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Zorrilla Lab Publications

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Obesity (as of 11/18/2024)

Linking drug and food addiction via compulsive appetite
Br J Pharmacol. 2022 Jun. doi: 10.1111/bph.15797
Laque, A., Wagner, G. E., Matzeu, A., De Ness, G. L., Kerr, T. M., Carroll, A. M., de Guglielmo, G., Nedelescu, H., Buczynski, M. W., Gregus, A. M., Jhou, T. C., Zorrilla, E. P., Martin-Fardon, R., Koya, E., Ritter, R. C., Weiss, F., Suto, N.
[ABSTRACT] [PUBLISHER LINK]

Decreased excitability of leptin-sensitive anterior insula pyramidal neurons in a rat model of compulsive food demand
Neuropharmacology. 2022 May. doi: 10.1016/j.neuropharm.2022.108980
Kirson, D., Spierling, S. R., Murphy, J., Chang, H., Vlkolinsky, R., Pucci, S. N., Prinzi, J., Williams, C. A., Fang, S. Y., Roberto, M., Zorrilla, E. P.
[ABSTRACT] [PUBLISHER LINK]

Insula to ventral striatal projections mediate compulsive eating produced by intermittent access to palatable food
Neuropsychopharmacology. 2020 Mar. doi: 10.1038/s41386-019-0538-x
Spierling, S. R., de Guglielmo, G., Kirson, D., Kreisler, A., Roberto, M., George, O., Zorrilla, E. P.
[ABSTRACT] [PUBLISHER LINK]

The duration of intermittent access to preferred sucrose-rich food affects binge-like intake, fat accumulation, and fasting glucose in male rats
Appetite. 2018 Nov. doi: 10.1016/j.appet.2018.07.025
Kreisler, A. D., Mattock, M., Zorrilla, E. P.
[ABSTRACT] [PUBLISHER LINK]

Intermittent, extended access to preferred food leads to escalated food reinforcement and cyclic whole-body metabolism in rats: Sex differences and individual vulnerability
Physiol Behav. 2018 Aug. doi: 10.1016/j.physbeh.2018.04.001
Spierling, S. R., Kreisler, A. D., Williams, C. A., Fang, S. Y., Pucci, S. N., Kines, K. T., Zorrilla, E. P.
[ABSTRACT] [PUBLISHER LINK]

Self-administered nicotine increases fat metabolism and suppresses weight gain in male rats
Psychopharmacology (Berl). 2018 Apr. doi: 10.1007/s00213-018-4830-y
Rupprecht, L. E., Kreisler, A. D., Spierling, S. R., de Guglielmo, G., Kallupi, M., George, O., Donny, E. C., Zorrilla, E. P., Sved, A. F.
[ABSTRACT] [PUBLISHER LINK]

Extended vs. brief intermittent access to palatable food differently promote binge-like intake, rejection of less preferred food, and weight cycling in female rats
Physiol Behav. 2017 Aug. doi: 10.1016/j.physbeh.2017.03.039
Kreisler, A. D., Garcia, M. G., Spierling, S. R., Hui, B. E., Zorrilla, E. P.
[ABSTRACT] [PUBLISHER LINK]

Maternal Western diet increases adiposity even in male offspring of obesity-resistant rat dams: early endocrine risk markers
Am J Physiol Regul Integr Comp Physiol. 2016 Dec. doi: 10.1152/ajpregu.00023.2016
Frihauf, J. B., Fekete, E. M., Nagy, T. R., Levin, B. E., Zorrilla, E. P.
[ABSTRACT] [PUBLISHER LINK]

Interleukin-18 null mutation increases weight and food intake and reduces energy expenditure and lipid substrate utilization in high-fat diet fed mice
Brain Behav Immun. 2014 Mar. doi: 10.1016/j.bbi.2013.12.001
Zorrilla, E. P., Conti, B.
[ABSTRACT] [PUBLISHER LINK]

Centrally administered urocortin 2 decreases gorging on high-fat diet in both diet-induced obesity-prone and -resistant rats
Int J Obes (Lond). 2013 Dec. doi: 10.1038/ijo.2013.22
Cottone, P., Sabino, V., Nagy, T. R., Coscina, D. V., Levin, B. E., Zorrilla, E. P.
[ABSTRACT] [PUBLISHER LINK]

Rimonabant precipitates anxiety in rats withdrawn from palatable food: role of the central amygdala
Neuropsychopharmacology. 2014 Nov. doi: 10.1038/npp.2013.153
Blasio, A., Iemolo, A., Sabino, V., Petrosino, S., Steardo, L., Rice, K. C., Orlando, P., Iannotti, F. A., Di Marzo, V., Zorrilla, E. P., Cottone, P.
[ABSTRACT] [PUBLISHER LINK]

Effects of CB1 and CRF1 receptor antagonists on binge-like eating in rats with limited access to a sweet fat diet: Lack of withdrawal-like responses
Physiol Behav. 2012 Sep. doi: 10.1016/j.physbeh.2012.06.017
Parylak, S. L., Cottone, P., Sabino, V., Rice, K. C., Zorrilla, E. P.
[ABSTRACT] [PUBLISHER LINK]

Oligoclonal antibody targeting ghrelin increases energy expenditure and reduces food intake in fasted mice
Mol Pharm 9, 281-289, (2012)
Zakhari, J. S., Zorrilla, E. P., Zhou, B., Mayorov, A. V., Janda, K. D.
[ABSTRACT] [PUBLISHER LINK] [PUBMED CENTRAL]

The dark side of food addiction
Physiol Behav 104, 149-156, (2011)
Parylak, S. L., Koob, G. F., Zorrilla, E. P.
[ABSTRACT] [PUBLISHER LINK] [PUBMED CENTRAL]

Systemic urocortin 2, but not urocortin 1 or stressin 1-A, suppresses feeding via CRF2 receptors without malaise and stress
Br J Pharmacol 164, 1959-1975, (2011)
Fekete, E. M., Zhao, Y., Szucs, A., Sabino, V., Cottone, P., Rivier, J., Vale, W. W., Koob, G. F., Zorrilla, E. P.
[ABSTRACT] [PUBLISHER LINK] [PUBMED CENTRAL]

 

Consummatory, anxiety-related and metabolic adaptations in female rats with alternating access to preferred food
Psychoneuroendocrinology 34, 38-49, (2009)
Cottone, P., Sabino, V., Steardo, L., Zorrilla, E. P.
[ABSTRACT] [PUBLISHER LINK] [PUBMED CENTRAL]

 

CRF system recruitment mediates dark side of compulsive eating
Proc Natl Acad Sci U S A 106, 20016-20020, (2009)
Cottone, P., Sabino, V., Roberto, M., Bajo, M., Pockros, L., Frihauf, J. B., Fekete, E. M., Steardo, L., Rice, K. C., Grigoriadis, D. E., Conti, B., Koob, G. F., Zorrilla, E. P.
[ABSTRACT] [PUBLISHER LINK] [PUBMED CENTRAL]

Insights into the roles of the inflammatory mediators IL-1, IL-18 and PGE2 in obesity and insulin resistance
Swiss Med Wkly 138, 665-673, (2008)
Osborn, O., Gram, H., Zorrilla, E. P., Conti, B., Bartfai, T.
[ABSTRACT] [PUBLISHER LINK]

Catalytic antibody degradation of ghrelin increases whole-body metabolic rate and reduces refeeding in fasting mice
Proc Natl Acad Sci U S A 105, 17487-17492, (2008)
Mayorov, A. V., Amara, N., Chang, J. Y., Moss, J. A., Hixon, M. S., Ruiz, D. I., Meijler, M. M., Zorrilla, E. P., Janda, K. D.
[ABSTRACT] [PUBLISHER LINK] [PUBMED CENTRAL]

Opioid-dependent anticipatory negative contrast and binge-like eating in rats with limited access to highly preferred food
Neuropsychopharmacology 33, 524-535, (2008)
Cottone, P., Sabino, V., Steardo, L., Zorrilla, E. P.
[ABSTRACT] [PUBLISHER LINK]

Intermittent access to preferred food reduces the reinforcing efficacy of chow in rats
Am J Physiol Regul Integr Comp Physiol 295, R1066-1076, (2008)
Cottone, P., Sabino, V., Steardo, L., Zorrilla, E. P.
[ABSTRACT] [PUBLISHER LINK] [PUBMED CENTRAL]

Interleukin-18 controls energy homeostasis by suppressing appetite and feed efficiency
Proc Natl Acad Sci U S A 104, 11097-11102, (2007)
Zorrilla, E. P., Sanchez-Alavez, M., Sugama, S., Brennan, M., Fernandez, R., Bartfai, T., Conti, B.
[ABSTRACT] [PUBLISHER LINK] [PUBMED CENTRAL]

Galanin type 1 receptor knockout mice show altered responses to high-fat diet and glucose challenge
Physiol Behav 91, 479-485, (2007)
Zorrilla, E. P., Brennan, M., Sabino, V., Lu, X., Bartfai, T.
[ABSTRACT] [PUBLISHER LINK] [PUBMED CENTRAL]

Role of the corticotropin-releasing factor receptor type 2 in the control of food intake in mice: a meal pattern analysis
Eur J Neurosci 26, 2303-2314, (2007)
Tabarin, A., Diz-Chaves, Y., Consoli, D., Monsaingeon, M., Bale, T. L., Culler, M. D., Datta, R., Drago, F., Vale, W. W., Koob, G. F., Zorrilla, E. P., Contarino, A.
[ABSTRACT] [PUBLISHER LINK] [PUBMED CENTRAL]

Extended access to nicotine self-administration leads to dependence: Circadian measures, withdrawal measures, and extinction behavior in rats
J Pharmacol Exp Ther 320, 180-193, (2007)
O'Dell, L. E., Chen, S. A., Smith, R. T., Specio, S. E., Balster, R. L., Paterson, N. E., Markou, A., Zorrilla, E. P., Koob, G. F.
[ABSTRACT] [PUBLISHER LINK]

Physiology, pharmacology, and therapeutic relevance of urocortins in mammals: ancient CRF paralogs
Front Neuroendocrinol 28, 1-27, (2007)
Fekete, E. M., Zorrilla, E. P.
[ABSTRACT] [PUBLISHER LINK] [PUBMED CENTRAL]

Delayed satiety-like actions and altered feeding microstructure by a selective type 2 corticotropin-releasing factor agonist in rats: intra-hypothalamic urocortin 3 administration reduces food intake by prolonging the post-meal interval
Neuropsychopharmacology 32, 1052-1068, (2007)
Fekete, E. M., Inoue, K., Zhao, Y., Rivier, J. E., Vale, W. W., Szucs, A., Koob, G. F., Zorrilla, E. P.
[ABSTRACT] [PUBLISHER LINK] [PUBMED CENTRAL]

FG 7142 specifically reduces meal size and the rate and regularity of sustained feeding in female rats: evidence that benzodiazepine inverse agonists reduce food palatability
Neuropsychopharmacology 32, 1069-1081, (2007)
Cottone, P., Sabino, V., Steardo, L., Zorrilla, E. P.
[ABSTRACT] [PUBLISHER LINK]

Feeding microstructure in diet-induced obesity susceptible versus resistant rats: central effects of urocortin 2
J Physiol 583, 487-504, (2007)
Cottone, P., Sabino, V., Nagy, T. R., Coscina, D. V., Zorrilla, E. P.
[ABSTRACT] [PUBLISHER LINK] [PUBMED CENTRAL]

Vaccination against weight gain
Proc Natl Acad Sci U S A 103, 13226-13231, (2006)
Zorrilla, E. P., Iwasaki, S., Moss, J. A., Chang, J., Otsuji, J., Inoue, K., Meijler, M. M., Janda, K. D.
[ABSTRACT] [PUBLISHER LINK] [PUBMED CENTRAL]

Transgenic mice with a reduced core body temperature have an increased life span
Science 314, 825-828, (2006)
Conti, B., Sanchez-Alavez, M., Winsky-Sommerer, R., Morale, M. C., Lucero, J., Brownell, S., Fabre, V., Huitron-Resendiz, S., Henriksen, S., Zorrilla, E. P., de Lecea, L., Bartfai, T.
[ABSTRACT] [PUBLISHER LINK]

Unlimited access to heroin self-administration: independent motivational markers of opiate dependence
Neuropsychopharmacology 31, 2692-2707, (2006)
Chen, S. A., O'Dell, L. E., Hoefer, M. E., Greenwell, T. N., Zorrilla, E. P., Koob, G. F.
[ABSTRACT] [PUBLISHER LINK]

Urocortin 2-deficient mice exhibit gender-specific alterations in circadian hypothalamus-pituitary-adrenal axis and depressive-like behavior
J Neurosci 26, 5500-5510, (2006)
Chen, A., Zorrilla, E., Smith, S., Rousso, D., Levy, C., Vaughan, J., Donaldson, C., Roberts, A., Lee, K. F., Vale, W.
[ABSTRACT] [PUBLISHER LINK]

Leptin and post-prandial satiety: acute central leptin more potently reduces meal frequency than meal size in the rat
Psychopharmacology (Berl) 177, 324-335, (2005)
Zorrilla, E. P., Inoue, K., Valdez, G. R., Tabarin, A., Koob, G. F.
[ABSTRACT] [PUBLISHER LINK]

Measuring meals: structure of prandial food and water intake of rats
Am J Physiol Regul Integr Comp Physiol 288, R1450-1467, (2005)
Zorrilla, E. P., Inoue, K., Fekete, E. M., Tabarin, A., Valdez, G. R., Koob, G. F.
[ABSTRACT] [PUBLISHER LINK]

Resistance to diet-induced obesity in mu-opioid receptor-deficient mice: evidence for a "thrifty gene"
Diabetes 54, 3510-3516, (2005)
Tabarin, A., Diz-Chaves, Y., Carmona Mdel, C., Catargi, B., Zorrilla, E. P., Roberts, A. J., Coscina, D. V., Rousset, S., Redonnet, A., Parker, G. C., Inoue, K., Ricquier, D., Penicaud, L., Kieffer, B. L., Koob, G. F.
[ABSTRACT] [PUBLISHER LINK]

Human urocortin 2, a corticotropin-releasing factor (CRF)2 agonist, and ovine CRF, a CRF1 agonist, differentially alter feeding and motor activity
J Pharmacol Exp Ther 310, 1027-1034, (2004)
Zorrilla, E. P., Reinhardt, L. E., Valdez, G. R., Inoue, K., Rivier, J. E., Vale, W. W., Koob, G. F.
[ABSTRACT] [PUBLISHER LINK]

Reduction of anxiety after restricted feeding in the rat: implication for eating disorders
Biol Psychiatry 55, 1075-1081, (2004)
Inoue, K., Zorrilla, E. P., Tabarin, A., Valdez, G. R., Iwasaki, S., Kiriike, N., Koob, G. F.
[ABSTRACT] [PUBLISHER LINK] [REQUEST PDF]

Nibbling at CRF receptor control of feeding and gastrocolonic motility
Trends Pharmacol Sci 24, 421-427, (2003)
Zorrilla, E. P., Tache, Y., Koob, G. F.
[ABSTRACT] [PUBLISHER LINK]

Human urocortin II, a selective agonist for the type 2 corticotropin-releasing factor receptor, decreases feeding and drinking in the rat
J Pharmacol Exp Ther 305, 385-393, (2003)
Inoue, K., Valdez, G. R., Reyes, T. M., Reinhardt, L. E., Tabarin, A., Rivier, J., Vale, W. W., Sawchenko, P. E., Koob, G. F., Zorrilla, E. P.
[ABSTRACT] [PUBLISHER LINK]