GENOMIC MOSAICISM

LP RECEPTORS

MULTIPLE SCLEROSIS

NERVOUS SYSTEM DEVELOPMENT

NON-BRAIN DISEASE

OTHER BRAIN DISEASE

265.  Vogt J, Kirischuk S, Unichenko P, Schluter L, Pelosi A, Endle H, Yang JW, Schmarowski N, Cheng J, Thalman C, Strauss U, Prokudin A, Bharati BS, Aoki J, Chun J, Lutz B, Luhmann HJ, Nitsch R.  Synaptic phospholipid signaling modulates axon outgrowth via glutamate-dependent Ca2+-mediated molecular pathways.  Cereb Cortex epub ahead of print 2016 Nov 30.

264.  Fang V, Chaluvadi VS, Ramos-Perez WD, Mendoza A, Baeyens A, Rivera R, Chun J, Cammer M, Schwab SR.  Gradients of the signaling lipid S1P in lymph nodes position natural killer cells and regulate their interferon-γ response.Nature Immunol epub ahead of print 2016 Nov 14. doi:10.1038/ni.3619.

263.  Gazit SL, Mariko B, Therond P, Decouture B, Xiong Y, Couty L, Bonnin P, Baudrie V, Le Gall SM, Dizier B, Zoghdani N, Ransinan J, Hamilton JR, Gaussem P, Tharaux PL, Chun J, Coughlin SR, Bachelot-Loza C, Hla T, Ho-Tin-Noe B, Camerer E.  Platelet and erythrocyte sources of S1P are redundant for vascular development and homeostasis, but both rendered essential after plasma S1P depletion in anaphylactic shock.  Circ Res 2016;119(8):e110-e126.

262.  Lake BB, Ai R, Kaeser GE, Salathia NS, Yung YC, Liu R, Wildberg A, Gao D, Fung H-L, Chen S, Vijayaraghavan R, Wong J, Chen C, Sheng X, Kaper F, Shen R, Ronaghi M, Fan JB, *Wang W, *Chun J, *Zhang K.  Neuronal subtypes and diversity revealed by single-nucleus RNA sequencing of the human brain.  Science 2016;352(6293):1586-1590. *Co-senior authors.  PMC5038589

261.  Clay H, Wilsbacher LD, Wilson SJ, Duong DN, McDonald M, Lam I, Park KE, Chun J, Coughlin SR.  Sphingosine 1-phosphate receptor-1 in cardiomyocytes is required for normal cardiac development.  Dev Biol 2016;418(1):157-165.  PMC5031538

260.  Keul P, van Borren MM, GhanemA, Muller FU, Baartscheer A, Verkerk AO, Stumpel F, Schulte JS, Hamdani N, Linke WA, van Loenen P, Matus M, Schmitz W, Stypmann J, Tiemann K, Ravesloot JH, Alewijinse AE, Hermann S, Spijkers LJ, Herr D, Heusch G, Schafers M, Peters SL, Chun J, Levkau B.  Spingosine 1-phosphate receptor 1 regulates cardiac function by modulating Ca2+ sensitivity and Na+/H+ exchange and mediates protection by ischemic preconditioning.  J Am Heart Assoc 2016;5(5):pii: e003393.  PMC4889204

259.  Alfonzo-Mendez MA, Castillo-Badillo JA, Romero-Avila MT, Rivera R, Chun J, Garcia-Sainz JA.  Carboxyl terminus-truncated alpha1D-adrenoceptors inhibit the ERK pathway.  Naunyn Schmiedebergs Arch Pharmacol 2016;389(8):911-920.

258.  Funke M, Knudsen L, Lagares D, Ebener S, Probst CK, Fontaine BA, Franklin A, Kellner M, Kuhnel M, Matthieu S, Grothausmann, Chun J, Roberts JD Jr, Ochs M, Tager AM.  Lyosphosphatidic acid signaling through the lysophosphatidic acid-1 receptor is required for alveolarization.  Am J Respir Cell Mol Biol 2016;55(1):105-116.  PMC4942205

257.  Herr DR, Reolo MJ, Peh YX, Wang W, Lee CW, Rivera R, Paterson IC, Chun J.  Sphingosine 1-phosphate receptor 2 (S1P2) attenuates reactive oxygen species formation and inhibits cell death:  implications for otoprotective therapy.  Sci Rep 2016;6:24541.  PMC4832229

256.  Nishioka T, Arima N, Kano K, Hama K, Itai E, Yukiura H, Kise R, Inoue A, Kim SH, Solnica-Krezel L, Moolenaar WH, Chun J, Aoki J.  ATX-LPA1 axis contributes to proliferation of chondrocytes by regulating fibronectin assembly leading to proper cartilage formation.  Sci Rep 2016;6:23433. doi:10.1038/srep23433.  PMC4804234

255.  Kitada Y, Kajita K, Taguchi K, Mori I, Yamauchi M, Ikeda T, Kawashima M, Asano M, Kajita T, Ishizuka T, Banno Y, Kojima I, Chun J, Kamata S, Ishii I, Morita H.  Blockade of sphingosine 1-phosphate receptor 2 signaling attenuates high-fat diet-induced adipocyte hypertrophy and systemic glucose intolerance in mice.  Endocrinology 2016;157(5):1839-1851.

254.  Fan J, Salathia N, Liu R, Kaeser GE, Yung YC, Herman JL, Kaper F, Fan JB, Zhang K, Chun J, Kharchenko PV.  Characterizing transcriptional heterogeneity through pathway and gene set overdispersion analysis.  Nat Methods 2016;13(3):241-244.  PMC4772672

252.  Moon E, Han JE, Jeon S, Ryu JH, Choi JW, Chun J.  Exogenous S1P exposure potentiates ischemic stroke damage that is reduced possibly by inhibiting S1P receptor signaling.  Mediators Inflamm 2015;492659.  PMC4630407

251.  Kihara Y, Groves A, Rivera RR, Chun J.  Dimethyl fumarate inhibits integrin α4 expression in multiple sclerosis models.  Ann Clin Transl Neurol 2015;2(10):978-983.  doi:10.1002/acn3.251.  PMC4603381  DOWNLOAD PDF

250.  Garcia-Diaz B, Riquelme R, Varela-Nieto I, Jimenez AJ, de Diego I, Gomez-Conde AL, Matas-Rico E, Aguirre JA, Chun J, Pedraza C, Santin LJ, Fernandez O, Rodriguez de Fonseca F, Estivill-Torrus G.  Loss of lysophosphatidic acid receptor LPA1 alters oligodendrocyte differentiation and myelination in the mouse cerebral cortex.  Brain Struct Funct 2015;220(6):3701-3720.

249.  Santos-Nogueira E, Lopez-Serrano C, Hernandez J, Lago N, Astudillo AM, Balsinde J, Estivill-Torrus G, de Fonseca FR, Chun J, Lopez-Vales R.  Activation of lysophosphatidic acid receptor type 1 contributes to pathophysiology of spinal cord injury.  J Neurosci 2015;35(28):10224-35.  doi:10.1523/JNEUROSCI.4703-14.2015.  PMC4502263  DOWNLOAD PDF

248.  Xu K, Ma L, Li Y, Wang F, Zheng G-Y, Sun Z, Jiang F, Chen Y, Liu H, Dang A, Chen X, Chun J, Tian X-L.  Genetic and functional evidence supports LPAR1 as a susceptibility gene for hypertension.  Hypertension 2015;doi:10.1161/hypertensionaha.115.05515

247.  Chrencik JE, Roth CB, Terakado M, Kurata H, Omi R, Kihara Y, Warshaviak D, Nakade S, Asmar-Rovira G, Mileni M, Mizuno H, Griffith MT, Rodgers C, Han GW, Velasquez J, Chun J*, Stevens RC*, Hanson MA*.  Crystal structure of antagonist bound human lysophosphatidic acid receptor 1.  Cell 2015;161:1633-1643.  *co-senior authors.  PMC4476059  DOWNLOAD PDF

246.  Mirendil H, Thomas EA, De Loera C, Okada K, Inomata Y, Chun J.  LPA signaling initiates schizophrenia-like brain and behavioral changes in a mouse model of prenatal brain hemorrhage. Transl Psychiatry 2015;5:e541.  doi:10.1038/tp.2015.33.  PMC4462599  DOWNLOAD PDF

245.  Gonzalez de San Ramon E, Manuel I, Giralt MT, Chun J, Estivill-Torrus G, Rodridguez de Fonseca F, Santin LJ, Ferrer I, Rodriguez-Puertas R.  Anatomical location of LPA1 activation and LPA phospholipid precursors in rodent and human brain.  J Neurochem 2015;134(3):471-485.  doi:10.1111/jnc.13112.

244.  Suardiaz M, Galan-Arriero I, Avila-Martin G, Estivill-Torrus G, de Fonseca FR, Chun J, Gomez-Soriano J, Bravo-Esteban E, Taylor J.  Spinal cord compression injury in lysophosphatidic acid 1 receptor-null mice promotes maladaptive pronociceptive descending control.  Eur J Pain 2015.  doi:10.1002/ejp.695.

243.  Bushman DM, Kaeser GE, Siddoway B, Westra JW, Rivera RR, Rehen SK, Yung YC, Chun J.  Genomic mosaicism with increased amyloid precursor protein (APP) gene copy number in single neurons from sporadic Alzheimer's disease brains.  eLife 2015;4:e05116.  doi:10.7554/eLife.0516.  PMC4337608  LINK TO ARTICLE

242.  Sheng X, Yung YC, Chen A, Chun J.  Lysophosphatidic acid signalling in development. Development 2015;142:1390-1395.  doi:10.1242/dev.121723.  PMC4392601  DOWNLOAD PDF

241.  Yung YC, Stoddard NC, Mirendil H, Chun J.  Lysophosphatidic acid signaling in the nervous system.  Neuron 2015;85(4):669-682.  doi:10.1016/j.neuron.2015.01/009. PMC4400838  DOWNLOAD PDF

240.  Stoddard NC, Chun J.  Promising pharmacological directions in the world of lysophosphatidic acid signaling.  Biomol Ther (Seoul) 2015;23(1):1-11.  PMC4286743  DOWNLOAD PDF

239.  Kihara Y, Mizuno H, Chun J.  Lysophospholipid receptors in drug discovery.  Exp Cell Res 2015;333(2):171-177.  doi:10.1016/j.yexcr.2014.11.020.  PMC4408218  DOWNLOAD PDF

238.  Keller J, Catala-Lehnen P, Huebner AK, Jeschke A, Heckt T, Lueth A, Krause M, Koehne T, Albers J, Schulze J, Schilling S, Haberland M, Denninger H, Neven M, Hermans-Borgmeyer I, Streichert T, Breer S, Barvencik F, Levkau B, Rathkolb B, Wolf E, Calzada-Wack J, Neff F, Gailus-Durner V, Fuchs H, de Angelis MH, Klutmann S, Tsourdi E, Hofbauer LC, Kleuser B, Chun J, Schinke T, Amling M.  Calcitonin controls bone formation by inhibiting the release of sphingosine 1-phosphate from osteoclasts.  Nat Commun 2014;5:5215.  PMC4205484  DOWNLOAD PDF

237.  Chun J.  An introduction to the JLR thematic series on lysophospholipids.  J Lipid Res 2014;55(5):798.  PMC3995457  DOWNLOAD PDF

236.  David M, Machuca-Gayet I, Kikuta J, Ottewell P, Mima F, Leblanc R, Bonnelye E, Ribeiro J, Holen I, Vales RL, Jurdic P, Chun J, Clezardin P, Ishii M, Peyruchaud O.  Lysophosphatidic acid receptor type 1 (LPA₁) plays a functional role in osteoclast differentiation and bone resorption activity.  J Bio Chem 2014;289(10):6551-6564.  PMC3945319  DOWNLOAD PDF

235.  Wu DD, Zhang F, Hao F, Chun J, Xu X, Cui MZ.  Matricellular protein cyr61 bridges lysophosphatidic acid and integrin pathways leading to cell migration.  J Biol Chem 2014;289(9):5774-5783.  PMC3937649  DOWNLOAD PDF

234.  Yung YC, Stoddard NC, Chun J.  LPA receptor signaling: Pharmacology, physiology, and pathophysiology.  J Lipid Res 2014;55(7):1192-1214.  PMC4076099  DOWNLOAD PDF

233.  Kihara Y, Maceyka M, Spiegel S, Chun J.  Lysophospholipid receptor nomenclature review:  IUPHAR Review 8.  Br J Pharmacol 2014;171(15):3575-3594.  PMC4128058  DOWNLOAD PDF

232.  Anliker B, Choi JW, Lin ME, Gardell SE, Rivera R, Kennedy G, Chun J.  Lysophosphatidic acid (LPA) and its receptor, LPA₁, influence embryonic Schwann cell migration, myelination, and cell-to-axon segregation. Glia 2013;61(12):2009-2022.  PMC3941654  DOWNLOAD PDF

227.  Huang LS, Fu P, Patel P, Harijith A, Sun T, Zhao Y, Garcia JG, Chun J, Natarajan V.  Lysophosphatidic acid receptor 2 deficiency confers protection against bleomycin-induced lung injury and fibrosis in mice.  Am J Respir Cell Mol Biol 2013;49(6):912-922.  DOWNLOAD PDF

226.  Ma L, Nagai J, Chun J, Ueda H.  An LPA species (18:1 LPA) plays key roles in the self-amlification of spinal LPA production in the peripheral neuropathic pain model.  Mol Pain 2013;9(1):29. PMC3691926  DOWNLOAD PDF

225.  Miyabe Y, Miyabe C, Iwai Y, Takayasu A, Fukuda S, Yokoyama W, Nagai J, Jona M, Tokuhara Y, Ohkawa R, Albers HM, Ovaa H, Aoki J, Chun J, Yatomi Y, Ueda H, Miyasaka M, Miyasaka N, Nanki T.  Lysophosphatidic acid receptor 1 is essential for development of arthritis.  Arthritis Rheum 2013;65(8):2037-2047.  DOWNLOAD PDF

224.  Lee SJ, Leoni G, Neurmann PA, Chun J, Nusrat A, Yun CC.  Distinct phospholipase C-β isozymes mediate lysophosphatidic acid receptor 1 effects on intestinal epithelial homeostatis and wound closure.  Mol Cell Biol 2013;33(10):2016-2028.  PMC3647975  DOWNLOAD PDF

223.  Halder SK, Yano R, Chun J, Ueda H.  Involvement of LPA₁ receptor signaling in cerebral ischemia-induced neuropathic pain.  Neuroscience 2013;235:10-15.  DOWNLOAD PDF

222.  Sakai N, Chun J, Duffield JS, Wada T, Luster AD, Tager AM.  LPA₁-induced cytoskeleton reorganization drives fibrosis through CTGF-dependent fibroblast proliferation.  FASEB J 2013;27(5):1830-1846.  PMC3633809  DOWNLOAD PDF

221.  Zhao Y, Fu P, Zhao J, Mialki RK, Wei J, Huang L, Chun J, Leme AS, Shapiro SD, Natarajan V.  Sepsis by using cecal ligation and single puncture causes alveolar space enlargement in LPA₂ knockout mice. J Aller Ther 2012;S4 005.  doi:  10.4172/2155-6121.S4-005.  DOWNLOAD PDF

220.  Mirendil H, Lin ME, Chun J.  Lysophosphatidic acid (LPA) receptor signaling. In Lysophospholipid receptors: signaling and biochemistry. Edited by Chun J, Hla T, Spiegel S, Moolenaar W.  John Wiley & Sons, Inc., Hoboken, NJ. 2013.

219.  Lysophospholipid receptors:  signaling and biochemistry. Edited by Chun J, Hla T, Spiegel S, Moolenaar W.  John Wiley & Sons, Inc., Hoboken, NJ. 2013. 

218.  Groves A, Kihara Y, Chun J.  Fingolimod:  Direct CNS effects of sphingosine 1-phosphate (S1P) receptor modulation and implications in multiple sclerosis therapy.  J Neurol Sci 2013;328(1-2):9-18.  PMC3640626  DOWNLOAD PDF

217.  Bushman DM, Chun J.  The genomically mosaic brain:  aneuploidy and more in neural diversity and disease. Semin Cell Dev Biol 2013;24(4):357-369.  PMC3637860  DOWNLOAD PDF

216.  Choi JW, Chun J.  Lysophospholipids and their receptors in the central nervous system.  Biochim Biophys Acta 2013;1831(1):20-32. PMC3693945   DOWNLOAD PDF

215.  Peterson SE, Yang AH, Bushman DM, Westra JW, Yung YC, Barral S, Mutoh T, Rehen SK, Chun J.  Aneuploid cells are differentially susceptible to caspase-mediated death during embryonic cerebral cortical development.  J Neurosci 2012;32(46):16213-16222. PMC3614491   DOWNLOAD PDF

214.  Garcia-Fernandez M, Castilla-Ortega E, Pedraza C, Blanco E, Hurtado-Guerrero I, Barbancho MA, Chun J, Rodriguez-de-Fonseca F, Estivill-Torrus G, Nunez LJ.  Chronic immobilization in the malpar1 knockout mice increases oxidative stress in the hippocampus.  Int J Neurosci 2012;122(10):583-589.

213.  Castilla-Ortega E, Pedraza C, Chun J, Fonseca FR, Estivill-Torrus G, Santin LJ.  Hippocampal c-Fos activation in normal and LPA₁-null mice after two object recognition tasks with different memory demands.  Behav Brain Res 2012;232(2):400-405.  DOWNLOAD PDF

212.  Lin ME, Rivera RR, Chun J.  Targeted deletion of LPA₅ identifies novel roles for lysophosphatidic acid signaling in development of neuropathic pain.  J Biol Chem 2012;287(21):17608-17617. PMC3366844   DOWNLOAD PDF

211.  Ye X, Diao H, Chun J.  11-deoxy prostaglandin F(2a), a thromboxane A2 receptor agonist, partially alleviates embryo crowding in Lpar3((-/-)) females.  Fertil Steril 2012;97(3):757-763. PMC3315158    DOWNLOAD PDF

210.  Funke M, Xhao Z, Xu Y, Chun J, Tager AM.  The lysophosphatidic acid receptor LPA1 promotes epithelial cell apoptosis following lung injury.  Am J Respir Cell Mol Biol 2012;46(3):355-364. PMC3326436   DOWNLOAD PDF

209.  Cheng HY, Dong A, Panchatcharam M, Mueller P, Yang F, Li Z, Mills G, Chun J, Morris AJ, Smyth SS.  Lysophosphatidic acid signaling protects pulmonary vasculature from hypoxia induced remodeling.  Arterioscler Thromb Vasc Biol 2012;32(1):24-32. PMC3241874    DOWNLOAD PDF

207.  Cohen JA, Chun J.  Reply.  Ann Neurol 2011;70(4):674.

206.  Akahoshi N, Ishizaki Y, Yasuda H, Murashima YL, Shinba T, Goto K, Himi T, Chun J, Ishii I.  Frequent spontaneous seizures followed by spatial working memory/anxiety deficits in mice lacking sphingosine 1-phosphate receptor 2.  Epilepsy Behav 2011;22(4):659-665.    DOWNLOAD PDF

205.  Castillo-Badillo JA, Molina-Munoz T, Romero-Avila MT, Vazquez-Macias A, Rivera R, Chun J, Garcia-Sainz JA.  Sphingosine 1-phosphate-mediated a(1B)-adrenoceptor desensitization and phosphorylation:  Direct and paracrine/autocrine actions.  Biochim Biophys Acta 2011;1823(2):245-254. PMC22019450   DOWNLOAD PDF

204.  Castilla-Ortega E, Hoyo-Becerra C, Pedraza C, Chun J, Rodriguez De Fonseca F, Estivill-Torrus G, Santin LJ.  Aggravation of chronic stress effects on hippocampal neurogenesis and spatial memory in LPA(1) receptor knockout mice.  PLoS One 2011;6(9):e25522. PMC3183048.   Correction in PLoS One. 2011;6(11). doi: 10.1371/annotation/c105dab8-59b8-467a-9223-5bd92936e49a   DOWNLOAD PDF

203.  Yung YC, Mutoh T, Lin ME, Noguchi K, Rivera RR, Choi JW, Kingsbury MA, Chun J.  Lysophosphatidic acid signaling may initiate fetal hydrocephalus.  Sci Transl Med 2011;3:99ra87.  PMC3653407    DOWNLOAD PDF

202.  Herr KJ, Herr DR, Lee CW, Noguchi K, Chun J.  Stereotyped fetal brain disorganization is induced by hypoxia and requires lysophosphatidic acid receptor 1 (LPA₁) signaling.  Proc Natl Acad Sci USA 2011;108(37):15444-15449. PMC3174597    DOWNLOAD PDF

201.  Zhao J, He D, Su Y, Berdyshev EV, Chun J, Natarajan V, Zhao Y.  Lysophosphatidic acid receptor 1 modulates lipopolysaccharide-induced inflammation in alveolar epithelial cells and murine lungs.  Am J Physiol Physiol Lung Cell Mol Physiol 2011;301(4):L547-L556. PMC3191756    DOWNLOAD PDF

200.  Peterson SE, Westra JW, Rehen SK, Young H, Bushman DM, Paczkowski CM, Yung YC, Lynch CL, Tran HT, Nickey KS, Wang YC, Laurent LC, Loring JF, Carpenter MK, Chun J.  Normal human pluripotent stem cell lines exhibit pervasive mosaic aneuploidy.  PLoS ONE 2011;6(8):e23018. PMC3156708    DOWNLOAD PDF

199.  Peterson SE, Chun J, Loring J.  FISH analysis of human pluripotent stem cells.  Methods Mol Biol 2011;767:191-200.  DOWNLOAD PDF

198.  Gennero I, Laurencin-Dalicieux S, Conte-Auriol F, Briand-Mesange F, Laurencin D, Rue J, Beton N, Malet N, Mus M, Tokumura A, Bourin P, Vico L, Brunel G, Oreffo RO, Chun J, Salles JP.  Absence of the lysophosphatidic acid receptor LPA1 results in abnormal bone development and decreased bone mass.  Bone 2011;49(3):395-403. PMC3697734    DOWNLOAD PDF

197.  Zhou Z, Subramanian P, Sevilmis G, Globke B, Soehnlein O, Karshovska E, Megens R, Heyll K, Chun J, Saulnier-Blache JS, Reinholz M, van Zandvoort M, Weber C, Schober A.  Lipoprotein-derived lysophosphatidic acid promotes atherosclerosis by releasing CXCL1 from the endothelium.  Cell Metab 2011;13(5):592-600.   DOWNLOAD PDF

196.  Zhao C, Sardella A, Chun J, Poubelle PE, Fernandes MJ, Bourgoin SG.  TNF-a promotes LPA₁- and LPA₃-mediated recruitment of leukocytes in vivo through CXCR2 ligand chemokines.  J Lipid Res 2011;52(7):1307-1318. PMC3111742    DOWNLOAD PDF

195.  Ye X, Herr DR, Diao H, Rivera R, Chun J.  Unique uterine localization and regulation may differentiate LPA3 from other lysophospholipid receptors for its role in embryo implantation.  Fertil Steril 2011;95(6):2107-2113. PMC308461    DOWNLOAD PDF

194.  Soliven B, Miron V, Chun J.  The neurobiology of sphingosine 1-phosphate signaling and sphingosine 1-phosphate receptor modulators.  Neurol Suppl 2011;76(8 Suppl 3):S9-14.  

193.  Park Hopson K, Truelove J, Chun J, Wang Y, Waeber C.  S1P activates store-operated calcium entry via receptor- and non-receptor-mediated pathways in vascular smooth muscle cells.  Am J Physiol Cell Physiol 2011;300(4):C919-C926. PMC3074633    DOWNLOAD PDF

192.  Castelino FV, Seiders J, Bain G, Brooks SF, King CD, Swaney JS, Lorrain DS, Chun J, Luster AD, Tager AM.  Amerlioration of dermal fibrosis by genetic deletion or pharmacologic antagonism of lysophosphatidic acid receptor 1 in a mouse model of scleroderma.  Arthritis Rheum 2011;63(5):1405-1415.  PMC3086986    DOWNLOAD PDF

191.  Herzog C, Schmitz M, Levkau B, Herrgott I, Mersmann J, Larmann J, Kai J, Winterhalter M, Chun J, Ulrich Muller F, Echtermeyer F, Hildebrand R, Theilmeier G.  Intravenous sphingosylphosphorylcholine protects ischemic and post-ischemic myocardial tissue in a mouse model of myocardial ischemia/reperfusion injury.  Mediat Inflam 2011;425191. PMC3022218    DOWNLOAD PDF

190.  Choi JW, Gardell SE, Herr DR, Rivera R, Lee CW, Noguchi K, Teo ST, Yung YC, Lu M, Kennedy G, Chun J.  FTY720 (fingolimod) efficacy in an animal model of multiple sclerosis requires astrocyte sphingosine 1-phosphate receptor (S1P₁) modulation. Proc Natl Acad Sci USA 2011;108(2):751-756. PMC3021041    DOWNLOAD PDF

189.  Diao H, Aplin JD, Xiao S, Chun J, Li Z, Chen S, Ye X.  Altered spatiotemporal expression of collagen types I, III, IV, and VI in Lpar3-deficient peri-implantation mouse uterus. Biol Reprod 2011;84(2):255-265. PMC3071265    DOWNLOAD PDF

188.  Chun J, Westra JW, Bushman, D.  A reply to Iourov I. et al.  Neurodegen Dis 2011;8(1-2):38-40. 

187.  Cohen JA, Chun J.  Reply.  Ann Neurol 2011;70(4):674.

186.  Chun J, Brinkmann V.  A mechanistically novel, first oral therapy for multiple sclerosis:  the development of fingolimod (FTY720, Gilenya). Discov Med 2011;12(64):213-228. PMC3694567   DOWNLOAD PDF

185.  Cohen JA, Chun J.  Mechanisms of fingolimod’s efficacy and adverse effects in multiple sclerosis.  Ann Neurol 2011;69(5):759-777.   DOWNLOAD PDF

184.  Noguchi K, Chun J.  Roles for lysophospholipid S1P receptors in Multiple Sclerosis.  Crit Rev Biochem Mol Bio 2011;46(1):2-10.   DOWNLOAD PDF

183.  Shea BS, Brooks SF, Fontaine BA, Chun J, Luster AD, Tager AM.  Prolonged exposure to sphingosine 1-phosphate receptor 1 agonists exacerbates vascular leak, fibrosis, and mortality after lung injury.  Am J Respir Cell Mol Biol 2010;43(6):662-673.  PMC2993087    DOWNLOAD PDF

182.  Nagai J, Uchida H, Matsushita Y, Yano R, Ueda M, Niwa M, Aoki J, Chun J, Ueda H.  Autotaxin and lysophosphatidic acid1 receptor-mediated demyelination of dorsal root fibers by sciatic nerve injury and intrathecal lysophosphatidycholine.  Mol Pain 2010;6:78. PMC2989310    DOWNLOAD PDF

181.  Lin S, Lee SJ, Shim H, Chun J, Yun CC.  The absence of LPA receptor 2 reduces the tumorigenesis by ApcMin mutation in the intestine.  Am J Physiol Gastrointest Liver Physiol 2010;299(5):G1128-G1138. PMC2993170    DOWNLOAD PDF

180.  Westra JW, Rivera RR, Bushman DM, Yung YC, Peterson SE, Barral S, Chun J.  Neuronal DNA content variation (DCV) with regional and individual differences in the human brain.  J Comp Neuro 2010;518(19):3981-4000. PMC2932632    DOWNLOAD PDF

179.  Dubin AE, Herr DR, Chun J.  Diversity of lysophosphatidic acid receptor-mediated intracellular calcium signaling in early cortical neurogenesis.  J Neuroscience 2010;30(21):7300-7039.  PMC2932640    DOWNLOAD PDF

178.  Castilla-Ortega E, Sánchez-López J, Hoyo-Becerra C, Matas-Rico E, Zambrana-Infantes E, Chun J, Fonseca FR, Pedraza C, Estivill-Torrús G, Santin LJ.  Exploratory, anxiety and spatial memory impairments are dissociated in mice lacking the LPA₁ receptor.  Neurobiol Learn Mem 2010;94(1):73-82.  PMC3684252    DOWNLOAD PDF

177.  Xie W, Uchida H, Nagai J, Ueda M, Chun J, Ueda H.  Calpain-mediated down-regulation of myelin-associated glycoprotein in lysophosphatidic acid-induced neuropathic pain.  J Neurochem 2010;113(4):1002-1011. PMC2908211    DOWNLOAD PDF

176.  Diao H, Xiao S, Cui J, Chun J, Xu Y, Ye X.  Progesterone receptor-mediated up-regulation of transthyretin (TTR) in preimplantation mouse uterus.  Fertil Steril 2010;93(8):2750-2753.  PMC3646416    DOWNLOAD PDF

175.  Imasawa T, Koike K, Ishii I, Chun J, Yatomi Y.  Blockade of sphingosine 1-phosphate receptor 2 signaling attenuates streptozotocin-induced apoptosis of pancreatic beta-cells.  Biochem Biophys Res Comm 2010;392(2):207-211. PMC3649530   DOWNLOAD PDF

174.  Lin S, Yeruva S, He P, Singh AK, Zhang H, Chen M, Lamprecht G, de Jonge HR, Tse M, Donowitz M, Hogema BM, Chun J, Seidler U, Yun CC.  Lysophosphatidic acid stimulates the intestinal brush border Na⁺/H⁺ exchanger 3 and fluid absorption via LPA₅ and NHERF2.  Gastroenterology 2010;138(2):649-658. PMC2976485    DOWNLOAD PDF

173.  Birgbauer E, Chun J.  Lysophospholipid receptors LPA_1-3 are not required for the inhibitory effects of LPA on mouse retinal growth cones.  Eye and Brain 2010;2:1-13.    DOWNLOAD PDF    Click here to see the supplemental video for Figure 1.

172.  Takuwa N, Ohkura SI, Takashima SI, Ohtani K, Okamoto Y, Tanaka T, Hirano K, Usui S, Wang F, Du W, Yoshioka K, Banno Y, Sasaki M, Ichi I, Okamura M, Sugimoto N, Mizugishi K, Nakanuma Y, Ishii I, Takamura M, Kaneko S, Kojo S, Satouchi K, Mitumori K, Chun J, Takuwa Y.  S1P3-mediated cardiac fibrosis in sphingosine kinase 1 transgenic mice involves reactive oxygen species.  Cardiovasc Res 2010;85(3):484-493.  PMC2802201 

171.  Lee CW, Choi JW, Chun J.  Neurological S1P signaling as an emerging mechanism of action of oral FTY720 (Fingolimod) in multiple sclerosis.  Arch Pharm Res 2010;33(10):1567-1574.    DOWNLOAD PDF

170.  Chun J, Hla T, Lynch KR, Spiegel S, Moolenaar WH.  International Union of Basic and Clinical Pharmacology. LXXVIII.  Lysophospholipid Receptor Nomenclature. Pharmacol Rev 2010;62(4):579-587. PMC2993255   LINK TO PDF

169.  Chun J.  Targeting the lysophospholipid S1P receptor for the treatment of Multiple Sclerosis. Drugs Future 2010;35(6):495-501.  

168.  Choi JW, Herr DR, Noguchi K, Yung YC, Lee CW, Mutoh T, Lin M-E, Teo ST, Park KE, Mosley AN, Chun J.  LPA receptors:  Subtypes and biological actions.  Ann Rev Pharmacol Toxicol 2010;50:157–186.   DOWNLOAD PDF

167.  Chun J, Hartung H-P.  Mechanism of action of oral Fingolimod (FTY720) in multiple sclerosis.  Clin Neuropharm 2010;33(2):91-101. PMC2859693    DOWNLOAD PDF

166.  Ye X, Chun J.  Lysophosphatidic acid (LPA) signaling in vertebrate reproduction.  Trends Endocrin Metab 2010;21(1):17-24. PMC2818173    DOWNLOAD PDF

165.  Lin ME, Herr DR, Chun J.  Lysophosphatidic acid (LPA) receptors:  signaling properties and disease relevance.  Prostaglandins Other Lipid Mediat 2010;91(3-4):130-138.  PMC2845529.    DOWNLOAD PDF

164.  Zhao Y, Tong J, He D, Pendyala S, Evgeny B, Chun J, Sperling AI, Natarajan V.  Role of lysophosphatidic acid receptor LPA2 in the development of allergic airway inflammation in a murine model of asthma.  Respiratory Res 2009;10:114.  PMC2788521    DOWNLOAD PDF

163.  Ma L, Uchida H, Nagai J, Inoue M, Chun J, Aoki J, Ueda H.  Lysophosphatidic acid-3 receptor-mediated feed-forward production of lysophosphatidic acid:  an initiator of nerve injury-induced neuropathic pain.  Mol Pain 2009;5:64.  PMC2780384    DOWNLOAD PDF

162.  Jenne CN, Enders A, Rivera R, Watson SR, Bankovich AJ, Pereira JP, Xu Y, Roots CM, Beilke NJ, Banerjee A, Reiner SL, Miller SA, Weinmann AS, Goodnow CC, Lanier LL, Cyster JG, Chun J.  T-bet dependent S1P5 expression in NK cells promotes egress from lymph nodes and bone marrow.  J Exper Med 2009;206(11):2469-2481.  PMC2768857    DOWNLOAD PDF

161.  Trimbuch T, Beed P, Vogt J, Schuchmann S, Maier N, Kintscher M, Breustedt J, Schuelke M, Streu N, Kieselmann O, Brunk I, Laube G, Strauss U, Battefeld A, Wende H, Birchmeier C, Wiese S, Sendtner M, Kawabe H, Kishimoto-Suga M, Brose N, Baumgart J, Geist B, Aoki J, Savaskan NE, Brauer AU, Chun J, Ninnemann O, Schmitz D, Nitsch R.  Synaptic PRG-1 modulates excitatory transmission via lipid phosphate-mediated signaling.  Cell 2009;138(6):1222-1235. PMC3716297    DOWNLOAD PDF

160.  Santin L, Bilbao A, Pedraza C, Matas-Rico E, Lopez-Barroso D, Castilla-Ortega E, Sanchez-Lopez J, Riquelme R, Varela-Nieto I, de la Villa P, Suardiaz M, Chun J, Fonseca FR, Estivill-Torrus G.  Behavioral phenotype of maLPA1-null mice:  Increased anxiety-like behavior and spatial memory deficits.  Genes Brain Behav 2009;8(8):772-784.    DOWNLOAD PDF

159.  Nieuwenhuis B, Lüth A, Chun J, Huwiler A, Pfeilschifter J, Schäfer-Korting M, Kleuser B.  Involvement of the ABC-transporter ABCC1 and the sphingosine 1-phosphate receptor subtype S1P3 in the cytoprotection of human fibroblasts by the glucocorticoid dexamethasone.  J Mol Med 2009;87(6):645-657.    DOWNLOAD PDF

158.  Westra JW, Barral S, Chun J.  A reevaluation of tetraploidy in the Alzheimer’s disease brain.  Neurodegen Dis 2009;6(5-6):221-229. PMC2837890    DOWNLOAD PDF

157.  Lin S, Wang D, Iver S, Ghaleb AM, Shim H, Yang VW, Chun J, Yun CC.  The absence of LPA(2) attenuates tumor formation in an experimental model of colitis-associated cancer.  Gastroenterology 2009;136(5):1711-20.  PMC2691721    DOWNLOAD PDF

156.  Ikeda H, Watanabe N, Ishii I, Shimosawa T, Kume Y, Yomiya T, Inoue Y, Nishikawa T, Ohtomo N, Tanoue Y, Iitsuka S, Fujita R, Omata M, Chun J, Yatomi Y.  Sphingosine 1-phosphate regulates regeneration and fibrosis after liver injury via sphingosine 1-phosphate receptor 2 (S1P2).  J Lipid Res 2009;50(3):556-564.  PMC2638109    DOWNLOAD PDF

155.  Yung YC, Kennedy G, Chun J.  Identification of neural programmed cell death through the detection of DNA fragmentation in situ and by PCR.  In Current Protocols in Neuroscience, Unit 3.8, Taylor G (Ed.), John Wiley & Sons, July 2009.  PMC2774705    DOWNLOAD PDF

154.  Teo ST, Yung YC, Herr DR, Chun J.  Lysophosphatidic acid in vascular development and disease.  IUBMB Life 2009;61(8):791-799.   DOWNLOAD PDF

153.  Mutoh T, Chun J.  Lysophosphatidic acid and sphingosine 1-phosphate activation of G Protein-Coupled Receptors.  In Bradshaw RA & Dennis EA (eds.) Handbook of Cell Signaling, second edition, Elsevier, 2009.

152.  Noguchi K, Herr D, Mutoh T, Chun J.  Lysophosphatidic acid (LPA) and its receptors.  Curr Opin Pharmacol 2009;9(1):15-23.   DOWNLOAD PDF

151.  Paczkowski C, Chun J.  Genomic disorder and gene expression in the developing CNS. In Squire LR (eds), Encyclopedia of Neuroscience, vol. 4, pp. 679-684.  Oxford:  Academic Press, 2009.

150.  Xie W, Matsumoto M, Chun J, Ueda H.  Involvement of LPA₁ receptor signaling in the reorganization of spinal input through Abeta-fibers in mice with partial sciatic nerve injury.  Mol Pain 2008;4:46.  PMC2599895    DOWNLOAD PDF

149.  Matas-Rico E, Garcia-Diaz B, Llebrez-Zayas P, Lopez-Barroso D, Santin L, Pedraza C, Smith-Fernandez A, Fernandez-Llebrez P, Tellez T, Redondo M, Chun J, Rodriguez de Fonseca F, Estivill-Torrus G.  Deletion of lysophosphatidic acid receptor LPA₁ reduces neurogenesis in the mouse dentate gyrus.  Mol Cell Neurosci 2008;39(3):342-355.  PMC3667670    DOWNLOAD PDF

148.  Panchatcharam M, Miriyala S, Yang F, Rojas M, Vallant C, Dong A, Lynch K, Chun J, Morris AJ, Smyth SS.  Lysophosphatidic acid receptors 1 and 2 play roles in regulation of vascular injury responses but not blood pressure. Circ Res 2008;103(6):662-670.  PMC2637300    DOWNLOAD PDF

147.  Tölle M, Pawlak A, Schuchardt M, Kawamura A, Tietge UJ, Lorkowski S, Keul P, Assmann G, Chun J, Levkau B, van der Giet M, Nofer JR.  HDL-associated lysosphingolipids inhibit NAD(P)H oxidase-dependent monocyte chemoattractant protein-1 production.  Arterioscler Thromb Vasc Biol 2008;28(8):1542-1548.  PMC2723752    DOWNLOAD PDF

146.  Ye X, Skinner MK, Kennedy G, Chun J.  Age-dependent loss of sperm production in mice via impaired lysophosphatidic acid signaling.  Biol Reprod 2008;79(2):328-336.  PMC2574971    DOWNLOAD PDF

145.  Choi JW, Lee CW, Chun J.  Biological roles of lysophospholipid receptors revealed by genetic null mice:  an update.  Biochem Biophys Acta 2008;1781:531-539.  PMC2657083    DOWNLOAD PDF

144.  Inoue M, Xie W, Matsushita Y, Chun J, Aoki J, Ueda H.  Lysophosphatidylcholine induces neuropathic pain through an action of autotaxin to generate lysophosphatidic acid.  Neurosci 2008;152(2):296-298.    DOWNLOAD PDF

143.  Means CK, Miyamoto S, Chun J, Brown JH.  S1P₁ receptor localization confers selectivity for G_i mediated camp and contractile responses.  J Biol Chem 2008;283(18):11954-11963.  PMC2335351    DOWNLOAD PDF

142.  Niessen F, Schaffner F, Furlan-Freguia C, Pawlinski R, Bhattacharjee G, Chun J, Derian CK, Andrade-Gordon P, Rosen H, Ruf W.  Dendritic cell PAR1-S1P3 signalling couples coagulation and inflammation.  Nature 2008;452(7187):654-658.    DOWNLOAD PDF

141.  Inoue M, Ma L, Aoki J, Chun J, Ueda H.  Autotaxin, a synthetic enzyme of lysophosphatidic acid (LPA), mediates the induction of nerve-injured neuropathic pain.  Mol Pain 2008;4(1):6.  PMC2277392    DOWNLOAD PDF

140.  Spohr TC, Choi JW, Gardell SE, Herr D, Rehen SK, Gomes FC, Chun J. LPA receptor-dependent secondary effects via astrocytes promote neuronal differentiation.  J Biol Chem 2008;283(12):7470-7479. PMC2276323    DOWNLOAD PDF

139.  Lee CW, Kim NH, Choi HK, Sun Y, Nam JS, Rhee HJ, Chun J, Huh SO. Lysophosphatidic acid-induced c-fos up-regulation involves cyclic AMP response element-binding protein activated by mitogen- and stress-activated protein kinase-1. J Cell Biochem 2008;104(3):785-94.    DOWNLOAD PDF

138.  Westra JW, Peterson SE, Yung YC, Mutoh T, Barral S, Chun J.  Aneuploid mosaicism in the developing and adult cerebellar cortex.  J Comp Neurol 2008 507(6):1944-1951.    DOWNLOAD PDF

137.  Salomone S, Potts EM, Tyndall S, Ip PC, Chun J, Brinkmann V, Waeber C.  Analysis of sphingosine 1-phosphate receptors involved in constriction of isolated cerebral arteries with receptor null mice and pharmacological tools.  Br J Pharm 2008;153(1):140-147.   DOWNLOAD PDF

136.  Tager AM, LaCamera P, Shea BS, Campanella GK, Selman M, Zhao Z, Polosukhin Z, Wain J, Karimi-Shah BA, Kim ND, Hart WK, Pardo A, Blackwell TS, Xu Y, Chun J, Luster AD.  The lysophosphatidic acid receptor LPA₁ links pulmonary fibrosis to lung injury by mediating fibroblast recruitment and vascular leak.  Nat Med 2008;14(1):45-54.   DOWNLOAD PDF

135.  Shano S, Moriyama R, Chun J, Fukushima N.  Lysophosphatidic acid stimulates astrocyte proliferation through LPA₁.  Neurochem Intl 2008;52(1-2):216-220.  PMC17692995    DOWNLOAD PDF

134.  Estivill-Torrus G, Llebrez-Zayas P, Matas-Rico E, Santin L, Pedraza C, De Diego I, Del Arco I, Fernandez-Llebrez P, Chun J, Rodriguez De Fonseca F.  Absence of LPA₁ signaling results in defective cortical development. Cerebral Cortex 2008;18(4):938-950.    DOWNLOAD PDF

133.  Mutoh T, Chun J.  Lysophospholipid activation of g protein-coupled receptors.  Subcell Biochem 2008;49:269-297. 

132.  Peterson S, Rehen S, Westra W, Yung Y, Chun J.  Spectral karyotyping and fluorescent in situ hybridization.  In Human Stem Cell Manual:  A Laboratory Guide, Chapter 6, pp. 71-84. Loring JF, Wesselschmidt Rl, Schwartz PH (eds).  Elsevier, 2007.

131.  Peterson SE, Westra JW, Paczkowski CM, Chun J.  Chromosomal mosaicism in neural stem cells.  In Neural Stem Cells Methods and Protocols, Chapter 16, pp. 197-204.  Weiner LP (ed.). Humana Press, 2008.  DOWNLOAD PDF

130.  Chun J.  “Extracellular Lipid Signals.” In the Wiley Encyclopedia of Chemical Biology, Tadhg P. Begley (ed.), 2008.

129.  Hama K, Aoki J, Inoue A, Endo T, Amano T, Motoki R, Kanai M, Ye X, Chun J, Matsuji N, Suzuki H, Shibasaski M, Arai H.  Embryo spacing and implantation timing are differentially regulated by LPA3-mediated lysophosphatidic acid signaling.  Biol Reprod 2007;77(6):954-9.   DOWNLOAD PDF

128.  Chun J.  How the lysophospholipid got its receptor.  The Scientist 2007;21(9):48-54.   DOWNLOAD PDF

 127. Chan LC, Peters W, Xu Y, Chun J, Farese Jr. RV, Cases S.  LPA₃ receptor mediates chemotaxis of immature murine dendritic cells to unsaturated lysophosphatidic acid (LPA).  J Leukocyte Biol 2007;82(5):1193-1200.    DOWNLOAD PDF

126.  Pradere J-P, Klein J, Gres S, Guigne C, Neau E, Valet P, Calise D, Chun J, Bascands J-L, Saulnier-Blache J-S, Schanstra JP. LPA₁ receptor activation promotes renal interstitial fibrosis.  J Am Soc Nephrology 2007;18(12):3110-3118.    DOWNLOAD PDF

125. Chun J.  The sources of a lipid conundrum.  Science 2007;316:208-210.    DOWNLOAD PDF

124.  Serriere-Lanneau V, Teixeira-Clerc F, Li L, Schippers M, de Wries W, Julien B, Tran-Van-Nhieu J, Manin S, Poelstra K, Chun J, Carpentie S, Levade T, Mallat A, Lotersztajn S.  The sphingosine 1-phosphate receptor S1P₂triggers hepatic wound healing.  FASEB J 2007;21(9):2005-2013.    DOWNLOAD PDF

123.  Means CK, Xiao CY, Li Z, Zhang T, Omens JH,  Ishii I, Chun J, Brown JH.  Sphingosine 1-phosphate S1P2 and S1P3 receptor-mediated Akt activation protects against in vivo myocardial ischemia-reperfusion injury.  Am J Physiol Heart Circ Physiol 2007;92(6):H2944-H2951.    DOWNLOAD PDF

122.  Walter DH, Rochwalsky U, Reinhold J, Seeger F, Aicher A, Urbich C, Spyridopoulos I, Chun J, Brinkmann V, Keul P, Levkau B, Zeiher AM, Dimmeler S, Haendeler J. Sphingosine-1-phosphate stimulates the functional capacity of progenitor cells by activation of the CXCR₄-dependent signaling pathway via the S1P₃ receptor.  Arterioscler Thromb Vasc Biol 2007;27:275-282.    DOWNLOAD PDF

121.  Herr D, Grillet N, Schwander M, Rivera R, Müller U, Chun J.  Sphingosine 1-phosphate signaling is required for maintenance of hair cells largely via activation of S1P2.  J Neurosci 2007;27(6):1474-1478.    DOWNLOAD PDF

120.  Lee CW, Rivera R, Dubin AE, Chun J.  LPA₄/GPR23 is a lysophosphatidic acid (LPA) receptor utilizing Gs, Gq/Gi-mediated calcium signaling and G12/13-mediated Rho activation.  J Biol Chem 2007;281(33):23589-23597.    DOWNLOAD PDF

119.  Rajendran RS, Zupanc MM, Losche A, Westra J, Chun J, Zupanc GKH.  Numerical chromosome variation and mitotic segregation defects in the adult brain of teleost fish.  Dev Neurobiol 2007;67(10):1334-1347.    DOWNLOAD PDF

118.  Keller CD, Gil PR, Tolle M, van der Giet M, Chun J, Radeke HH, Schafer-Korting M, Kleuser B.  Immunomodulator FTY720 induces myofibroblast differentiation via the lysophospholipid receptor S1P₃ and Smad3 signaling.  Am J Path 2007;170(1):281-292.  PMC1762708    DOWNLOAD PDF

117.  Rivera R, Chun J.  Potential therapeutic roles of lysophospholipid signaling in autoimmune related disease. Future Lipidology 2007;2(5):535-545.

116.  Herr D, Chun J.  Effects of LPA and S1P on the nervous system and implications for their involvement in disease.  Cur Drug Targ 2007;8:155-167.    DOWNLOAD PDF

115.  Fukushima N, Shano S, Moriyama R, Chun J.  Lysophosphatidic acid stimulates neuronal differentiation of cortical neuroblasts through the LPA₁-G_i/o pathway.  Neurochem Int 2007;50:302-307.    DOWNLOAD PDF

114.  Rehen SK, Kingsbury MA, Almeida BSV, Herr D, Peterson S, Chun J.  A new method of embryonic culture for assessing global changes in brain organization.  J Neurosci Meth 2006;158:100-108.    DOWNLOAD PDF

113.  Inoue M, Yamaguchi A, Kawakami M, Chun J, Ueda H.  Loss of spinal substance P pain transmission under the condition of LPA₁ receptor-mediated neuropathic pain.  Mol Pain 2006;2:25.  PMC1562366    DOWNLOAD PDF

112.  Theilmeier G, Schmidt C, Herrmann J, Keul P, Schäfers M, Herrgott I, Mersmann J, Larmann J, Hermann S, Stypmann J, Schober O, Hildebrand R, Schulz R, Heusch G, Haude M, von Wnuck Lipinski K, Herzog C, Schmitz M, Erbel R, Chun J, Levkau, B.  High-density lipoproteins and their constituent sphingosine-1-phosphate directly protect the heart against ischemia/reperfusion injury in vivo via the S1P₃ lysophospholipid receptor.  Circulation 2006;114:1403-1409.   DOWNLOAD PDF

111.  Lee CW, Rivera R, Gardell S, Dubin AE, Chun J.  GPR92 as a new G12/13 and Gq coupled lysophosphatidic acid receptor that increases cAMP:  LPA₅.  J Biol Chem 2006;281:23589-23597.    DOWNLOAD PDF

110.  Chao C, Herr D, Chun J, Xu Y.  Ser18 and Ser23 phosphorylation is required for p53-dependent apoptosis and tumor suppression.  EMBO J 2006;25:2615-2622.  PMC1478190    DOWNLOAD PDF

109.  Birgbauer E, Chun J.  New developments in the biological functions of lysophospholipids.  Cell Mol Life Sci 2006;63:2695-2701.    DOWNLOAD PDF

108.  Kingsbury MA, Yung YC, Peterson SE, Westra JW, Chun J.  Aneuploidy in the normal and diseased brain.  Cell Mol Life Sci 2006;63:2626-2641.  DOWNLOAD PDF

107.  Rivera R, Chun J.  Biological effects of lysophospholipids.  Rev Physiol Biochem Pharmacol 2008;160:25-46.   DOWNLOAD PDF

106.  Gardell SE, Dubin AE, Chun J.  Emerging medicinal roles for lysophospholipid receptors.  Trends in Mol Med 2006;12:65-75 .  DOWNLOAD PDF

105.  Chun J, Rosen H.  Lysophospholipid receptors as potential drug targets in tissue transplantation and autoimmune diseases.  Cur Pharm Design 2006;12:161-171.  DOWNLOAD PDF

104.  Ye X, Hama K, Contos JJ, Anliker B, Inoue A, Skinner MK, Suzuki H, Amano T, Arai H, Aoki J, Chun J.  LPA₃-mediated lysophosphatidic acid signalling in embryo implantation and spacing.  Nature 2005;435:104-108.  (See also News & Views.)  PMC1369590    DOWNLOAD PDF

103.  Barbeito L, Chun J, Binder LI, Neto VM, Perry G, Scazzochio C, Violini G.  The end of a Chilean institute.  Science 2005;308:792-793.   DOWNLOAD PDF

102.  Kingsbury MA, Friedman B, McConnell MJ, Rehen SK, Yang AH, Kaushal D, Chun J.  Aneuploid neurons are functionally active and integrated into brain circuitry.  Proc Natl Acad Sci USA 2005;102:6143-6147. PMC1087909    DOWNLOAD PDF

101.  Rehen SK, Yung YC, McCreight MP, Yang AH, Almeida BSV, Kingsbury MA, Cabral KMS, Kaushal D, McConnell MJ, Anliker B, Fontanoz M, Chun J.  Constitutional aneuploidy in the normal human brain.  J Neurosci 2005;25:2176-2180. (cover art)    DOWNLOAD PDF

100.  Tölle M, Levkau B, Keul P, Brinkmann V, Giebing G, Schönfelder G, Schäfers M, von Wnuck Lipinski K, Jankowski J, Jankowski V, Chun J, Zidek W, van der Giet M.  The immunomodulator FTY720 induces eNOS-dependent arterial vasodilation via the lysophospholipid receptor S1P3.  Circ Res 2005;96:913-920.   DOWNLOAD PDF

99.  Goparaju SK, Jolly PS, Watterson KR, Bektas M, Alvarez S, Sarkar S, Mel L, Ishii I, Chun J, Milstien S, Spiegel S.  The S1P₂ receptor negatively regulates PDGF-induced motility and proliferation.  Mol Cell Biol 2005;25:4237-4249.  PMC1087716    DOWNLOAD PDF

98.  Li H, Ye X, Mahanivong C, Bian D, Chun J, Huang S.  Signaling mechanisms responsible for lysophosphatidic acid-induced urokinase plasminogen activator expression in ovarian cancer cells.  J Biol Chem 2005;280:10564-10571.   DDOWNLOAD PDF

97.  Simon MF, Daviaud D, Pradere JP, Gres S, Guigne C, Wabitsch M, Chun J, Valet P, Saulnier-Blache JS.  Lysophosphatidic acid inhibits adipocyte differentiation via lysophosphatidic acid 1 receptor-dependent down-regulation of peroxisome proliferator-activated receptor gamma2.  J Biol Chem 2005;280:14656-14662.  Download PDF

96.  Chun J.  Lysophospholipids in the nervous system.  J Prostagland Lipid Mediators 2005;77:46-51.    DOWNLOAD PDF

95.  Rehen S, Chun J.  Cell Death (during development of the central nervous system).  In Brain Development:  Normal Processes and the Effects of Alcohol and Nicotine, Chapter 5, pp. 73-90. Miller MW (ed.). Oxford University Press, 2005.

94.  Girkontaite I, SakkV, Wagner M, Borggrefe T, Tedford K, Chun J, Fischer K-D.  The sphingosine-1-phosphate lysophospholipid receptor S1P₃ regulates MAdCAM-1+ endothelial cells in splenic marginal sinus organization.  J Exp Med 2004;200:1491-1501.  PMC2211946    DOWNLOAD PDF

93.  Levkau B, Hermann S, Theilmeier G, van der Giet M, Chun J, Schober O, Schäfers M.  HDL stimulates myocardial perfusion in vivo.  Circulation 2004;110:3355-3359.   DOWNLOAD PDF

92.  McConnell MJ, Kaushal D, Yang AH, Kingsbury MA, Rehen SK, Treuner K, Helton R, Annas EG, Chun J, Barlow C.  Failed clearance of aneuploid embryonic neural progenitor cells leads to excess aneuploidy in Atm-deficient but not the Trp53-deficient adult cerebral cortex.  J Neurosci 2004;24:8090-8096.   DOWNLOAD PDF

91.  Webb M, Tham C-S, Lin F-F, Lariosa-Willingham K, Yu N, Hale J, Mandala S, Chun J, Rao TS.  Sphingosine 1-phosphate receptor agonists attenuate relapsing-remitting experimental autoimmune encephalitis in SJL mice.  J Neuroimmunol 2004;153:108-121.   DOWNLOAD PDF

90.  Inoue M, Rashid H, Ryousuke Fujita R, Contos JJA, Chun J, Ueda H.  Initiation of neuropathic pain requires lysophosphatidic acid receptor signaling.  Nature Med 2004;10:712-718.   DOWNLOAD PDF

89.  Rao TS, Lariosa-Willingham KD, Lin F-F, Yu N, Tham C-S, Chun J, Webb M.  Growth factor pre-treatment differentially regulates phosphoinositide turnover downstream of  lysophospholipid receptor and metabotropic glutamate receptors in cultured rat cerebrocortical astrocytes.  Int J Devel Neurosci 2004;22:131-135.   DOWNLOAD PDF

88.  Hama K, Aoki J, Fukay M, Kishi Y, Ohta H, Sakai T, Suzuki R, Watanabe M, Chun J, Arai H. Lysophosphatidic acid and autotaxin stimulate cell motility of neoplastic and non-neoplastic cells through LPA₁.  J Biol Chem 2004;279:17634-17639.    DOWNLOAD PDF

87.  Sanna G, Alfonso A, Liao J, Ahn M-Y, Peterson MS, Jo E, Webb B, Lefebvre S, Chun J, Gray N, Rosen H. Sphingosine 1-phosphate (S1P) receptor subtypes S1P1 and S1P3, respectively, regulate lymphocyte recirculation and heart rate.  J Biol Chem 2004;279:13839-13848.  DOWNLOAD PDF

86.  Nofer J-R, van der Giet M, Tölle M, Wolinska I, Sokoll A, von Wnuck-Lipinski K, Baba HA, Gödecke A, Ishii I, Kleuser B, Volker W, Fobker M, Zidek W, Assmann G, Chun J, Levkau B.  HDL induces NO-dependent vasorelaxation via the lysophospholipid receptor S1P₃:  role of HDL-associated lysophospholipids.  J Clin Invest 2004;113:569-581.  PMC338256   DOWNLOAD PDF

85.  Baudhuin LM, Ying J, Zaslavsky A, Ishii I, Chun J, Yan Xu Y.  S1P₃-mediated Akt activation and crosstalk with platelet-derived growth factor receptor (PDGFR).  FASEB J 2004;18:341-343.  DOWNLOAD PDF

84.  Chun J.  Choices, choices, choices.  Nature Neurosci 2004;7:323-325.   DOWNLOAD PDF

83.  Anliker B, Chun J. Lysophospholipid G protein-coupled receptors.  J Biol Chem 2004;279:20555-20558.  DOWNLOAD PDF

82.  Anliker B, Chun J.  Cell surface receptors in lysophospholipid signaling.  Sem Cell and Devel Biol 2004;15:457-465.   DOWNLOAD PDF

81.  Ishii I, Fukushima N, Ye X, Chun J.  Lysophospholipid receptors:  Signaling and biology.  Ann Rev Biochem 2004;73:321-354.  DOWNLOAD PDF

80.  Kingsbury MA, Rehen SK, Ye X, Chun J.  Genetics and cell biology of lysophosphatidic acid receptor-mediated signaling during cortical neurogenesis. J Cell Biochem 2004;92:1004-12.    DOWNLOAD PDF

79.  Kingsbury MA, Rehen SK, Contos JJA, Higgins C, Chun J.  Non-proliferative effects of lysophosphatidic acid enhance cortical growth and folding.  Nature Neurosci 2003;6:1292-1299.  (See also News & Views).   DOWNLOAD PDF

78.  Yang AH, Kaushal D, Rehen SK, Kriedt K, Kingsbury MA, McConnell MJ, Chun J.  Chromosome segregation defects contribute to aneuploidy in normal neural progenitor cells.  J Neurosci 2003;23:10454-10462.   DOWNLOAD PDF

77.  Olivera A, Rosenfeldt H, Bektas M, Wang F, Ishii I, Chun J, Milstien S, Spiegel S.  Sphingosine kinase type 1 induces G_12/13-mediated stress fiber formation yet promotes growth and survival independent of G protein coupled receptors.  J Biol Chem 2003;278:46452-46460.   DOWNLOAD PDF

76.  Rao TS, Lariosa-Willingham KD, Lin F-F, Palfreyman EL, Yu N, Chun J, Webb M.  Pharmacological characterization of lysophospholipid receptor signal transduction pathways in rat cerebrocortical astrocytes.  Brain Res 2003;990:182-194.   DOWNLOAD PDF

75.  Liu H, Toman RE, Goparaju S,  Maceyka M,  Nava VE, Sankala H, Payne SG, Bektas M, Ishii I, Chun J, Milstien S, Spiegel S.  Sphingosine kinase type 2 is a putative BH3-only protein that induces apoptosis.  J Biol Chem 2003;278:40330-40336.    DOWNLOAD PDF

74.  Zhao X, Ueba T, Christie BR, Barkho B, McConnell MJ, Nakashima K, Lein ES, Eadie BD, Willhoite AR, Muotri AR, Summers RG, Chun J, Lee K-F, Gage FH.  Mice lacking methyl-CpG binding protein 1 have deficits in adult neurogenesis and hippocampal function.  Proc Natl Acad Sci USA 2003;100:6777-6782.  PMC164523    DOWNLOAD PDF

73.  Kaushal D, Contos JJA, Treuner K, Yang AH, Kingsbury MA, Rehen SK, McConnell MJ, Okabe M, Barlow C, Chun J.  Alteration of gene expression by chromosome loss in the postnatal mouse brain.  J Neurosci 2003;23:5599-5606.   DOWNLOAD PDF

72.  McGiffert C, Contos JJA, Friedman B, Chun J.  Embryonic brain expression analysis of lysophospholipid receptor genes suggests roles for s1p1 in neurogenesis and s1p1-3 in angiogenesis.  FEBS Lett 2002;531:103-108.    DOWNLOAD PDF

71.  Contos JJA, Ye X, Sah V, Chun J.  Tandem genomic arrangement of a G protein (Gna15) and G protein-coupled receptor (s1p4/lpC1/Edg6) gene.  FEBS Lett 2002;531:99-102.  DOWNLOAD PDF

70.  Contos JJA, Ishii I, Fukushima N, Kingsbury MA, Ye X, Kawamura S, Brown JH, Chun J.  Characterization of LPA2 (EDG-4) and LPA1/LPA2 (EDG-2/EDG-4) lysophosphatidic acid receptor knockout mice:  signaling deficits without obvious phenotypic abnormality attributable to LPA2.  Mol Cell Biol 2002;22:6921-6929.  PMC134025    DOWNLOAD PDF

69.  Ishii I, Ye X, Friedman B, Kawamura S, Contos JJA, Kingsbury MA, Yang AH, Zhang G, Brown JH, Chun J.  Marked perinatal lethality and cellular signaling deficits in mice null for the two sphingosine 1-phosphate receptors, S1P2/LPB2/EDG-5 and S1P3/LPB3/EDG-3.  J Biol Chem 2002;277:25152-25159.  DOWNLOAD PDF

68.  Fukushima N, Ishii I, Habara Y, Allen CB, Chun J.  Dual regulation of actin rearrangement through lysophosphatidic acid receptor in neuroblast cell lines.  Mol Biol Cell 2002;13:2692-2705.  PMC117935    DOWNLOAD PDF

67.  Fukushima N, Weiner JA, Kaushal J, Contos JJA, Rehen SK, Kingsbury MA, Kim KY, Chun J.  Lysophosphatidic acid influences the morphology and motility of young, postmitotic cortical neurons.  Mol Cell Neurosci 2002;20:271-282.    DOWNLOAD PDF

66.  Ishii I, Chun J.  Anandamide-induced neuroblastoma cell rounding via the CB1 cannabinoid receptors. Neuroreport 2002;13:593-596.  

65.  Ye X, Ishii I,  Kingsbury MA, Chun J.  Lysophosphatidic acid as a novel cell survival/apoptotic factor.  Biochim Biophys Acta 2002;1585:108-113.   DOWNLOAD PDF

64.  Ye X, Fukushima N, Kingsbury MA, Chun J.  Lysophosphatidic acid in neural signaling.  Neuroreport 2002;13:2169-2175.   DOWNLOAD PDF

63.  Fukushima N, Ye X, Chun J.  Neurobiology of lysophosphatidic acid signaling.  The Neuroscientist 2002;8:540-550. 

62.  Yang AH, Ishii I, Chun J.  In vivo roles of lysophospholipid receptors revealed by gene targeting studies in mice. Biochim Biophys Acta 2002;1582:197-203.  DOWNLOAD PDF

61.  Rehen SK, McConnell MJ, Kaushal D, Kingsbury MA, Yang AH, Chun J.  Genetic mosaicism in the brain:  A new paradigm for neuronal diversity.  Dir in Science 2002;1:53-55.  

60.  Chun J, Goetzl EJ, Hla,TL, Igarashi Y, Lynch KR, Moolenaar WH, Pyne S, Tigyi G.  International Union of Pharmacology.  XXXIV.  Lysophospholipid receptor nomenclature.  Pharmacol Rev 2002;54:265-269.   LINK TO PDF

59.  Rehen SK, McConnell MJ, Kaushal D, Kingsbury MA, Yang AH, Chun J.  Chromosomal variation in neurons of the developing and adult mammalian nervous system. Proc Natl Acad Sci USA 2001;98:13361-13366.  PMC60876    DOWNLOAD PDF

58.  Ishii I, Friedman B, Ye X-Q, Kawamura S, McGiffert C, Contos JJA, Kingsbury M, Zhang G, Brown JH, Chun J.  Selective loss of sphingosine 1-phosphate signaling with no obvious phenotypic abnormality in mice lacking its G protein-coupled receptor, LPB3/EDG-3.  J Biol Chem 2001;276:33697-33704.    DOWNLOAD PDF

57.  Weiner JAW, Fukushima N, Contos JJA, Scherer SS, Chun J.  Regulation of Schwann cell morphology and adhesion by receptor-mediated lysophosphatidic acid signaling.  J Neurosci 2001;21:7069-7078.    DOWNLOAD PDF

56.  Moeller T, Contos JJ, Musante DB, Chun J, Ransom BR.  Expression and function of lysophosphatidic acid receptors in cultured rodent microglial cells.  J Biol Chem 2001;276:25946-25952.    DOWNLOAD PDF

55.  Contos JJA, Chun J.  The mouse lpA3/Edg7 lysophosphatidic acid receptor gene:  sequence, genomic structure, chromosomal location and expression pattern. Gene 2001;267:243-253.    DOWNLOAD PDF

54.  Kimura Y, Schmitt A, Fukushima N, Ishii I, Kimura H, Nebreda AR, Chun J.  Two novel Xenopus homologs of mammalian LP_A1/edg-2 function as lysophosphatidic acid receptors in Xenopus oocytes and mammalian cells.  J Biol Chem 2001;276:15028-15215.    DOWNLOAD PDF

53.  Fukushima N, Chun J.  The LPA receptors.  J Prostagland Lipid Mediat 2001;64:21-31.    DOWNLOAD PDF

52.  Fukushima N, Ishii I, Contos JJA, Weiner JA, Chun J.  Lysophospholipid receptors. Ann Rev Pharmacol Toxicol 2001;41:507-534.    DOWNLOAD PDF

51.  Chun J.  Selected comparison of immune and nervous system development.  Adv Immunol 2001;77:297-322.    DOWNLOAD PDF

50.  Hagihara K, Watanabe K, Chun J, Yu Yamaguchi Y.  Glypican-4 is an FGF2-binding heparan sulfate proteoglycan expressed in neural precursor cells.  Dev Dyn 2000;219:353-367.  DOWNLOAD PDF

49.  Contos JJA, Ishii I, Chun J.  Lysophosphatidic acid receptors.  Mol Pharmacol 2000;58:1188-1196.   DOWNLOAD PDF

48.  Contos JJ, Fukushima N, Weiner JA, Kaushal D, Chun J.  Requirement for the lp_A1 lysophosphatidic acid receptor gene in normal suckling behavior.  Proc Natl Acad Sci USA 2000;97:13384-13389.  PMC27233    DOWNLOAD PDF

47.  Fukushima N, Weiner JA, Chun J.  Lysophosphatidic acid (LPA) is a novel extracellular regulator of cortical neuroblast morphology.  Dev Biol 2000;228:6-18.    DOWNLOAD PDF

46.  Ishii I, Contos JJA, Fukushima N, Chun J.  Functional comparisons of the lysophosphatidic acid receptors LP_A1, LP_A2 and LP_A3 in neuronal cell lines using a retrovirus expression system.  Mol Pharmacol 2000;58:895-902.    DOWNLOAD PDF

45.  Pompeiano M, Blaschke AJ, Flavell RA, Srinivasan A, Chun J.  Decreased apoptosis in proliferative and postmitotic regions of the caspase 3 deficient embryonic CNS.  J Comp Neurol 2000;423:1-12.    DOWNLOAD PDF

44.  Contos JJA, Chun J.  Genomic characterization of the lysophosphatidic acid receptor gene, lpA2/Edg4, and identification of a frameshift mutation in a previously characterized cDNA.  Genomics 2000;64:155-169.    DOWNLOAD PDF

43.  Gu Y, Sekiguchi J, Gao Y, Dikkes P, Frank K, Ferguson D, Hasty P, Chun J, Alt FW.  Defective embryoic neurogenesis in ku, but not DNA-PKcs, deficient mice.  Proc Natl Acad Sci USA 2000;97:2668-2673.  PMC15987    DOWNLOAD PDF

42.  Chun J.  An alternative view of cell death, DNA breaks and possible rearrangements.  Trends in Neurosci 2000;23:407-408.    DOWNLOAD PDF

41.  Chun J, Weiner JA, Fukushima N, Contos JJA, Zhang G, Kumura Y, Dubin A, Ishii I, Hecht JH, Akita C, Kaushal D.  Neurobiology of receptor-mediated lysophospholipid signaling:  From the first lysophospholipid (LP) receptor to roles in nervous system function and development.  Ann NY Acad Sci 2000;905:110-117.    DOWNLOAD PDF

40.  Marszalek JR, Weiner JA, Farlow SJ, Chun J, Goldstein LSB.  Novel dendritic kinesin sorting identified by different process targeting of two related kinesins:  KIF21A and KIF21B.  J Cell Biol 1999;145:469-479. PMC2185086    DOWNLOAD PDF

39.  Weiner JA, Chun J.  Schwann cell survival mediated by the signaling phospholipid lysophosphatidic acid.  Proc Natl Acad Sci 1999;96:5233-5238.  PMC21847    DOWNLOAD PDF

38.  Dubin AE, Bahnson T, Weiner JA, Fukushima N, Chun J.  Lysophosphatidic acid (LPA) stimulates neurotransmitter-like conductance changes that precede GABA and L-glutamate in early, presumptive cortical neuroblasts.  J Neurosci 1999;19:1371-1381.    DOWNLOAD PDF

37.  Nagai Y, Onodera O, Chun J, Strittmatter WJ, Burke JR.  Expanded polyglutamine domain proteins bind neurofilament and alter the neurofilament network.  Exp Neurol 1999;155:195-203.    DOWNLOAD PDF

36.  Zhang G, Contos JJA, Weiner JA, Fukushima N, Chun J.  Comparative analysis of three murine G-protein coupled receptors activated by sphingosine-1-phosphate. Gene 1999;227:89-99.    DOWNLOAD PDF

35.  Contos JJA, Chun J.  Complete cDNA sequence, genomic structure and chromosomal localization of the LPA receptor gene, vzg-1/lpA1/Gpcr26.  Genomics 1998;51:364-378.    DOWNLOAD PDF

34.  Weiner JA, Hecht JH, Chun J.  The lysophosphatidic acid receptor gene vzg-1/lpA1/edg-2 is expressed by mature oligodendrocytes during myelination in the postnatal murine brain.  J Comp Neurol 1998;398:587-589.    DOWNLOAD PDF

33.  Pompeiano M, Hvala M, Chun J.  Onset of apoptotic DNA fragmentation can precede cell elimination by days in the small intestinal vilus.  Cell Death and Diff 1998;5:702-709.    DOWNLOAD PDF

32.  Fukushima N, Kimura Y, Chun J.  A single receptor encoded by vzg-1/lpa1/edg-2 couples to G-proteins and mediates multiple cellular responses to lysophosphatidic acid (LPA).  Proc Natl Acad Sci USA 1998;95:6151-6156.  PMC27607    DOWNLOAD PDF

31.  Blaschke AJ, Weiner JA, Chun J.  Programmed cell death is a universal feature of embryonic and postnatal neuroproliferative regions throughout the CNS.  J Comp Neurol 1998;396:39-50.    DOWNLOAD PDF

30.  Huang LJ, Durick K, Weiner JA, Chun J, Taylor SS.  D-AKAP2, a novel protein kinase A anchoring protein that contains a potential RGS domain.  Proc Natl Acad Sci USA 1997;94:11184-11189.  PMC23409    DOWNLOAD PDF

29.  McWhirter JR, Goulding M, Weiner J, Chun J, Murre C.  A novel fibroblast growth factor gene expressed in the developing nervous system is a downstream target of the chimeric homeodomain oncoprotein E2A-Pbx1. Development 1997;124:3221-3232.    DOWNLOAD PDF

28.  Bain G, Engel I, Maandag ECR, te Riele HPJ, Voland JR, Sharp LL, Chun J, Huey B, Pinkel D, Murre C.  E2A deficient mice rapidly develop T cell leukemias.  Mol Cell Biol 1997;17:4782-4791.  PMC232330    DOWNLOAD PDF

27.  Weiner JA, Chun J.  Maternally-derived immunoglobulin light chain is present in the fetal mammalian CNS.  J Neurosci 1997;17:3148-3156.    DOWNLOAD PDF

26.  Weiner JA, Chun J.  Png-1, a nervous system-specific zinc finger gene, identifies regions containing postmitotic neurons during mammalian embryonic development. J Comp Neurol 1997;381:130-142.   DOWNLOAD PDF

25.  Huang LJ, Durick K, Weiner JA, Chun J, Taylor SS. Identification of a novel protein kinase A anchoring protein that binds both type I and type II regulatory subunits.  J Biol Chem 1997;272:8057-8064.    DOWNLOAD PDF

24.  Staley K, Blaschke AJ, Chun J.  Apoptotic DNA fragmentation is detected by a semi-quantitative ligation-mediated PCR of blunt DNA ends.  Cell Death and Differen 1997;4:66-75.    DOWNLOAD PDF

23.  Hecht JH, Weiner JA, Post SR, Chun J.  Ventricular zone gene -1 (Vzg-1) encodes a lysophosphatidic acid receptor expressed in neurogenic regions of the developing cerebral cortex.  J Cell Biol 1996;135:1071-1083.  PMC2133395    DOWNLOAD PDF

22.  Chun J, Jaenisch R.  Clonal cell lines produced by birth-date targeting of neocortical neuroblasts using multiple oncogenes transduced by retroviruses.  Mol Cell Neurosci 1996;7:304-321.    DOWNLOAD PDF

21.  Blaschke AJ, Staley K, Chun J.  Widespread programmed cell death in proliferative and postmitotic regions of the fetal cerebral cortex.  Development 1996;122:1165-1174 (see comment in Neuron 1996;16:693).   DOWNLOAD PDF

20.  Chun J.  Developmental neurobiology:  A genetic Cheshire cat?  Curr Biol 1999;9:651-654.    Download PDF

19.  Chun J.  Lysophospholipid receptors:  Implications for neural signaling.  Crit Rev Neurobiol 1999;13:151-168.

18.  Chun J.  The first cloned and identified lysophospholipid (LP) receptor gene, vzg-1:  Implications for the nervous system and related receptors. Adv Exp Med Biol 1999;469:357-62.

17.  Chun J, Schatz DG.  Developmental neurobiology:  Alternative “ends” to a familiar story?  Curr Biol 1999;9:R251-R253.    DOWNLOAD PDF

16.  Chun J, Contos JJA, Munroe D.  A growing family of receptor genes for lysophosphatidic acid (LPA) and other lysophospholipids (LPs).  Cell Biochem Biophys 1999;30:213-242.

15.  Chun J, Schatz DG.  Rearranging views on neurogenesis:  Neuronal death in the absence of DNA end-joining proteins.  Neuron 1999;22:7-10.    DOWNLOAD PDF

14.  Chun J.  Detection of cells undergoing programmed cell death using in situ end labeling plus (ISEL+). In Apoptosis Detection, CHAPTER 5, pp. 35-45, in “Apoptosis detection and assay methods.” Zhu L, Chun J (eds.). BioTechniques Books, Natick, MA, 1998.

13.  Chun J.  Apoptotic DNA fragmentation detection using ligation mediated PCR (LMPCR).  In Apopotosis Detection, CHAPTER 4, pp. 23-33, in “Apoptosis detection and assay methods.” Zhu L, Chun J (eds.). BioTechniques Books, Natick, MA, 1998.

12.  Chun J, Blaschke AJ.  Unit 3.8, Identification of neural programmed cell death through the detection of DNA fragmentation in situ and by PCR.  In Current Protocols in Neuroscience.  Gerfen C, Mckay R (eds.).  John Wiley and Sons, Inc., 1997.  PMC2774705

11.  Chun JJM.  A protocol using retrovirally-introduced multiple oncogenes in the production of neuron-like cell lines from the murine central nervous system. NeuroProtocols 1993;3:214-221.

10.  Turka LA, Schatz DG, Oettinger MA, Chun JJM, Gorka C, Lee K, McCormack WT, Thompson CB.  Thymocyte expression of the recombination activating genes RAG-1 and RAG-2 can be terminated by T-cell receptor stimulation in vitro.  Science 1991;253:778-781.

9.  Chun JJM, Schatz DG, Oettinger MA, Jaenisch R, Baltimore D.  The Recombination activating gene-1 (RAG-1) transcript is present in the murine central nervous system.  Cell 1991;64:189-200.

8.  Chun JJM, Shatz CJ.  The earliest-generated neurons of the cat cerebral cortex:  characterization by MAP2 and neurotransmitter immunohistochemistry during fetal life.  J Neurosci 1989;9:1648-1667.

7.  Chun JJM, Shatz CJ.  Interstitial cells of the adult neocortical white matter are the remnant of the early generated subplate neuron population.  J Comp Neurol 1989;282:555-569.

6.  Chun JJM, Shatz CJ.  Redistribution of synaptic vesicle antigens is correlated with the disappearance of a transient synaptic zone in the developing cerebral cortex.  Neuron 1988;1:297-310.

5.  Chun JJM, Shatz CJ.  A fibronectin-like molecule is present in the developing cat cerebral cortex and is correlated with subplate neurons.  J Cell Biol 1988;106:857-872.  PMC2115079

4.  Chun JJM, Nakamura MJ, Shatz CJ.  Transient cells of the developing mammalian telencephalon are peptide-immunoreactive neurons.  Nature 1987;325:617-620.

3.  Chun JJM, Schatz DG.  Recombination activating gene -1 (RAG-1) transcription in the mammalian CNS.  Chapter 22.  In Neuronal Cell Death and Repair, Vol. 6. Cuello AC (ed.).  Elsevier Science Publishers, Amsterdam, 1993.

2.  Schatz DG, Chun JJM.  V(D)J recombination and the transgenic brain blues.  New Biologist 1992;4:188-196.  

1.  Shatz CJ, Chun JJM, Luskin MB.  The role of the subplate in the development of the mammalian telencephalon.  In:  Development of the Cerebral Cortex, Vol. 7. Peters A, Jones EG (eds.).  Plenum Publishing Corp., New York, NY, 1988.