|
|
|
 | ||
Publications
Penchala SC., Connelly S., Wang Y., Park MS., Zhao L., Baranczak A., Rappley I., Vogel H., Liedtke M., Witteles RM., Powers ET., Reixach N., Chan WK., Wilson IA., Kelly JW., Graef IA., Alhamadsheh MM. (2013) AG10 inhibits amyloidogenesis and cellular toxicity of the familial amyloid cardiomyopathy-associated V122I transthyretin. Proc Natl Acad Sci USA Epub ahead of print. PMID: 23716704.
Zhao L., Buxbaum JN., Reixach N. (2013). Age-related oxidative modifications of transthyretin modulate its amyloidogenicity. Biochemistry 52: 1913-26. PMID: 23414091.
Yonemoto IT., Li W., Khullar A., Reixach N., Gerratana B. (2012). Mutasynthesis of a potent anticancer sibiromycin analogue. ACS Chem Biol. 7 : 973-77. PMID: 22390171.
Li X., Masliah E., Reixach N., Buxbaum JN. (2011). Neuronal production of transthyretin in human and murine Alzheimer's disease: is it protective? J. Neurosci. 31: 12483-90.
Alhamadsheh MM., Connelly S., Cho A., Reixach N., Powers ET., Pan DW., Wilson IA., Kelly JW., Graef IA. (2011). Potent kinetic stabilizers that prevent transthyretin-mediated cardiomyocyte proteotoxicity. Science Translational Medicine. 3:97ra81
Bourgault S., Choi S., Buxbaum JN., Kelly JW., Price JL., Reixach N. (2011). Mechanisms of transthyretin cardiomyocyte toxicity inhibition by resveratrol analogs. Biochem Biophys Res Commun. 410:707-13. PMID: 21557933.
Bourgault S., Solomon JP., Reixach N., Kelly JW. (2011). Sulfated Glycosaminoglycans Accelerate Transthyretin Amyloidogenesis by Quaternary Structural Conversion. Biochemistry. 50:1001-15. PMID: 21194234.
Johnson SM., Wiseman RL., Reixach N., Paulsson JF., Choi S., Powers ET., Buxbaum JN., Kelly JW. (2010) Understanding and Ameliorating the TTR amyloidoses. (pp 967-1003) In Protein Misfolding Diseases: Current and Emerging Principles and Therapies. Wiley Series in Protein and Peptide Science. Ramirez-Alvarado M., Kelly JW., Dobson CM. Eds. John Wiley & Sons Inc., USA
Choi S., Connelly S., Reixach N., Wilson IA., Kelly JW. (2010). Chemoselective small molecules that covalently modify one lysine in a non-enzyme protein in plasma. Nat Chem Biol. 6:133-9.
Choi S., Reixach N., Connelly S., Johnson SM., Wilson IA., Kelly JW. (2010) A substructure combination strategy to create potent and selective transthyretin kinetic stabilizers that prevent amyloidogenesis and cytotoxicity. J Am Chem Soc. 132:1359-70.
Buxbaum JN., Reixach N. (2009) Transthyretin: the servant of many masters. Cell Mol Life Sci. 66:3095-101.
Buxbaum, JN., Ye, Z., Reixach, N., Friske, L., Levy, C., Das, P., Golde, T., Masliah, E., Roberts, AR., Bartfai, T. (2008) Transthyretin protects Alzheimer's mice from the behavioral and biochemical effects of Abeta toxicity. Proc Natl Acad Sci U S A., 105:2681-6.
Reixach, N., Foss, T., Santelli, E., Pascual, J., Kelly, JW., Buxbaum, JN. (2008) Human-Murine Transthyretin Heterotetramers are Kinetically Stable and Non-amyloidogenic: A lesson in the generation of transgenic models of diseases involving oligomeric proteins. J Biol Chem, 283:2098-107.
Tagoe CE., Reixach, N., Friske, L., Mustra, D., French, D., Gallo, G., Buxbaum, JN. (2007) In vivo stabilization of mutant human transthyretin in transgenic mice. Amyloid, 14:227-236
Maleknia, S., Reixach, N., Buxbaum, JN. (2006) Oxidation inhibits amyloid fibril formation of transthyretin. FEBS J., 273:5400-6.
Reixach, N., Adamski-Werner, S., Koziol, J., Kelly, JW., Buxbaum, JN. (2006). Cell Based Screening of inhibitors of transthyretin aggregation. Biochem Biophys Res Commun, 348:889-897.
Shinchuk, L., Sharma, D., Blondelle SE., Reixach, N., Inouye, H., Kirschner DA. (2005) Poly-(L-alanine) expansions form core b-sheets that nucleate amyloid assembly. Proteins: Structure Function and Bioinformatics, 61:579-589.
Reixach, N., Deechongkit, S., Jiang, X., Kelly, JW., Buxbaum, JN. (2004) Tissue damage in the amyloidoses: Transthyretin monomers and nonnative oligomers are the major cytotoxic species in tissue culture. Proc Natl Acad Sci U S A., 101: 2817-22
Buxbaum, JN., Tagoe, C., Gallo, G., Reixach, N., French, D. (2003). The pathogenesis of transthyretin tissue deposition: lessons from transgenic mice. Amyloid, 10:2-6.
Boggiano C., Reixach, N., Pinilla, C., Blondelle, SE. (2003). Successful identification of novel agents to control infectious diseases from screening mixture-based peptide combinatorial libraries in complex cell-based bioassays. Biopolymers, 71: 103-116.
Blondelle SE., Reixach N., Boggiano C. (2000) Identification of new antagonists of HIV-1 infectivity from synthetic combinatorial libraries. FASEB J, 14: A185.
Inouye H., Lim A., Shinchuk LB., Bond J., Reixach N., Deverin S., Makhov AM., Griffith JD., Costello CE., Blondelle SE., Kirschner D. (2000) Amyloid structure modeled using designed polypeptides. J. Neurochem. 74: S12-S12 Suppl.
Reixach, N., Ostresh, JM., Houghten, RA., Blondelle, SE. (2000) Inhibition of β-amyloid-induced neurotoxicity by imidazopyridoindoles derived from a synthetic combinatorial library. J. Struct. Biol., 130:247-258.
Reixach, N., Lafont, R., Camps, F., Casas, J. (1999) Biotransformations of putative phytoecdysteroid biosynthetic precursors in tissue cultures of Polypodium vulgare. European Journal of Biochemistry, 266:608-615.
Messeguer, J., Melé, E., Reixach, N., Irurre-Santilari, J., Casas, J. (1998) Polypodium vulgare (L) (wood fern): In vitro culture and the production of phytoecdysteroids. In Biotechnology in Agriculture and Forestry vol. 41. Medicinal and Aromatic Plants X (Ed. YPS Bajaj) Springer-Verlag Berlin Heidelberg.
Reixach, N., Irurre-Santilari, J., Camps, F., Melé, E., Messeguer, J., Casas, J. (1997) Phytoecdysteroid overproduction in Polypodium vulgare (L) prothalli. Phytochemistry, 46:1183-1187.
Reixach, N., Irurre-Santilari, J., Casas, J., Melé, E., Messeguer, J., Camps, F. (1996) Biosynthesis of ecdysteroids in in vitro prothalli cultures of Polypodium vulgare. Phytochemistry, 43:597-602
Coll, J.; Reixach, N., Sánchez-Baeza, F., Casas, J., Camps, F. (1994) Identification of new ecdysteroids from Polypodium vulgare. Tetrahedron, 50:7247-7252