Transhydrogenase
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Superposition of three copies of the co-crystal structure of soluble TH domains. The large membrane
component of the intact enzyme resides below the soluble domains in this view. |
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Major effort is focused on transhydrogenase (TH), a mitochondrial enzyme and large integral membrane protein. Structure determination will elucidate the mechanism by which TH transduces the proton motive force generated by respiration into the chemistry required to maintain a reducing environment. Understanding of TH function is relevant to type 2 diabetes and neurodegenerative diseases.
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Projects
Transhydrogenase
CYP24A1
HIV Protease
Cytochrome ba3 oxidase
Cytochrome P450s |
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