The new method, designed in the Baran lab, reduces the chemical synthesis of ingenol from 37 steps to just 14, facilitating its commercial development.
As proof-of-principle, a drug candidate from the Disney lab powerfully neutralizes the myotonic dystrophy defect in cell culture
“Essentially, we have shown an important link between cell-based screening assays and what occurs naturally in animal models,” says Associate Professor Laura Bohn.
The finding from the Cravatt lab, which points to a regulator of important cellular processes, could lead to new insights into the causes of diabetes, cancer and other disorders.
The five-year study, led by Professor Paul Robbins, will focus on identifying how cellular damage drives the aging process.