janda KD. An immunotherapeutic program for the treatment of nicotine addiction: Hapten design and synthesis. J Org Chem. 2001;66(12):4115-21. PMID: 11397142.
Larsen NA, Zhou B, Heine A, Wirsching P, Janda KD, Wilson IA. Crystal structure of a cocaine-binding antibody. J Mol Biol. 2001;311(1):9-15. PMID: 11469854.
Matsushita M, Hoffman TZ, Ashley JA, Zhou B, Wirsching P, Janda KD. Cocaine catalytic antibodies: The primary importance of linker effects. Bioorg Med Chem Lett. 2001;11(2):87-90. PMID: 11206477.
Carrera MR, Ashley JA, Zhou B, Wirsching P, Koob GF, Janda KD. Cocaine vaccines: Antibody protection against relapse in a rat model. Proc Natl Acad Sci USA. 2000;97(11):6202-6. PMID: 10823960.
Janda KD. New directions in immunopharmacotherapy. In: Mulzer J, Bohlmann R, editors. The Role of Natural Products in Drug Discovery (Ernst Schering Research Foundation Workshop 32). 2000/11/15 ed. Berlin, Heidelberg: Springer Verlag; 2000. p. 315-46.
Sakurai M, Wirsching P, Janda KD. Design and synthesis of a cocaine-diamide hapten for vaccine development. Tetrahedron Lett. 1996;37(31):5479-82.
Carrera MR, Ashley JA, Parsons LH, Wirsching P, Koob GF, Janda KD. Suppression of psychoactive effects of cocaine by active immunization. Nature. 1995;378(6558):727-30. PMID: 7501020.
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