Using a novel molecular analysis technique, scientists at The Scripps Research Institute have identified the chemical underpinnings of Captagon, also known as fenethylline, an illegal amphetamine-type stimulant that has been linked to substance abuse and ‘pharmacoterrorism’ in the Middle East. The study, published in the journal Nature, also identified a potential vaccine candidate that counteracted Captagon’s effects in mouse studies.
Keary M. Engle, an assistant professor of chemistry at The Scripps Research Institute, has been awarded a $1.25 million grant from NIH’s National Institute of General Medical Sciences (NIGMS). The R35 grant, also known as an “Outstanding Investigator Award” and “Maximizing Investigators' Research Award (MIRA) for Early Stage Investigators,” will support the Engle Laboratory’s development of powerful new molecule-building techniques for drug discovery. The five-year award provides general, long-term support for research programs that are deemed especially promising. It is aimed at scientists who are just starting their careers to help free them from the usual pressure to compete for shorter-term grants.
The Scripps Research Institute today announced the appointment of two new faculty members – Alexander Adibekian, Ph.D., who will join the Department of Chemistry in Jupiter, FL as associate professor, and Li Ye, Ph.D. who joins the Department of Neuroscience in La Jolla, Ca as an assistant professor.
Two new studies led by scientists at The Scripps Research Institute (TSRI) could guide future therapies to improve health and lifespan. Together, the studies in animal models shed light on how reducing calorie intake directly influences lifespan by also reducing body temperature. Importantly, the researchers also identified a molecule that responds to lower body temperatures to regulate lifespan in fruit flies, giving scientists a target for future pharmaceuticals that may increase longevity.