CATALYTIC ANTIBODIES
Lin M, Eubanks LM, Karadkhelkar NM, Blake S, Janda KD. Catalytic Antibody Blunts Carfentanil-Induced Respiratory Depression. ACS Pharmacol Transl Sci. 2023;6(5):802-11. PMID: 37200811.
Brogan AP, Dickerson TJ, Janda KD. Catalytic antibodies: Past, Present, and Future. In: Begley TP, editor. Wiley Encyclopedia of Chemical Biology: John Wiley & Sons; 2009. p. 1987-2003.
Mayorov AV, Amara N, Chang JY, Moss JA, Hixon MS, Ruiz DI, Meijler MM, Zorrilla EP, Janda KD. Catalytic antibody degradation of ghrelin increases whole-body metabolic rate and reduces refeeding in fasting mice. Proc Natl Acad Sci U S A. 2008;105(45):17487-92. PMID: 18981425.
Brogan AP, Eubanks LM, Koob GF, Dickerson TJ, Janda KD. Antibody-catalyzed oxidation of △(9)-tetrahydrocannabinol. J Am Chem Soc. 2007;129(12):3698-702. PMID: 17335216.
De Lamo Marin S, Xu Y, Meijler MM, Janda KD. Antibody catalyzed hydrolysis of a quorum sensing signal found in Gram-negative bacteria. Bioorg Med Chem Lett. 2007;17(6):1549-52. PMID: 17254784.
McKenzie KM, Mee JM, Rogers CJ, Hixon MS, Kaufmann GF, Janda KD. Identification and characterization of single chain anti-cocaine catalytic antibodies. J Mol Biol. 2007;365(3):722-31. PMID: 17084858.
Xu Y, Hixon MS, Yamamoto N, McAllister LA, Wentworth AD, Wentworth P, Jr., Janda KD. Antibody-catalyzed anaerobic destruction of methamphetamine. Proc Natl Acad Sci U S A. 2007;104(10):3681-6. PMID: 17360412.
Zhu X, Dickerson TJ, Rogers CJ, Kaufmann GF, Mee JM, McKenzie KM, Janda KD, Wilson IA. Complete reaction cycle of a cocaine catalytic antibody at atomic resolution. Structure. 2006;14(2):205-16. PMID: 16472740.
Carrera MR, Trigo JM, Wirsching P, Roberts AJ, Janda KD. Evaluation of the anticocaine monoclonal antibody GNC92H2 as an immunotherapy for cocaine overdose. Pharmacol Biochem Behav. 2005;81(4):709-14. PMID: 16005948.
Toker JD, Tremblay MR, Yli-Kauhaluoma J, Wentworth AD, Zhou B, Wentworth P, Jr., Janda KD. Exploring the scope of the 29G12 antibody catalyzed 1,3-dipolar cycloaddition reaction. J Org Chem. 2005;70(20):7810-5. PMID: 16277300.
Xu Y, Yamamoto N, Ruiz DI, Kubitz DS, Janda KD. Squaric monoamide monoester as a new class of reactive immunization hapten for catalytic antibodies. Bioorg Med Chem Lett. 2005;15(19):4304-7. PMID: 16046128.
Dickerson TJ, Yamamoto N, Janda KD. Antibody-catalyzed oxidative degradation of nicotine using riboflavin. Bioorg Med Chem. 2004;12(18):4981-7. PMID: 15336277.
Janda KD, Chen D-W. Catalytic antibodies. In: Atwood JL, Steed JW, editors. Encyclopedia of Supramolecular Chemistry. 1st ed. New York, NY: Marcel Dekker Inc.; 2004. p. 193-205.
McDunn JE, Dickerson TJ, Janda KD. Antibody catalysis of disfavored chemical reactions. In: Keinan E, editor. Catalytic Antibodies. Weinheim, Germany: Wiley-VCH Verlag Gmbh & Co; 2004. p. 184-216.
Xu Y, Yamamoto N, Janda KD. Catalytic antibodies: Hapten design strategies and screening methods. Bioorg Med Chem. 2004;12(20):5247-68. PMID: 15388154.
Cannizzaro CE, Ashley JA, Janda KD, Houk KN. Experimental determination of the absolute enantioselectivity of an antibody-catalyzed Diels-Alder reaction and theoretical explorations of the origins of stereoselectivity. J Am Chem Soc. 2003;125(9):2489-506. PMID: 12603137.
Dickerson TJ, Tremblay MR, Hoffman TZ, Ruiz DI, Janda KD. Catalysis of the photo-Fries reaction: Antibody-mediated stabilization of high energy states. J Am Chem Soc. 2003;125(50):15395-401. PMID: 14664584.
Hasserodt J, Janda KD. Catalytic antibodies. In: Horvath IT, editor. Encyclopedia of Catalysis. New York: Wiley; 2003. p. 440-76.
Matsushita M, Yoshida K, Yamamoto N, Wirsching P, Lerner RA, Janda KD. High-throughput screening by using a blue-fluorescent antibody sensor. Angew Chem Int Ed Engl. 2003;42(48):5984-7. PMID: 14679549.
Wentworth P, Jr., Nieva J, Takeuchi C, Galve R, Wentworth AD, Dilley RB, DeLaria GA, Saven A, Babior BM, Janda KD, Eschenmoser A, Lerner RA. Evidence for ozone formation in human atherosclerotic arteries. Science. 2003;302(5647):1053-6. PMID: 14605372.
Wentworth P, Jr., Wentworth AD, Zhu X, Wilson IA, Janda KD, Eschenmoser A, Lerner RA. Evidence for the production of trioxygen species during antibody-catalyzed chemical modification of antigens. Proc Natl Acad Sci U S A. 2003;100(4):1490-3. PMID: 12576548.
Zhu X, Heine A, Monnat F, Houk KN, Janda KD, Wilson IA. Structural basis for antibody catalysis of a cationic cyclization reaction. J Mol Biol. 2003;329(1):69-83. PMID: 12742019.
Delgado M, Lee KJ, Altobell L, 3rd, Spanka C, Wentworth P, Jr., Janda KD. A parallel approach to the discovery of carrier delivery vehicles to enhance antigen immunogenicity. J Am Chem Soc. 2002;124(18):4946-7. PMID: 11982344.
Dickerson T, Córdova A, Chen D-W, Janda KD. The use of enzymes and catalytic antibodies in the asymmetric aldol reaction. In: Horvath IT, editor. Encyclopedia of Catalysis. 1st ed. New York: Wiley; 2002.
Dickerson TJ, Janda KD. Aqueous aldol catalysis by a nicotine metabolite. J Am Chem Soc. 2002;124(13):3220-1. PMID: 11916401.
Isomura S, Ashley JA, Wirsching P, Janda KD. Antibody-catalyzed cleavage of the D-Ala-D-Lac depsipeptide: An immunological approach to the problem of vancomycin resistance. Bioorg Med Chem Lett. 2002;12(6):861-4. PMID: 11958980.
Jones LH, Altobell LJ, 3rd, MacDonald MT, Boyle NA, Wentworth P, Jr., Lerner RA, Janda KD. Active immunization with a glycolipid transition state analogue protects against endotoxic shock. Angew Chem Int Ed Engl. 2002;41(22):4241-4. PMID: 12434351.
Kim GT, Wenz M, Park JI, Hasserodt J, Janda KD. Polyene substrates with unusual methylation patterns to probe the active sites of three catalytic antibodies. Bioorg Med Chem. 2002;10(5):1249-62. PMID: 11886788.
Nicholas KM, Wentworth P, Jr., Harwig CW, Wentworth AD, Shafton A, Janda KD. A cofactor approach to copper-dependent catalytic antibodies. Proc Natl Acad Sci U S A. 2002;99(5):2648-53. PMID: 11880619.
Wentworth P, Jr., McDunn JE, Wentworth AD, Takeuchi C, Nieva J, Jones T, Bautista C, Ruedi JM, Gutierrez A, Janda KD, Babior BM, Eschenmoser A, Lerner RA. Evidence for antibody-catalyzed ozone formation in bacterial killing and inflammation. Science. 2002;298(5601):2195-9. PMID: 12434011.
Brümmer O, Hoffman TZ, Janda KD. Metalloantibodies: Mercury(II)-dependent acyl transferases. Bioorg Med Chem. 2001;9(9):2253-7. PMID: 11553463.
Brümmer O, Hoffman TZ, Chen D-W, Janda KD. Antibody-catalyzed hydrolysis of oligomeric esters: A model for the degradation of polymeric materials. Chem Commun. 2001;1:19-20.
Chen D-W, Kubiak RJ, Ashley JA, Janda KD. Reactive immunization elicits catalytic antibodies for polyester hydrolysis. J Chem Soc, Perkin Trans 1. 2001;10.1039/B105412K(21):2796-803.
Chen DW, Beuscher AEt, Stevens RC, Wirsching P, Lerner RA, Janda KD. Preparation of stilbene-tethered nonnatural nucleosides for use with blue-fluorescent antibodies. J Org Chem. 2001;66(5):1725-32. PMID: 11262119.
Córdova A, Janda KD. Synthesis and catalytic antibody functionalization of dendrimers. J Am Chem Soc. 2001;123(34):8248-59. PMID: 11516276.
Córdova A, Tremblay MR, Clapham B, Janda KD. A sequential application of kinetic resolution and polymer-supported scavenging for the isolation of chiral secondary alcohols. J Org Chem. 2001;66(16):5645-8. PMID: 11485501.
Jones LH, Harwig CW, Wentworth P, Jr., Simeonov A, Wentworth AD, Py S, Ashley JA, Lerner RA, Janda KD. Conversion of enediynes into quinones by antibody catalysis and in aqueous buffers: Implications for an alternative enediyne therapeutic mechanism. J Am Chem Soc. 2001;123(15):3607-8. PMID: 11472138.
Matsushita M, Hoffman TZ, Ashley JA, Zhou B, Wirsching P, Janda KD. Cocaine catalytic antibodies: The primary importance of linker effects. Bioorg Med Chem Lett. 2001;11(2):87-90. PMID: 11206477.
Tremblay Martin R, Dickerson Tobin J, Janda Kim D. Advances in antibody catalysis of cycloaddition reactions. Adv Synth Catal. 2001;343(6-7):577-85.
Wentworth P, Jr., Janda KD. Catalytic antibodies: Structure and function. Cell Biochem Biophys. 2001;35(1):63-87. PMID: 11898856.
Wentworth P, Jr., Jones LH, Wentworth AD, Zhu X, Larsen NA, Wilson IA, Xu X, Goddard WA, 3rd, Janda KD, Eschenmoser A, Lerner RA. Antibody catalysis of the oxidation of water. Science. 2001;293(5536):1806-11. PMID: 11546867.
Harwig CW, Hoffman TZ, Wentworth AD, Janda KD. A one-pot multistep approach to alpha-azido-phosphonate and phosphonothioate diesters: Key intermediates in the synthesis of haptens for the generation of antibody ligases. Bioorg Med Chem Lett. 2000;10(9):915-8. PMID: 10853659.
Hasserodt J, Janda KD, Lerner RA. Antibodies mimic natural oxidosqualene−cyclase action in steroid ring a formation. J Am Chem Soc. 2000;122(1):40-5.
Hasserodt J, Janda KD, Lerner RA. A class of 4-aza-lithocholic acid-derived haptens for the generation of catalytic antibodies with steroid synthase capabilities. Bioorg Med Chem. 2000;8(5):995-1003. PMID: 10882011.
Simeonov A, Matsushita M, Juban EA, Thompson EH, Hoffman TZ, Beuscher AEt, Taylor MJ, Wirsching P, Rettig W, McCusker JK, Stevens RC, Millar DP, Schultz PG, Lerner RA, Janda KD. Blue-fluorescent antibodies. Science. 2000;290(5490):307-13. PMID: 11030644.
Toker JD, Wentworth P, Hu Y, Houk KN, Janda KD. Antibody-catalysis of a bimolecular asymmetric 1,3-dipolar cycloaddition reaction. J Am Chem Soc. 2000;122(13):3244-5.
Wentworth AD, Jones LH, Wentworth P, Jr., Janda KD, Lerner RA. Antibodies have the intrinsic capacity to destroy antigens. Proc Natl Acad Sci U S A. 2000;97(20):10930-5. PMID: 11005865.
Brümmer O, Gao C, Mao S, Weiner DP, Janda KD. Design, synthesis and characterization of panning agents for the selection of metalloantibodies. Lett Pept Sci. 1999;6(5-6):295-302.
Brümmer O, Wentworth P, Weiner DP, Janda KD. Phosphorodithioates: Synthesis and evaluation of new haptens for the generation of antibody acyl transferases. Tetrahedron Lett. 1999;40(41):7307-10.
Datta A, Wentworth P, Shaw JP, Simeonov A, Janda KD. Catalytically distinct antibodies prepared by the reactive immunization versus transition state analogue hapten manifolds. J Am Chem Soc. 1999;121(45):10461-7.
Gao C, Brümmer O, Mao S, Janda KD. Selection of human metalloantibodies from a combinatorial phage single-chain antibody library. J Am Chem Soc. 1999;121(27):6517-8.
Janda KD, Wentworth AD. A merging of chemistry and biology in terms of antibody catalysis. Phosphorus, Sulfur, and Silicon and the Related Elements. 1999;144(1):117-20.
Paschall CM, Hasserodt J, Jones T, Lerner RA, Janda KD, Christianson DW. Convergence of catalytic antibody and terpene cyclase mechanisms: Polyene cyclization directed by carbocation-𝞹 Interaction. Angew Chem Int Ed Engl. 1999;38(12):1743-7. PMID: 29711206.
Spivak DA, Hoffman TZ, Moore AH, Taylor MJ, Janda KD. A comparison of flexible and constrained haptens in eliciting antibody catalysts for paraoxon hydrolysis. Bioorg Med Chem. 1999;7(6):1145-50. PMID: 10428386.
Taylor MJ, Yli-Kauhaluoma JT, Ashley JA, Wirsching P, Lerner RA, Janda KD. The α-ketoamide group: A new motif for the elicitation of catalytic antibodies for acyl-transfer reactions. J Chem Soc, Perkin Trans 1. 1999;10.1039/A902475A(9):1133-4.
Wentworth P, Janda KD. Antibody catalysis of phosphodiester hydrolysis: A survey of hapten strategies. Phosphorus, Sulfur, and Silicon and the Related Elements. 1999;144(1):247-50.
Wentworth P, Jr., Janda KD. Catalytic antibodies. In: Jacobsen EN, Pfaltz A, Yamamoto H, editors. Comprehensive Asymmetric Catalysis. New York: Springer-Verlag; 1999. p. 1403-22.
Gao C, Lavey BJ, Lo C-HL, Datta A, Wentworth P, Janda KD. Direct selection for catalysis from combinatorial antibody libraries using a boronic acid probe: Primary amide bond hydrolysis. J Am Chem Soc. 1998;120(10):2211-7.
Heine A, Stura EA, Yli-Kauhaluoma JT, Gao C, Deng Q, Beno BR, Houk KN, Janda KD, Wilson IA. An antibody exo Diels-Alderase inhibitor complex at 1.95 angstrom resolution. Science. 1998;279(5358):1934-40. PMID: 9506943.
Lerner RA, Barbas CF, 3rd, Janda KD. Making enzymes. In: Folkman J, Goeddel DV, Hogan BLM, Hood L, Klausner RD, Lerner RA, et al., editors. The Harvey Lectures 1996-1997: Wiley-Liss; 1998. p. 1-40.
Lin C-H, Z. Hoffman T, Xie Y. An antibody transesterase derived from reactive immunization that utilizes a wide variety of alcohol substrates. Chem Commun. 1998;10.1039/A801569D(10):1075-6.
Taylor MJ, Hoffman TZ, Yli-Kauhaluoma JT, Lerner RA, Janda KD. A light-activated antibody catalyst. J Am Chem Soc. 1998;120(49):12783-90.
Wentworth P, Janda KD. Catalytic antibodies. Curr Opin Chem Biol. 1998;2(1):138-44. PMID: 9667908.
Wentworth P, Jr., Liu Y, Wentworth AD, Fan P, Foley MJ, Janda KD. A bait and switch hapten strategy generates catalytic antibodies for phosphodiester hydrolysis. Proc Natl Acad Sci U S A. 1998;95(11):5971-5. PMID: 9600901.
Gao C, Lin CH, Lo CH, Mao S, Wirsching P, Lerner RA, Janda KD. Making chemistry selectable by linking it to infectivity. Proc Natl Acad Sci U S A. 1997;94(22):11777-82. PMID: 9342313.
Hasserodt J, Janda KD. Syntheses of octahydroquinoline-N-oxides: Haptens designed to elicit catalytic antibodies that control a terpenoid-like cascade cyclisation. Tetrahedron. 1997;53(33):11237-56.
Hasserodt J, Janda KD, Lerner RA. Formation of bridge-methylated decalins by antibody-catalyzed tandem cationic cyclization. J Am Chem Soc. 1997;119(26):5993-8.
Janda KD, Lo LC, Lo CH, Sim MM, Wang R, Wong CH, Lerner RA. Chemical selection for catalysis in combinatorial antibody libraries. Science. 1997;275(5302):945-8. PMID: 9020070.
Li T, Lerner RA, Janda KD. Antibody-catalyzed cationic reactions: Rerouting of chemical transformations via antibody catalysis. Acc Chem Res. 1997;30(3):115-21.
Lin CH, Hoffman TZ, Wirsching P, Barbas CF, 3rd, Janda KD, Lerner RA. On roads not taken in the evolution of protein catalysts: Antibody steroid isomerases that use an enamine mechanism. Proc Natl Acad Sci U S A. 1997;94(22):11773-6. PMID: 9342312.
Lo C-HL, Wentworth P, Jung KW, Yoon J, Ashley JA, Janda KD. Reactive immunization strategy generates antibodies with high catalytic proficiencies. J Am Chem Soc. 1997;119(42):10251-2.
Weiner DP, Wiemann T, Wolfe MM, Wentworth P, Janda KD. A pentacoordinate oxorhenium(V) metallochelate elicits antibody catalysts for phosphodiester cleavage. J Am Chem Soc. 1997;119(17):4088-9.
Wentworth Jr P, Janda KD. Synthesis of oxorhenium (V) and oxotechnetium (V) complexes as inhibitors of ribonucleases and for the generation of catalytic antibodies. Synlett. 1997;1997(05):537-43.
Hasserodt J, Janda KD, Lerner RA. Antibody catalyzed terpenoid cyclization. J Am Chem Soc. 1996;118(46):11654-5.
Janda KD, Shevlin CG, Lo C-HL. Catalytic antibodies: Chemical and biological approaches. In: Atwood JL, Davies JED, MacNicol DD, Vögtle F, editors. Comprehensive Supramolecular Chemistry. 1st ed: Pergamon, New York; 1996. p. 43-72.
Lavey BJ, Janda KD. Catalytic antibody mediated hydrolysis of paraoxon. J Org Chem. 1996;61(21):7633-6. PMID: 11667704.
Lavey BJ, Janda KD. Antibody catalyzed hydrolysis of a phosphotriester. Bioorg Med Chem Lett. 1996;6(13):1523-4.
Li T, Janda KD, Lerner RA. Cationic cyclopropanation by antibody catalysis. Nature. 1996;379(6563):326-7. PMID: 8552185.
Lo C-HL, Gao C, Mao S, Matsui K, Lerner RA, Janda KD. Chain shuffling: Investigations into the specificity and selectivity of antibody catalysis. Isr J Chem. 1996;36(2):195-8.
Lo LC, Lo C-HL, Janda KD, Kassel DB, Raushel FM. A versatile mechanism based reaction probe for the direct selection of biocatalysts. Bioorg Med Chem Lett. 1996;6(17):2117-20.
Sakurai M, Wirsching P, Janda KD. Synthesis of a nucleoside hapten with a [P(O)-O-N] linkage to elicit catalytic antibodies with phosphodiesterase activity. Bioorg Med Chem Lett. 1996;6(9):1055-60.
Yli-Kauhaluoma JT, Ashley JA, Lo C-HL, Coakley J, Wirsching P, Janda KD. Catalytic antibodies with peptidyl−prolyl cis−trans isomerase activity. J Am Chem Soc. 1996;118(23):5496-7.
Yli-Kauhaluoma JT, Janda KD. Catalytic antibodies: The rerouting of chemical reactions. Towards electrophilic aromatic substitution by carbon dioxide. Ann NY Acad Sci. 1996;799:26-31. PMID: 8958069.
Janda KD, Shevlin CG, Lerner RA. Oxepane synthesis along a disfavored pathway: The rerouting of a chemical reaction using a catalytic antibody. J Am Chem Soc. 1995;117(9):2659-60.
Lavey BJ, Janda KD. Applying antibody catalysis to organic synthesis. In: Wang HY, Imanaka T, editors. Antibody Expression and Engineering (ACS Symposium Series, No 604). 1st ed: American Chemical Society; 1995. p. 123.
Lerner RA, Janda KD. Catalytic antibodies: Evolution of protein function in real time. In: Jollès P, Jörnvall H, editors. Interface between Chemistry and Biochemistry (Experientia Supplementum): Birkhäuser Verlag; 1995. p. 121-38.
Li T, Janda KD, Hilton S, Lerner RA. An antibody-catalyzed nucleophilic substitution reaction at a primary carbon that appears to proceed by an ionization mechanism. J Am Chem Soc. 1995;117(8):2367-8.
Li T, Janda KD. Synthesis of a bifunctional hapten designed to mimic both transition state and to induce “bait and switch” catalysis. Bioorg Med Chem Lett. 1995;5(17):2001-4.
Li T, Hilton S, Janda KD. The potential application of catalytic antibodies to protecting group removal: Catalytic antibodies with broad substrate tolerance. J Am Chem Soc. 1995;117(8):2123-7.
Li T, Hilton S, Janda KD. Remarkable ability of different antibody catalysts to control and diversify the product outcome of cationic cyclization reactions. J Am Chem Soc. 1995;117(11):3308-9.
Rosenblum JS, Lo L-C, Li T, Janda KD, Lerner RA. Antibody-catalyzed phosphate triester hydrolysis. Angew Chem Int Ed Engl. 1995;34(20):2275-7.
Wirsching P, Ashley JA, Lo CH, Janda KD, Lerner RA. Reactive immunization. Science. 1995;270(5243):1775-82. PMID: 8525366.
Yli-Kauhaluoma JT, Ashley JA, Lo C-H, Tucker L, Wolfe MM, Janda KD. Anti-metallocene antibodies: A new approach to enantioselective catalysis of the Diels-Alder reaction. J Am Chem Soc. 1995;117(27):7041-7.
Cravatt BF, Ashley JA, Janda KD, Boger DL, Lerner RA. Crossing extreme mechanistic barriers by antibody catalysis: Syn elimination to a cis olefin. J Am Chem Soc. 1994;116(13):6013-4.
Janda KD. Catalytic antibodies and enzyme inhibitors. Pure & Appl Chem. 1994;66(4):703-8.
Janda KD, Lo CH, Li T, Barbas CF, 3rd, Wirsching P, Lerner RA. Direct selection for a catalytic mechanism from combinatorial antibody libraries. Proc Natl Acad Sci U S A. 1994;91(7):2532-6. PMID: 8146149.
Janda KD, Chen Y-CJ. Chemical and biological approaches to catalytic antibodies. In: Rosenberg M, Moore GP, editors. Handbook of Experimental Pharmacology: The Pharmacology of Monoclonal Antibodies. 1st ed: Springer; 1994. p. 209-41.
Li T, Janda KD, Ashley JA, Lerner RA. Antibody catalyzed cationic cyclization. Science. 1994;264(5163):1289-93. PMID: 8191282.
Shevlin CG, Hilton S, Janda KD. Automation of antibody catalysis: A practical methodology for the use of catalytic antibodies in organic synthesis. Bioorg Med Chem Lett. 1994;4(2):297-302.
Yli-Kauhaluoma J, Janda KD. Twisted α-keto amides as transition-state analogues for acyl-transfer reactions: Synthesis of the immunoconjugates. Bioorg Med Chem. 1994;2(6):521-8. PMID: 7528089.
Ashley JA, Lo CHL, McElhaney GP, Wirsching P, Janda KD. Catalytic antibody model for PLP-dependent decarboxylases. J Am Chem Soc. 1993;115(6):2515-6.
Chen YCJ, Danon T, Sastry L, Mubaraki M, Janda KD, Lerner RA. Catalytic antibodies from combinatorial libraries. J Am Chem Soc. 1993;115(1):357-8.
Gouverneur VE, Houk KN, de Pascual-Teresa B, Beno B, Janda KD, Lerner RA. Control of the exo and endo pathways of the Diels-Alder reaction by antibody catalysis. Science. 1993;262(5131):204-8. PMID: 8211138.
Ikeda S, Janda KD. Recent development on the research of catalytic antibodies and their applications. Journal of Synthetic Organic Chemistry (Japan). 1993;51(4):284-97.
Janda KD. Catalytic antibodies: The rerouting of chemical reactions. Biochem Soc Trans. 1993;21(4):1090-5. PMID: 8131905.
Janda KD, Shevlin CG, Lerner RA. Antibody catalysis of a disfavored chemical transformation. Science. 1993;259(5094):490-3. PMID: 8424171.
Na J, Houk KN, Shevlin CG, Janda KD, Lerner RA. The energetic advantage of 5-exo versus 6-endo epoxide openings: a preference overwhelmed by antibody catalysis. J Am Chem Soc. 1993;115(18):8453-4.
Wade WS, Ashley JA, Jahangiri GK, McElhaney G, Janda KD, Lerner RA. A highly specific metal-activated catalytic antibody. J Am Chem Soc. 1993;115(11):4906-7.
Ashley JA, Janda KD. Antibody catalysis in low water content media. J Org Chem. 1992;57(25):6691-3.
Chen YCJ, Janda KD. A new approach toward the inhibition of ribonucleases: A water-stable ribonucleoside-technetium chelate. J Am Chem Soc. 1992;114(4):1488-9.
Fernholz E, Schloeder D, Liu KKC, Bradshaw CW, Huang H, Janda K, Lerner RA, Wong CH. Specificity of antibody-catalyzed transesterifications using enol esters: A comparison with lipase reactions. J Org Chem. 1992;57(17):4756-61.
Gibbs RA, Benkovic PA, Janda KD, Lerner RA, Benkovic SJ. Substituent effects of an antibody-catalyzed hydrolysis of phenyl esters: Further evidence for an acyl-antibody intermediate. J Am Chem Soc. 1992;114(9):3528-34.
Reymond JL, Janda KD, Lerner RA. Highly enantioselective protonation catalyzed by an antibody. J Am Chem Soc. 1992;114(6):2257-8.
Benkovic SJ, Adams J, Janda KD, Lerner RA. A catalytic antibody uses a multistep kinetic sequence. Ciba Found Symp. 1991;159:4-12. PMID: 1959451.
Fujii I, Lerner RA, Janda KD. Enantiofacial protonation by catalytic antibodies. J Am Chem Soc. 1991;113(22):8528-9.
Harada A, Janda KD, Lerner RA. Abzymes to enzymes. Kagaku to Kogyo (Japan). 1991;44:1108.
Hein MB, Tang Y, McLeod DA, Janda KD, Hiatt A. Evaluation of immunoglobulins from plant cells. Biotechnol Prog. 1991;7(5):455-61. PMID: 1367994.
Ikeda S, Weinhouse MI, Janda KD, Lerner RA, Danishefsky SJ. Asymmetric induction via a catalytic antibody. J Am Chem Soc. 1991;113(20):7763-4.
Janda KD, Benkovic SJ, McLeod DA, Schloeder DM, Lerner RA. Substrate attenuation: An approach to improve antibody catalysis. Tetrahedron. 1991;47(14):2503-6.
Janda KD, Ashley JA, Jones TM, McLeod DA, Schloeder DM, Weinhouse MI, Lerner RA, Gibbs RA, Benkovic PA. Catalytic antibodies with acyl-transfer capabilities: Mechanistic and kinetic investigations. J Am Chem Soc. 1991;113(1):291-7.
Janda KD. Opportunities in organic synthesis for catalytic antibodies. Proceedings of 15th ABC Symposium, Kyoto, Japan. 1991;3:63.
Janda KD, Weinhouse MI, Danon T, Pacelli KA, Schloeder DM. Antibody bait and switch catalysis: A survey of antigens capable of inducing abzymes with acyl-transfer properties. J Am Chem Soc. 1991;113(14):5427-34.
McLeod DA, Brinkworth RI, Ashley JA, Janda KD, Wirsching P. Phosphonamidates and phosphonamidate esters as HIV-1 protease inhibitors. Bioorg Med Chem Lett. 1991;1(11):653-8.
Reymond J-L, Janda KD, Lerner RA. Antibody catalysis of glycosidic bond hydrolysis. Angew Chem Int Ed Engl. 1991;30(12):1711-3.
Sastry L, Mubaraki M, Janda KD, Benkovic SJ, Lerner RA. Screening combinatorial antibody libraries for catalytic acyl transfer reactions. Ciba Found Symp. 1991;159:145-51; discussion 51-5. PMID: 1835693.
Wirsching P, Ashley JA, Benkovic SJ, Janda KD, Lerner RA. An unexpectedly efficient catalytic antibody operating by ping-pong and induced fit mechanisms. Science. 1991;252(5006):680-5. PMID: 2024120.
Benkovic SJ, Adams JA, Borders CL, Jr., Janda KD, Lerner RA. The enzymic nature of antibody catalysis: Development of multistep kinetic processing. Science. 1990;250(4984):1135-9. PMID: 2251500.
Janda KD, Ashley JA, Jones TM, McLeod DA, Schloeder DM, Weinhouse MI. Immobilized catalytic antibodies in aqueous and organic solvents. J Am Chem Soc. 1990;112(24):8886-8.
Janda KD. New strategies for the design of catalytic antibodies. Biotechnol Prog. 1990;6(3):178-81. PMID: 1366610.
Janda KD, Weinhouse MI, Schloeder DM, Lerner RA, Benkovic SJ. Bait and switch strategy for obtaining catalytic antibodies with acyl-transfer capabilities. J Am Chem Soc. 1990;112(3):1274-5.
Janda KD, Benkovic SJ, Lerner RA. Catalytic antibodies with lipase activity and R or S substrate selectivity. Science. 1989;244(4903):437-40. PMID: 2717936.
Sastry L, Alting-Mees M, Huse WD, Short JM, Sorge JA, Hay BN, Janda KD, Benkovic SJ, Lerner RA. Cloning of the immunological repertoire in Escherichia coli for generation of monoclonal catalytic antibodies: Construction of a heavy chain variable region-specific cDNA library. Proc Natl Acad Sci U S A. 1989;86(15):5728-32. PMID: 2503822.
Janda KD, Schloeder D, Benkovic SJ, Lerner RA. Induction of an antibody that catalyzes the hydrolysis of an amide bond. Science. 1988;241(4870):1188-91. PMID: 3413482.
Janda KD, Lerner RA, Tramontano A. Antibody catalysis of bimolecular amide formation. J Am Chem Soc. 1988;110(14):4835-7.
Tramontano A, Janda K, Napper AD, Benkovic SJ, Lerner RA. Catalytic antibodies. Cold Spring Harb Symp Quant Biol. 1987;52:91-6. PMID: 3454298.
Tramontano A, Janda KD, Lerner RA. Chemical reactivity at an antibody binding site elicited by mechanistic design of a synthetic antigen. Proc Natl Acad Sci U S A. 1986;83(18):6736-40. PMID: 3462723.
Tramontano A, Janda KD, Lerner RA. Catalytic antibodies. Science. 1986;234(4783):1566-70. PMID: 3787261.
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