The Mayford Laboratory

Mark R. Mayford, Ph.D. Curriculum Vitae

Mark R. Mayford, Ph.D. 
The Scripps Research Institute
Institute for Childhood and Neglected Diseases
Department of Cell Biology
10550 North Torrey Pines Road, Mail Drop ICND-202
La Jolla, CA 92037
Tel:  858.784.9863
Fax: 858.784.9860
Email: mmayford@scripps.edu

Education

1989  Ph.D.,  Molecular Biology, University of Wisconsin, Madison, WI
1983  B.S., Biochemistry, University of Wisconsin, Madison, WI

Professional Experience

2000-present   Adjunct Assistant Professor, Department of Neurosciences, University of California, San Diego, La Jolla, CA

2000-present   Associate Professor, Department of Cell Biology, The Scripps Research Institute, La Jolla, CA

1997-2000   Assistant Professor, Department of Neurosciences, University of California, San Diego, La Jolla, CA

1994-1996   Associate Research Scientist, Howard Hughes Medical Institute, Columbia University, College of Physicians and Surgeons, New York, NY

1989-1994   Research Associate, Howard Hughes Medical Institute, Columbia University, College of Physicians and Surgeons, New York, NY

1986   Teaching Assistant, University of Wisconsin, Madison, Department of Genetics, Madison, WI

Awards

1997-2000   McKnight Scholar Award
1997-2000   Klingenstein Fellowship in the Neurosciences
1984-1987   NIH Predoctoral Fellowship

Memberships

Society for Neuroscience (1994-present)

University/Public Service

Reviewing Editor Hippocampus (2002-present)

NIH-ENU Center Steering Committee (2002-2006)

NIH-NIDA-B Study Section (Ad-hoc) (1997-1998)

Lecturer, Molecular and Cellular Neurobiology-Neurosciences 268 (1998-present)

Member, Neurosciences Faculty Search Committee (1998)

Member, Neuroscience Graduate Admissions Committee (1998)

Doctoral Student Thesis Advisor (1997-present)

Organizer, Neurosciences Graduate Program Seminar Series (1997-2000)

Member, Neurosciences Chair Evaluation Committee (1997)

Member, Center for the Neurobiology of Learning and Memory (1997-present)

Bibliography

Original Articles

Colvis CM, Pollock JD, Goodman RH, Impey S, Dunn J, Mandel G, Champagne FA, Mayford M, Korzus E, Kumar A, Renthal W, Theobald DEH and Nestler E. (2005) Epigenetic Mechanisms and Gene Networks in the Nervous System. J. Neurosci., 25(45):10379-10389.

Limbäck-Stokin K, Korzus E, Nagaoka-Yasuda R and Mayford M.  (2004) Nuclear Calcium/Calmodulin Regulates Memory Consolidation.  J. Neurosci., 24(48): 10858-10867.

Korzus E, Rosenfeld M and Mayford M.  (2004) CBP Histone Acetyltransferase Activity is Critical Component of Memory Consolidation.  Neuron, 42, 961-972.

Miller S, Yasuda M, Coats JK, Jones Y, Martone ME and Mayford M.  (2002) Disruption of Dendritic Translation of CaMKII Impairs Stabilization of Synaptic Plasticity and Memory Consolidation.  Neuron, 36, 507-519.

Bejar R, Yasuda R, Krugers H, Hood K and Mayford M. (2002) Transgenic CAMKII Activation:  Dose Dependent Effects on Synaptic Plasticity, Learning, and Memory in Mice. J Neurosci., 22, 5719-5726.

Glazewski S, Bejar R, Mayford M and Fox K.  (2001) The effect of autonomous alpha-CamKII expression on sensory responses and experience-dependent plasticity in mouse barrel cortex.  Neuropharmacology, 41, 771-8.

Krestel HE, Mayford M, Seeburg PH and Sprengel R. (2001)  A GFP-equipped bidirectional expression module well suited for monitoring tetracycline-regulated gene expression in mouse.  Nucleic Acids Res., 29:E39.

Sandberg R, Yasuda R, Pankratz DG, Carter TA, Del Rio JA, Wodicka L, Mayford M, Lockhart DJ and Barlow C.  (2000) Regional and strain-specific gene expression mapping in the adult mouse brain.  Proc Natl Acad Sci U S A, 97:11038-43.

Wiedenmayer C, Myers M, Mayford M and Barr G. (2000)  Olfactory based spatial learning in neonatal mice and its dependence on CaMKII. Neuro., 5, 1051-1055.

Mayford M and Kandel ER. (1999) Genetic approaches to memory storage.  Trends Genet., 15, 11, 463-470.

Mansuy IM, Winder DG, Moallem TM, Osman M, Mayford M, Hawkins RD and Kandel ER. (1998) Inducible and reversible gene expression with the rtTA system for the study of memory. Neuron, 21, 257-265.

Mansuy IM, Mayford M, Jacob B, Kandel ER and Bach ME. (1998) Restricted and regulated overexpression reveals calcineurin as a key component in the transition from short-term to long-term memory.  Cell, 92, 39-50.

Mayford M, Mansuy IM, Muller RU and Kandel ER. (1997)  Memory and behavior: A second generation of genetically modified mice. Curr. Biol., 7, 580-589.

Kojima N, Wang J, Mansuy IM, Grant SGN, Mayford M and Kandel ER. (1997)  Rescuing impairment of long-term potentiation in fyn-deficient mice by introducing a Fyn transgene Proc. Natl. Acad. Sci. USA, 94, 4761-4765.

Mayford M, Bach ME and Kandel ER. (1996) CaMKII function in the nervous system explored from a genetic perspective. Cold Spring Harbor Symp., 59,  219-223.
 

Tsien JZ, Chen DF, Gerber D, Tom C, Mercer E, Anderson DJ, Mayford M, Kandel ER and Tonegawa S. (1996) Subregion- and cell type-restricted gene knockout in mouse brain.  Cell, 87, 1317-1326.

Rotenberg A, Mayford M, Hawkins RD, Kandel ER and Muller R. (1996) Mice expressing activated CaMKII lack frequency LTP and do not form stable place cells in the CA1 region of the hippocampus.  Cell, 87, 1351-1361.

Mayford M, Bach ME, Huang Y-Y, Wang L, Hawkins RD and Kandel ER. (1996)  Control of memory formation through regulated expression of a CaMKII transgene. Science, 274, 1678-1683.

Mayford M, Baranes D, Podsypanina K and Kandel ER. (1996)  The 3' untranslated region of CaMKIIa is a cis-acting signal for the localization and translation of mRNA in dendrites. Proc. Natl. Acad. Sci. USA, 93, 13250-13255.

Bach M-E, Hawkins RD, Osman M, Kandel ER and Mayford M. (1995)  Impairment of spatial but not contextual memory in CaMKII mutant mice with a selective loss of hippocampal LTP in the range of the theta frequency. Cell, 81, 905-915.

Mayford M, Wang J, Kandel ER and O'Dell T. (1995)  CaMKII Regulates the frequency-response function of hippocampal synapses for the production of both long-term depression and long-term potentiation. Cell, 81, 891-904.

Mayford M, Barzilai A, Keller F, Schacher S and Kandel ER. (1992)  Modulation of an NCAM-related cell adhesion molecule with long-term synaptic plasticity in Aplysia.  Science, 256, 638-644.

Invited Articles

Miller S and Mayford M. (1999) Cellular and molecular mechanisms of memory: The LTP connection. Curr. Opin. Genet. Dev., 9, 333-337.

Mansuy I, Mayford M and Kandel ER. (1999)  Regulated temporal and spatial expression of mutants of CaMKII and calcineurin with the tetracycline-controlled transactivator (tTA) and reverse tTA (rtTA) systems.  Handbook of Molecular-Genetic Techniques for Brain and Behavior Research (Techniques in the Behavioral and Neural Sciences, 13, chapter 3.1.4.

Mayford M. (1996) Genetic studies of CaMKII function in the nervous system.  In Gene targeting and new developments in neurobiology, eds. S. Nakanishi, A. J. Silva, S. Aizawa and M. Katsuki, pp. 239-250.  Tokyo: Karger.

Mayford M. (1996) Ca2+/Calmodulin dependent protein kinase and neuronal function.  In Protein phosphorylation, ed. F. Marks, pp. 149-178.  Weinheim: Verlag Chemie.

Mayford M, Able T and Kandel ER. (1995) Transgenic approaches to cognition. Curr. Opin. in Neuro., 5, 141-148.

Mayford M and Kandel ER. (1994) Molecular mechanisms of synaptic plasticity. Biomed Res., 15 Suppl. 1, 57-60.