The Kralli Laboratory

Publications

Cho Y., Hazen B.C., Gandra P.G., Ward S.R., Schenk S., Russell A.P. and A. Kralli (2016). Perm1 enhances mitochondrial biogenesis, oxidative capacity and fatigue resistance in adult skeletal muscle. FASEB J. 2015 Oct 19. pii: fj.15-276360. PubMed 

Gantner M.L., Hazen B.C., Conkright J. and A. Kralli (2014). GADD45γ regulates the thermogenic capacity of brown adipose tissue. Proc. Natl. Acad. Sci. U S A. 111, 11870-11875. (Epub 2014 Jul 28). PMCID:PMC4136592. PubMed  

Brown E.L., Snow R.J., Wright C.R., Cho Y., Wallace M.A., Kralli A. and A.P. Russell (2014). PGC-1α and PGC-1β increase CrT expression and creatine uptake in myotubes via ERRα. Biochim. Biophys. Acta 1843, 2937-2943. PMID: 25173818. PubMed    

Gan Z., Rumsey J., Hazen B.C., Lai L., Leone T.C., Vega R.B., Xie H., Conley K.E., Auwerx J., Smith S.R., Olson E.N., Kralli A. and D.P. Kelly. (2013). Nuclear Receptor-microRNA Circuitry Links Muscle Fiber Type to Energy Metabolism. J. Clin. Invest. 123, 2564-2575. PMCID: PMC3668841. PubMed

Foletta V.C., Brown E..L, Cho Y., Snow R.J., Kralli A. and A.P. Russell. (2013). Ndrg2 is a PGC-1α/ERRα target gene that controls protein synthesis and expression of contractile-type genes in C2C12 myotubes. Biochim Biophys Acta. 1833:3112-23. DOI: 10.1016/j.bbamcr.2013.08.011. PMID: 24008097. PubMed

Cho Y., Hazen B.C., Russell A.P. and A. Kralli. (2013). Peroxisome proliferator-activated receptor γ coactivator 1 (PGC-1)- and estrogen-related receptor (ERR)-induced regulator in muscle 1 (Perm1) is a tissue-specific regulator of oxidative capacity in skeletal muscle cells. J Biol Chem. 288:25207-18. DOI: 10.1074/jbc.M113.489674. PMCID: PMC3757184. PubMed

Enguix N., Pardo R., González A., Simó R., Kralli A. and J. A. Villena. (2013). Mice lacking PGC-1β in adipose tissue reveal a dissociation between mitochondrial dysfunction and insulin resistance. Mol Metab. 2013 2:215-26. DOI: 10.1016/j.molmet.2013.05.004. PMCID: PMC3773830. PubMed

Chambers K.T., Chen Z., Lai L., Leone T.C., Towle H.C., Kralli A., Crawford P.A. and B. N. Finck. (2013). PGC-1β and ChREBP partner to cooperatively regulate hepatic lipogenesis in a glucose concentration-dependent manner. Mol Metab. 2:194-204. DOI: 10.1016/j.molmet.2013.05.001. PMCID: PMC3773825. PubMed

Russell A.P., Wada S., Vergani L., Hock M.B., Lamon S., Léger B., Ushida T., Cartoni R., Wadley G.D., Hespel P., Kralli A., Soraru G., Angelini C. and T. Akimoto. (2013). Disruption of skeletal muscle mitochondrial network genes and miRNAs in amyotrophic lateral sclerosis. . Neurobiol Dis. 49, 107-117. PMID: 22975021 PubMed

Pardo R., Enguix N., Lasheras J., Feliu J.E., Kralli A. and J.A. Villena. (2011). Rosiglitazone-Induced Mitochondrial Biogenesis in White Adipose Tissue Is Independent of Peroxisome Proliferator-Activated Receptor γ Coactivator-1a. PLoS One 6, e26989. PMCID: PMC3210129 PubMed

Wallace M.A., Hock M.B., Hazen B.C., Kralli A., Snow R.J. and A.P. Russell. (2011). Striated muscle activator of Rho signalling (STARS) is a PGC-1α/oestrogen-related receptor-α target gene and is upregulated in human skeletal muscle after endurance exercise. J. Physiol. 589, 2027-2039. PMCID: PMC3090601 PubMed

Tiraby C., Hazen B.C., Gantner M.L. and A. Kralli. (2011). Estrogen-Related Receptor gamma promotes mesenchymal-to-epithelial transition and suppresses breast tumor growth. Cancer Res. 71, 2518-2528. PubMed

Chang J.S., Huypens P., Zhang Y., Black C., Kralli A., Gettys TW. (2010). Regulation of NT-PGC-1alpha subcellular localization and function by protein kinase A-dependent modulation of nuclear export by CRM1. J Biol Chem. 285(23):18039-50. Epub 2010 Mar 29. PMID:20351112 [PubMed - in process] Related citations. PubMed

Zhang Y., Huypens P., Adamson A.W., Chang J.S., Henagan T.M., Boudreau A., Lenard N.R., Burk D., Kleine J., Perwitz N., Shin J., Fasshauer M., Kralli A., Gettys T.W. (2009). Alternative mRNA splicing produces a novel biologically active short isoform of PGC-1alpha. J Biol Chem. 284(47):32813-26. Epub 2009 Sep 22. PMID:19773550 [PubMed - indexed for MEDLINE] Related citations. PubMed

Hock M.B. and A. Kralli (2009). Transcriptional Control of Mitochondrial Biogenesis and Function. Annu. Rev. Physiol. 71, 177-203. PubMed

Hallberg M., Morganstein D.L., Kiskinis E., Shah K., Kralli A., Dilworth S.M., White R., Parker M.G. and M. Christian (2008). A functional interaction between RIP140 and PGC-1α regulates the expression of the lipid droplet protein CIDEA. Mol. Cell. Biol. 28, 6785-95. PubMed

Villena J.A. and A. Kralli (2008). ERRα: a metabolic function for the oldest orphan. Trends Endocrinol. Metab. 19, 269-76. PubMed

Olson B.L., Hock M.B., Ekholm-Reed S., Wohlschlegel J.A., Dev K.K., Kralli A1., and S.I. Reed1 (2008). SCFCdc4 Acts Antagonistically to the PGC-1α Transcriptional Coactivator by Targeting It for Ubiquitin-Mediated Proteolysis. Genes Dev. 22, 252-64. 1co-correspoding authors PubMed

Kressler D., Hock M.B., and A. Kralli (2007). Coactivators PGC-1β and SRC-1 Interact Functionally to Promote the Agonist Activity of the Selective Estrogen Receptor Modulator Tamoxifen. J. Biol. Chem. 281, 99-106. PubMed

Chen E.I., Hewel J., Krueger J.S., Tiraby C., Weber M.R., Kralli A., Becker K., Yates J.R. 3rd, and B. Felding-Habermann (2007). Adaptation of Energy Metabolism in Breast Cancer Brain Metastases. Cancer Res. 67, 1472-1486. PubMed

Sano, M., Izumi Y., Helenius K., Asakura M., Rossi D. J., Xie M., Taffet G., Hu L., Pautler R. G., Wilson C. R., Boudina S., Abel E. D., Taegtmeyer H., Scaglia F., Graham B. H., Kralli A., Shimizu N., Tanaka H., Makela T. P., and M.D. Schneider (2007). Menage-a-Trois 1 Is Critical for the Transcriptional Function of PPARgamma Coactivator 1. Cell Metab. 5, 129-142. PubMed

Villena J.A., Hock M.B., Chang W.Y., Barcas J.E., Giguère V., and A. Kralli (2007). Orphan nuclear receptor ERRα is essential for adaptive thermogenesis. Proc. Natl. Acad. Sci. USA 104, 1418-1423. PubMed

Thijssen-Timmer D.C., Platvoet-Ter Schiphorst M., Kwakkel J., Emter R., Kralli A., Wiersinga W.M., and O. Bakker (2006). PGC-1α regulates the isoform mRNA ratio of the alternatively spliced thyroid hormone receptor alpha transcript. J. Mol. Endocr. 37, 251-257. PubMed

Herzog B., Cardenas J., Hall R.K., Villena J.A., Budge P.J., Giguere V., Granner D.K., and A. Kralli (2006). Estrogen-related receptor α is a repressor of Phosphoenolpyruvate Carboxykinase gene transcription. J. Biol. Chem. 281, 99-106. PubMed

Teyssier C., Ma H., Emter R., Kralli A.¹, and M.R. Stallcup¹ (2005). Activation of Nuclear Receptor Coactivator PGC-1α by Arginine Methylation. Genes Dev. 19, 1466-73. ¹co-correspoding authors PubMed

Cartoni R., Léger B., Hock M.B., Praz M., Crettenand A., Pich S., Ziltener J., Dériaz O., Zorzano A., Gobelet C., Kralli A., and A. P. Russell (2005). Mitofusins 1/2 and ERRα expression are increased in human skeletal muscle after physical exercise. Journal of Physiology 567, 349-58. PubMed

Schreiber S.N., Emter R., Hock M.B., Knutti D., Cardenas J., Podvinec M., Oakeley E.J. and A. Kralli (2004). The estrogen-related receptorα (ERRα) functions in PPARγ coactivator 1α (PGC-1α)-induced mitochondrial biogenesis. Proc. Natl. Acad. Sci. USA 101, 6472-6477. PubMed

Russell A.P., Feilchenfeldt J., Schreiber S., Praz M., Crettenand A., Gobelet C., Meier C.A., Bell D.R., Kralli A., Giacobino J.P., and O. Deriaz (2003). Endurance training in humans leads to fiber type-specific increases in levels of peroxisome proliferator-activated receptor-gamma coactivator-1 and peroxisome proliferator-activated receptor-alpha in skeletal muscle. Diabetes. 52, 2874-2881. PubMed

Schreiber S.N., Knutti D., Brogli K., Uhlmann T. and A. Kralli (2003). The transcriptional coactivator PGC-1 regulates the expression and activity of the orphan nuclear receptor estrogen-related receptor alpha (ERRalpha). J. Biol. Chem. 278, 9013-9018. PubMed

Emter R., Heese-Peck A. and A. Kralli (2002). ERG6 and PDR5 regulate small lipophilic drug accumulation in yeast cells via distinct mechanisms. FEBS Letters 521, 57-61. PubMed

Kressler, D., Schreiber, S., Knutti, D. and A. Kralli (2002). The PGC-1- related protein PERC is a selective coactivator of estrogen receptor alpha. J. Biol. Chem. 277, 13918-25. PubMed

Knutti D. and A. Kralli (2001). PGC-1, a versatile coactivator. Trends in Endocrinology & Metabolism 12, 360-365. PubMed

Knutti D., Kressler D. and A. Kralli (2001). Regulation of the transcriptional coactivator PGC-1 via MAPK-sensitive interaction with a repressor. Proc. Natl. Acad. Sci. USA 98, 9713-9718. PubMed

Sitcheran R., Emter R., Kralli A. and K.R. Yamamoto (2000). A genetic analysis of glucocorticoid receptor signaling: identification and characterization of Ligand-Effect Modulators in S. cerevisiae. Genetics 156, 963-972. PubMed

Knutti D., Kaul A. and A. Kralli (2000). A tissue-specific coactivator of steroid receptors, identified in a functional genetic screen. Mol. Cell. Biol. 20, 2411-2422. PubMed

Mäser P., Sütterlin C., Kralli A. and R. Kaminsky (1999). A nucleoside transporter from Trypanosoma brucei involved in drug resistance.Science 285, 242-244. PubMed

Garabedian M.J., Iniguez-Lluhi J.A. and A. Kralli (1999). Yeast as a system for the study of nuclear receptor function. In "Steroid/Nuclear Receptor Superfamily: Practical Approach" edit. D. Picard, Oxford University Press, 233-259.

Egner R., Rosenthal F.E., Kralli A., Sanglard D. and K. Kuchler (1998). Genetic separation of FK506 susceptibility and drug transport in the yeast Pdr5 ATP binding cassette multidrug resistance transporter. Mol. Biol. Cell 9, 523-543. PubMed

Kralli A. and K.R. Yamamoto (1996). An FK506-sensitive transporter selectively decreases intracellular levels and potency of steroid hormones. J. Biol. Chem. 271, 17152-17156. PubMed

Bohen S.P., Kralli A. and K.R. Yamamoto (1995). Hold 'em and Fold 'em: Chaperones and Signal Transduction. Science 268, 1303-1304. PubMed

Kralli A., Bohen S.P. and K.R. Yamamoto (1995). LEM1, an ATP-Binding Cassette transporter, selectively modulates the biological potency of steroid hormones. Proc. Natl. Acad. Sci. USA 92, 4701-4705. PubMed

Ye X., Kralli A., Ge R., Ricciardi R.P. and B.B. Knowles (1994). Down-regulation of MHC class I antigen in insulinoma cells controlled by the R1 element of the H-2 enhancer. Oncogene 9, 1195-204. PubMed

Kralli A., Ge R., Graeven U., Ricciardi R.P. and R. Weinmann (1992). Negative regulation of the major histocompatibility complex class I enhancer in adenovirus type 12-transformed cells via a retinoic acid response element. Journal of Virology 66, 6979-88. PubMed

Ge R., Kralli A., Weinmann R. and R.P. Ricciardi (1992). Down-regulation of the major histocompatibility complex class I enhancer in adenovirus type 12-transformed cells is accompanied by an increase in factor binding. Journal of Virology 66, 6969-78. PubMed

Horikoshi N., Maguire K., Kralli A., Maldonado E., Reinberg D. and R. Weinmann (1991). Direct interaction between adenovirus E1A protein and the TATA box binding transcription factor IID. Proc. Natl. Acad. Sci. USA 88, 5124-5128. PubMed