Publications

Rappazzo CG, Tse LV, Kaku CI, Wrapp D, Sakharkar M, Huang D, Deveau LM, Yockachonis TJ, Herbert AS, Battles MB, O'Brien CM, Brown ME, Geoghegan JC, Belk J, Peng L, Yang L, Hou Y, Scobey TD, Burton DR, Nemazee D, Dye JM, Voss JE, Gunn BM, McLellan JS, Baric RS, Gralinski LE, Walker LM. Broad and potent activity against SARS-like viruses by an engineered human monoclonal antibody. Science. 2021 Feb 19;371(6531):823-829. doi: 10.1126/science.abf4830. Epub 2021 Jan 25. PubMed PMID: 33495307; PubMed Central PMCID: PMC7963221.

Yuan M, Huang D, Lee CD, Wu NC, Jackson AM, Zhu X, Liu H, Peng L, van Gils MJ, Sanders RW, Burton DR, Reincke SM, Prüss H, Kreye J, Nemazee D, Ward AB, Wilson IA. Structural and functional ramifications of antigenic drift in recent SARS-CoV-2 variants. Science. 2021 Aug 13;373(6556):818- 823. doi: 10.1126/science.abh1139. Epub 2021 May 20. PubMed PMID: 34016740; PubMed Central PMCID: PMC8284396.

Bangaru, S., Ozorowski, G., Turner, H. L., Antanasijevic, A., Huang, D., Wang, X., Torres, J. L., Diedrich, J. K., Tian, J. H., Portnoff, A. D., Patel, N., Massare, M. J., Yates, J. R., 3rd, Nemazee, D., Paulson, J. C., Glenn, G., Smith, G., & Ward, A. B. 2020. Structural analysis of full-length SARS-CoV-2 spike protein from an advanced vaccine candidate. bioRxiv : the preprint server for biology, 2020.08.06.234674.

Rogers, T. F., Zhao, F., Huang, D., Beutler, N., Burns, A., He, W. T., Limbo, O., Smith, C., Song, G., Woehl, J., Yang, L., Abbott, R. K., Callaghan, S., Garcia, E., Hurtado, J., Parren, M., Peng, L., Ricketts, J., Ricciardi, M. J., Rawlings, S. A., … Burton, D. R. 2020. Rapid isolation of potent SARS-CoV-2 neutralizing antibodies and protection in a small animal model. bioRxiv : the preprint server for biology, 2020.05.11.088674.

Rogers, T. F., Zhao, F., Huang, D., Beutler, N., Burns, A., He, W. T., Limbo, O., Smith, C., Song, G., Woehl, J., Yang, L., Abbott, R. K., Callaghan, S., Garcia, E., Hurtado, J., Parren, M., Peng, L., Ramirez, S., Ricketts, J., Ricciardi, M. J., … Burton, D. R. 2020. Isolation of potent SARS-CoV-2 neutralizing antibodies and protection from disease in a small animal model. Science (New York, N.Y.), 369(6506), 956–963.

Xiao, C., Nemazee, D., & Gonzalez-Martin, A. 2020. MicroRNA control of B cell tolerance, autoimmunity and cancer. Seminars in cancer biology, 64, 102–107.

Bhullar, D., & Nemazee, D. 2020. B Cells Carrying Antigen Receptors Against Microbes as Tools for Vaccine Discovery and Design. Current topics in microbiology and immunology, 428, 165–180.

Suhandynata, R. T., Hoffman, M. A., Huang, D., Tran, J. T., Kelner, M. J., Reed, S. L., McLawhon, R. W., Voss, J. E., Nemazee, D., & Fitzgerald, R. L. 2020. Commercial Serology Assays Predict Neutralization Activity Against SARS-CoV-2. Clinical chemistry, hvaa262. Advance online publication.

Phillips, N., Ke, E., Nham, A., Seidl, M., Freeman, B., Abadejos, J. R., Xiao, C., Nemazee, D., Ku, M., & Kirak, O. 2020. Prediabetes Induced by a Single Autoimmune B Cell Clone. Frontiers in immunology, 11, 1073.

Wu, N. C., Yuan, M., Bangaru, S., Huang, D., Zhu, X., Lee, C. D., Turner, H. L., Peng, L., Yang, L., Burton, D. R., Nemazee, D., Ward, A. B., & Wilson, I. A. 2020. A natural mutation between SARS-CoV-2 and SARS-CoV determines neutralization by a cross-reactive antibody. PLoS pathogens, 16(12), e1009089.

Huang, D., Tran, J. T., Olson, A., Vollbrecht, T., Tenuta, M., Guryleva, M. V., Fuller, R. P., Schiffner, T., Abadejos, J. R., Couvrette, L., Blane, T. R., Saye, K., Li, W., Landais, E., Gonzalez-Martin, A., Schief, W., Murrell, B., Burton, D. R., Nemazee, D., & Voss, J. E. 2020. Vaccine elicitation of HIV broadly neutralizing antibodies from engineered B cells. Nature communications, 11(1), 5850.

Rappazzo, C. G., Tse, L. V., Kaku, C. I., Wrapp, D., Sakharkar, M., Huang, D., Deveau, L. M., Yockachonis, T. J., Herbert, A. S., Battles, M. B., O'Brien, C. M., Brown, M. E., Geoghegan, J. C., Belk, J., Peng, L., Yang, L., Scobey, T. D., Burton, D. R., Nemazee, D., Dye, J. M., … Walker, L. M. 2020. An Engineered Antibody with Broad Protective Efficacy in Murine Models of SARS and COVID-19. bioRxiv : the preprint server for biology, 2020.11.17.385500.

Wec, A. Z., Wrapp, D., Herbert, A. S., Maurer, D., Haslwanter, D., Sakharkar, M., Jangra, R. K., Dieterle, M. E., Lilov, A., Huang, D., Tse, L. V., Johnson, N. V., Hsieh, C. L., Wang, N., Nett, J. H., Champney, E., Burnina, I., Brown, M., Lin, S., Sinclair, M., … Walker, L. M. 2020. Broad sarbecovirus neutralizing antibodies define a key site of vulnerability on the SARS-CoV-2 spike protein. bioRxiv : the preprint server for biology, 2020.05.15.096511.

Wec, A. Z., Wrapp, D., Herbert, A. S., Maurer, D. P., Haslwanter, D., Sakharkar, M., Jangra, R. K., Dieterle, M. E., Lilov, A., Huang, D., Tse, L. V., Johnson, N. V., Hsieh, C. L., Wang, N., Nett, J. H., Champney, E., Burnina, I., Brown, M., Lin, S., Sinclair, M., … Walker, L. M. 2020. Broad neutralization of SARS-related viruses by human monoclonal antibodies. Science (New York, N.Y.), 369(6504), 731–736.

Grødeland, G., Baranowska-Hustad, M., Abadejos, J., Blane, T. R., Teijaro, J., Nemazee, D., & Bogen, B. 2020. Induction of Cross-Reactive and Protective Antibody Responses After DNA Vaccination With MHCII-Targeted Stem Domain From Influenza Hemagglutinin. Frontiers in immunology, 11, 431.

Song, G., He, W. T., Callaghan, S., Anzanello, F., Huang, D., Ricketts, J., Torres, J. L., Beutler, N., Peng, L., Vargas, S., Cassell, J., Parren, M., Yang, L., Ignacio, C., Smith, D. M., Voss, J. E., Nemazee, D., Ward, A. B., Rogers, T., Burton, D. R., … Andrabi, R. 2020. Cross-reactive serum and memory B cell responses to spike protein in SARS-CoV-2 and endemic coronavirus infection. bioRxiv : the preprint server for biology, 2020.09.22.308965.

Antanasijevic, A., Ueda, G., Brouwer, P., Copps, J., Huang, D., Allen, J. D., Cottrell, C. A., Yasmeen, A., Sewall, L. M., Bontjer, I., Ketas, T. J., Turner, H. L., Berndsen, Z. T., Montefiori, D. C., Klasse, P. J., Crispin, M., Nemazee, D., Moore, J. P., Sanders, R. W., King, N. P., … Ward, A. B. 2020. Structural and functional evaluation of de novo-designed, two-component nanoparticle carriers for HIV Env trimer immunogens. PLoS pathogens, 16(8), e1008665.

Melo M, Porter E, Zhang Y, Silva M, Li N, Dobosh B, Liguori A, Skog P, Landais E, Menis S, Sok D,
Nemazee D, Schief WR, Weiss R, Irvine DJ. Immunogenicity of RNA Replicons Encoding HIV Env
Immunogens Designed for Self-Assembly into Nanoparticles. Mol Ther. 2019 Dec 4;27(12):2080-2090.
doi: 10.1016/j.ymthe.2019.08.007. Epub 2019 Aug 19. PubMed PMID: 31515132; PubMed Central
PMCID: PMC6904793.

Huang, D., Abbott, R. K., Havenar-Daughton, C., Skog, P. D., Al-Kolla, R., Groschel, B., Blane, T. R., Menis, S., Tran, J. T., Thinnes, T. C., Volpi, S. A., Liguori, A., Schiffner, T., Villegas, S. M., Kalyuzhniy, O., Pintea, M., Voss, J. E., Phelps, N., Tingle, R., Rodriguez, A. R., … Crotty, S. 2020. B cells expressing authentic naive human VRC01-class BCRs can be recruited to germinal centers and affinity mature in multiple independent mouse models. Proceedings of the National Academy of Sciences of the United States of America, 117(37), 22920–22931.

Sinha, R. K., Flynn, R., Zaiken, M., Paz, K., Gavin, A. L., Nemazee, D., Fernández, J. A., Xu, X., Griffin, J. H., & Blazar, B. R. 2019. Activated protein C ameliorates chronic graft-versus-host disease by PAR1-dependent biased cell signaling on T cells. Blood, 134(9), 776–781.

Bancroft, T., DeBuysscher, B. L., Weidle, C., Schwartz, A., Wall, A., Gray, M. D., Feng, J., Steach, H. R., Fitzpatrick, K. S., Gewe, M. M., Skog, P. D., Doyle-Cooper, C., Ota, T., Strong, R. K., Nemazee, D., Pancera, M., Stamatatos, L., McGuire, A. T., & Taylor, J. J. 2019. Detection and activation of HIV broadly neutralizing antibody precursor B cells using anti-idiotypes. The Journal of experimental medicine, 216(10), 2331–2347.

Melo, M., Porter, E., Zhang, Y., Silva, M., Li, N., Dobosh, B., Liguori, A., Skog, P., Landais, E., Menis, S., Sok, D., Nemazee, D., Schief, W. R., Weiss, R., & Irvine, D. J. 2019. Immunogenicity of RNA Replicons Encoding HIV Env Immunogens Designed for Self-Assembly into Nanoparticles. Molecular therapy : the journal of the American Society of Gene Therapy, 27(12), 2080–2090.

Voss, J. E., Gonzalez-Martin, A., Andrabi, R., Fuller, R. P., Murrell, B., McCoy, L. E., Porter, K., Huang, D., Li, W., Sok, D., Le, K., Briney, B., Chateau, M., Rogers, G., Hangartner, L., Feeney, A. J., Nemazee, D., Cannon, P., & Burton, D. R. 2019. Reprogramming the antigen specificity of B cells using genome-editing technologies. eLife, 8, e42995.

Gavin, A.L, Huang, D., Huber, C., Mårtensson, A., Tardif, V., Skog, P.D., Blane, T.R., Thinnes, T.C., Osborn, K., Hayley, S. Chong, H.S., Kargaran, F., Kimm, P., Zeitjian, A., Sielski, R.L., Briggs, M., Schulz, S.R., Zarpellon, A., Cravatt, B., Pang, E.S., Teijaro, J., de la Torre, J.C., O'Keeffe, M., Hochrein, H., Damme, M., Teyton, L., Lawson, B.R., Nemazee D. 2018. PLD3 and PLD4 are single stranded acid exonucleases that regulate endosomal nucleic acid sensing. Nature Immunology, in press.

He, L., Kumar, S., Allen, J. D., Huang, D., Lin, X., Mann, C. J., Saye-Francisco, K. L., Copps, J., Sarkar, A., Blizard, G. S., Ozorowski, G., Sok, D., Crispin, M., Ward, A. B., Nemazee, D., Burton, D. R., Wilson, I. A., & Zhu, J. 2018. HIV-1 vaccine design through minimizing envelope metastability. Science advances, 4(11), eaau6769.

Gonzalez, A. C., Stroobants, S., Reisdorf, P., Gavin, A. L., Nemazee, D., Schwudke, D., D'Hooge, R., Saftig, P., & Damme, M. 2018. PLD3 and spinocerebellar ataxia. Brain : a journal of neurology, 141(11), e78.

Abbott, R.K, Lee, J.H. Menis, S., Skog, P., Rossi, M., Ota, T., Kulp, D. W. Bhullar, D., Kalyuzhniy, O., Havenar-Daughton, C., Schief*, W.R., Nemazee*, D., Crotty, S. 2017. Precursor frequency and affinity can determine competitive fitness of naïve B cell clones for germinal center responses, with implications for germline-targeting HIV vaccine design. Immunity 48:133-146. * co-senior author

Medina-Ramírez, M., Garces, F., Escolano, A., Skog, P., de Taeye, S.W., Del Moral-Sanchez, I., McGuire, A.T., Yasmeen, A., Behrens, A.J., Ozorowski, G., van den Kerkhof, T.L.G.M., Freund, N.T., Dosenovic, P., Hua, Y., Gitlin, A.D., Cupo, A., van der Woude, P., Golabek, M., Sliepen. K,, Blane. T,, Kootstra. N., van Breemen, M.J., Pritchard, L.K., Stanfield, R.L., Crispin, M., Ward,  A.B., Stamatatos, L., Klasse, P.J., Moore, J.P., Nemazee, D., Nussenzweig, M.C., Wilson, I.A., Sanders, R.W. 2017. Design and crystal structure of a native-like HIV-1 envelope trimer that engages multiple broadly neutralizing antibody precursors in vivo. J Exp Med. 214:2573-2590.

Kolenbrander, A., Grewe, B., Nemazee, D., Überla, K. , Temchura, V. 2017. Generation of T follicular helper cells in vitro: requirement for B-cell receptor cross-linking and cognate B- and T-cell interaction. Immunology. Sep 7. doi: 10.1111/imm.12834. [Epub ahead of print] PubMed PMID: 28881401

Martinic, M.M., Caminschi, I., O'Keeffe, M., Thinnes, T.C., Grumont, R., Gerondakis, S., McKay, D.B., Nemazee, D., Gavin, A.L. 2017. The Bacterial Peptidoglycan-Sensing Molecules NOD1 and NOD2 Promote CD8(+) Thymocyte Selection. J Immunol. 198:2649-2660. PMID: 28202617; PMCID: PMC5360474.

Nemazee, D. Mechanisms of central tolerance for B cells. 2017. Nat. Rev. Immunol. 17(5):281-294.

Ingale J, Stano A, Guenaga J, Sharma SK, Nemazee D, Zwick MB, Wyatt RT. 2016. High-Density Array of Well-Ordered HIV-1 Spikes on Synthetic Liposomal Nanoparticles Efficiently Activate B Cells. Cell Rep. 15:1986-99.

Gonzalez-Martin A, Adams BD, Lai M, Shepherd J, Salvador-Bernaldez M, Salvador JM, Lu J, Nemazee D, Xiao C. 2016. The microRNA miR-148a functions as a critical regulator of B cell tolerance and autoimmunity. Nat Immunol. 17:433-440.

He, L., de Val, N., Morris, C., Vora, N., Thinnes, T., Kong, L., Azadnia, P., Sok, D., Zhou, B., Burton, D., Wilson, I., Nemazee, D., Ward, A. and Zhu, J. 2016. Presenting native-like trimeric HIV-1 antigens with self-assembling nanoparticles. Nat. Com. 7:12041.

Lai, M., Gonzalez-Martin, A., Cooper, A.B., Oda, H., Jin, H.Y., Shepherd, J., He, L., Zhu, J., Nemazee, D. and Xiao, C. 2016. Regulation of B Cell Development and Tolerance by Different Members of the miR-17~92 Family MicroRNAs. Nat. Com. 7:12207.

Briney, B., Sok, D., Jardine, J.G., Kulp, D.W., Skog, P., Menis, S., Jacak, R., Kalyuzhniy, O.,  de Val, N., Sesterhenn, F., Le, K.M., Ramos, A., Jones, M., Saye-Francisco, K.L., Blane, T.R., Spencer, S., Georgeson, E., Hu, X., Ozorowski, G., Adachi, Y., Kubitz, M., Sarkar, A., Wilson, I.A., Ward, A.B., Nemazee, D., Burton, D.R., Schief, W.R. 2016. Tailored Immunogens Direct Affinity Maturation toward HIV Neutralizing Antibodies. Cell. 166:1459-1470.

Lang, J., Ota, T., Kelly, M., Strauch, P., Freed, B. M., Torres, R. M., Nemazee, D., and Pelanda, R. 2016. Receptor editing and genetic variability in human autoreactive B cells. J. Exp. Med. 213: 93-108.

Jardine, J.G., Ota, T., Sok, D., Pauthner, M., Kulp, D.W., Kalyuzhniy, O., Skog, P.D., Thinnes, T.C., Bhullar, D., Briney, B., Menis, S., Jones, M., Kubitz, M., Spencer, S., Adachi, Y., Burton, D.R., Schief, W.R., Nemazee D. 2015.  Priming a broadly neutralizing antibody response to HIV-1 using a germline-targeting immunogen. Science. 2015 349:156-61.

Jardine, J., Julien, J.-P., Menis, S., Ota, T., Kalyuzhniy, O., McGuire, A., Sok, D., Huang, P.-S., MacPherson, S., Jones, M., Nieusma, T., Mathison, J., Baker, D., Ward, A.B., Burton, D.R.,  Stamatatos, L., Nemazee, D., Wilson,  I.A., Schief, W.R. 2013. Rational HIV immunogen design to target specific germline B cell receptors. Science, 340:711-716.

Ota, T., Doyle-Cooper, C., Cooper, A.B., Doores, K.J., Aoki-Ota, M., Le, K., Schief, W.R., Wyatt, R.T., Burton, D.R., Nemazee, D. 2013. B cells from knock-in mouse expressing broadly neutralizing HIV antibody b12 carry an innocuous BCR responsive to HIV vaccine candidates. J. Immunol. 191:3179-3185.

Doyle-Cooper, C., Hudson, K.E., Cooper, A.B., Ota, T., Skog, P., Dawson, P.E., Zwick, M.B., Schief, W.R., Burton, D.R., Nemazee, D. 2013. Immune tolerance negatively regulates B cells in knock-in mice expressing broadly neutralizing HIV antibody 4E10. J. Immunol. 191:3186-3191.

Aoki-Ota, M., Torkamani, A., Ota, T. Schork, N., Nemazee, D. 2012. Skewed primary Ig repertoire and V-J joining in C57BL/6 mice: implications for recombination accessibility and receptor editing. J Immunol. 188:2305-2315.

Ota, T., Doyle-Cooper, C., Cooper, A.B., Huber, M., Falkowska, E., Doores, K.J., Hangartner, L., Le, K., Sok, D., Jardine, J., Lifson, J., Wu, X., Mascola, J.R., Poignard, P., Binley, J.M., Chakrabarti, B.K., Schief, W.R., Wyatt, R.T., Burton, D.R., Nemazee, D. 2012. Anti-HIV B cell lines as candidate vaccine biosensors. J. Immunol. 189:4816-4824.

Doores, K.J., Huber, M., Le, K.M., Wang, S.K., Doyle-Cooper, C., Cooper, A., Pantophlet , R., Wong, C.H., Nemazee, D. , Burton, D.R. 2012. 2G12 B cell lines inform HIV carbohydrate vaccine design strategies. J. Virol. 87: 2234-2241.

Doores, K. J., Huber, M., Le, K. M., Wang, S. K., Doyle-Cooper, C., Cooper, A., Pantophlet, R., Wong, C. H., Nemazee, D., & Burton, D. R. 2013. 2G12-expressing B cell lines may aid in HIV carbohydrate vaccine design strategies. Journal of virology, 87(4), 2234–2241.

Siggs OM, Arnold CN, Huber C, Pirie E, Xia Y, Lin P, Nemazee D, Beutler B. 2011. The P4-type ATPase ATP11C is essential for B lymphopoiesis in adult bone marrow. Nat Immunol. 12:434-440.

Ota, T., Ota, M., Duong, B.H., Gavin, A.L., Nemazee, D. 2011. Liver-expressed Ig superantigen induces tolerance of polyclonal B cells by clonal deletion, not -to- receptor editing. J.Exp.Med. 208:617-629.

Duong, B.H., Ota, T., Aoki-Ota, M., Cooper, A.B., Aït-Azzouzene, D., Vela, J.L., Gavin, A.L., Nemazee, D. 2011. Negative Selection by IgM Superantigen Defines a B Cell Central Tolerance Compartment and Reveals Mutations Allowing Escape. J Immunol. 187:5596-5605.

Duong, B.H., Ota, T., Aït-Azzouzene, D., Ota, M., Vela, J.L., Huber, C., Walsh, K., Gavin, A. L., Nemazee, D. 2010. Peripheral B cell tolerance and function in transgenic mice expressing an IgD superantigen. J. Immunol. 184:4143-4158.

Aït-Azzouzene, D., Kono, D.H., Gonzalez-Quintial, R., McHeyzer-Williams, L.J., Lim, M., Wickramarachchi, D., Gerdes, T., Gavin, A.L., Skog, P., McHeyzer-Williams, M.G., *Nemazee, D., *Theofilopoulos, A.N.  2010.  Deletion of IgG-switched autoreactive B cells and defects in Fas(lpr) lupus mice. J. Immunol. 185:1015-1027. *co-PI

Ota, M., Duong, B.H., Torkamani, A., Doyle, C., Gavin, A., Ota, T., Nemazee, D. 2010. Regulation of the B cell receptor repertoire and self reactivity by BAFF. J. Immunol., 185:4128-4136.

Duong, B.H., Tian, H., Ota, T, Completo, G., Han, S., Vela, J.L., Ota, M., Kubitz, M., Bovin, N. Paulson, J., Nemazee, D. 2010. Decoration of T-independent antigen with ligands for CD22 and Siglec-G can suppress immunity and induce B cell tolerance in vivo. J.Exp.Med. 207:173-187.

Siggs, O.M., Berger, M., Krebs, P., Arnold, C.N., Eidenschenk, C., Huber. C,, Pirie. E,, Smart, N.G., Khovananth, K., Xia, Y., McInerney, G., Karlsson-Hedestam, G.B., Nemazee, D., Beutler, B. 2010. A mutation of Ikbkg causes immune deficiency without impairing degradation of IkappaB alpha. Proc. Natl. Acad. Sci. U S A. 107:3046-3051.

Beck, K., Peak, M.M., Ota, T., Nemazee, D., Murre, C. 2009. Distinct roles for E12 and E47 in B cell specification and the sequential rearrangement of immunoglobulin light chain loci. J Exp Med. 206:2271-2284.

Ota, T., Aoki-Ota, M., Duong, B.H., Nemazee, D. 2009. Suppression of IgE B cells and IgE binding to Fc(epsilon)RI by gene therapy with single-chain anti-IgE. J. Immunol. 182:8110-8117.

Huber, C., Mårtensson, A., Bokoch, G.M., Nemazee, D., Gavin, A.L. 2008. FGD2, a CDC42-specific exchange factor expressed by antigen-presenting cells, localizes to early endosomes and active membrane ruffles. J. Biol. Chem. 283:34002-34012.

Vela, J.L., Aït-Azzouzene, D., Duong, B.H., Ota, T. and Nemazee, D. 2008. Recombination by the mouse immunoglobulin deleting element RS promotes immune tolerance and Ig B cell production. Immunity, 28:161.

Vela, J. L., Aït-Azzouzene, D., Duong, B. H., Ota, T., & Nemazee, D. 2008. Rearrangement of mouse immunoglobulin kappa deleting element recombining sequence promotes immune tolerance and lambda B cell production. Immunity, 28(2), 161–170. https://doi.org/10.1016/j.immuni.2007.12.011

Verkoczy, L., Duong, B., Skog, P., Aït-Azzouzene, D., Puri, K., Vela, J.L., Nemazee, D. 2007. Basal B cell receptor-directed phosphatidylinositol 3-kinase signaling turns off RAGs and promotes B cell-positive selection. J Immunol. 178:6332.

Lamoureux, J.L., Watson, L.C., Cherrier, M., Skog, P., Nemazee, D., Feeney, A.J. 2007.
Reduced receptor editing in lupus-prone MRL/lpr mice. J Exp Med. 204:2853.

Vela, J.L. and Nemazee, D. Role of RS/kappaDE in B cell receptor editing. 2007.
Adv Exp Med Biol. 596:169.

Wucherpfennig, K. W., Allen, P. M., Celada, F., Cohen, I. R., De Boer, R., Garcia, K. C., Goldstein, B., Greenspan, R., Hafler, D., Hodgkin, P., Huseby, E. S., Krakauer, D. C., Nemazee, D., Perelson, A. S., Pinilla, C., Strong, R. K., & Sercarz, E. E. 2007. Polyspecificity of T cell and B cell receptor recognition. Seminars in immunology, 19(4), 216–224.

Ait-Azzouzene, D., Gavin, A., Skog, P., Duong, B.,  and Nemazee, D. 2006. Effect of cell:cell competition and BAFF expression on peripheral B cell tolerance and B-1 cell survival in transgenic mice expressing a low level of Igkappa-reactive macroself antigen.  Eur. J. Immunol. 36:985-996.

Watson, L.C., Moffatt-Blue, C.S., McDonald, R.Z., Kompfner, E., Ait-Azzouzene, D., Nemazee, D, Theofilopoulos, A.N., Kono, D.H., and Feeney, A.J. 2006.  Paucity of V-D-D-J rearrangements and VH replacement events in lupus prone and nonautoimmune TdT-/- and TdT+/+ mice.   J. Immunol. 177:1120-1128.

Nemazee, D., Gavin, A., Hoebe, K., and Beutler, B. 2006.  Immunology: Toll-like receptors and antibody responses. Nature.  441:7091.

Gavin, A., Hoebe, K., Duong, B., Ota, T., Martin, C., Beutler, B., Nemazee, D. 2006. Adjuvant-enhanced antibody responses in the absence of toll-like receptor signaling. Science. 314-:1936-1938.

Ait-Azzouzene, D., Verkoczy, L., Duong, B., Skog, P., Gavin, A., and Nemazee, D. 2006. Split tolerance in peripheral B cell subsets in mice expressing a low level of Ig-reactive ligand.  J. Immunol.  176:939-948.

Nemazee, D. Receptor editing in lymphocyte development and central tolerance. 2006.
Nat Rev Immunol. 6:728.

Gavin, A., Duong, B., Skog, P., Aït-Azzouzene, D., Mårtensson, Greaves, D.R., Scott, M.  and Nemazee, D. 2005.  delta]BAFF, a splice isoform of BAFF, opposes full length BAFF activity in vivo in transgenic mouse models.  J. Immunol. 175:319-328.

Verkoczy, L.K., Martensson, A.S., Nemazee, D. 2004. The scope of receptor editing and its association with autoimmunity. Curr. Opin. Immunol. 16:808-814.

Ait-Azzouzene, D., Verkoczy, L., Peters, J., Gavin, A., Skog, P., Vela, J.L., and Nemazee, D.  2005. An immunoglobulin C-reactive single chain antibody fusion protein induces tolerance through receptor editing in a normal polyclonal immune system. J. Exp. Med. 201:817-828.

Verkoczy, L., Ait-Azzouzene, D., Skog, P., Martensson, A., Lang, J.,  Duong B., and Nemazee, D.  2005. A role for nuclear factor kappa B/rel transcription factors in the regulation of the recombinase activator genes.  Immunity 22:519-531.

Collins, C.E., Gavin, A.L., Migone, T.S., Hilbert, D.M., Nemazee, D., Stohl, W. 2005.  B lymphocyte stimulator (BLyS) isoforms in systemic lupus erythematosus: disease activity correlates better with blood leukocyte BLyS mRNA levels than with plasma BLyS protein levels.  Arthritis Res Ther. 8(1):R6 [Epub ahead of print] .

Peters, B., Sidney, J., Bourne, P., Bui, H.H., Buus, S., Doh, G., Fleri, W., Kronenberg, M., Kubo, R., Lund, O., Nemazee, D., Ponomarenko, J.V., Sathiamurthy, M., Schoenberger, S.P., Stewart, S., Surko, P., Way, S., Wilson, S., Sette, A. 2005. The design and implementation of the immune epitope database and analysis resource.
Immunogenetics. 57:326-336.

Silveira, P. A., Dombrowsky, J., Johnson, E., Chapman, H.D., Nemazee, D., and Serreze, D. V. 2004.  B-Cell Selection Defects Underlie the Development of Diabetogenic Antigen Presenting Cells in NOD Mice.  J. Immunol.  (in press).

Quong, M.W., Martensson, A., Langerak, A.W., Rivera, R.R., Nemazee, D. and Murre, C. 2004.  Receptor Editing and Marginal Zone B Cell Development are Regulated by the Helix-Loop-Helix Protein, E2A. J.Exp.Med. 199:1101-1112.

Ait-Azzouzene, D., Skog, P., Retter, M., Kouskoff, V., Hertz, M., Lang, J., Kench, J., Chumley, M., Melamed, D., Sudaria, J., Gavin, A., Martensson, A., Verkoczy, L., Duong, B., Vela, J, Nemazee, D. 2004.  Tolerance-induced receptor selection: scope, sensitivity, locus specificity, and relationship to lymphocyte-positive selection. Immunol. Rev. 197:219-230.

Peters, B., Sidney, J., Bourne, P., Bui, H.H., Buus, S., Doh, G., Fleri, W., Kronenberg, M., Kubo, R., Lund, O., Nemazee, D., Ponomarenko, J.V., Sathiamurthy, M., Schoenberger, S., Stewart, S., Surko, P., Way, S., Wilson, S., Sette, A.  2005. The immune epitope database and analysis resource: from vision to blueprint.  PLoS Biol. 3:379-381.

Gavin, A., Verkoczy, L., Aït-Azzouzene, D., Mårtensson, A., Skog, P., Vela, J.,  Duong, B. and Nemazee, D. 2004. Peripheral B Lymphocyte Tolerance. Keio J. Med., 53:151-158.

Nemazee, D., Hogquist, K.A. 2003. Antigen receptor selection by editing or downregulation of V(D)J recombination. Curr. Opin. Immunol.  15:182-189.

Gavin, A.L., Ait-Azzouzene, D., Ware, C.F., and Nemazee, D. 2003. delta BAFF, an alternate splice isoform that regulates receptor binding and biopresentation of the B cell survival cytokine, BAFF.  J.Biol.Chem. 278:38220-38228.

Pape, K.A., Kouskoff, V., Nemazee, D., Tang, H.L., Cyster, J.G., Tze, L.E., Hippen, K.L., Behrens, T.W., Jenkins, M.K. 2003. Visualization of the genesis and fate of isotype-switched B cells during a primary immune response.  J. Exp. Med.197:1677-1687.

Nemazee, D., Gavin, A. 2003. Do B cells take advantage of “missing self” recognition?  Curr. Dir. Autoimmun. 6:245-264.

Nemazee, D., Mårtensson, A., Verkoczy L. 2002. Haplotype exclusion and receptor editing: irreconcilable differences? Semin.Immunol. 14:191-198.

Casellas R, Shih TA, Kleinewietfeld M, Rakonjac J, Nemazee D, Rajewsky K, Nussenzweig MC. 2001. Contribution of receptor editing to the antibody repertoire.  Science.  291:1541-1544.

Kouskoff V, Nemazee D. 2001.  Role of receptor editing and revision in shaping the B and T lymphocyte repertoire.  Life Sci. 69:1105-1113.

Lang, J. and  Nemazee, D.  2000. B cell clonal elimination induced by membrane-bound self-antigen may require repeated antigen encounter or cell competition. Eur. J. Immunol 2000 30:689-696.

Nemazee, D.  2000.  Receptor editing in B cells.  Adv. Immunol. 74, 89-126.

Nemazee, D.  2000.  Receptor selection in B and T lymphocytes.  Annu. Rev. Immunol., 18, 19-51.

Chumley, M.J., Dal Porto, J. M., Kawaguchi, S., Cambier, J.C., Nemazee, D., and Hardy, R.R. 2000.  A V_H11V9 BCR drives generation of CD5+ B cells both in vivo and in vitro.  J. Immunol., 164:4586-4593.

Kouskoff, V., Lacaud, G., Retter, M., and Nemazee, D.  2000. B cell receptor expression level determines the fate of developing B lymphocytes: Receptor editing versus selection. Proc. Natl. Acad. Sci. USA, 97: 7435-7439.

Kouskoff, V., Lacaud, G., Nemazee, D. 2000. T-cell independent rescue of B lymphocytes from peripheral immune tolerance.  Science 287: 2501-2503.

Buhl AM, Nemazee D, Cambier JC, Rickert R, Hertz M. 2000. B-cell antigen receptor competence regulates B-lymphocyte selection and survival.Immunol Rev. 176:141-153.

Melamed, D., Miri, E., Leider, N., Nemazee, D. 2000. Unexpected autoantibody production in membrane Ig-mu-deficient/lpr mice.  J Immunol. 165: 4353-4358.

Nemazee, D., Weigert, M. 2000. Revising B cell receptors. J. Exp. Med. 191: 1813-1817.

Kench, J.A., Russell, D.M., Fadok, V.A., Worthen, G.S., Jones-Carson, J., Henson, J.E., Henson, P.M., and Nemazee, D. 1999. Aberrant Wound Healing and TGF- Production in the Autoimmune-Prone MRL/+ Mouse.  Clin. Immunol., 92, 300-310.

Retter, M.W. and Nemazee, D. 1999.   Receptor editing:  genetic reprogramming of autoreactive lymphocytes.  Cell Biochem. Biophys.,   Cell Biochem Biophys. 31:81-88.

Melamed D, Nemazee D. 1999. Immunoglobulin transgenes in B lymphocyte development, tolerance, and autoimmunity. Curr. Dir. Autoimmun. 1:1-30.

Benschop, R.J., Melamed, D., Nemazee, D., and Cambier, J.C.  1999. Distinct signal thresholds for antigen receptor-linked gene expression programs in mature and immature B cells: a potential basis for differential tolerance susceptibility.  J. Exp. Med., 190, 749-756.

Nemazee, D. 1998. Theoretical limits to massive receptor editing in immature B-cells.  Curr. Top. Immunol. Microbiol.  229, 163-171.

Hertz, M. and Nemazee, D.  1998.  Receptor editing and selection in B lymphocytes.  Curr. Opin. Immunol., 10, 208-213.

Melamed, D., Benschop, R. J.,  Cambier, J. C., and Nemazee, D. 1998.  Developmental regulation of B lymphocyte immune tolerance compartmentalizes clonal selection from receptor selection.  Cell  92, 173-182.

Hertz, M., Kouskoff, V., Nakamura, T., and Nemazee, D. 1998.  V(D)J recombinase induction in splenic B cells is inhibited by antigen receptor ligation. Nature 394, 292-295.

Aït-azzouzene, D., Gendron, M.-C., Houdayer, M., Langkopf, A., Bürki, K., Nemazee, D. and Kanellopoulos-Langevin, C.  1998.  Fetal alloantigens cause a partial deletion of specific maternal B lymphocytes in anti-H2-Kk Ig-transgenic mice.  J. Immunol. 161, 2677-2683.

Kench, J.A., Russell, D. M.  and Nemazee, D.  1998.  Efficient peripheral clonal elimination of B lymphocytes in MRL/lpr mice bearing autoantibody transgenes. J. Exp. Med., 188, 909-917.

Retter, M.W. and Nemazee, D. 1998.  Receptor editing occurs frequently during normal B cell development. J. Exp. Med., 188, 1231-1238.

Kouskoff, V., Kaye, B, Lang, P., Cambier, J., and Nemazee, D.  1998.  Partial agonist ligands of the B cell receptor induce differential lymphokine production and partial tyrosine phosphorylation. J. Exp. Med., 188, 1453-1464.

Hertz, M.  and Nemazee, D. 1997.  BCR ligation induces receptor editing in IgM+D- bone marrow B-cells in vitro.  Immunity 6, 429-436.

Melamed, D., Kench, J.A., Rolink, A., and Nemazee, D. 1997.  Functional B cell receptor transgene allows IL-7 independent maturation of B cell precursors.  J. Immunol.  159, 1233-1239.

Melamed, D. and Nemazee, D. 1997.  Self-antigen does not accelerate immature B cell apoptosis, but stimulates receptor editing as a consequence of developemental arrest.   Proc. Natl. Acad. Sci. USA 94, 9267-9272.

Papavasiliou, F., Casellas, R., Suh, H., Qin, X., Besmer, R., Pelanda, R., Nemazee, D., Rajewsky, K., and Nussenzweig, M.C.  1997.  V(D)J recombination in mature B cells:  a new mechanism for altering antibody responses.  Science  278, 298-301.

Lang, J.L., Strasser, A., Korsmeyer, S., Harris, A., and Nemazee, D. 1997.  Enforced Bcl-2 expression inhibits antigen-mediated clonal elimination of peripheral B-cells in an antigen dose-dependent manner, and promotes receptor editing in immature B-cells.  J. Exp. Med., 186, 1513-1522.

Pelanda, R., Schwers, S., Sonoda, S., Torres, R., Nemazee, D. and Rajewsky, K. 1997.  Site, efficiency, and consequence of receptor editing in anti-MHC I Ig-targeted mice.  Immunity, 7, 765-775.

Foster, M.H., Liu, Q., Chen, H., Nemazee, D., Cooperstone, B.G. 1997. Anti-laminin reactivity and glomerular immune deposition by in vitro recombinant antibodies. Autoimmunity  26:231-43.

Nemazee, D. 1996.  Can receptor editing play an important role in normal B-cell development?  J. Autoimmun. 9, 259-261.

Nemazee, D. 1996. Self antigen-mediated selection in mouse B-cell development.  In: Handbook of Experimental Immunology, 5th ed. Weir et al. eds.  Volume III: 83.1-82.8.

Rubio, C.F., Kench, J., Russell, D.M., Yawger, R., and Nemazee, D. 1996. Analysis of central B-cell tolerance in autoimmune-prone MRL/lpr mice bearing autoantibody transgenes. J. Immunol. 157, 65-71.

Lang, J.L., Brunmark, A., Jackson, M., Russell, D.M., Yawger, R., and Nemazee, D. 1996.  Efficient deletion of immature, but not mature, autoreactive B-cells by ultra-low affinity, membrane-bound self antigens. J. Exp. Med. 184, 1685-1697.

Nemazee, D. 1996. On the limits of receptor editing.  Proceedings of the symposium on Immune Tolerance, Fondation Mérieux.  Eds. Banchereau, J., Dodet, B., Schwartz, R. and Trannoy, E.   Elsevier, Paris.  pp. 85-92.

Nemazee, D. 1995.  Does immunological tolerance explain the waste in the B-lymphocyte immune system?  Experiment and theory.  Ann. N.Y.Acad.Sci. 764, 397–401.

Nemazee, D. 1995.  B lymphocyte tolerance in the mouse.  In  Immunoglobulin Genes, 2nd edition. F.W. Alt, ed. Academic Press, pp.365-378.

Nemazee, D. 1995.  Antigen receptor "capacity" and the sensitivity of self tolerance.  Immunol. Today 17, 25-29.

Spanopoulou, E., Roman, C.A.J., Corcoran, L., Schissel, M., Silver, D.P., Storb, U., Nemazee, D. , Nussenzweig, M., Shinton, S.A., Hardy, R.R. and Baltimore, D. 1994.  Expression of functional immunoglobulin transgenes allows ordered B-cell differentiation to progress in Rag-1 deficient mice.  Genes & Devel.  8, 1030-1042.

Nemazee, D. 1993.  Mechanisms and meaning of B-lymphocte tolerance. In Molecular Mechanisms of Immunological Self-Recognition.  F.W. Alt and H. J. Vogel, eds. Academic Press, San Diego, pp 19-23.

Tiegs, S.L., Russell, D.M. and Nemazee, D. 1993. Receptor editing in self-reactive bone marrow B-cells.  J.Exp.Med.  177, 1009-1020.

Nemazee, D. 1993.  Promotion and prevention of autoimmunity by B lymphocytes.  Curr.Opin. Immunol. 4, 866-872.

Cuende, E., Kroemer, G., Alonso, J.M., Nemazee, D., Martinez-A, C. and Ales-Martinez, J.E.  1992.  Inability of IL-2 and IL-10 to counteract B cell clonal deletion.  Cell. Immunol. 142,94-102.

Nemazee, D. 1992. Mechanisms and meaning of B-lymphocte tolerance.  Res. Immunol. 143, 272-275.

Nemazee, D. 1992.  Receptor editing in immature self-reactive B-cells.  In "Progress in Immunology", Vol. 8 (Springer Verlag, Berlin) pp 35-42.

Carbone, A., Harbeck, R., Dallas, A., Nemazee, D., Finkel, T., O'Brien, R., Kubo, R. and Born, W. 1991.  Alpha beta T lymphocyte depleted mice, a model for gamma/deltaT lymphocyte functional studies.  Immunol. Rev. 120, 35-50.

Nemazee, D., Russell, D., Arnold, B., Haemmerling, G., Allison, J., Miller, J.F.A.P., Morahan, G. and Buerki, K. 1991.  Clonal Deletion of Autospecific B Lymphocytes.  Immunol. Rev.122, 117-132.

Nemazee, D., Guiet, C., Buerki, K., and Marshak-Rothstein, A. 1991.  B Lymphocytes from the autoimmune-prone mouse strain MRL/lpr manifest an intrinsic defect in tetraparental MRL/lpr ↔DBA/2 chimeras.  J. Immunol. 147, 2536-2539.

Russell, D.M., Dembic, Z., Morahan, G., Miller, JFAP, Bürki, K. and Nemazee, D.  1991.  Peripheral deletion of self-reactive B-cells.  Nature 354, 308-311.

Nemazee, D.A., and K. Bürki. 1989.  Clonal deletion of B lymphocytes in a transgenic mouse bearing anti-MHC class I antibody genes.  Nature. 337:562-566.

Nemazee, D.A. and K. Bürki. 1989. Clonal deletion of autoreactive B lymphocytes in bone marrow chimeras. Proc. Natl. Acad. Sci. USA 86, 8039-8043.

Nemazee, D.A. and K. Bürki. 1989. Are autoreactive B cells deleted?   in "Progress in Immunology", Vol. 7 (Springer Verlag, Berlin) pp 369-376.

Schlomchik, M., Nemazee, D.A., Van Snick, J. and Weigert, M. 1987.  Variable region sequences of murine IgM anti-IgG monoclonal autoantibodies (rheumatoid factors).  II.  Comparison of hybridomas derived by polysaccharide stimulation and secondary protein immunization.  J. Exp. Med. 165:970-987.

Rammensee, H.-G., Julius, M.H., Nemazee, D.A., Langhorne, J., Lamers, R. and Kohler, G. 1987.  Targeting cytotoxic T cells to antigen-specific B lymphocytes.  Eur. J. Immunol. 17:433-436.

Nemazee, D.A. 1987.  In Proceedings of the EMBO Workshop on Tolerance (eds. Matzinger, P., Flajlnik, M., Nemazee, D.A., Rammensee, H.-G., Stockinger, G., Rolink, T., and Nicklin, L.)  Vol 2.52-54.

Schlomchik, M., Nemazee, D.A., Sato, V., Van Snick, J., Carson, D. and Weigert, M. 1986.  Variable region sequences of murine IgM anti-IgG1 monoclonal autoantibodies (rheumatoid factors):  a structural explanation for the high frequency of IgM anti-IgG1 B cells.  J. Exp. Med. 164:407-427.

Wysocki, L.J., Margolies, M.N., Huang, B., Nemazee, D.A., Wechsler, D.S., Sato, V.L., Smith, J.A. and Gefter, M.D. 1985.  Combinatorial diversity within variable regions bearing the predominant anti-p-azophenylarsonate idiotype of strain A mice.  J. Immunol 134:2740-2747.

Nemazee, D.A. 1985.  Assays for the detection or rheumatoid factor producing cells.  Immunological Meth. III:279-288.

Nemazee, D.A. 1985.  Immune complexes can trigger specific T cell dependent, autoanti-IgG antibody production in mice.  J. Exp. Med. 161:242-256.

Nemazee, D.A., Studer, S., Steinmetz, M., Dembic, and Kiefer, M. 1985.  The lymphoproliferating cells of MRL lpr/lpr mice are a polyclonal population that bear the T lymphocyte receptor for antigen.  Eur. J. Immunol. 15:760-764.

Nemazee, D.A. and V.L. Sato. 1983.  Induction of rheumatoid antibodies in the mouse.  Regulated autoantibody in the secondary humoral response.  J. Exp. Med. 158:529-545.

Nemazee, D.A. and V.L. Sato. 1982.  "Enhancing" antibody:  a novel component of the immune response.  Proc. Natl. Acad. Sci. USA 79:3828-38.

 

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