The Wüthrich Laboratory

Research

For 50 years, Wüthrich groups at the ETH Zürich, Zürich, Switzerland, The Scripps Research Institute, La Jolla, CA, USA and the iHuman Institute of ShanghaiTech University, Shanghai, China have worked on nuclear magnetic resonance spectroscopy (NMR) with biological macromolecules. Contributions include the method for macromolecular structure determination with NMR in solution and the use of the principles of transverse relaxation-optimized spectroscopy (TROSY) for NMR experiments with large supramolecular assemblies. Applications over the years were focused on differentiation in higher organisms, immune suppression and neuropathology.  As of April 1, 2019, research using NMR techniques is continued at ShanghaiTech University, with a focus on G protein-coupled receptors (GPCRs). At The Scripps Research Institute and the ETH Zürich, projects on the general theme “healthcare in the ageing human societies of the 21^st century” are pursued, mainly considering the impact of sarcopenia on the human healthspan.