Matthew Disney, a professor on the Florida campus of The Scripps Research Institute (TSRI), and Leonard Petrucelli, chairman of the Department of Neuroscience for the Mayo Clinic in Jacksonville, have been awarded $500,000 by the ALS Association from proceeds from last summer’s Ice Bucket Challenge.
The grant will support work on pre-clinical evaluations of potential drug candidates, specifically small molecules that target a mutation in the C9orf72 gene that causes the common genetic form of amyotrophic lateral sclerosis (ALS).
ALS, the disease that killed well-known baseball player Lou Gehrig, is a progressive neurodegenerative disease that destroys motor neuron cells that control muscle movement. More than 30,000 Americans have ALS and nearly 6,000 are diagnosed with the disease each year.
Joseph Schonhoft, research associate in the Kelly lab, is one of just 16 newly named Damon Runyon Fellows nationwide. The four-year award supports outstanding postdoctoral scientists conducting basic and translational cancer research in the laboratories of leading senior investigators.
In his current project, Schonhoft aims to understand how immune cells abnormally proliferate and secrete antibody proteins that cause organ and tissue damage during diseases such as amyloidosis and certain multiple myelomas, information that could be used to develop new diagnostic probes to improve the effectiveness of current clinical treatments.
Since its founding in 1946, the nonprofit Damon Runyon Cancer Research Foundation has supported nearly 3,500 innovative early-career researchers, including 12 scientists who went on to receive the Nobel Prize and others who are heads of cancer centers and leaders of renowned research programs. Fewer than 10 percent of applications are ultimately funded through the foundation’s competitive award programs.
TSRI will host a public screening of the documentary “It Seems Like Magic…But It’s Science: A Quest to End Parkinson’s Disease,” the story of stem cell research advocates and their 2013 trek to Mt. Everest, on Thursday, July 30, 4:30 to 6:30 PM, at The Auditorium at TSRI.
Following the screening, a discussion session will be held with researchers, doctors, hikers and filmmakers. The event is presented by TSRI, Scripps Health and Summit 4 Stem Cell. RSVP to Chelsea Luedeke at (858) 784-7083 or cluedeke@scripps.edu. For more information, see the Loring lab announcements webpage.
Send comments to: mikaono[at]scripps.edu