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Publications

  • Rybakin, V., and N. R. Gascoigne. (2012). Negative selection assay based on stimulation of T cell receptor transgenic thymocytes with peptide-MHC tetramers. PloS one 7:e43191.
  • Fu, G., J. Hu, N. Niederberger-Magnenat, V. Rybakin, J. Casas, P. P. Yachi, S. Feldstein, B. Ma, J. A. Hoerter, J. Ampudia, S. Rigaud, F. Lambolez, A. L. Gavin, K. Sauer, H. Cheroutre, and N. R. Gascoigne. (2011). Protein  Kinase C eta Is Required for T Cell Activation and Homeostatic Proliferation. Science signaling 4:ra84.
  • Rybakin, V., J. P. Clamme, J. Ampudia, P. P. Yachi, and N. R. Gascoigne. (2011). CD8alphaalpha and -alphabeta isotypes are equally recruited to the immunological synapse through their ability to bind to MHC class I. EMBO Rep 12:1251-6.
  • Gascoigne, N. R., and E. Palmer. (2011). Signaling in thymic selection. Current opinion in immunology 23:207-12.
  • Gascoigne, N. R. (2011). T cell receptor structures: three for the price of one. Immunity 35:1-3.
  • Brockmeyer, C., W. Paster, D. Pepper, C. P. Tan, D. C. Trudgian, S. McGowan, G. Fu, N. R. Gascoigne, O. Acuto, and M. Salek. (2011). T cell receptor (TCR)-induced tyrosine phosphorylation dynamics identifies THEMIS as a new TCR signalosome component. The Journal of biological chemistry 286:7535-47.
  • Singleton, K. L., K. T. Roybal, Y. Sun, G. Fu, N. R. Gascoigne, N. S. van Oers, and C. Wulfing. (2009). Spatiotemporal patterning during T cell activation is highly diverse. Science signaling 2:ra15.
  • Gascoigne, N. R., J. Ampudia, J. P. Clamme, G. Fu, C. Lotz, M. Mallaun, N. Niederberger, E. Palmer, V. Rybakin, P. P. Yachi, and T. Zal. (2009). Visualizing intermolecular interactions in T cells. Current topics in microbiology and immunology 334:31-46.
  • Fu, G., S. Vallee, V. Rybakin, M. V. McGuire, J. Ampudia, C. Brockmeyer, M. Salek, P. R. Fallen, J. A. Hoerter, A. Munshi, Y. H. Huang, J. Hu, H. S. Fox, K. Sauer, O. Acuto, and N. R. Gascoigne. (2009). Themis controls thymocyte selection through regulation of T cell antigen receptor-mediated signaling. Nature immunology 10:848-56.
  • Fu, G., and N. R. Gascoigne. (2009). Multiplexed labeling of samples with cell tracking dyes facilitates rapid and accurate internally controlled calcium flux measurement by flow cytometry. Journal of immunological methods 350:194-9.
  • Mallaun, M., D. Naeher, M. A. Daniels, P. P. Yachi, B. Hausmann, I. F. Luescher, N. R. Gascoigne, and E. Palmer. (2008). The T cell receptor's alpha-chain connecting peptide motif promotes close approximation of the CD8 coreceptor allowing efficient signal initiation. Journal of immunology 180:8211-21.
  • Gascoigne, N. R. (2008). Do T cells need endogenous peptides for activation? Nature reviews. Immunology 8:895-900.
  • Yachi, P. P., C. Lotz, J. Ampudia, and N. R. Gascoigne. (2007). T cell activation enhancement by endogenous pMHC acts for both weak and strong agonists but varies with differentiation state. The Journal of experimental medicine 204:2747-57.
  • Zal, T., M. A. Zal, C. Lotz, C. J. Goergen, and N. R. Gascoigne. (2006). Spectral shift of fluorescent dye FM4-64 reveals distinct microenvironment of nuclear envelope in living cells. Traffic 7:1607-13.
  • Yachi, P. P., J. Ampudia, T. Zal, and N. R. Gascoigne. (2006). Altered peptide ligands induce delayed CD8-T cell receptor interaction--a role for CD8 in distinguishing antigen quality. Immunity 25:203-11.
  • Daniels, M. A., E. Teixeiro, J. Gill, B. Hausmann, D. Roubaty, K. Holmberg, G. Werlen, G. A. Hollander, N. R. Gascoigne, and E. Palmer. (2006). Thymic selection threshold defined by compartmentalization of Ras/MAPK signalling. Nature 444:724-9.
  • Yachi, P. P., J. Ampudia, N. R. Gascoigne, and T. Zal. (2005). Nonstimulatory peptides contribute to antigen-induced CD8-T cell receptor interaction at the immunological synapse. Nature immunology 6:785-92.
  • Zal, T., and N. R. Gascoigne. (2004). Photobleaching-corrected FRET efficiency imaging of live cells. Biophysical journal 86:3923-39.
  • Zal, T., and N. R. Gascoigne. (2004). Using live FRET imaging to reveal early protein-protein interactions during T cell activation. Current opinion in immunology 16:418-27.
  • Gronski, M. A., J. M. Boulter, D. Moskophidis, L. T. Nguyen, K. Holmberg, A. R. Elford, E. K. Deenick, H. O. Kim, J. M. Penninger, B. Odermatt, A. Gallimore, N. R. Gascoigne, and P. S. Ohashi. (2004). TCR affinity and negative regulation limit autoimmunity. Nature medicine 10:1234-9.
  • Gascoigne, N. R., and T. Zal. (2004). Molecular interactions at the T cell-antigen-presenting cell interface. Current opinion in immunology 16:114-9.
  • Niederberger, N., K. Holmberg, S. M. Alam, W. Sakati, M. Naramura, H. Gu, and N. R. Gascoigne. (2003). Allelic exclusion of the TCR alpha-chain is an active process requiring TCR-mediated signaling and c-Cbl. Journal of immunology 170:4557-63.
  • Holmberg, K., S. Mariathasan, T. Ohteki, P. S. Ohashi, and N. R. Gascoigne. (2003). TCR binding kinetics measured with MHC class I tetramers reveal a positive selecting peptide with relatively high affinity for TCR. Journal of immunology 171:2427-34.
  • Zal, T., M. A. Zal, and N. R. Gascoigne. (2002). Inhibition of T cell receptor-coreceptor interactions by antagonist ligands visualized by live FRET imaging of the T-hybridoma immunological synapse. Immunity 16:521-34.
  • Sim, B. C., L. Zerva, M. I. Greene, and N. R. Gascoigne. (1996). Control of MHC restriction by TCR Valpha CDR1 and CDR2. Science 273:963-6.
  • Alam, S. M., P. J. Travers, J. L. Wung, W. Nasholds, S. Redpath, S. C. Jameson, and N. R. Gascoigne. (1996). T-cell-receptor affinity and thymocyte positive selection. Nature 381:616-20.

REVIEWS

  • Fu, G., and N. R. Gascoigne. (2012). The role of protein kinase C eta in T cell biology. Front Immunol 3:177.
  • Gascoigne, N. R., and G. Fu. (2012). Tespa1: another gatekeeper for positive selection. Nature immunology 13:530-2.
  • Gascoigne, N. R., J. Casas, J. Brzostek, and V. Rybakin. (2011). Initiation of TCR phosphorylation and signal transduction. Front Immunol 2:72.