The Ruf Laboratory

Research

The Ruf laboratory is focused on vascular and cancer biology, in particular on protease pathways in thrombosis, inflammation, angiogenesis and tumor progression. Recent focus is on non-coagulant, signaling roles of the coagulation cascade, on signaling specificity of protease activated receptors and on the application of genomic approaches and animal models to study those pathways.

Recent overview articles:

Ruf, W., Dorfleutner, A., Riewald, M. Specificity of coagulation factor signaling. J. Thromb. Haemost. 1:1495-1503, 2003. (Link to full text article.)

Ruf, W. Emerging roles of tissue factor in viral hemorrhagic fever. Trends Immunol 25:461-464, 2004. (Link to PubMed Abstract.)

Belting, M., Ahamed, J., Ruf, W. Signaling of the tissue factor coagulation pathway in angiogenesis and cancer. Arteriocler. Thromb. Vasc. Biol. 25:1545-1550, 2005. (Link to full text article.)