Publications

Taylor S, Deng S, Bendelac A, Teyton L and Savage PB. Glycolipids as Antigens for Semi-Invariant Natural Killer T Cells. In: Barchi JJ, editor. Comprehensive Glycoscience (Second Edition), Elsevier; (2021). Vol 3, p. 470-484.  doi: 10.1016/B978-0-12-819475-1.00095-X

Srivastava N, Hu H, Vomund AN, Peterson OJ, Baker RL, Kathryn H, Teyton L, Wan X and Unanue ER. Chromogranin A Deficiency Confers Protection from Autoimmune Diabetes Via Multiple Mechanisms.  Diabetes. doi: 10.2337/db21-0513. Epub online ahead of print (2021). PMID: 34497137.

Muller-Calleja N, Hollerbach A, Royce J, Ritter S, Pedrosa D, Madhusudhan T, Teifel S, Meineck M, Hauser F, Canisius A, Nguyen TS, Braun J, Bruns K, Etzold A, Zechner U, Strand S, Radsak M, Strand D, Gu JM, Weinmann-Menke J, Esmon CT, Teyton L, Lackner KJ and Ruf W. Lipid presentation by the protein C receptor links coagulation with autoimmunity.  Science. 371:eabc0956 (2021). PMID: 33707237.

Kirschbaum C, Greis K, Mucha E, Kain L, Deng S, Zappe A, Gewinner S, Schollkopf W, von Helden G, Meijer G, Savage PB, Marianski M, Teyton L and Pagel K. Unravelling the structural complexity of glycolipids with cryogenic infrared spectroscopy.  Nat Commun. 12:1201 (2021). PMID: 33619275.

Hollerbach A, Muller-Calleja N, Pedrosa D, Canisius A, Sprinzl MF, Falter T, Rossmann H, Bodenstein M, Werner C, Sagoschen I, Munzel T, Schreiner O, Sivanathan V, Reuter M, Niermann J, Galle PR, Teyton L, Ruf W and Lackner KJ. Pathogenic lipid-binding antiphospholipid antibodies are associated with severity of COVID-19.  J Thromb Haemost. 19:2335-2347 (2021). PMID: 34242469.

Pothlichet J, Rose T, Bugault F, Jeammet L, Meola A, Haouz A, Saul F, Geny D, Alcami J, Ruiz-Mateos E, Teyton L, Lambeau G and Theze J. PLA2G1B is involved in CD4 anergy and CD4 lymphopenia in HIV-infected patients.  J Clin Invest. 130:2872-2887 (2020). PMID: 32436864.

Cook DP, Cunha J, Martens PJ, Sassi G, Mancarella F, Ventriglia G, Sebastiani G, Vanherwegen AS, Atkinson MA, Van Huynegem K, Steidler L, Caluwaerts S, Rottiers P, Teyton L, Dotta F, Gysemans C and Mathieu C. Intestinal Delivery of Proinsulin and IL-10 via Lactococcus lactis Combined With Low-Dose Anti-CD3 Restores Tolerance Outside the Window of Acute Type 1 Diabetes Diagnosis.  Front Immunol. 11:1103 (2020). PMID: 32582188.

Sharma S, Pettus J, Gottschalk M, Abe B, Gottlieb P and Teyton L. Single-Cell Analysis of CD4 T Cells in Type 1 Diabetes: From Mouse to Man, How to Perform Mechanistic Studies.  Diabetes. 68:1886-1891 (2019). PMID: 31540941.

Sharma S, Gioia L, Abe B, Holt M, Costanzo A, Kain L, Su A and Teyton L. Corrigendum to "Using single cell analysis for translational studies in immune mediated diseases: Opportunities and challenges" [Erratum for Mol. Immunol. 103 (2018) 191-199].  Mol Immunol. 107:165 (2019). PMID: 30732931.

Polonskaya Z, Savage PB, Finn MG and Teyton L. High-affinity anti-glycan antibodies: challenges and strategies.  Curr Opin Immunol. 59:65-71 (2019). PMID: 31029911.

Lotteau V, Teyton L, Burroughs D and Charron D. DRα-DQß Mismatched Isotype Pairing Occurs in EBV Transformed B Cell Lines. In: Mani JC and Dornand J, editors. Lymphocyte Activation and Differentiation: De Gruyter; (2019). p. 813-818.  doi:10.1515/9783110850253-135

Gumperz J, Kronenberg M and Teyton L. Editorial introduction.  Mol Immunol. 114:269 (2019). PMID: 31398666.

Gioia L, Holt M, Costanzo A, Sharma S, Abe B, Kain L, Nakayama M, Wan X, Su A, Mathews C, Chen YG, Unanue E and Teyton L. Position beta57 of I-A(g7) controls early anti-insulin responses in NOD mice, linking an MHC susceptibility allele to type 1 diabetes onset.  Sci Immunol. 4:eaaw6329 (2019). PMID: 31471352.

Teyton L. Role of lipid transfer proteins in loading CD1 antigen-presenting molecules.  J Lipid Res. 59:1367-1373 (2018). PMID: 29559523.

Sharma S, Gioia L, Abe B, Holt M, Costanzo A, Kain L, Su A and Teyton L. Using single cell analysis for translational studies in immune mediated diseases: Opportunities and challenges.  Mol Immunol. 103:191-199 (2018). PMID: 30300798.

Ito Y, Ashenberg O, Pyrdol J, Luoma AM, Rozenblatt-Rosen O, Hofree M, Christian E, Ferrari de Andrade L, Tay RE, Teyton L, Regev A, Dougan SK and Wucherpfennig KW. Rapid CLIP dissociation from MHC II promotes an unusual antigen presentation pathway in autoimmunity.  J Exp Med. 215:2617-2635 (2018). PMID: 30185635.

Holt M, Costanzo A, Gioia L, Abe B, Su AI and Teyton L. Gene Profiling and T Cell Receptor Sequencing from Antigen-Specific CD4 T Cells.  Methods Mol Biol. 1712:217-238 (2018). PMID: 29224077.

Gavin AL, Huang D, Huber C, Martensson A, Tardif V, Skog PD, Blane TR, Thinnes TC, Osborn K, Chong HS, Kargaran F, Kimm P, Zeitjian A, Sielski RL, Briggs M, Schulz SR, Zarpellon A, Cravatt B, Pang ES, Teijaro J, de la Torre JC, O'Keeffe M, Hochrein H, Damme M, Teyton L, Lawson BR and Nemazee D. PLD3 and PLD4 are single-stranded acid exonucleases that regulate endosomal nucleic-acid sensing.  Nat Immunol. 19:942-953 (2018). PMID: 30111894.

Fahl SP, Coffey F, Kain L, Zarin P, Dunbrack RL, Jr., Teyton L, Zuniga-Pflucker JC, Kappes DJ and Wiest DL. Role of a selecting ligand in shaping the murine gammadelta-TCR repertoire.  Proc Natl Acad Sci U S A. 115:1889-1894 (2018). PMID: 29432160.

Teyton L. New Directions for Natural Killer T Cells in the Immunotherapy of Cancer.  Frontiers in Immunology. 8:Article 1480 (2017). PMID: 29209309.

Polonskaya Z, Deng S, Sarkar A, Kain L, Comellas-Aragones M, McKay CS, Kaczanowska K, Holt M, McBride R, Palomo V, Self KM, Taylor S, Irimia A, Mehta SR, Dan JM, Brigger M, Crotty S, Schoenberger SP, Paulson JC, Wilson IA, Savage PB, Finn MG and Teyton L. T cells control the generation of nanomolar-affinity anti-glycan antibodies.  J Clin Invest. 127:1491-1504 (2017). PMID: 28287405.

Montenegro-Burke JR, Aisporna AE, Benton HP, Rinehart D, Fang M, Huan T, Warth B, Forsberg E, Abe BT, Ivanisevic J, Wolan DW, Teyton L, Lairson L and Siuzdak G. Data Streaming for Metabolomics: Accelerating Data Processing and Analysis from Days to Minutes.  Anal Chem. 89:1254-1259 (2017). PMID: 27983788.

Deng S, Kain L, Pereira CS, Mata S, Macedo MF, Bendelac A, Teyton L and Savage PB. Psychosine variants as antigens for natural killer T cells.  Chem Sci. 8:2204-2208 (2017). PMID: 28507675.

Vartabedian VF, Savage PB and Teyton L. The processing and presentation of lipids and glycolipids to the immune system.  Immunol Rev. 272:109-119 (2016). PMID: 27319346.

Boudinot P, Mondot S, Jouneau L, Teyton L, Lefranc MP and Lantz O. Restricting nonclassical MHC genes coevolve with TRAV genes used by innate-like T cells in mammals.  Proc Natl Acad Sci U S A. 113:E2983-2992 (2016). PMID: 27170188.

Kain L, Costanzo A, Webb B, Holt M, Bendelac A, Savage PB and Teyton L. Endogenous ligands of natural killer T cells are alpha-linked glycosylceramides.  Mol Immunol. 68:94-97 (2015). PMID: 26141240.

Tefit JN, Crabe S, Orlandini B, Nell H, Bendelac A, Deng S, Savage PB, Teyton L and Serra V. Efficacy of ABX196, a new NKT agonist, in prophylactic human vaccination.  Vaccine. 32:6138-6145 (2014). PMID: 25218293.

Kain L, Webb B, Anderson BL, Deng S, Holt M, Costanzo A, Zhao M, Self K, Teyton A, Everett C, Kronenberg M, Zajonc DM, Bendelac A, Savage PB and Teyton L. The identification of the endogenous ligands of natural killer T cells reveals the presence of mammalian alpha-linked glycosylceramides.  Immunity. 41:543-554 (2014). PMID: 25367571.

Deng S, Bai L, Reboulet R, Matthew R, Engler DA, Teyton L, Bendelac A and Savage PB. A peptide-free, liposome-based oligosaccharide vaccine, adjuvanted with a natural killer T cell antigen, generates robust antibody responses in vivo.  Chem Sci. 5:1437-1441 (2014). PMID: 24683450.

Bai L, Deng S, Reboulet R, Mathew R, Teyton L, Savage PB and Bendelac A. Natural killer T (NKT)-B-cell interactions promote prolonged antibody responses and long-term memory to pneumococcal capsular polysaccharides.  Proc Natl Acad Sci U S A. 110:16097-16102 (2013). PMID: 24043771.

Presa M, Ortiz AZ, Garabatos N, Izquierdo C, Rivas EI, Teyton L, Mora C, Serreze D and Stratmann T. Cholera toxin subunit B peptide fusion proteins reveal impaired oral tolerance induction in diabetes-prone but not in diabetes-resistant mice.  Eur J Immunol. 43:2969-2979 (2013). PMID: 23925934.

Anderson BL, Teyton L, Bendelac A and Savage PB. Stimulation of natural killer T cells by glycolipids.  Molecules. 18:15662-15688 (2013). PMID: 24352021.

Freigang S, Kain L and Teyton L. Transport and uptake of immunogenic lipids.  Mol Immunol. 55:179-181 (2013). PMID: 23174352.

Witherden DA, Watanabe M, Garijo O, Rieder SE, Sarkisyan G, Cronin SJ, Verdino P, Wilson IA, Kumanogoh A, Kikutani H, Teyton L, Fischer WH and Havran WL. The CD100 receptor interacts with its plexin B2 ligand to regulate epidermal gammadelta T cell function.  Immunity. 37:314-325 (2012). PMID: 22902232.

Bai L, Constantinides MG, Thomas SY, Reboulet R, Meng F, Koentgen F, Teyton L, Savage PB and Bendelac A. Distinct APCs explain the cytokine bias of alpha-galactosylceramide variants In vivo.  J Immunol. 188:3053-3061 (2012). PMID: 22393151.

Komori HK, Witherden DA, Kelly R, Sendaydiego K, Jameson JM, Teyton L and Havran WL. Cutting Edge: Dendritic epidermal gammadelta T cell ligands are rapidly and locally expressed by keratinocytes following cutaneous wounding.  J Immunol. 188:2972-2976 (2012). PMID: 22393149.

Freigang S, Landais E, Zadorozhny V, Kain L, Yoshida K, Liu Y, Deng S, Palinski W, Savage P, Bendelac A and Teyton L. Scavenger receptors target glycolipids for natural killer T cell activation.  J Clin Invest. 122:3943-3954 (2012). PMID: 23064364.

Deng S, Mattner J, Zang Z, Bai L, Teyton L, Bendelac A and Savage PB. Impact of sugar stereochemistry on natural killer T cell stimulation by bacterial glycolipids.  Org Biomol Chem. 9:7659-7662 (2011). PMID: 21927724.

Disse J, Petersen HH, Larsen KS, Persson E, Esmon N, Esmon CT, Teyton L, Petersen LC and Ruf W. The endothelial protein C receptor supports tissue factor ternary coagulation initiation complex signaling through protease-activated receptors.  J Biol Chem. 286:5756-5767 (2011). PMID: 21149441.

Witherden DA, Verdino P, Rieder SE, Garijo O, Mills RE, Teyton L, Fischer WH, Wilson IA and Havran WL. The junctional adhesion molecule JAML is a costimulatory receptor for epithelial gammadelta T cell activation.  Science. 329:1205-1210 (2010). PMID: 20813954.

Garcia KC, Degano M, Stanfield RL, Brunmark A, Jackson MR, Peterson PA, Teyton L and Wilson IA. JI Pillars Article:  (Reprinted from Science, Vol. 274: 209–219 (1996))  An alpha beta T Cell Receptor Structure at 2.5 angstrom and Its Orientation in the TCR-MHC Complex.  J Immunol. 185:209-219 (2010). PMID: 21084669.

Freigang S, Zadorozhny V, McKinney MK, Krebs P, Herro R, Pawlak J, Kain L, Schrantz N, Masuda K, Liu Y, Savage PB, Bendelac A, Cravatt BF and Teyton L. Fatty acid amide hydolase shapes NKT cell respones by influencing the serum transport of liipid antigen in mice.  J Clin Invest. 120:1873-1884 (2010). PMID: 20484813.

Yoshida K, Corper AL, Herro R, Jabri B, Wilson IA and Teyton L. The diabetogenic mouse MHC class II molecule I-Ag7 is endowed with a switch that modulates TCR affinity.  J Clin Invest. 120:1578-1590 (2010). PMID: 20407212.

Bai L, Sagiv Y, Liu Y, Freigang S, Yu KO, Teyton L, Porcelli SA, Savage PB and Bendelac A. Lysosomal recycling terminates CD1d-mediated presentation of short and polyunsaturated variants of the NKT cell lipid antigen alphaGalCer.  Proc Natl Acad Sci U S A. 106:10254-10259 (2009). PMID: 19506241.

Yin N, Long X, Goff R, Zhou D, Cantu Iii C, Mattner J, Saint-Mezard P, Teyton L, Bendelac A and Savage P. Alpha Anomers of iGb3 and Gb3 Stimulate Cytokine Production by Natural Killer T Cells.  ACS Chem Biol. 4:191-197 (2009). PMID: 19175331.

Landais E, Romagnoli PA, Corper AL, Shires J, Altman J, Wilson IA, Garcia KC and Teyton L. New design of MHC class II tetramers to accommodate fundamental principles of antigen presentation.  J Immunol. 183:7949-7957 (2009). PMID: 19923463.

Teyton L. Natural killer T cell recognition of lipid antigens.  F1000 Biol Rep. 1:97 (2009). PMID: 20948595.

Hovhannisyan Z, Angela Weiss A, Martin A, Wiesner M, Tollefsen S, Yoshida K, Ciszewski C, Curran SA, Murray JA, David CS, Sollid LM, Koning F, Teyton L and Jabri B. The role of HLA-DQ8 b57 polymorphism on the anti-gluten T cell response in celiac disease.  Nature. 456:534-538 (2008). PMID: 19037317.

Costantino V, Fattorusso E, Imperatore C, Mangoni A, Freigang S and Teyton L. Corrugoside, a new immunostimulatory alpha-galactoglycosphingolipid from the marine sponge Axinella corrugata.  Bioorg Med Chem. 16:2077-2085 (2008). PMID: 18037298.

Mattner J, Savage PB, Leung P, Oertelt SS, Wang V, Trivedi O, Scanlon ST, Pendem K, Teyton L, Hart J, Ridgway WM, Wicker LS, Gershwin ME and Bendelac A. Liver autoimmunity triggered by microbial activation of natural killer T cells.  Cell host & microbe. 3:304-315 (2008). PMID: 18474357.

Liu Y, Deng S, Bai L, Freigang S, Mattner J, Teyton L, Bendelac A and Savage PB. Synthesis of diglycosylceramides and evaluation of their iNKT cell stimulatory properties.  Bioorganic & medicinal chemistry letters. 18:3052-3055 (2008). PMID: 18206371.

Shore DA, Issafras H, Landais E, Teyton L and Wilson IA. The crystal structure of CD8 in complex with YTS156.7.7 Fab and interaction with other CD8 antibodies define the binding mode of CD8 alphabeta to MHC class I.  J Mol Biol. 384:1190-1202 (2008). PMID: 18929574.

Levin D, DiPaolo RJ, Brinster C, Revilleza MJ, Boyd LF, Teyton L, Natarajan K, Mage MG, Shevach EM and Margulies DH. Availability of autoantigenic epitopes controls phenotype, severity, and penetrance in TCR Tg autoimmune gastritis.  Eur J Immunol. 38:3339-3353 (2008). PMID: 19039784.

Zajonc DM, Savage P, Bendelac A, Wilson IA and Teyton L. Crystal structures of mouse CD1-i Gb3 complex and its cognate V[alpha]14 T cell receptor suggest a model for dual recognition of foreign and self glycolipids.  J Mol Biol. 377:1104-1116 (2008). PMID: 18295796.

Long X, Deng S, Mattner J, Zang Z, Zhou D, McNary N, Goff RD, Teyton L, Bendelac A and Savage PB. Synthesis and evaluation of stimulatory properties of Sphingomonadaceae glycolipids.  Nat Chem Biol. 3:559-564 (2007). PMID: 17660835.

Scherer EM, Zwick MB, Teyton L and Burton DR. Difficulties in eliciting broadly neutralizing anti-HIV antibodies are not explained by cardiolipin autoreactivity.  AIDS. 21:2131-2139 (2007). PMID: 18090039.

Teyton L. The saga of MHC-bound peptides: a renaissance for antigen presentation?  J Clin Invest. 117:3164-3166 (2007). PMID: 17975658.

Homann D, Lewicki H, Brooks D, Eberlein J, Mallet-Designe V, Teyton L and Oldstone MB. Mapping and restriction of a dominant viral CD4(+) T cell core epitope by both MHC class I and MHC class II.  Virology. 363:113-123 (2007). PMID: 17320138.

Novak J, Beaudoin L, Park S, Griseri T, Teyton L, Bendelac A and Lehuen A. Prevention of type 1 diabetes by invariant NKT cells is independent of peripheral CD1d expression.  J Immunol. 178:1332-1340 (2007). PMID: 17237379.

Sagiv Y, Bai L, Wei DG, Agami R, Savage PB, Teyton L and Bendelac A. A distal effect of microsomal triglyceride transfer protein deficiency on the lysosomal recycling of CD1d.  J Exp Med. 204:921-928 (2007). PMID: 17403933.

Schrantz N, Sagiv Y, Liu Y, Savage PB, Bendelac A and Teyton L. The Niemann-Pick type C2 protein loads isoglobotrihexosylceramide onto CD1d molecules and contributes to the thymic selection of NKT cells.  J Exp Med. 204:841-852 (2007). PMID: 17389239.

Bendelac A, Savage PB and Teyton L. The biology of NKT cells.  Annu Rev Immunol. 25:297-336 (2007). PMID: 17150027.

Savage PB, Teyton L and Bendelac A. Glycolipids for natural killer T cells.  Chem Soc Rev. 35:771-779 (2006). PMID: 16936925.

Brooks DG, Trifilo MJ, Edelmann KH, Teyton L, McGavern DB and Oldstone MB. Interleukin-10 determines viral clearance or persistence in vivo.  Nat Med. 12:1301-1309 (2006). PMID: 17041596.

Liu Y, Goff RD, Zhou D, Mattner J, Sullivan BA, Khurana A, Cantu C, 3rd, Ravkov EV, Ibegbu CC, Altman JD, Teyton L, Bendelac A and Savage PB. A modified alpha-galactosyl ceramide for staining and stimulating natural killer T cells.  J Immunol Methods. 312:34-39 (2006). PMID: 16647712.

Wei DG, Curran SA, Savage PB, Teyton L and Bendelac A. Mechanisms imposing the Vbeta bias of Valpha14 natural killer T cells and consequences for microbial glycolipid recognition.  J Exp Med. 203:1197-1207 (2006). PMID: 16651387.

Sagiv Y, Hudspeth K, Mattner J, Schrantz N, Stern RK, Zhou D, Savage PB, Teyton L and Bendelac A. Cutting edge: impaired glycosphingolipid trafficking and NKT cell development in mice lacking Niemann-Pick type C1 protein.  J Immunol. 177:26-30 (2006). PMID: 16785493.

Shore DA, Teyton L, Dwek RA, Rudd PM and Wilson IA. Crystal structure of the TCR co-receptor CD8alphaalpha in complex with monoclonal antibody YTS 105.18 Fab fragment at 2.88 A resolution.  J Mol Biol. 358:347-354 (2006). PMID: 16530222.

Mattner J, Debord KL, Ismail N, Goff RD, Cantu C, 3rd, Zhou D, Saint-Mezard P, Wang V, Gao Y, Yin N, Hoebe K, Schneewind O, Walker D, Beutler B, Teyton L, Savage PB and Bendelac A. Exogenous and endogenous glycolipid antigens activate NKT cells during microbial infections.  Nature. 434:525-529 (2005). PMID: 15791258.

Wei DG, Lee H, Park SH, Beaudoin L, Teyton L, Lehuen A and Bendelac A. Expansion and long-range differentiation of the NKT cell lineage in mice expressing CD1d exclusively on cortical thymocytes.  J Exp Med. 202:239-248 (2005). PMID: 16027237.

Benlagha K, Wei DG, Veiga J, Teyton L and Bendelac A. Characterization of the early stages of thymic NKT cell development.  J Exp Med. 202:485-492 (2005). PMID: 16087715.

Brooks DG, Teyton L, Oldstone MB and McGavern DB. Intrinsic functional dysregulation of CD4 T cells occurs rapidly following persistent viral infection.  J Virol. 79:10514-10527 (2005). PMID: 16051844.

Zajonc DM, Cantu C, 3rd, Mattner J, Zhou D, Savage PB, Bendelac A, Wilson IA and Teyton L. Structure and function of a potent agonist for the semi-invariant natural killer T cell receptor.  Nat Immunol. 6:810-818 (2005). PMID: 16007091.

Kelker MS, Foss TR, Peti W, Teyton L, Kelly JW, Wuthrich K and Wilson IA. Crystal structure of human triggering receptor expressed on myeloid cells 1 (TREM-1) at 1.47 A.  J Mol Biol. 342:1237-1248 (2004). PMID: 15351648.

Goff RD, Gao Y, Mattner J, Zhou D, Yin N, Cantu C, 3rd, Teyton L, Bendelac A and Savage PB. Effects of lipid chain lengths in alpha-galactosylceramides on cytokine release by natural killer T cells.  J Am Chem Soc. 126:13602-13603 (2004). PMID: 15493902.

Malherbe L, Hausl C, Teyton L and McHeyzer-Williams MG. Clonal selection of helper T cells is determined by an affinity threshold with no further skewing of TCR binding properties.  Immunity. 21:669-679 (2004). PMID: 15539153.

Reiser JB, Teyton L and Wilson IA. Crystal structure of the Drosophila peptidoglycan recognition protein (PGRP)-SA at 1.56 A resolution.  J Mol Biol. 340:909-917 (2004). PMID: 15223330.

Zhou D, Cantu C, 3rd, Sagiv Y, Schrantz N, Kulkarni AB, Qi X, Mahuran DJ, Morales CR, Grabowski GA, Benlagha K, Savage P, Bendelac A and Teyton L. Editing of CD1d-bound lipid antigens by endosomal lipid transfer proteins.  Science. 303:523-527 (2004). PMID: 14684827.

Zhou D, Mattner J, Cantu C, 3rd, Schrantz N, Yin N, Gao Y, Sagiv Y, Hudspeth K, Wu YP, Yamashita T, Teneberg S, Wang D, Proia RL, Levery SB, Savage PB, Teyton L and Bendelac A. Lysosomal glycosphingolipid recognition by NKT cells.  Science. 306:1786-1789 (2004). PMID: 15539565.

Ranheim EA, Tarbell KV, Krogsgaard M, Mallet-Designe V, Teyton L, McDevitt HO and Weissman IL. Selection of aberrant class II restricted CD8+ T cells in NOD mice expressing a glutamic acid decarboxylase (GAD)65-specific T cell receptor transgene.  Autoimmunity. 37:555-567 (2004). PMID: 15763918.

Mitra AK, Celia H, Ren G, Luz JG, Wilson IA and Teyton L. Supine orientation of a murine MHC class I molecule on the membrane bilayer.  Curr Biol. 14:718-724 (2004). PMID: 15084288.

Robey IF, Peterson M, Horwitz MS, Kono DH, Stratmann T, Theofilopoulos AN, Sarvetnick N, Teyton L and Feeney AJ. Terminal deoxynucleotidyltransferase deficiency decreases autoimmune disease in diabetes-prone nonobese diabetic mice and lupus-prone MRL-Fas(lpr) mice.  J Immunol. 172:4624-4629 (2004). PMID: 15034081.

Cantu C, 3rd and Teyton L. Linking lipid metabolism to immunity: The role of lipid transfer proteins in the selection of iNKT cells.  Discovery medicine. 4:115-117 (2004). PMID: 20705005.

Stratmann T, Martin-Orozco N, Mallet-Designe V, Poirot L, McGavern D, Losyev G, Dobbs CM, Oldstone MB, Yoshida K, Kikutani H, Mathis D, Benoist C, Haskins K and Teyton L. Susceptible MHC alleles, not background genes, select an autoimmune T cell reactivity.  J Clin Invest. 112:902-914 (2003). PMID: 12975475.

Forestier C, Park SH, Wei D, Benlagha K, Teyton L and Bendelac A. T cell development in mice expressing CD1d directed by a classical MHC class II promoter.  J Immunol. 171:4096-4104 (2003). PMID: 14530331.

Stratmann T and Teyton L. Getting a grip on antigen-specific CD4 T cells: Tracking autoimmune T cells in vivo.  Discovery medicine. 3:42-43 (2003). PMID: 20704862.

Cantu C, 3rd, Benlagha K, Savage PB, Bendelac A and Teyton L. The paradox of immune molecular recognition of alpha-galactosylceramide: low affinity, low specificity for CD1d, high affinity for alpha beta TCRs.  J Immunol. 170:4673-4682 (2003). PMID: 12707346.

Mallet-Designe VI, Stratmann T, Homann D, Carbone F, Oldstone MB and Teyton L. Detection of low-avidity CD4+ T cells using recombinant artificial APC: following the antiovalbumin immune response.  J Immunol. 170:123-131 (2003). PMID: 12496391.

Zhu Y, Rudensky AY, Corper AL, Teyton L and Wilson IA. Crystal structure of MHC class II I-Ab in complex with a human CLIP peptide: prediction of an I-Ab peptide-binding motif.  J Mol Biol. 326:1157-1174 (2003). PMID: 12589760.

Zajonc DM, Elsliger MA, Teyton L and Wilson IA. Crystal structure of CD1a in complex with a sulfatide self antigen at a resolution of 2.15 A.  Nat Immunol. 4:808-815 (2003). PMID: 12833155.

Lee PT, Putnam A, Benlagha K, Teyton L, Gottlieb PA and Bendelac A. Testing the NKT cell hypothesis of human IDDM pathogenesis.  J Clin Invest. 110:793-800 (2002). PMID: 12235110.

Procopio DO, Almeida IC, Torrecilhas AC, Cardoso JE, Teyton L, Travassos LR, Bendelac A and Gazzinelli RT. Glycosylphosphatidylinositol-anchored mucin-like glycoproteins from Trypanosoma cruzi bind to CD1d but do not elicit dominant innate or adaptive immune responses via the CD1d/NKT cell pathway.  J Immunol. 169:3926-3933 (2002). PMID: 12244192.

Honey K, Benlagha K, Beers C, Forbush K, Teyton L, Kleijmeer MJ, Rudensky AY and Bendelac A. Thymocyte expression of cathepsin L is essential for NKT cell development.  Nat Immunol. 3:1069-1074 (2002). PMID: 12368909.

Apostolopoulos V, Yu M, Corper AL, Li W, McKenzie IF, Teyton L, Wilson IA and Plebanski M. Crystal structure of a non-canonical high affinity peptide complexed with MHC class I: a novel use of alternative anchors.  J Mol Biol. 318:1307-1316 (2002). PMID: 12083519.

Apostolopoulos V, Yu M, Corper AL, Teyton L, Pietersz GA, McKenzie IF, Wilson IA and Plebanski M. Crystal structure of a non-canonical low-affinity peptide complexed with MHC class I: a new approach for vaccine design.  J Mol Biol. 318:1293-1305 (2002). PMID: 12083518.

Luz JG, Huang M, Garcia KC, Rudolph MG, Apostolopoulos V, Teyton L and Wilson IA. Structural comparison of allogeneic and syngeneic T cell receptor-peptide-major histocompatibility complex complexes: a buried alloreactive mutation subtly alters peptide presentation substantially increasing V(beta) Interactions.  J Exp Med. 195:1175-1186 (2002). PMID: 11994422.

Bendelac A, Teyton L and Savage PB. Lipid presentation by CD1: the short and the long lipid story.  Nat Immunol. 3:421-422 (2002). PMID: 11976717.

Lee PT, Benlagha K, Teyton L and Bendelac A. Distinct functional lineages of human V(alpha)24 natural killer T cells.  J Exp Med. 195:637-641 (2002). PMID: 11877486.

Chiu YH, Park SH, Benlagha K, Forestier C, Jayawardena-Wolf J, Savage PB, Teyton L and Bendelac A. Multiple defects in antigen presentation and T cell development by mice expressing cytoplasmic tail-truncated CD1d.  Nat Immunol. 3:55-60 (2002). PMID: 11731798.

Tarbell KV, Lee M, Ranheim E, Chao CC, Sanna M, Kim SK, Dickie P, Teyton L, Davis M and McDevitt H. CD4(+) T cells from glutamic acid decarboxylase (GAD)65-specific T cell receptor transgenic mice are not diabetogenic and can delay diabetes transfer.  J Exp Med. 196:481-492 (2002). PMID: 12186840.

Stetson DB, Mohrs M, Mallet-Designe V, Teyton L and Locksley RM. Rapid expansion and IL-4 expression by Leishmania-specific naive helper T cells in vivo.  Immunity. 17:191-200 (2002). PMID: 12196290.

Benlagha K, Kyin T, Beavis A, Teyton L and Bendelac A. A thymic precursor to the NK T cell lineage.  Science. 296:553-555 (2002). PMID: 11968185.

Zhou XT, Forestier C, Goff RD, Li C, Teyton L, Bendelac A and Savage PB. Synthesis and NKT cell stimulating properties of fluorophore- and biotin-appended 6"-amino-6"-deoxy-galactosylceramides.  Org Lett. 4:1267-1270 (2002). PMID: 11950339.

Rudolph MG, Huang M, Teyton L and Wilson IA. Crystal structure of an isolated V(alpha) domain of the 2C T-cell receptor.  J Mol Biol. 314:1-8 (2001). PMID: 11724527.

Rudolph MG, Speir JA, Brunmark A, Mattsson N, Jackson MR, Peterson PA, Teyton L and Wilson IA. The crystal structures of K(bm1) and K(bm8) reveal that subtle changes in the peptide environment impact thermostability and alloreactivity.  Immunity. 14:231-242 (2001). PMID: 11290333.

Wolan DW, Teyton L, Rudolph MG, Villmow B, Bauer S, Busch DH and Wilson IA. Crystal structure of the murine NK cell-activating receptor NKG2D at 1.95 A.  Nat Immunol. 2:248-254 (2001). PMID: 11224525.

Homann D, Teyton L and Oldstone MB. Differential regulation of antiviral T-cell immunity results in stable CD8+ but declining CD4+ T-cell memory.  Nat Med. 7:913-919 (2001). PMID: 11479623.

Park SH, Weiss A, Benlagha K, Kyin T, Teyton L and Bendelac A. The mouse CD1d-restricted repertoire is dominated by a few autoreactive T cell receptor families.  J Exp Med. 193:893-904 (2001). PMID: 11304550.

Stratmann T, Apostolopoulos V, Mallet-Designe V, Corper AL, Scott CA, Wilson IA, Kang AS and Teyton L. The I-Ag7 MHC class II molecule linked to murine diabetes is a promiscuous peptide binder.  J Immunol. 165:3214-3225 (2000). PMID: 10975837.

Degano M, Garcia KC, Apostolopoulos V, Rudolph MG, Teyton L and Wilson IA. A functional hot spot for antigen recognition in a superagonist TCR/MHC complex.  Immunity. 12:251-261 (2000). PMID: 10755612.

Benlagha K, Weiss A, Beavis A, Teyton L and Bendelac A. In vivo identification of glycolipid antigen-specific T cells using fluorescent CD1d tetramers.  J Exp Med. 191:1895-1903 (2000). PMID: 10839805.

Crowley MP, Fahrer AM, Baumgarth N, Hampl J, Gutgemann I, Teyton L and Chien Y. A population of murine gammadelta T cells that recognize an inducible MHC class Ib molecule.  Science. 287:314-316 (2000). PMID: 10634788.

Corper AL, Stratmann T, Apostolopoulos V, Scott CA, Garcia KC, Kang AS, Wilson IA and Teyton L. A structural framework for deciphering the link between I-Ag7 and autoimmune diabetes.  Science. 288:505-511 (2000). PMID: 10775108.

Teyton L, Apostolopoulos V, Cantu C, 3rd, Celia H, Mallet-Designe V, Stefanko R, Stramann T and Wallace M. Function and dysfunction of T cell receptor: structural studies.  Immunol Res. 21:325-330 (2000). PMID: 10852133.

Kieke MC, Shusta EV, Boder ET, Teyton L, Wittrup KD and Kranz DM. Selection of functional T cell receptor mutants from a yeast surface-display library.  Proc Natl Acad Sci U S A. 96:5651-5656 (1999). PMID: 10318939.

Celia H, Wilson-Kubalek E, Milligan RA and Teyton L. Structure and function of a membrane-bound murine MHC class I molecule.  Proc Natl Acad Sci U S A. 96:5634-5639 (1999). PMID: 10318936.

Manning TC, Parke EA, Teyton L and Kranz DM. Effects of complementarity determining region mutations on the affinity of an alpha/beta T cell receptor: measuring the energy associated with CD4/CD8 repertoire skewing.  J Exp Med. 189:461-470 (1999). PMID: 9927508.

Garcia KC, Teyton L and Wilson IA. Structural basis of T cell recognition.  Annu Rev Immunol. 17:369-397 (1999). PMID: 10358763.

Cai Z, Brunmark AB, Luxembourg AT, Garcia KC, Degano M, Teyton L, Wilson I, Peterson PA, Sprent J and Jackson MR. Probing the activation requirements for naive CD8+ T cells with Drosophila cell transfectants as antigen presenting cells.  Immunol Rev. 165:249-265 (1998). PMID: 9850865.

Speir JA, Garcia KC, Brunmark A, Degano M, Peterson PA, Teyton L and Wilson IA. Structural basis of 2C TCR allorecognition of H-2Ld peptide complexes.  Immunity. 8:553-562 (1998). PMID: 9620676.

Scott CA, Peterson PA, Teyton L and Wilson IA. Crystal structures of two I-Ad-peptide complexes reveal that high affinity can be achieved without large anchor residues.  Immunity. 8:319-329 (1998). PMID: 9529149.

Luxembourg AT, Borrow P, Teyton L, Brunmark AB, Peterson PA and Jackson MR. Biomagnetic isolation of antigen-specific CD8+ T cells usable in immunotherapy.  Nat Biotechnol. 16:281-285 (1998). PMID: 9528010.

Garcia KC, Degano M, Pease LR, Huang M, Peterson PA, Teyton L and Wilson IA. Structural basis of plasticity in T cell receptor recognition of a self peptide-MHC antigen.  Science. 279:1166-1172 (1998). PMID: 9469799.

Scott CA, Garcia KC, Stura EA, Peterson PA, Wilson IA and Teyton L. Engineering protein for X-ray crystallography: the murine Major Histocompatibility Complex class II molecule I-Ad.  Protein Sci. 7:413-418 (1998). PMID: 9521118.

Liljedahl M, Winqvist O, Surh CD, Wong P, Ngo K, Teyton L, Peterson PA, Brunmark A, Rudensky AY, Fung-Leung WP and Karlsson L. Altered antigen presentation in mice lacking H2-O.  Immunity. 8:233-243 (1998). PMID: 9492004.

Garcia KC and Teyton L. T-cell receptor peptide-MHC interactions: biological lessons from structural studies.  Curr Opin Biotechnol. 9:338-343 (1998). PMID: 9720260.

Manning TC, Schlueter CJ, Brodnicki TC, Parke EA, Speir JA, Garcia KC, Teyton L, Wilson IA and Kranz DM. Alanine scanning mutagenesis of an alphabeta T cell receptor: mapping the energy of antigen recognition.  Immunity. 8:413-425 (1998). PMID: 9586632.

Aichinger G, Karlsson L, Jackson MR, Vestberg M, Vaughan JH, Teyton L, Lechler RI and Peterson PA. Major histocompatibility complex class II-dependent unfolding, transport, and degradation of endogenous proteins.  J Biol Chem. 272:29127-29136 (1997). PMID: 9360989.

Garcia KC, Tallquist MD, Pease LR, Brunmark A, Scott CA, Degano M, Stura EA, Peterson PA, Wilson IA and Teyton L. Alphabeta T cell receptor interactions with syngeneic and allogeneic ligands: affinity measurements and crystallization.  Proc Natl Acad Sci U S A. 94:13838-13843 (1997). PMID: 9391114.

Smirnov AV, English DS, Rich RL, Lane J, Teyton L, Schwabacher AW, Luo S, Thornburg RW and Petrich JW. Photophysics and Biological Applications of 7-Azaindole and Its Analogs.  J Phys Chem B. 101:2758-2769 (1997). DOI 10.1021/jp9630232.

Garcia KC, Degano M, Stanfield RL, Scott C, Brunmark A, Peterson PA, Wilson IA and Teyton L. Structural Basis of T cell Recognition. In: Brown F, Burton D, Doherty P, Mekalanos J and Norrby E, editors. Vaccine 97: Cold Spring Harbor Laboratory Press (1997).

Garcia KC, Degano M, Stanfield RL, Brunmark A, Jackson MR, Peterson PA, Teyton L and Wilson IA. An alphabeta T cell receptor structure at 2.5 A and its orientation in the TCR-MHC complex.  Science. 274:209-219 (1996). PMID: 8824178.

Huang JF, Teyton L and Harper JF. Activation of a Ca(2+)-dependent protein kinase involves intramolecular binding of a calmodulin-like regulatory domain.  Biochemistry. 35:13222-13230 (1996). PMID: 8855961.

Lang J, Jackson M, Teyton L, Brunmark A, Kane K and Nemazee D. B cells are exquisitely sensitive to central tolerance and receptor editing induced by ultralow affinity, membrane-bound antigen.  J Exp Med. 184:1685-1697 (1996). PMID: 8920858.

Scott CA, Garcia KC, Carbone FR, Wilson IA and Teyton L. Role of chain pairing for the production of functional soluble IA major histocompatibility complex class II molecules.  J Exp Med. 183:2087-2095 (1996). PMID: 8642319.

Eastman S, Deftos M, DeRoos PC, Hsu DH, Teyton L, Braunstein NS, Hackett CJ and Rudensky A. A study of complexes of class II invariant chain peptide: major histocompatibility complex class II molecules using a new complex-specific monoclonal antibody.  Eur J Immunol. 26:385-393 (1996). PMID: 8617308.

Garcia KC, Scott CA, Brunmark A, Carbone FR, Peterson PA, Wilson IA and Teyton L. CD8 enhances formation of stable T-cell receptor/MHC class I molecule complexes.  Nature. 384:577-581 (1996). PMID: 8955273.

Wilson IA, Garcia KC, Degano M, Stanfield RL, Zeng Z, Segelke B, Stura EA, Castano AR, Jewell DA, Brunmark A, Jackson MR, Peterson PA and Teyton L, editors. Structural Basis of Cellular Immune Recognition. Proceedings of Copenhagen Meetings; 1996.

Pond L, Kuhn LA, Teyton L, Schutze MP, Tainer JA, Jackson MR and Peterson PA. A role for acidic residues in di-leucine motif-based targeting to the endocytic pathway.  J Biol Chem. 270:19989-19997 (1995). PMID: 7650016.

Jackson MR, Fruh K, Karlsson L, Teyton L, Yang Y and Peterson PA. Assembly and intracellular transport of MHC class I and class II molecules.  Cold Spring Harb Symp Quant Biol. 60:249-261 (1995). PMID: 8824398.

Teyton L. Assembly and transport of major histocompatibility complex molecules.  Nouv Rev Fr Hematol. 36 Suppl 1:S33-36 (1994). PMID: 7909942.

Teyton L and Peterson PA. Assembly and transport of MHC class II molecules.  New Biol. 4:441-447 (1992). PMID: 1515409.

Teyton L and Peterson PA. Invariant chain--a regulator of antigen presentation.  Trends Cell Biol. 2:52-56 (1992). PMID: 14731527.

Temime N, Joliviere A, Lando D, Teyton L and Charron D. Autocrine stimulation of interleukin 1 in human adherent synovial lining cells: down regulation by interferon gamma.  Hum Immunol. 31:261-270 (1991). PMID: 1917593.

Teyton L, O'Sullivan D, Dickson PW, Lotteau V, Sette A, Fink P and Peterson PA. Invariant chain distinguishes between the exogenous and endogenous antigen presentation pathways.  Nature. 348:39-44 (1990). PMID: 2234057.

Lotteau V, Teyton L, Peleraux A, Nilsson T, Karlsson L, Schmid SL, Quaranta V and Peterson PA. Intracellular transport of class II MHC molecules directed by invariant chain.  Nature. 348:600-605 (1990). PMID: 2250716.

Lotteau V, Sands J, Teyton L, Turmel P, Charron D and Strominger JL. Modulation of HLA class II antigen expression by transfection of sense and antisense DR alpha cDNA.  J Exp Med. 169:351-356 (1989). PMID: 2462612.

Lotteau V, Teyton L, Turmel P and Charron D. DRα-DQβ: A Novel Class II Molecule Whose Expression is Influenced by the Ratio of α β Chains Transcripts. In: Dupont B, editor. Immunobiology of HLA: Springer Berlin Heidelberg; (1989). p. 273-275.

Teyton L, Lotteau V and Charron D. In Vivo Expression of a Soluble Form of HLA Class I Antigens in Rheumatoid Synovial Cells. In: Dupont B, editor. Immunobiology of HLA. Berlin, Heidelberg: Springer; (1989). p. 425-426.

Lotteau V, Teyton L, Burroughs D and Charron D. DRα-DQß Mismatched Isotype Pairing Occurs in EBV Transformed B Cell Lines. In: Mani JC and Dormand J, editors. Lymphocyte Activation and Differentiation, Fundamental and Clinical Aspects. Berlin: De Gruyter; (1988). p. 813-818.

Mauviel A, Teyton L, Bhatnagar R, Penfornis H, Laurent M, Hartmann D, Bonaventure J, Loyau G, Saklatvala J and Pujol JP. Interleukin-1 alpha modulates collagen gene expression in cultured synovial cells.  Biochem J. 252:247-255 (1988). PMID: 2844146.

Lotteau V, Teyton L, Burroughs D and Charron D. A novel HLA class II molecule (DR alpha-DQ beta) created by mismatched isotype pairing.  Nature. 329:339-341 (1987). PMID: 3306409.

Teyton L, Lotteau V, Turmel P, Arenzana-Seisdedos F, Virelizier JL, Pujol JP, Loyau G, Piatier-Tonneau D, Auffray C and Charron DJ. HLA DR, DQ, and DP antigen expression in rheumatoid synovial cells: a biochemical and quantitative study.  J Immunol. 138:1730-1738 (1987). PMID: 3102596.

Lotteau V, Teyton L, Tongio MM, Soulier A, Thomsen M, Sasportes M and Charron D. Biochemical polymorphism of the HLA-DP heavy chain.  Immunogenetics. 25:403-407 (1987). PMID: 3596675.

Charron D and Teyton L. Autoimmunity in rheumatoid arthritis. A qualitative and quantitative approach to the role of Ia antigens.  Concepts Immunopathol. 4:200-214 (1987). PMID: 3297335.

Arenzana-Seisdedos F, Teyton L and Virelizier JL. Immunoregulatory mediators in the pathogenesis of rheumatoid arthritis.  Scand J Rheumatol Suppl. 66:13-17 (1987). PMID: 3131870.

Charron DJ, Lotteau V, Haziot A and Teyton L. Techniques biochimiques d’analyse des antigènes de membrane. In: Charron D, editor. Techniques en Immunologie. Paris: INSERM; (1987).

Teyton L, Lotteau V, Brandely M, Turmel P, Viguier M, Pujol JP, Loyau G and Charron DJ. Effects of cyclosporin A on IFNg induction of Ia antigens on adherent synovial lining cells.  Clinical Immunol (Int Congress Series). 718:159-163 (1987)

Teyton L, Lotteau V, Boyer B and Charron DJ. A quantitative dot immunobinding assay for human HLA class II antigens using nitrocellulose membrane filters.  J Immunol Methods. 89:73-79 (1986). PMID: 3517174.

Charron DJ, Haziot A, Lotteau V, Neel D, Merlu B and Teyton L. Biochemical Diversity of the Human MHC Class II Antigens. In: Feldmann M and McMichael A, editors. Regulation of Immune Gene Expression. Totowa, NJ: Humana Press; (1986). p. 61-72.

Charron DJ, Teyton L, Lotteau V, Merlu B, Néel D and Haziot A. Molecular diversity of the human Ia system In: Brochier J, Clot J and Sany J, editors. Immune Intervention: Anti-Ia antibodies in the treatment of autoimmune diseases. UK: Academic Press; (1986). p. 1-12.

Teyton L and Pouletty P. Le lupus érythémateux disséminé : physiopathologie, diagnostic, évolution et pronostic.  Concours Médical. 107:3311 (1985).

Teyton L, Lotteau V, Boyer B and Charron DJ, editors. A quantitative dot immunobinding assay for human HLA class II antigens (Abstract). Conférence Européenne d’Histocompatibilité; 1985.

Charron DJ and Teyton L. Fonction de la région HLA-D. In: Sany J and Clot J, editors. 5éme Cours d’Immunorhumatologie de Montpellier (1985).

Teyton L, Lotteau V, Pulol JP, Loyau G and Charron DJ. HLA-DR HLA-DQ, and HLA-DP Expression on synovial lining cells from rheumatoid-arthritis: A molecular and quantitative study (Abstract).  Human Immunol. 14:135-136 (1985).

Teyton L, Mora JJ, Loyau G, Mahoudeau J, L'Hirondel JL, Lebrun E, Dumas M and Ollivier D. [Cleidocranial dysostosis. Contribution to its study a propos of 2 personal cases (an isolated and a familial form)].  Rev Med Interne. 5:76-82 (1984). PMID: 6718841.

Mora JJ, Teyton L, Loyau G and Ollivier D. [Tuberculosis complicating the course of acute systemic lupus erythematosus].  LARC Med. 3:417-418 (1983). PMID: 6888110.

Teyton L, Loyau G and Freymuth F. Polyarthrite rhumatoide : le point sur sa pathogénie, le rôle possible du virus d’Epstein-Barr.  Revue de Médecine. 24:13 (1983).

Guaydier-Souquières G, Teyton L, Loyau G and L’Hirondel JL. Métastase synoviale révélatrice d’un adénocarcinome.  LARC Médical. 3:300 (1983).

Teyton L, Mora JJ and Loyau G. Scanner et bilan d’un abcès pottique.  LARC Med. 3:309 (1983)

Mora JJ, Teyton L, Souquières G, L’Hirondel JL and Loyau G. Métastase synoviale révélatrice d’un adénocarcinome.  Rhumatologie. 34:499 (1982).

Teyton L. Traitement des brucelloses ostéo-articulaires.  NPM Médecine. 10:729 (1981)

Freymuth F, Langeard MM, Daon F, Teyton L, Guihard P, L’Hirondel L and Venezia R. Infections à virus respiratoire syncitial.  Revue Institut Pasteur de Lyon. 13:111 (1980).