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Complete Publications

  1. Wilson, M.R., Arroyave, C.M., Miles, L. and Tan, E.M. Immune reactants in cryoproteins: Relationship to complement activation. Rheum. Dis., 1977, 36:540-548. PMID: 339851  PMCID: PMC1000160.
  2. Bouma, B.N., Miles, L.A., Beretta, G. and Griffin, J.H. Human plasma prekallikrein. Studies of its activation by activated Factor XII and of its inactivation by diisopropyl phosphofluoridate. Biochemistry, 1980, 19:1151-1160. PMID:6768384.
  3. Miles, L.A., Burnier, J.P., Verlander, M.S., Goodman, M., Kleiss, A.J. and Griffin, J.H. Inactivation of purified human alpha2-antiplasmin and purified human C1 inhibitor by synthetic fibrinolytic agents. Blood, 1981, 57:1015-1026. PMID:6452920.
  4. Miles, L.A., Plow, E.F., Donnelly, K.J., Hougie, C. and Griffin, J.H. A bleeding disorder due to deficiency of alpha2-antiplasmin. Blood, 1982, 59:1246-1251. PMID:7082827.
  5. Miles, L.A. Mechanisms of intrinsic fibrinolysis. Ph.D. Dissertation, University of California, San Diego, 1982.
  6. Miles, L.A., Rothschild, Z. and Griffin, J.H. Dextran sulfate-dependent fibrinolysis in whole human plasma: Dependence on Factor XII and Prekallikrein. Lab. Clin. Med., 1983, 101:214-225. PMID:6185600.
  7. Miles, L.A., Greengard, J.S. and Griffin, J.H. A comparison of the abilities of plasma kallikrein, β-Factor XIIa, Factor XIa and urokinase to activate plasminogen. Res., 1983, 29:407-417. PMID:6344314.
  8. Miles, L.A. and Plow, E.F. Binding and activation of plasminogen on the platelet surface. Biol. Chem., 1985, 260:4303-4311. PMID:3920216.
  9. Miles, L.A., Ginsberg, M.H., White, J.G. and Plow, E.F. Plasminogen interacts with human platelets through two distinct mechanisms. Clin. Invest., 1986, 77:2001-2009. PMID: 3086385, PMCID: PMC370561.
  10. Miles, L.A. and Plow, E.F. Topography of the high affinity lysine binding site of plasminogen as defined with a specific antibody probe. Biochemistry, 1986, 25:6926-6933. PMID:3099830.
  11. Plow, E.F., Freaney, D.E. Plescia, J. and Miles, L.A. The plasminogen system and cell surfaces: Evidence for plasminogen and urokinase receptors on the same cell type. Cell. Biol., 1986, 103:2411-2420. PMID: 3023400, PMCID: PMC2114571.
  12. Miles, L.A. and Plow, E.F. Receptor mediated binding of the fibrinolytic components, plasminogen and urokinase, to peripheral blood cells. Haemost., 1987, 58:936-942. PMID:2829380.
  13. Miles, L.A., Levin, E.G., Plescia, J., Collen, D. and Plow, E.F. Plasminogen receptors, urokinase receptors and their modulation on human endothelial cells. Blood, 1988, 72:628-635. PMID:2840987.
  14. Miles, L.A., Dahlberg, C.M. and Plow, E.F. The cell-binding domains of plasminogen and their function in plasma. J. Biol. Chem., 1988, 263:11928-11934. PMID:3403557.
  15. Beebe, D.P., Miles, L.A. and Plow, E.F. A linear amino acid sequence involved in the interaction of t-PA with its endothelial cell receptor. Blood, 1989, 74:2034-2037. PMID:2478220.
  16. Miles, L.A., Dahlberg, C.M., Levin, E.G. and Plow, E.F. Gangliosides interact directly with plasminogen and urokinase and may mediate binding of these fibrinolytic components to cells. Biochemistry, 1989, 28:9337-9343. PMID:2611234.
  17. Miles, L.A., Fless, G.M., Levin, E.G., Scanu, A.M. and Plow, E.F. A potential basis for the thrombotic risks associated with lipoprotein(a). Nature, 1989, 339:301-303. PMID:2542796.
  18. Felez, J., Miles, L.A., Plescia, J. and Plow, E.F. Regulation of plasminogen receptor expression on human monocytes and monocytoid cell lines. Cell Biol., 1990, 111:1673-1683. PMID: 2170426, PMCID: PMC2116253.
  19. Miles, L.A., Dahlberg, C.M., Plescia, J., Felez, J., Kato, K. and Plow, E.F. Role of cell-surface lysines in plasminogen binding to cells: Identification of α-enolase as a candidate plasminogen receptor. Biochemistry, 1991, 30:1682-1691. PMID:1847072.
  20. Felez, J., Chanquia, C.J., Levin, E.G., Miles, L.A. and Plow, E.F. Binding of tissue plasminogen activator to human monocytes and monocytoid cells. Blood, 1991, 78:2318-2327. PMID:1932747.
  21. Felez, J. Chanquia, C., Fabregas, P., Plow, E.F. and Miles, L.A. Competition between plasminogen and tissue plasminogen activator (t-PA) for cellular binding sites. Blood, 1993, 82:2433-2441. PMID:8400293.
  22. Scanu, A.M., Miles, L.A., Fless, G.M., Pfaffinger, D., Eisenbart, J., Jackson, E., Hoover-Plow, J.L., Brunck, T. and Plow, E.F. Rhesus monkey lipoprotein(a) binds to lysine sepharose and U937 monocytoid cells less efficiently than human lipoprotein(a): evidence for the dominant role of Kringle 437. Clin. Invest., 1993, 91:283-291. PMID: 8423225, PMCID: PMC330025.
  23. Hoover-Plow, J. L., Miles, L.A., Fless, G.M., Scanu, A.M., and Plow, E.F. Comparison of the lysine binding functions of lipoprotein (a) and plasminogen. Biochemistry, 1993, 32:13681-13687. PMID:8257702.
  24. Levin, E.G., Miles, L.A., Fless, G.M., Scanu, A.M., Baynham, P., Curtiss, L.K. and Plow, E.F. Lipoproteins inhibit the secretion of tissue plasminogen activator from human endothelial cells. Thromb., 1994, 14:438-442. PMID:8123649.
  25. Miles, L.A., Fless, G.M., Scanu, A.M., Baynham, P., Sebald, M.T., Skocir, P., Curtiss, L.K., Levin, E.G., Hoover-Plow, J.L. and Plow, E.F. Interaction of Lp(a) with plasminogen binding sites on cells. Thromb. Haemost., 1995, 73(3):458-465. PMID:7667829.
  26. Redlitz, A., Fowler, B.J., Plow, E.F. and Miles, L.A. The role of an enolase-related molecule in plasminogen binding to cells. J. Biochem., 1995, 227:407-415. PMID:7851415.
  27. Almenar-Queralt, A., Duperray, A., Miles, L.A., Felez, J. and Altieri, D.C. Apical topography and modulation of ICAM-1 expression on activated endothelium. J. Pathol., 1995, 147:1278-1288. PMID: 7485391, PMCID: PMC1869507.
  28. Felez, J., Miles, L.A., Fabregas, P., Jardi, M., Plow, E.F. and Lijnen, H.R. Characterization of cellular binding sites and interactive regions within reactants required for enhancement of plasminogen activation by tPA on the surface of leukocytic cells. Haemost., 1996, 76:577-584. PMID:8902999.
  29. Kim, Sun-Ok, Plow, E.F. and Miles, L.A. Regulation of plasminogen receptor expression on monocytoid cells by β1-integrin-dependent cellular adherence to extracellular matrix proteins. Biol. Chem., 1996, 271:23761-23767. PMID:8798602.
  30. Jardí, M., Inglés-Esteve, J., Burgal, M., Azqueta, C., Velasco, F., Miles, L.A. and Felez, J. Distinct patterns of urokinase receptor (uPAR) expression by leukemic cells and peripheral blood cells. Hemostasis, 1996, 76:1009-1019. PMID:8972026.
  31. Parmer, R.J., Mahata, M., Mahata, S., Sebald, M.T., O'Connor, D.T. and Miles, L.A. Tissue plasminogen activator (t-PA) is targeted to the regulated secretory pathway: Catecholamine storage vesicles as a reservoir for the rapid release of t-PA. J. Biol. Chem., 1997, 272:1976-1982. PMID:8999889.
  32. Jenkins, G.R., Seiffert, D., Parmer, R.J. and Miles, L.A. Regulation of plasminogen gene expression by interleukin-6. Blood, 1997, 89:2394-2403. PMID:9116283.
  33. Arza, B., Félez, J., Lopez-Alemany, R., Miles, L.A. and Muñoz-Cánoves, P. Identification of an epitope of α-enolase (a candidate plasminogen receptor) by phage display. Haemost., 1997, 78:1097-1103. PMID:9308760.
  34. Miles, L.A., Sebald, M.T., Fless, G.M., Scanu, A.M., Curtiss, L.K., Plow, E.F. and Hoover-Plow, J.L. Interaction of lipoprotein(a) with the extracellular matrix.  Fibrinolysis Proteolysis, 1998, 12:79-87. PMID: None.
  35. Fowler, B., Mackman, N., Parmer, R.J., and Miles, L.A. Binding of human single chain urokinase to Chinese hamster ovary cells and cloning of hamster u-PAR. Haemost., 1998, 80:148-154. PMID:9684801.
  36. Xue, S., Green, M.A., LoGrasso, P.V., Boettcher, B.R., Madison, E.L., Curtiss, L.K. and Miles, L.A. Comparison of the effects of apo(a) kringle IV-10 and plasminogen kringles on the interactions of lipoprotein(a) with regulatory molecules. Haemost., 1999, 81:428-435. PMID:10102473.
  37. Oka, H., Kugiyama, K., Doi, H., Sugiyama, S., Matsumura, T., Ogata, N., Miles, L.A. and Yasue, H. Lysophosphatidylcholine induces Urokinase-type plasminogen activator and its receptor in human macrophages through a redox-sensitive pathway. Thromb. Vasc. Biol., 2000, 20:244-250. PMID:10634825.
  38. Pozzi, A., Moberg, P.E., Miles, L.A., Wagner, S., Soloway, P. and Gardner, H. Elevated matrix metallaprotease and angiostatin levels in integrin α1 knockout mice cause reduced tumor vascularization. Natl. Acad. Sci., 2000, 5:2202-2207. PMID: 10681423, PMCID: PMC15778 (Identified as one of the most cited papers in the research area of matrix metalloprotease inhibition by ISI Essential Science Indicators).
  39. Parmer, R.J., Mahata, M., Gong, Y., Mahata, S.R., Jiang, Q., O’Connor, D.T., Xi, X-P., and Miles, L.A. Processing of chromogranin A by plasmin provides a novel mechanism for regulating catecholamine secretion. Clin. Invest., 2000, 106:907-915. PMID: 11018079, PMCID: PMC381423.
  40. Hawley, S.B., Green, M.A. and Miles, L.A. Discriminating between cell surface and intracellular plasminogen- binding proteins: heterogeneity in profibrinolytic plasminogen-binding proteins on monocytoid cells. Haemost., 2000, 84:882-890. PMID: 11127872.
  41. Hawley, S.B., Tamura, T.-A., and Miles, L.A. Purification, cloning and characterization of a profibrinolytic plasminogen binding protein: TIP49a. Biol. Chem., 2001, 276:179-186. PMID:11027681.
  42. Schleef, R.R., Olman, M.A., Miles, L.A., and Chuang, J.L. Modulating the fibrinolytic system of peripheral blood mononuclear cells with adenovirus. Gene Ther., 2001, 12:439-445. PMID:11242535.
  43. Gong, Y., Kim, S-O., Felez, J., Grella, D.K., Castellino, F.J. and Miles, L.A. Conversion of glu-plasminogen to lys-plasminogen is necessary for optimal stimulation of plasminogen activation on the endothelial cell surface. Biol. Chem., 2001, 276:19078-19083. PMID:11264290.
  44. Jiang, Q., Taupenot, L., Mahata, S.K., O’Connor, D.T., Miles, L.A., Parmer, R.J. Proteolytic cleavage of chromogranin A (CgA) by plasmin: selective liberation of a specific bioactive CgA fragment that regulates catecholamine release. Biol. Chem., 2001, 276:25022-25029. PMID:11342539.
  45. Xue, S., Madison, E.L.and Miles, L.A. The Kringle V-protease domain is a fibrinogen binding region within Apo(a). Haemost., 2001, 86:1229-1237. PMID:11816712.
  46. Tarui, T., Miles, L.A., and Takada, Y. Specific interaction of angiostatin with integrin v in endothelial cells. J. Biol. Chem., 2001, 276:39562-39568. PMID:11514539.
  47. Zhang, L., Seiffert, D., Fowler, B.J., Jenkins, G.R., Thinnes, T.D., Loskutoff, D.J., Parmer, R.J., and Miles, L.A. Plasminogen has a broad extrahepatic distribution in vivo. Haemost., 2002, 87:493-501. PMID:11916082.
  48. Yoshinaga, H., Nakahara, M., Koyama, T., Shibamiya, A., Nakazawa, F., Miles, L.A., Hirosawa, S., and Aoki, N. A single thymine nucleotide deletion responsible for congenital deficiency of plasmin inhibitor. Haemost., 2002, 88:144-148. PMID:12152655.
  49. Tarui, T., Manjumdar, M., Miles, L.A., Ruf, W., and Takada, Y. Plasmin-induced migration of endothelial cells: a potential target for the anti-angiogenic action of angiostatin, Biol. Chem., 2002, 277:33564-33570. PMID:12087108.
  50. Bannach, F.G., Gutierrez, A., Fowler, B.J., Bugge, T.H., Degen, J.L., Parmer, R.J., and Miles, L.A. Localization of regulatory elements mediating constitutive and cytokine-stimulated plasminogen gene expression. Biol. Chem., 2002, 277:38579-38588. PMID:12149246.
  51. Albrecht, S., Magdolen, V., Herzog, U., Miles, L. Kirschenhofer, A., Baretton, G., and Luther, T. Soluble tissue factor interferes with angiostatin-mediated inhibition of endothelial cell proliferation by lysine-specific interaction with plasminogen kringle domains. Haemost., 2002, 88:1054-1059. PMID:12529759.
  52. López-Alemany, R., Longstaff, C., Hawley, S., Mirshahi, M., Fábregas, P., Jardi, M., Merton, E., Miles, L.A., Félez, J., Inhibition of cell surface plasminogen activation by a monoclonal antibody against a-enolase, J. Hematol., 2003 72:234-242. PMID:12666133.
  53. Zhang, L., Gong, Y., Grella, D., Castellino, F.J., and Miles, L.A. Endogenous plasmin converts Glu-plasminogen to Lys-plasminogen on the monocytoid cell surface. Haemost., 2003, 1:1264-1270. PMID:12871329.
  54. Wang, N., Zhang, L., Miles, L.A., and Hoover-Plow, J. Plasminogen regulates pro-ipiomelanocortin processing, Thromb. Haemost., 2004, 2:785-796. PMID:15099286.
  55. Bannach, F.G., Gutierrez-Fernandez, A., Parmer, R. J., and Miles, L.A. Interleukin-6-induced plasminogen gene expression in murine hepatocytes is mediated by transcription factor CCAAT/enhancer binding protein b(C/EBPb), Thromb. Haemost., 2004, 2:2205-2212. PMID:15613028.
  56. Griffin, M. O, Jinno, M., Miles, L.A., and Villarreal, F.J. Reduction of myocardial infarct size by doxycycline: a role for plasmin inhibition, Cell Biochem., 2005, 270:1-11. PMID:15792348.
  57. Mitchell, J.W., Baik, N. Castellino, F.J., and Miles, L.A. Plasminogen inhibits TNFa apoptosis in monocytes, Blood, 2006, 107:4383-4390. PMID: 16478887, PMCID: PMC1895791.
  58. Miles, L.A., Andronicos, N.M., Baik, N., and Parmer, R.J. Cell-surface actin binds plasminogen and modulates neurotransmitter release from catecholaminergic cells. Neurosci., 2006, 26:13017-13024. PMID: 17167091.
  59. Gutierrez-Fernandez, A., Parmer, R.J., and Miles, L.A. Plasminogen gene expression is regulated by nerve growth factor. Thromb. Haemost., 2007, 5:1715-1725. PMID: 17663741.
  60. Gutierrez-Fernandez, A., Gingles, N.A, Bai, H., Castellino, F.J., Parmer, R.J., and Miles, L.A., Plasminogen enhances neuritogenesis on laminin-1, Neurosci., 2009, 29:12393-12400. PMID: 19812315, PMCID: PMC2789650.
  61. Andronicos, N.M., Chen, E.I., Baik, N., Bai, H., Parmer, C.M., Kiosses, W.B., Kamps, M.P., Yates, J.R., III, Parmer, R.J., and Miles, L.A. Proteomics-based discovery of a novel, structurally unique, and developmentally regulated plasminogen receptor, Plg-RKT, a major regulator of cell surface plasminogen activation. Blood, 2010,115:1319-1330. Plenary Paper. PMID: 19897580, PMCID: PMC2826757.
  62. Jiang, Q., Gingles, N.A., Olivier, M.A., Miles, L.A., and Parmer, R.J. The anti-fibrinolytic SERPIN, plasminogen activator inhibitor 1 (PAI-1), is targeted to and released from catecholamine storage vesicles. Blood, 2011, 117:7155-7162. PMID: 21596853, PMCID: PMC3143556.
  63. Han, J., Baik, N., Kim, K-H, Yang, J-M, Han, G, Gong, Y., Jardi, M., Castellino, F.J., Felez, J., Parmer, R.J. and Miles, L.A. Monoclonal antibodies detect receptor-induced binding sites (RIBS) in Glu-plasminogen. Blood, 2011, 118:1653-1662. PMID: 21680799, PMCID: PMC3156051.
  64. Bai, H. Baik, N., Kiosses, W.B., Krajewski, S., Miles, L.A., and Parmer, R.J. The novel plasminogen receptor, Plg-RKT regulates catecholamine release. Biol. Chem., 2011, 286:33125-33133. PMID: 6165997, PMCID: PMC3190921.
  65. Lighvani, S., Baik, N., Diggs, J.E., Khaldoyanidi, S., Parmer, R.J, and Miles, L.A. Regulation of macrophage migration by a novel plasminogen receptor Plg-RKT. Blood, 2011, 118:5622-5630. PMID: 21940822, PMCID: PMC3217361.
  66. Felez, J., Jardi, M., Fabregas, P., Parmer, R.J., and Miles, L.A. Monoclonal antibodies against receptor-induced binding sites detect cell-bound plasminogen in blood. Blood, 2012, 120:678-681. PMID: 22649107, PMCID: PMC3401219.
  67. Gingles, N.A., Bai H., Miles, L.A., and Parmer, R.J. Peptidergic regulation of plasminogen activator inhibitor-1 gene expression in vivo. Thromb. Haemost., 2013,11:1707-1715. PMID: 23800036, PMCID: PMC3965269.
  68. Briens, A., Bardou, I., Lebas, H., Miles, L.A., Parmer, R.J., Vivien, D., and Docagne, F. Astrocytes regulate the balance between plasminogen activation and plasmin clearance via cell-surface actin. Cell Discovery 2017 Feb 21;3:17001. doi: 10.1038/celldisc.2017.1. eCollection 2017. PMID:  28417010, PMCID: PMC5318850.
  69. Miles, L.A., Baik, N., Lighvani, S., Khaldoyanidi, S., Varki, N.M., Bai, H., Mueller, B.M., and Parmer, R.J. Deficiency of plasminogen receptor, Plg-RKT, causes defects in plasminogen binding and inflammatory macrophage recruitment in vivo. Thromb. Haemostat. 2017, 15(1):155-162. doi: 10.1111/jth.13532. PMID: 27714956, PMCID: PMC5280214 Highlighted as an Editors’ pick and designated as an “In Focus” article and subject of a Commentary.
  70. Sugimoto, M.A., Ribeiro, A.L.C., Costa, B.R.C., Vago, J.P., Lima, K.M., Carneiro, F.S., Ortiz, M.M.O., Lima, G.L.N., Carmo, A.A.F., Rocha, R.M., Perez, D.A., Reis, A.C., Pinho, V., Miles, L.A., Garcia, C.C., Teixeira, M.A., Sousa, L.P. Plasmin and plasminogen induce macrophage reprogramming and regulate key steps of inflammation resolution via annexin A1. Blood, 2017, May 25;129(21):2896-2907. PMID: 28320709, PMCID: PMC5445571.
  71. Miles, L.A., Baik, N., Bai, H., Makarenkova, H.P., Kiosses ,W.B., Krajewski, S., Castellino, F.J., Valenzuela, A., Varki, N.M., Mueller, B.M., Parmer, R.J. The plasminogen receptor, Plg-RKT, is essential for mammary lobuloalveolar development and lactation. J Thromb Haemost. 2018, 16(5):919-932. PMID: 29495105, PMCID: PMC5965281.
  72. Thaler, B., Baik, N., Hohensinner, P.J., Baumgartner, J., Panzenbock, A., Stojkovic, S., Demyanets, S., Huk, I., Rega-Kaun, G., Kaun, C., Prager, M., Fischer, M.B., Huber, K., Speidl, W.S., Parmer, R.J., Miles, L.A.* and Wojta, J.* Differential expression of Plg-RKT and its effects on migration of proinflammatory monocyte and macrophage subsets. Blood, 2019, 134(6):561-567. PMID: 31221672, PMCID: PMC6688429.
    *both authors contributed equally
  73. Vago, J.P., Sugimoto, M.A., Lima, K.M., Lima, G.L., Baik, N., Teixeira, M.M., Perretti, M., Parmer, R.J., Miles, L.A.* and Sousa, L.P.* Plasminogen and the plasminogen receptor, Plg-RKT, regulate macrophage phenotypic and functional changes. Immunol. 2019, 10:1458. PMID: 31316511, PMCID: PMC6611080.
    *both authors contributed equally
  74. Parmer, R.J., Yun, G., Yoo, S.H., and Miles, L.A. Neuroendocrine Targeting of Tissue Plasminogen Activator (t-PA). Neurol. Disord. Stroke., 2020, 7(1): 1153. PMID: 32549050.
  75. Whyte, C.S., Morrow, G.B., Baik, N., Booth, N.A., Jalal, M.M., Parmer, R.J., Miles, L.A., and Mutch, N.J. Exposure of plasminogen and the novel plasminogen receptor, Plg-RKT, on activated human and murine platelets, Blood, 2020, doi: 10.1182/blood.2020007263. PMID: 32842150.
  76. Ny, L., Parmer, R.J., Shen, Y., Holmberg, S., Broden, J., Wilczynska, M., Ny, T., and Miles, L.A. The plasminogen receptor, Plg-RKT, plays a role in inflammation and fibrinolysis during cutaneous wound healing in mice. Cell Death Dis, 11(12):1054 PMID: 33311441: doi: 10.1038/s41419-020-03230-1
  77. Samad, F., Bai, H., Baik, N., Hader, P., Rega-Kaun,G., Kaun, C., Prager, M., Wojta, J., Wang, J., Parmer, R.J., and Miles, L.A. Plg-RKT regulates adipose function and metabolic homeostasis,
    Submitted, EMBO Journal,
  78. Miles, L.A., Vago, J.P., Sousa, L.P., and Parmer, R.J. Functions of the Plasminogen Receptor, Plg-RKT. Thrombosis and Haemostasis, 2020. PMID: 29495105, PMCID: PMC5965281.
  79. Miles, L.A., Ny, L., Wilczynska, M., Shen, Y., Ny, T., Parmer, R.J. Plasminogen Receptors and Fibrinolysis. Int J Mol Sci., Feb 8;22(4):1712. doi: 10.3390/ijms22041712. PMID: 33567773, Review.

Reviews & Invited Articles

  1. Miles, L.A., Griffin, J.H., and Bouma, B.N. Some considerations of factor XII-dependent fibrinolytic pathways. In: International Workshop on Regulation of Coagulation, F. Taylor and K. Mann (Eds.) Elsevier, p. 543, 1979.
  2. Miles, L.A., Rothschild, Z., and Griffin, J.H. Dextran sulfate-dependent fibrinolytic activity in whole human plasma. In: Progress in Fibrinolysis, Churchill Livingstone, London, Vol VI, p. 58-61, 1983.
  3. Miles, L.A. and Plow, E.F. Fibrinolysis and cell surfaces. In: Fundamental and Clinical Fibrinolysis, Castellino et al, (Eds.) Elsevier Science Publishers BV, p. 111-123, 1987.
  4. Miles, L.A. and Griffin, J.H. The role of molecules immunologically related to urokinase in contact system-dependent fibrinolysis. In: Fundamental and Clinical Fibrinolysis, Castellino et al, (Eds.) Elsevier Science Publishers BV, p. 45-55, 1987.
  5. Plow, E.F. and Miles, L.A. Fibrinolytic mechanisms of polymorphonuclear leukocytes. In: Fibrinolysis: Current Prospects, P.J. Gaffney, J.F. Castellino, E.F. Plow and A. Takada (Eds.) John Libbey & Co. Ltd, England, p. 81-86, 1988.
  6. Miles, L.A. and Plow, E.F. Plasminogen receptors: Ubiquitous sites for cellular regulation of fibrinolysis. Fibrinolysis 2:61-71, 1988.
  7. Plow, E.F., Miles, L.A. and Collen, D. Platelet Alpha2-Antiplasmin. In: Methods in Enzymology, J. Hawiger (Ed.) Academic Press, 169:296-300, 1989. PMID: 2716530.
  8. Plow, E.F. and Miles, L.A. Relationship between plasminogen receptors and Lp(a). In: Lipoprotein(a), A.M. Scanu (Ed.) Academic Press, p. 117-128,
  9. Miles, L.A. and Plow, E.F. Lp(a): An interloper into the fibrinolytic system? Haemost. 63:331-335, 1990. PMID:2169655.
  10. Plow, E.F. and Miles, L.A. Plasminogen receptors in the mediation of pericellular proteolysis. Cell Differ. Dev., 32:293-298, 1990. PMID:1965955.
  11. Plow, E.F., Felez, J. and Miles, L.A. Cellular regulation of fibrinolysis. Haemost., 66:32-36, 1991. PMID: 1656542.
  12. Miles, L.A. Lipoprotein(a) fibrinolysis and thrombosis. Sangre, 37(Suppl 1):37-41, 1992.
  13. Plow, E.F. and Miles, L.A. The role of platelet receptors for components of the plasminogen system in the regulation of fibrinolysis. In: Thrombosis: An Update, G.G.N. Serneri et al., (Eds.) Scientific Press, Florence, Italy, p. 119-132, 1992.
  14. Wasi, S., Murray, S., Dahlberg, C.M., Plow, E.F. and Miles, L.A. Receptors for plasminogen on bovine lymphatic endothelial cells. In: Progress in Lymphology-XII, R.V. Cluzan, A.P. Pecking, F.M. Lokiec, (Eds). Elsevier Science Publishers B.V., p. 75-76, 1992.
  15. Parmer, R.J., Miles, L.A., Xi, X-P, Gill, B.M., Wu, H-J and O'Connor, D.T. Processing of chromaffin granule proteins: A profusion of proteases? Intl., 22:361-367, 1993. PMID: 8457772.
  16. Plow, E.F. and Miles, L.A. Interaction of the fibrinolytic system with the vessel wall. In: Thrombosis and Hemorrhage, J. Loscalzo and A.I. Schafer (Eds.) Blackwell Scientific Publishers, Boston, MA, p. 339-348, 1994.
  17. Miles, L.A. Regulation of fibrinolysis and proteolysis by plasminogen receptors. Clin. Hematol., 15:107-115, 1993.
  18. Miles, L.A. and Plow, E.F. Lipoprotein(a) and fibrinolysis. In: Fibrinolysis in Disease, Glas-Greenwalt, P. (Ed.), CRC Press, Inc., Chapter 8, p. 70-77, 1995.
  19. Plow, E.F., Herren, T., Redlitz, A., Miles, L.A. and Hoover-Plow, J.L. The cell biology of the plasminogen system. FASEB J., 9:939-945, 1995. PMID: 7615163.
  20. Todd, R.F., III, Barnathan, J., Bohuslav, J., Chapman, H.A., Cohen, R.L., Felez, J., Howell, A., Johnson, J.G., Knapp, W., Kramer, M., Miles, L.A., Nykjaer, A., Ralfkiaer, E. and Schuren, E. M15 Cluster Report: CD87. In: Leucocyte Typing V: White Cell Differentiation Antigens, Schlossman, S.F., Boumsell, L., Gilks, W., Harlan, J.M., Kishimoto, T., Morimoto, C., Ritz, J., Shaw, S., Silverstein, R.L., Springer, T.A., Tedder, T.F., Todd, R.F. III (Eds.), Oxford University Press, p. 932-939, 1995.
  21. Plow, E.F., Ugarova, T. and Miles, L.A. Interaction of the fibrinolytic system with the vessel wall. In: Thrombosis and and Hemorrhage, Second Edition, J. Loscalzo, A. Schafer, (Eds.), Chapter 18:373-385, 1998.
  22. Parmer, R.J. and Miles, L.A. Targeting of tissue plasminogen activator to the regulated pathway of secretion. Cardiovasc. Med., 8:306-312, 1998. PMID: 14987555.
  23. Parmer, R.J., Mahata, S.K., Jiang, Q., Taupenot, L., Gong, Y., Mahata, M., O’Connor, D.T., and Miles, L.A. Tissue plasminogen activator and chromaffin cell function. Exp. Med. Biol, 482:179-192, 2000. PMID: 11192579.
  24. Parmer, R.J., Mahata, S.K., Jiang, Q., Taupenot, L., Gong, Y., Mahata, M., O’Connor, D.T., and Miles, L.A. Tissue plasminogen activator and chromaffin cell function. In: Chromogranins: Functional and Clinical Aspects, Helle, K and Aunis, D. (Eds.); Kluwer Academic/Plenum Publishers: New York, Chapter 14, 179-192, 2000.
  25. Plow, E.F., Redlitz, A., Hawley, S.B., Xue, S., Herrin, T., Hoover-Plow, J.L. and Miles, L.A. Assembly of the plasminogen system on cell surfaces. In: Handbook of Experimental Pharmacology. Fibrinolytics and Antifibrinolytics, Bachmann, F. (Ed.), Springer-Verlag: Berlin, Chapter 6, pp 141-170,
  26. Jiang, Q., Yasothornsrikul, S., Taupenot, L., Miles, L.A., and Parmer, R.J. The local chromaffin cell plasminogen/ plasmin system and the regulation of catechomine secretion. N.Y. Acad. Sci., 971:445-449, 2002. PMID: 12438162.
  27. Miles, L.A., Hawley, S.B., and Parmer, R.J. Chromaffin cell plasminogen receptors. N.Y. Acad. Sci., 971:497-501, 2002. PMID: 12438164.
  28. Miles, L.A., Castellino, F.J., and Gong,Y. Critical role for conversion of Glu-plasminogen to Lys-plasminogen for optimal stimulation of plasminogen activation on cell surfaces. Trends Cardiovasc. Med., 13:21-30, 2003. PMID: 12554097.
  29. Miles, L.A., Andronicos, N.M., Felez, J., Grella, D.K., Castellino F.J. and Gong, Y. The Role of lys-pg in cell-mediated plasmin production. In: Plasminogen Regulation, Waisman, D. (Ed.) Academic/Plenum Publishers, New York. pp. 103-119, 2003.
  30. Gutierrez, A., Garcia-Bannach, F., Zhang, L., Jenkins, G.R., Parmer, R.J., and Miles, L.A. Regulation of plasminogen gene expression. In: Plasminogen Regulation, Waisman, D. (Ed.) Academic/Plenum Publishers, New York. pp. 67-80, 2003.
  31. Miles, L.A., and Ellis, V. α-enolase comes muscling in on plasminogen activation, Haemost., 90:564-565, 2003. PMID: 14515173.
  32. Miles, L.A., Hawley, S. B., Baik, N., Andronicos, N. M., Castellino, F.J. and Parmer, R.J. Plasminogen receptors: the sine qua non of cell surface plasminogen activation, Biosci., 10:1754-1762, 2005. PMID: 15769664.
  33. Miles, L.A., and Parmer, R.J. PAI-1: Cardiac friend or foe? Blood, 10:1862-1863, 2010. PMID: 20223930.
  34. Miles, L.A., and Parmer, R.J. S100A10: A complex inflammatory role. Blood, 116:1022-1024, PMID: 20724548.
  35. Miles, L.A., Andronicos, N.M., Chen, E.I., Baik, N., Bai, H., Parmer, C.M., Lighvani, S., Nangia, S., Kiosses, W.B., Kamps, M.P., Yates III, J.R. and Parmer, R.J. Identification of the novel plasminogen receptor, Plg-RKT. In: Proteomics/Book 1: Human Diseases and Protein Functions, ISBN 978-953-307-832-8, Man, T.K. and Flores, R.J.(Eds.), Intech, Chapter 10: 219-238, 2012. Available from:

http://www.intechopen.com/articles/show/title/identification-of-the-novel-plasminogen-receptor-plg-rkt

  1. Miles, L.A., Lighvani, S., Baik, N., Andronicos, N., Chen, E.I., Parmer, C.M., Khaldoyanidi, S., Diggs, J., Kiosses, W., Kamps, M.P., Yates, J.R., and Parmer, R.J. The plasminogen receptor, Plg-RKT, and macrophage function. Biomed. Biotechnol., 2012;2012:250464. PMID: 23125524, PMCID: PMC3484331.
  2. Miles, L.A., Plow, E.F., Waisman, D.M., and Parmer, R.J. Plasminogen receptors. Biomed. Biotechnol., 2012;2012:130735. PMID: 23226936, PMCID: PMC3511834.
  3. Miles, L.A. and Parmer, R.J. Plasminogen receptors: the first quarter century. Thromb. Hemost., 39(4):329-337, 2013. PMID: 23532575, PMCID: PMC3938387.
  4. Miles, L.A., Lighvani, S., Baik, N., Parmer, C.M., Khaldoyanidi, S., Mueller, B.M., Parmer, R.J. New insights into the role of Plg-RKT in macrophage recruitment. Rev. Cell. Mole. Biol., 309:259-302, 2014. PMID: 24529725, PMCID: PMC4060795.
  5. Miles, L.A., and Parmer, R.J. Setting the table for macrophages. Blood, 124(5):665-666, 2014. PMID: 25082858, PMCID: PMC4118476.
  6. Miles, L.A., and Parmer, R.J. Angry macrophages patrol for fibrin. Blood, 127(9):1079-1080, 2016. doi: 10.1182/blood-2016-01-687673. PMID: 26941388, PMCID: PMC4778160.
  7. Miles, L.A., and Parmer, R.J. t-PA and Anger Management for Macrophages. Blood, 130(11):1280-1281, 2017. PMID: 28912293, PMCID: PMC5600143.
  8. Miles, L.A., Vago, J.P., Sousa, L.P., and Parmer, R.J. Functions of the Plasminogen Receptor, Plg-RKT. Thrombosis and Haemostasis, 2020. PMID: 29495105, PMCID: PMC5965281.
  9. Miles, L.A., Ny, L., Wilczynska, M., Shen, Y., Ny, T., Parmer, R.J. Plasminogen Receptors and Fibrinolysis. Int J Mol Sci., 2021, Feb 8;22(4):1712. doi: 10.3390/ijms22041712. PMID: 33567773, Review.