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The Feeney Lab

Selected Publications

Barajas-Mora, E.M., Kleiman, E., Xu, J., Carrico, N.C., Oltz, E.M., Murre, C. and Feeney, A.J. A novel enhancer orchestrates nuclear architecture to generate a diverse antigen receptor repertoire. Molecular Cell 73:48-60 (2019).

Kleiman, E., Loguercio, S. and Feeney, A.J. Epigenetic enhancer marks and transcription factor binding influence V rearrangement in pre-B cells and pro-B cells. Frontiers in Immunology, 9:2074 (2018).

Kleiman, E., Xu, J. and Feeney, A.J. Cutting Edge: Proper orientation of CTCF sites in Cer required for normal J-distal and proximal Vgene usage. J. Immunol. 201: 1633-1638 (2018).

Loguercio S., Barajas-Mora, E.M, Shih, H.-Y., Krangel, M., and Feeney, A.J. Variable extent of lineage-specificity and developmental state-specificity of cohesin and CTCF binding within the immunoglobulin and T cell receptor loci. Frontiers in Immunology, 9:45 (2018).

Kleiman, E., Jia, H., Loguercio S., Su, A.I. and Feeney, A.J. YY1 plans an essential role at all stages of B cell differentiation. Proc Natl Acad Sci USA 113:E3911-20 (2016).

Gerasimova T., Guo C., Gosh, A., Qui, X., Montefiori, L., Verma-Gaur, J., Choi, N.M., Feeney, A.J. and Sen R. A structural hierarchy mediated by multiple nuclear factors establishes IgH locus conformation. Genes Dev. 29:1683-1695 (2015).

Choi, N.M. and Feeney, A.J. CTCF and ncRNA regulate the 3-dimensional structure of antigen receptor loci to facilitate V(D)J recombination. Frontiers in B Cell Biology 5:49 (2014).

Predeus, A.V., Gopalakrishnan, S., Huang, Y., Tang, J., Feeney, A.J., Oltz, E.M., and Artyomov, M.N. Targeted chromatin profiling reveals novel enhancers in Ig H and Ig L chain loci. J. Immunol. 192: 1064-1074 (2014).

Kumar, S., Wuerffel, R., Achour, I., Lajoie, B., Sen, R., Dekker, J., Feeney, A.J. and Kenter, A.L. Flexible ordering of antibody class switch and V(D)J joining during B-cell ontogeny. Genes Dev. 27: 2439-2444 (2013).

Gopalakrishnan, S., Majumder, K., Predeus, A., Huang, Y., Koues, O.I., Verma-Gaur, J., Loguercio, S., Su, A.I., Feeney, A.J., Artyomov, M.N. and Oltz, E.M. Unifying model for molecular determinants of the preselection Vbeta repertoire. Proc Natl Acad Sci USA 110:E3206-3215 (2013).

Choi, N.M., Loguercio, S., Verma-Gaur, J., Degner, S.C., Torkamani, A., Su, A.I., Oltz, E.M., Artyomov, M. and Feeney, A.J. Deep sequencing of the murine Igh repertoire reveals complex regulation of nonrandom V gene rearrangement frequencies. J. Immunol. 191:2393-2402 (2013).

Shih, H.-Y., Verma-Gaur, J., Torkamani, A., Feeney, A.J., Galjart, N. and Krangel, M.S. Tcra gene recombination is supported by a Tcra enhancer- and CTCF-dependent chromatin hub. Proc Natl Acad Sci USA 109:E3943-E3502 (2012).

Verma-Gaur, J., Torkamani, A., Schaffer, L., Head, S.R., Schork, N.J. and Feeney, A.J. Noncoding transcription within the Igh distal VH region at PAIR elements affects the 3D structure of the Igh locus in pro-B cells. Proc Natl Acad Sci USA 109:17004-17009 (2012).

Volpi, S.A., Verma-Gaur, J., Hassan, R., Ju, Z., Roa, S., Chatterjee, S., Werling, U., Hou, H., Jr., Will, B., Steidl, U., Scharff, M., Edelman, W., Feeney, A.J. and Birshtein, B.K. Germline deletion of Igh 3' regulatory region elements hs 5, 6, 7 (hs5-7) affects B cell-specific regulation, rearrangement, and insulation of the Igh locus. J. Immunol. 188:2556-2566 (2012).

Degner, S.C., Verma-Gaur, J., Wong, T.P., Bossen, C., Iverson, G.M., Torkamani, A., Vettermann, C., Lin, Y.C., Ju, Z., Schulz, D., Murre, C.S., Birshtein, B.K., Schork, N.J., Schlissel, M.S., Riblet, R., Murre, C. and Feeney, A.J. CCCTC-binding factor (CTCF) and cohesin influence the genomic architecture of the Igh locus and antisense transcription in pro-B cells. Proc Natl Acad Sci USA 108:9566-9571 (2011).

Xu, C.R. and Feeney, A.J. The epigenetic profile of Ig genes is dynamically regulated during B cell differentiation and is modulated by pre-B cell receptor signaling. J. Immunol. 182:1362-1369 (2009). Chosen as a featured article in "In This Issue".

Degner, S.C., Wong, T.P., Jankevicius, G. and Feeney, A.J. Cutting edge: developmental stage-specific recruitment of cohesin to CTCF sites throughout immunoglobulin loci during B lymphocyte development. J. Immunol. 182:44-48 (2009). Evaluated by the Faculty of 1000 Biology.

Carey, J.B., Moffatt-Blue, C.S., Watson, L.C., Gavin, A.L. and Feeney, A.J. Repertoire-based selection into the marginal zone compartment during B cell development. J. Exp. Med. 205:2043-2052 (2008). Evaluated by the Faculty of 1000 Biology.

Xu, C.R., Schaffer, L., Head, S.R. and Feeney, A.J. Reciprocal patterns of methylation of H3K36 and H3K27 on proximal vs. distal IgVH genes are modulated by IL-7 and Pax5. Proc Natl Acad Sci USA 105:8685-8690 (2008).