Welcome to Dave Stout's lab
home Research Publications Lab Members Contacts The Scripps Research Institute

Transhydrogenase

  HIV crystal collage
Superposition of three copies of the co-crystal structure of soluble TH domains. The large membrane
component of the intact enzyme resides below the soluble domains in this view.
 
 


Major effort is focused on transhydrogenase (TH), a mitochondrial enzyme and large integral membrane protein. Structure determination will elucidate the mechanism by which TH transduces the proton motive force generated by respiration into the chemistry required to maintain a reducing environment. Understanding of TH function is relevant to type 2 diabetes and neurodegenerative diseases.

 

 

 

 

 

 

 

 

Projects

Transhydrogenase

CYP24A1

HIV Protease

Cytochrome ba3 oxidase

Cytochrome P450s

Home    |    Research    |    Publications    |    Lab Members    |    Contacts    |    Scripps Research