Scripps Research Logo

The Ruf Lab

Selected Publications

Sevinsky, J.R., Rao, L.V.M., and Ruf, W. Ligand induced protease receptor translocation into caveolae: A mechanism for regulating cell surface proteolysis of the tissue factor dependent coagulation pathway. J. Cell Biol. 133:293-304, 1996.

Dickinson, C.D., Kelly, C.R., Ruf, W. Identification of surface residues mediating cofactor binding and catalytic function of the serine protease factor VIIa. Proc. Natl. Acad. Sci. USA 93:14379-14384, 1996.

Mueller, B.M., Ruf, W. Requirement for binding of catalytically active factor VIIa in tissue factor-dependent experimental metastasis. J. Clin. Invest. 101:1372-1378, 1998.

Ott, I., Fischer, E.G., Miyagi, Y., Mueller, B.M., Ruf, W. A role for tissue factor in cell adhesion and migration mediated by interaction with actin binding protein 280. J. Cell Biol. 140:1241-1253, 1998.

Petrovan, R.J., Ruf, W. Residue Met156 contributes to the labile enzyme conformation of coagulation factor VIIa. J. Biol. Chem. 276:6616-6620, 2001.

Riewald, M., Ruf, W. Mechanistic coupling of protease signaling and initiation of coagulation by tissue factor. Proc. Natl. Acad. Sci. USA. 98:7742-7, 2001.

Riewald, M., Petrovan, R.J., Donner, A., Mueller, B.M., Ruf, W. Activation of endothelial cell protease activated receptor 1 by the protein C pathway. Science 296:1880-1882, 2002.

Dorfleutner, A., Ruf, W. Regulation of tissue factor cytoplasmic domain phosphorylation by palmitoylation. Blood 102:3998-4005, 2003.

Belting, M., Dorrell, M.I., Sandgren, S., Aguilar, E., Ahamed, J., Dorfleutner, A., Carmeliet, P., Mueller, B.M., Friedlander, M., Ruf,W. Regulation of angiogenesis by tissue factor cytoplasmic domain signaling. Nature Med. 10:502-9, 2004.

Ahamed, J., Ruf, W. Protease activated receptor 2 dependent phosphorylation of the tissue factor cytoplasmic domain. J. Biol. Chem. 279:23038-44, 2004.

Dorfleutner, A., Hintermann, E., Tarui, T., Takada, Y., Ruf, W. Crosstalk of integrin a3b1 and tissue factor in cell migration. Mol. Biol. Cell 15:4416-4425, 2004.

Riewald, M., Ruf, W. Protease-activated receptor-1 signaling by activated protein C in cytokine-perturbed endothelial cells is distinct from thrombin signaling. J Biol. Chem. 280:19808-19814, 2005.

Ahamed, J., Belting, M., Ruf, W. Regulation of tissue factor-induced signaling by endogenous and recombinant tissue factor pathway inhibitor-1. Blood 105:2384-2391, 2005.