BACTERIAL CELL-CELL COMMUNICATION
Rayo J, Gregor R, Jacob NT, Dandela R, Dubinsky L, Yashkin A, Aranovich A, Thangaraj M, Ernst O, Barash E, Malitsky S, Florea BI, Krom BP, Wiemer EAC, Kickhoefer VA, Rome LH, Mathison JC, Kaufmann GF, Overkleeft HS, Cravatt BF, Zor T, Janda KD, Ulevitch RJ, Kravchenko VV, Meijler MM. Immunoediting role for major vault protein in apoptotic signaling induced by bacterial N-acyl homoserine lactones. Proc Natl Acad Sci U S A. 2021;118(12). PMID: 33723037.
Blake S, Thanissery R, Rivera AJ, Hixon MS, Lin M, Theriot CM, Janda KD. Salicylanilide analog minimizes relapse of Clostridioides difficile infection in mice. J Med Chem. 2020;63(13):6898-908. PMID: 32482070.
Collins KC, Tsuchikama K, Lowery CA, Zhu J, Janda KD. Dissecting AI-2-mediated quorum sensing through C5-analogue synthesis and biochemical analysis. Tetrahedron. 2016;72(25):3593-8. PMID: 27340303.
Gooyit M, Janda KD. Reprofiled anthelmintics abate hypervirulent stationary-phase Clostridium difficile. Sci Rep. 2016;6:33642. PMID: 27633064.
Gooyit MD, Janda KD. Modulation of the surface-layer protein of Clostridium difficile through Cwp84 inhibition. ACS Infect Dis. 2016;2(7):465-70. PMID: 27626098.
Tararina MA, Janda KD, Allen KN. Structural analysis provides mechanistic insight into nicotine oxidoreductase from Pseudomonas putida. Biochemistry. 2016;55(48):6595-8. PMID: 27933790.
Tsuchikama K, Gooyit M, Harris TL, Zhu J, Globisch D, Kaufmann GF, Janda KD. Glycation reactivity of a quorum-sensing signaling molecule. Angew Chem Int Ed Engl. 2016;55(12):4002-6. PMID: 26890076.
Zhu J, Cai X, Harris TL, Gooyit M, Wood M, Lardy M, Janda KD. Disarming Pseudomonas aeruginosa virulence factor LasB by leveraging a Caenorhabditis elegans infection model. Chem Biol. 2015;22(4):483-91. PMID: 25892201.
Fullagar JL, Garner AL, Struss AK, Day JA, Martin DP, Yu J, Cai X, Janda KD, Cohen SM. Antagonism of a zinc metalloprotease using a unique metal-chelating scaffold: Tropolones as inhibitors of P. aeruginosa elastase. Chem Commun (Camb). 2013;49(31):3197-9. PMID: 23482955.
Garner AL, Yu J, Struss AK, Kaufmann GF, Kravchenko VV, Janda KD. Immunomodulation and the quorum sensing molecule 3-oxo-C12-homoserine lactone: The importance of chemical scaffolding for probe development. Chem Commun (Camb). 2013;49(15):1515-7. PMID: 23328974.
Garner AL, Fullagar JL, Day JA, Cohen SM, Janda KD. Development of a high-throughput screen and its use in the discovery of Streptococcus pneumoniae immunoglobulin A1 protease inhibitors. J Am Chem Soc. 2013;135(27):10014-7. PMID: 23808771.
Kravchenko V, Garner AL, Mathison J, Seit-Nebi A, Yu J, Gileva IP, Ulevitch R, Janda KD. Facilitating cytokine-mediated cancer cell death by proteobacterial N-acylhomoserine lactones. ACS Chem Biol. 2013;8(6):1117-20. PMID: 23517377.
Lowery CA, Matamouros S, Niessen S, Zhu J, Scolnick J, Lively JM, Cravatt BF, Miller SI, Kaufmann GF, Janda KD. A chemical biology approach to interrogate quorum-sensing regulated behaviors at the molecular and cellular level. Chem Biol. 2013;20(7):903-11. PMID: 23890008.
Struss AK, Nunes A, Waalen J, Lowery CA, Pullanikat P, Denery JR, Conrad DJ, Kaufmann GF, Janda KD. Toward implementation of quorum sensing autoinducers as biomarkers for infectious disease states. Anal Chem. 2013;85(6):3355-62. PMID: 23391272.
Zhu J, Hixon MS, Globisch D, Kaufmann GF, Janda KD. Mechanistic insights into the LsrK kinase required for autoinducer-2 quorum sensing activation. J Am Chem Soc. 2013;135(21):7827-30. PMID: 23672516.
Garner AL, Struss AK, Fullagar JL, Agrawal A, Moreno AY, Cohen SM, Janda KD. 3-Hydroxy-1-alkyl-2-methylpyridine-4(1H)-thiones: Inhibition of the Pseudomonas aeruginosa virulence factor LasB. ACS Med Chem Lett. 2012;3(8):668-72. PMID: 23181168.
Globisch D, Lowery CA, McCague KC, Janda KD. Uncharacterized 4,5-dihydroxy-2,3-pentanedione (DPD) molecules revealed through NMR spectroscopy: Implications for a greater signaling diversity in bacterial species. Angew Chem Int Ed Engl. 2012;51(17):4204-8. PMID: 22378693.
Kravchenko VV, Gloeckner C, Stowe GN, Kang YJ, Tobias PS, Mathison JC, Ulevitch RJ, Kaufmann GF, Janda KD. The use of small molecule probes to study spatially separated stimulus-induced signaling pathways. Bioorg Med Chem Lett. 2012;22(5):2043-5. PMID: 22300658.
Romano AA, Hahn T, Davis N, Lowery CA, Struss AK, Janda KD, Bottger LH, Matzanke BF, Carrano CJ. The Fe(III) and Ga(III) coordination chemistry of 3-(1-hydroxymethylidene) and 3-(1-hydroxydecylidene)-5-(2-hydroxyethyl)pyrrolidine-2,4-dione: Novel tetramic acid degradation products of homoserine lactone bacterial quorum sensing molecules. J Inorg Biochem. 2012;107(1):96-103. PMID: 22178671.
von Hoven G, Kloft N, Neukirch C, Ebinger S, Bobkiewicz W, Weis S, Boller K, Janda KD, Husmann M. Modulation of translation and induction of autophagy by bacterial exoproducts. Med Microbiol Immunol. 2012;201(4):409-18. PMID: 22991039.
Garner AL, Park J, Zakhari JS, Lowery CA, Struss AK, Sawada D, Kaufmann GF, Janda KD. A multivalent probe for AI-2 quorum-sensing receptors. J Am Chem Soc. 2011;133(40):15934-7. PMID: 21913711.
Garner AL, Yu J, Struss AK, Lowery CA, Zhu J, Kim SK, Park J, Mayorov AV, Kaufmann GF, Kravchenko VV, Janda KD. Synthesis of 'clickable' acylhomoserine lactone quorum sensing probes: Unanticipated effects on mammalian cell activation. Bioorg Med Chem Lett. 2011;21(9):2702-5. PMID: 21190852.
Kaufmann GF, Park J, Mayorov AV, Kubitz DM, Janda KD. Generation of quorum quenching antibodies. Methods Mol Biol. 2011;692:299-311. PMID: 21031321.
Kirchdoerfer RN, Garner AL, Flack CE, Mee JM, Horswill AR, Janda KD, Kaufmann GF, Wilson IA. Structural basis for ligand recognition and discrimination of a quorum-quenching antibody. J Biol Chem. 2011;286(19):17351-8. PMID: 21454495.
Lowery CA, Kaufmann GF, Janda KD. Determination of acyl homoserine lactone and tetramic acid concentrations in biological samples. Methods Mol Biol. 2011;692:101-11. PMID: 21031307.
Tsuchikama K, Lowery CA, Janda KD. Probing autoinducer-2 based quorum sensing: The biological consequences of molecules unable to traverse equilibrium states. J Org Chem. 2011;76(17):6981-9. PMID: 21678949.
Zakhari JS, Kinoyama I, Struss AK, Pullanikat P, Lowery CA, Lardy M, Janda KD. Synthesis and molecular modeling provide insight into a Pseudomonas aeruginosa quorum sensing conundrum. J Am Chem Soc. 2011;133(11):3840-2. PMID: 21348514.
Lowery CA, Salzameda NT, Sawada D, Kaufmann GF, Janda KD. Medicinal chemistry as a conduit for the modulation of quorum sensing. J Med Chem. 2010;53(21):7467-89. PMID: 20669927.
Lowery CA, Park J, Gloeckner C, Meijler MM, Mueller RS, Boshoff HI, Ulrich RL, Barry CE, 3rd, Bartlett DH, Kravchenko VV, Kaufmann GF, Janda KD. Defining the mode of action of tetramic acid antibacterials derived from Pseudomonas aeruginosa quorum sensing signals. J Am Chem Soc. 2009;131(40):14473-9. PMID: 19807189.
Lowery CA, Abe T, Park J, Eubanks LM, Sawada D, Kaufmann GF, Janda KD. Revisiting AI-2 quorum sensing inhibitors: Direct comparison of alkyl-DPD analogues and a natural product fimbrolide. J Am Chem Soc. 2009;131(43):15584-5. PMID: 19824634.
Kaufmann GF, Park J, Janda KD. Bacterial quorum sensing: A new target for anti-infective immunotherapy. Expert Opin Biol Ther. 2008;8(6):719-24. PMID: 18476783.
Kaufmann GF, Park J, Mee JM, Ulevitch RJ, Janda KD. The quorum quenching antibody RS2-1G9 protects macrophages from the cytotoxic effects of the Pseudomonas aeruginosa quorum sensing signalling molecule N-3-oxo-dodecanoyl-homoserine lactone. Mol Immunol. 2008;45(9):2710-4. PMID: 18304641.
Kravchenko VV, Kaufmann GF, Mathison JC, Scott DA, Katz AZ, Grauer DC, Lehmann M, Meijler MM, Janda KD, Ulevitch RJ. Modulation of gene expression via disruption of NF-κB signaling by a bacterial small molecule. Science. 2008;321(5886):259-63. PMID: 18566250
Lowery CA, Park J, Kaufmann GF, Janda KD. An unexpected switch in the modulation of AI-2-based quorum sensing discovered through synthetic 4,5-dihydroxy-2,3-pentanedione analogues. J Am Chem Soc. 2008;130(29):9200-1. PMID: 18576653.
Lowery CA, Dickerson TJ, Janda KD. Interspecies and interkingdom communication mediated by bacterial quorum sensing. Chem Soc Rev. 2008;37(7):1337-46. PMID: 18568160.
Park J, Kaufmann GF, Bowen JP, Arbiser JL, Janda KD. Solenopsin A, a venom alkaloid from the fire ant Solenopsis invicta, inhibits quorum-sensing signaling in Pseudomonas aeruginosa. J Infect Dis. 2008;198(8):1198-201. PMID: 18713055.
De Lamo Marin S, Xu Y, Meijler MM, Janda KD. Antibody catalyzed hydrolysis of a quorum sensing signal found in Gram-negative bacteria. Bioorg Med Chem Lett. 2007;17(6):1549-52. PMID: 17254784.
Debler EW, Kaufmann GF, Kirchdoerfer RN, Mee JM, Janda KD, Wilson IA. Crystal structures of a quorum-quenching antibody. J Mol Biol. 2007;368(5):1392-402. PMID: 17400249.
Park J, Jagasia R, Kaufmann GF, Mathison JC, Ruiz DI, Moss JA, Meijler MM, Ulevitch RJ, Janda KD. Infection control by antibody disruption of bacterial quorum sensing signaling. Chem Biol. 2007;14(10):1119-27. PMID: 17961824.
Kaufmann GF, Sartorio R, Lee SH, Mee JM, Altobell LJ, 3rd, Kujawa DP, Jeffries E, Clapham B, Meijler MM, Janda KD. Antibody interference with N-acyl homoserine lactone-mediated bacterial quorum sensing. J Am Chem Soc. 2006;128(9):2802-3. PMID: 16506750.
Shigenaga A, Moss JA, Ashley FT, Kaufmann GF, Janda KD. Solid-phase synthesis and cyclative cleavage of quorum sensing depsipeptide analogues by acylphenyldiazene activation. Synlett. 2006;2006(4):0551-4.
Kaufmann GF, Sartorio R, Lee SH, Rogers CJ, Meijler MM, Moss JA, Clapham B, Brogan AP, Dickerson TJ, Janda KD. Revisiting quorum sensing: Discovery of additional chemical and biological functions for 3-oxo-N-acylhomoserine lactones. Proc Natl Acad Sci U S A. 2005;102(2):309-14. PMID: 15623555.
Lowery CA, McKenzie KM, Qi L, Meijler MM, Janda KD. Quorum sensing in Vibrio harveyi: Probing the specificity of the LuxP binding site. Bioorg Med Chem Lett. 2005;15(9):2395-8. PMID: 15837332.
McKenzie KM, Meijler MM, Lowery CA, Boldt GE, Janda KD. A furanosyl-carbonate autoinducer in cell-to-cell communication of V. harveyi. Chem Commun (Camb). 2005;10.1039/b509396a(38):4863-5. PMID: 16193140.
Meijler MM, Hom LG, Kaufmann GF, McKenzie KM, Sun C, Moss JA, Matsushita M, Janda KD. Synthesis and biological validation of a ubiquitous quorum-sensing molecule. Angew Chem Int Ed Engl. 2004;43(16):2106-8. PMID: 15083457.
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