Selected Publications

Andronicos, N.M., Chen, E.I., Baik, N., Bai, H., Parmer, C.M., Kiosses, W.B., Kamps, M.P., Yates, J.R., III, Parmer, R.J., and Miles, L.A. Proteomics-based discovery of a novel, structurally unique, and developmentally regulated plasminogen receptor, Plg-R_KT, a major regulator of cell surface plasminogen activation. Blood, 2010,115:1319-1330. Plenary Paper. PMID: 19897580, PMCID: PMC2826757.

Jiang, Q., Gingles, N.A., Olivier, M.A., Miles, L.A., and Parmer, R.J. The anti-fibrinolytic SERPIN, plasminogen activator inhibitor 1 (PAI-1), is targeted to and released from catecholamine storage vesicles. Blood, 2011, 117:7155-7162. PMID: 21596853, PMCID: PMC3143556.

Han, J., Baik, N., Kim, K-H, Yang, J-M, Han, G, Gong, Y., Jardi, M., Castellino, F.J., Felez, J., Parmer, R.J. and Miles, L.A. Monoclonal antibodies detect receptor-induced binding sites (RIBS) in Glu-plasminogen. Blood, 2011, 118:1653-1662. PMID:  21680799, PMCID: PMC3156051.

Bai, H. Baik, N., Kiosses, W.B., Krajewski, S., Miles, L.A., and Parmer, R.J. The novel plasminogen receptor, Plg-R_KT regulates catecholamine release. J. Biol. Chem., 2011, 286:33125-33133. PMID: 6165997, PMCID: PMC3190921.

Lighvani, S., Baik, N., Diggs, J.E., Khaldoyanidi, S., Parmer, R.J, and Miles, L.A. Regulation of macrophage migration by a novel plasminogen receptor Plg-R_KT. Blood, 2011, 118:5622-5630. PMID: 21940822, PMCID: PMC3217361.

Felez, J., Jardi, M., Fabregas, P., Parmer, R.J., and Miles, L.A. Monoclonal antibodies against receptor-induced binding sites detect cell-bound plasminogen in blood. Blood, 2012, 120:678-681. PMID: 22649107, PMCID: PMC3401219.

Miles, L.A., Baik, N., Lighvani, S., Khaldoyanidi, S., Varki, N.M., Bai, H., Mueller, B.M., and Parmer, R.J. Deficiency of plasminogen receptor, Plg-R_KT, causes defects in plasminogen binding and inflammatory macrophage recruitment in vivo. J. Thromb. Haemostat. 2017, 15(1):155-162. doi: 10.1111/jth.13532. PMID: 27714956, PMCID: PMC5280214  Highlighted as an Editors’ pick and designated as an “In Focus” article and subject of a Commentary.

Miles, L.A., Baik, N., Bai, H., Makarenkova, H.P., Kiosses ,W.B., Krajewski, S., Castellino, F.J., Valenzuela, A., Varki, N.M., Mueller, B.M., Parmer, R.J. The plasminogen receptor, Plg-RKT, is essential for mammary lobuloalveolar development and lactation. J Thromb Haemost. 2018, 16(5):919-932. PMID: 29495105, PMCID: PMC5965281.

Thaler, B., Baik, N., Hohensinner, P.J., Baumgartner, J., Panzenbock, A., Stojkovic, S., Demyanets, S., Huk, I., Rega-Kaun, G., Kaun, C., Prager, M., Fischer, M.B., Huber, K., Speidl, W.S., Parmer, R.J., Miles, L.A.* and Wojta, J.*  Differential expression of Plg-RKT and its effects on migration of proinflammatory monocyte and macrophage subsets. Blood, 2019, 134(6):561-567. PMID: 31221672, PMCID: PMC6688429.
*both authors contributed equally

Vago, J.P., Sugimoto, M.A., Lima, K.M., Lima, G.L., Baik, N., Teixeira, M.M., Perretti, M., Parmer, R.J., Miles, L.A.* and Sousa, L.P.*  Plasminogen and the plasminogen receptor, Plg-RKT, regulate macrophage phenotypic and functional changes. Front. Immunol. 2019, 10:1458. PMID: 31316511, PMCID: PMC6611080.
*both authors contributed equally

Parmer, R.J., Yun, G., Yoo, S.H., and Miles, L.A.  Neuroendocrine Targeting of Tissue Plasminogen Activator (t-PA). J. Neurol. Disord. Stroke., 2020, 7(1): 1153. PMID: 32549050.

Whyte, C.S., Morrow, G.B., Baik, N., Booth, N.A., Jalal, M.M., Parmer, R.J., Miles, L.A., and Mutch, N.J. Exposure of plasminogen and the novel plasminogen receptor, Plg-R_KT, on activated human and murine platelets, Blood, 2020, doi: 10.1182/blood.2020007263. PMID: 32842150.

Ny, L., Parmer, R.J., Shen, Y., Holmberg, S., Broden, J., Wilczynska, M., Ny, T., and Miles, L.A. The plasminogen receptor, Plg-RKT, plays a role in inflammation and fibrinolysis during cutaneous wound healing in mice. Cell Death Dis, 11(12):1054 2020. PMID: 33311441: doi: 10.1038/s41419-020-03230-1

Miles, L.A., Vago, J.P., Sousa, L.P., and Parmer, R.J. Functions of the Plasminogen Receptor_, Plg-R_KT.  J. Thrombosis and Haemostasis, 2020. PMID: 29495105, PMCID: PMC5965281.

Miles, L.A., Ny, L., Wilczynska, M., Shen, Y., Ny, T., Parmer, R.J. Plasminogen Receptors and Fibrinolysis. Int J Mol Sci., 2021. Feb 8;22(4):1712. doi: 10.3390/ijms22041712. PMID: 33567773, Review.

Reviews & Invited Articles

Miles, L.A. and Parmer, R.J. Plasminogen receptors: the first quarter century. Semin. Thromb. Hemost., 39(4):329-337, 2013. PMID: 23532575, PMCID: PMC3938387.

Miles, L.A., Vago, J.P., Sousa, L.P., and Parmer, R.J. Functions of the Plasminogen Receptor_, Plg-R_KT.  J. Thrombosis and Haemostasis, 2020. PMID: 29495105, PMCID: PMC5965281.

Miles, L.A., Ny, L., Wilczynska, M., Shen, Y., Ny, T., Parmer, R.J. Plasminogen Receptors and Fibrinolysis. Int J Mol Sci., 2021, Feb 8;22(4):1712. doi: 10.3390/ijms22041712. PMID: 33567773, Review.