Gabriel Lander, assistant professor at The Scripps Research Institute (TSRI), has been chosen as one of just 22 2014 Pew Scholars in the Biomedical Sciences, a select group that will receive flexible funding from the Pew Charitable Trusts to investigate some of the world’s most pressing problems.
“We are pleased to welcome the newest class of scholars to a community that continues to yield extraordinary findings in the field of bioscience,” said Rebecca W. Rimel, president and CEO of Pew.
Launched in 1985, the program supports top U.S. scientists at the assistant professor level to seed innovation at the start of their independent research careers. More than 180 institutions were invited to nominate Pew Scholar candidates. Scholars are selected, based on proven creativity, by a national advisory committee composed of renowned scientists, including committee chair Craig C. Mello, a 2006 Nobel laureate in physiology or medicine and a 1995 Pew scholar.
Lander and his team are using electron microscopy to study the structure of dynein, a motor complex important in clearing toxic protein aggregates from neurons. Obtaining high-resolution, dynamic “snapshots” of this protein complex could help pinpoint the molecular triggers that lead to diseases such as Huntington’s, Parkinson’s and Alzheimer’s and pave the way for new treatments for these diseases.
Xin Zhang, research associate in the Kelly lab, has received a Burroughs Wellcome Career Award at the Scientific Interface (CASI), a five-year grant intended to bridge advanced postdoctoral training and the first three years of faculty service.
Supported by the independent private foundation Burroughs Wellcome Fund, CASI grants foster the early career development of researchers who are trained in physics, engineering, mathematics, chemistry and computation sciences and now are answering biological questions.
Zhang’s research focuses on proteins whose defective folding causes common enzyme deficiency disorders and cancers to find treatment for these diseases by improving the quality of cellular folding. The CASI award, said Zhang, “allows me to develop new chemical methodologies to scrutinize the cellular and molecular mechanisms that create and maintain the functional proteome.”
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