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Zorrilla Lab Publications

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Highlights (as of 7/4/2012)

Stress history increases alcohol intake in relapse: Relation to phosphodiesterase 10A
Addict Biol, (in press)
Logrip, M. L., Zorrilla, E. P.
[ABSTRACT] [PUBLISHER LINK]

Extended access cocaine self-administration differentially activates dorsal raphe and amygdala corticotropin-releasing factor systems in rats
Addict Biol 17, 300-308, (2012)
Zorrilla, E. P., Wee, S., Zhao, Y., Specio, S., Boutrel, B., Koob, G. F., Weiss, F.
[ABSTRACT]  [PUBLISHER LINK] [PUBMED CENTRAL]

Oligoclonal antibody targeting ghrelin increases energy expenditure and reduces food intake in fasted mice
Mol Pharm 9, 281-289, (2012)
Zakhari, J. S., Zorrilla, E. P., Zhou, B., Mayorov, A. V., Janda, K. D.
[ABSTRACT] [PUBLISHER LINK] [PUBMED CENTRAL]

Activation of sigma-receptors induces binge-like drinking in Sardinian alcohol-preferring rats
Neuropsychopharmacology 36, 1207-1218, (2011)
Sabino, V., Cottone, P., Blasio, A., Iyer, M. R., Steardo, L., Rice, K. C., Conti, B., Koob, G. F., Zorrilla, E. P.
[ABSTRACT] [PUBLISHER LINK]

The dark side of food addiction
Physiol Behav 104, 149-156, (2011)
Parylak, S. L., Koob, G. F., Zorrilla, E. P.
[ABSTRACT] [PUBLISHER LINK] [PUBMED CENTRAL]

Systemic urocortin 2, but not urocortin 1 or stressin 1-A, suppresses feeding via CRF2 receptors without malaise and stress
Br J Pharmacol 164, 1959-1975, (2011)
Fekete, E. M., Zhao, Y., Szucs, A., Sabino, V., Cottone, P., Rivier, J., Vale, W. W., Koob, G. F., Zorrilla, E. P.
[ABSTRACT] [PUBLISHER LINK] [PUBMED CENTRAL]

Progress in corticotropin-releasing factor-1 antagonist development
Drug Discov Today 15, 371-383, (2010)
Zorrilla, E. P., Koob, G. F.
[ABSTRACT] [PUBLISHER LINK] [PUBMED CENTRAL]

Neurobiological mechanisms of addiction: focus on corticotropin-releasing factor
Curr Opin Investig Drugs 11, 63-71, (2010)
Koob, G. F., Zorrilla, E. P.
[ABSTRACT] [PUBMED CENTRAL]

The sigma-receptor antagonist BD-1063 decreases ethanol intake and reinforcement in animal models of excessive drinking
Neuropsychopharmacology 34, 1482-1493, (2009)
Sabino, V., Cottone, P., Zhao, Y., Iyer, M. R., Steardo, L., Jr., Steardo, L., Rice, K. C., Conti, B., Koob, G. F., Zorrilla, E. P.
[ABSTRACT] [PUBLISHER LINK] [PUBMED CENTRAL]

Sigma-1 receptor knockout mice display a depressive-like phenotype
Behav Brain Res 198, 472-476, (2009)
Sabino, V., Cottone, P., Parylak, S. L., Steardo, L., Zorrilla, E. P.
[ABSTRACT] [PUBLISHER LINK] [PUBMED CENTRAL]

CRF system recruitment mediates dark side of compulsive eating
Proc Natl Acad Sci U S A 106, 20016-20020, (2009)
Cottone, P., Sabino, V., Roberto, M., Bajo, M., Pockros, L., Frihauf, J. B., Fekete, E. M., Steardo, L., Rice, K. C., Grigoriadis, D. E., Conti, B., Koob, G. F., Zorrilla, E. P.
[ABSTRACT] [PUBLISHER LINK] [PUBMED CENTRAL]

Catalytic antibody degradation of ghrelin increases whole-body metabolic rate and reduces refeeding in fasting mice
Proc Natl Acad Sci U S A 105, 17487-17492, (2008)
Mayorov, A. V., Amara, N., Chang, J. Y., Moss, J. A., Hixon, M. S., Ruiz, D. I., Meijler, M. M., Zorrilla, E. P., Janda, K. D.
[ABSTRACT] [PUBLISHER LINK] [PUBMED CENTRAL]

Opioid-dependent anticipatory negative contrast and binge-like eating in rats with limited access to highly preferred food
Neuropsychopharmacology 33, 524-535, (2008)
Cottone, P., Sabino, V., Steardo, L., Zorrilla, E. P.
[ABSTRACT] [PUBLISHER LINK]

Intermittent access to preferred food reduces the reinforcing efficacy of chow in rats
Am J Physiol Regul Integr Comp Physiol 295, R1066-1076, (2008)
Cottone, P., Sabino, V., Steardo, L., Zorrilla, E. P.
[ABSTRACT] [PUBLISHER LINK] [PUBMED CENTRAL]

Interleukin-18 controls energy homeostasis by suppressing appetite and feed efficiency
Proc Natl Acad Sci U S A 104, 11097-11102, (2007)
Zorrilla, E. P., Sanchez-Alavez, M., Sugama, S., Brennan, M., Fernandez, R., Bartfai, T., Conti, B.
[ABSTRACT] [PUBLISHER LINK] [PUBMED CENTRAL]

Remission and resurgence of anxiety-like behavior across protracted withdrawal stages in ethanol-dependent rats
Alcohol Clin Exp Res 31, 1505-1515, (2007)
Zhao, Y., Weiss, F., Zorrilla, E. P.
[ABSTRACT] [PUBLISHER LINK] [REQUEST PDF]

CRF-CRF1 system activation mediates withdrawal-induced increases in nicotine self-administration in nicotine-dependent rats
Proc Natl Acad Sci U S A 104, 17198-17203, (2007)
George, O., Ghozland, S., Azar, M. R., Cottone, P., Zorrilla, E. P., Parsons, L. H., O'Dell, L. E., Richardson, H. N., Koob, G. F.
[ABSTRACT] [PUBLISHER LINK] [PUBMED CENTRAL]

Physiology, pharmacology, and therapeutic relevance of urocortins in mammals: ancient CRF paralogs
Front Neuroendocrinol 28, 1-27, (2007)
Fekete, E. M., Zorrilla, E. P.
[ABSTRACT] [PUBLISHER LINK] [PUBMED CENTRAL]

Subtype-selective corticotropin-releasing factor receptor agonists exert contrasting, but not opposite, effects on anxiety-related behavior in rats
J Pharmacol Exp Ther 323, 846-854, (2007)
Zhao, Y., Valdez, G. R., Fekete, E. M., Rivier, J. E., Vale, W. W., Rice, K. C., Weiss, F., Zorrilla, E. P.
[Abstract]

Delayed satiety-like actions and altered feeding microstructure by a selective type 2 corticotropin-releasing factor agonist in rats: intra-hypothalamic urocortin 3 administration reduces food intake by prolonging the post-meal interval
Neuropsychopharmacology 32, 1052-1068, (2007)
Fekete, E. M., Inoue, K., Zhao, Y., Rivier, J. E., Vale, W. W., Szucs, A., Koob, G. F., Zorrilla, E. P.
[ABSTRACT] [PUBLISHER LINK] [PUBMED CENTRAL]

Feeding microstructure in diet-induced obesity susceptible versus resistant rats: central effects of urocortin 2
J Physiol 583, 487-504, (2007)
Cottone, P., Sabino, V., Nagy, T. R., Coscina, D. V., Zorrilla, E. P.
[ABSTRACT] [PUBLISHER LINK] [PUBMED CENTRAL]

Vaccination against weight gain
Proc Natl Acad Sci U S A 103, 13226-13231, (2006)
Zorrilla, E. P., Iwasaki, S., Moss, J. A., Chang, J., Otsuji, J., Inoue, K., Meijler, M. M., Janda, K. D.
[ABSTRACT] [PUBLISHER LINK] [PUBMED CENTRAL]

Transgenic mice with a reduced core body temperature have an increased life span
Science 314, 825-828, (2006)
Conti, B., Sanchez-Alavez, M., Winsky-Sommerer, R., Morale, M. C., Lucero, J., Brownell, S., Fabre, V., Huitron-Resendiz, S., Henriksen, S., Zorrilla, E. P., de Lecea, L., Bartfai, T.
[ABSTRACT] [PUBLISHER LINK]

Dissociation between opioid and CRF1 antagonist sensitive drinking in Sardinian alcohol-preferring rats
Psychopharmacology (Berl) 189, 175-186, (2006)
Sabino, V., Cottone, P., Koob, G. F., Steardo, L., Lee, M. J., Rice, K. C., Zorrilla, E. P.
[ABSTRACT] [PUBLISHER LINK] [REQUEST PDF]

Urocortin 2-deficient mice exhibit gender-specific alterations in circadian hypothalamus-pituitary-adrenal axis and depressive-like behavior
J Neurosci 26, 5500-5510, (2006)
Chen, A., Zorrilla, E., Smith, S., Rousso, D., Levy, C., Vaughan, J., Donaldson, C., Roberts, A., Lee, K. F., Vale, W.
[ABSTRACT] [PUBLISHER LINK]

Measuring meals: structure of prandial food and water intake of rats
Am J Physiol Regul Integr Comp Physiol 288, R1450-1467, (2005)
Zorrilla, E. P., Inoue, K., Fekete, E. M., Tabarin, A., Valdez, G. R., Koob, G. F.
[ABSTRACT] [PUBLISHER LINK]

Human urocortin 2, a corticotropin-releasing factor (CRF)2 agonist, and ovine CRF, a CRF1 agonist, differentially alter feeding and motor activity
J Pharmacol Exp Ther 310, 1027-1034, (2004)
Zorrilla, E. P., Reinhardt, L. E., Valdez, G. R., Inoue, K., Rivier, J. E., Vale, W. W., Koob, G. F.
[ABSTRACT] [PUBLISHER LINK]

Human urocortin II, a selective agonist for the type 2 corticotropin-releasing factor receptor, decreases feeding and drinking in the rat
J Pharmacol Exp Ther 305, 385-393, (2003)
Inoue, K., Valdez, G. R., Reyes, T. M., Reinhardt, L. E., Tabarin, A., Rivier, J., Vale, W. W., Sawchenko, P. E., Koob, G. F., Zorrilla, E. P.
[ABSTRACT] [PUBLISHER LINK]

Effects of antalarmin, a CRF type 1 receptor antagonist, on anxiety-like behavior and motor activation in the rat
Brain Res 952, 188-199, (2002)
Zorrilla, E. P., Valdez, G. R., Nozulak, J., Koob, G. F., Markou, A.
[ABSTRACT] [PUBLISHER LINK] [REQUEST PDF]

Changes in levels of regional CRF-like-immunoreactivity and plasma corticosterone during protracted drug withdrawal in dependent rats
Psychopharmacology (Berl) 158, 374-381, (2001)
Zorrilla, E. P., Valdez, G. R., Weiss, F.
[ABSTRACT] [PUBLISHER LINK] [REQUEST PDF]

The relationship of depression and stressors to immunological assays: a meta-analytic review
Brain Behav Immun 15, 199-226, (2001)
Zorrilla, E. P., Luborsky, L., McKay, J. R., Rosenthal, R., Houldin, A., Tax, A., McCorkle, R., Seligman, D. A., Schmidt, K.
[ABSTRACT] [PUBLISHER LINK] [REQUEST PDF]

Relation of stressors and depressive symptoms to clinical progression of viral illness
Am J Psychiatry 153, 626-635, (1996)
Zorrilla, E. P., McKay, J. R., Luborsky, L., Schmidt, K.
[ABSTRACT] [PUBLISHER LINK] [REQUEST PDF]