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S1P Publications


S1P Publications

84.  Fang V, Chaluvadi VS, Ramos-Perez WD, Mendoza A, Baeyens A, Rivera R, Chun J, Cammer M, Schwab SR.  Gradients of the signaling lipid S1P in lymph nodes position natural killer cells and regulate their interferon-γ response. Nature Immunol epub ahead of print 2016 Nov 14. doi:10.1038/ni.3619.

83.  Gazit SL, Mariko B, Therond P, Decouture B, Xiong Y, Couty L, Bonnin P, Baudrie V, Le Gall SM, Dizier B, Zoghdani N, Ransinan J, Hamilton JR, Gaussem P, Tharaux PL, Chun J, Coughlin SR, Bachelot-Loza C, Hla T, Ho-Tin-Noe B, Camerer E.  Platelet and erythrocyte sources of S1P are redundant for vascular development and homeostasis, but both rendered essential after plasma S1P depletion in anaphylactic shock.  Circ Res 2016;119(8):e110-e126.

82.  Lai MK, Chew WS, Torta F, Rao A, Harris GL, Chun J, Herr D.  Biological effects of naturally occurring sphingolipids, uncommon variants, and their analogs.  Neuromolecular Med 2016;18(3):396-414.

81.  Clay H, Wilsbacher LD, Wilson SJ, Duong DN, McDonald M, Lam I, Park KE, Chun J, Coughlin SR.  Sphingosine 1-phosphate receptor-1 in cardiomyocytes is required for normal cardiac development.  Dev Biol 2016;418(1):157-165.  PMC5031538

80.  Keul P, van Borren MM, Ghanem A, Muller FU, Baartscheer A, Verkerk AO, Stumpel F, Schulte JS, Hamdani N, Linke WA, van Loenen P, Matus M, Schmitz W, Stypmann J, Tiemann K, Ravesloot JH, Alewijnse AE, Hermann S, Spijkers LJ, Hiller KH, Herr D, Heush G, Schafers M, Peters SL, Chun J, Levkau B.  Sphingosine-1-phosphate receptor 1 regulates cardiac function by modulating Ca2+ sensitivity and Na+/H+ exchange and mediates protection by ischemic preconditioning.  J Am Heart Assoc 2016;5(5): pii: e003393.  PMC4889204

79.  Herr DR, Reolo MJ, Peh YX, Wang W, Lee CW, Rivera R, Paterson IC, Chun J.  Sphingosine 1-phosphate receptor 2 (S1P2) attenuates reactive oxygen species formation and inhibits cell death:  implications for otoprotective therapy.  Sci Rep 2016;6:24541.  PMC4832229

78.  Kitada Y, Kajita K, Taguchi K, Mori I, Yamauchi M, Ikeda T, Kawashima M, Asano M, Kajita T, Ishizuka T, Banno Y, Kojima I, Chun J, Kamata S, Ishii I, Morita H.  Blockade of sphingosine 1-phosphate receptor 2 signaling attenuates high-fat diet-induced adipocyte hypertrophy and systemic glucose intolerance in mice.  Endocrinology 2016;157(5):1839-1851.

77.  Moon E, Han JE, Jeon S, Ryu JH, Choi JW, Chun J.  Exogenous S1P exposure potentiates ischemic stroke damage that is reduced possibly by inhibiting S1P receptor signaling.  Mediators Inflamm 2015;492659.  PMC4630407

76.  Kihara Y, Groves A, Rivera RR, Chun J.  Dimethyl fumarate inhibits integrin α4 expression in multiple sclerosis models.  Ann Clin Transl Neurol 2015;2(10):978-983.  doi:10.1002/acn3.251.  PMC4603381  Download PDF

75.  Kihara Y, Mizuno H, Chun J.  Lysophospholipid receptors in drug discovery.  Exp Cell Res 2015;333(2):171-177.  doi:  10.1016/j.yexcr.2014.11.020.  PMC4408218  Download PDF

74.  Keller J, Catala-Lehnen P, Huebner AK, Jeschke A, Heckt T, Lueth A, Krause M, Koehne T, Albers J, Schulze J, Schilling S, Haberland M, Denninger H, Neven M, Hermans-Borgmeyer I, Streichert T, Breer S, Barvencik F, Levkau B, Rathkolb B, Wolf E, Calzada-Wack J, Neff F, Gailus-Durner V, Fuchs H, de Angelis MH, Klutmann S, Tsourdi E, Hofbauer LC, Kleuser B, Chun J, Schinke T, Amling M.  Calcitonin controls bone formation by inhibiting the release of sphingosine 1-phosphate from osteoclasts.  Nat Commun 2014;5:5215.  PMC4205484  Download PDF

73.  Herr DR, Lee CW, Wang W, Ware A, Rivera R, Chun J.  Sphingosine 1-phosphate receptors are essential mediators of eyelid closure during embryonic development.  J Biol Chem 2013;288(41):29882-29889.  PMC3795286  Download PDF

72.  Lysophospholipid receptors:  signaling and biochemistry. Edited by Chun J, Hla T, Spiegel S, Moolenaar W.  John Wiley & Sons, Inc., Hoboken, NJ. 2013. 

71.  Groves A, Kihara Y, Chun J.  Fingolimod:  Direct CNS effects of sphingosine 1-phosphate (S1P) receptor modulation and implications in multiple sclerosis therapy.  J Neurol Sci 2013;328(1-2):9-18.  PMC3640626  Download PDF

70.  Choi JW, Chun J.  Lysophospholipids and their receptors in the central nervous system.  Biochim Biophys Acta 2013;1831(1):20-32. PMC3693945  Download PDF

69.  Mutoh T, Rivera R, Chun J.  Insights into the pharmacological relevance of lysophospholipid receptors.  Br J Pharmacol 2012;165(4):829-844. PMC3312481  Download PDF

68.  Cohen JA, Chun J.  Reply.  Ann Neurol 2011;70(4):674.

67.  Akahoshi N, Ishizaki Y, Yasuda H, Murashima YL, Shinba T, Goto K, Himi T, Chun J, Ishii I.  Frequent spontaneous seizures followed by spatial working memory/anxiety deficits in mice lacking sphingosine 1-phosphate receptor 2.  Epilepsy Behav 2011;22(4):659-665.  Download PDF

66.  Castillo-Badillo JA, Molina-Munoz T, Romero-Avila MT, Vazquez-Macias A, Rivera R, Chun J, Garcia-Sainz JA.  Sphingosine 1-phosphate-mediated a(1B)-adrenoceptor desensitization and phosphorylation:  Direct and paracrine/autocrine actions.  Biochim Biophys Acta 2011;1823(2):245-254. PMC22019450  Download PDF

65.  Soliven B, Miron V, Chun J.  The neurobiology of sphingosine 1-phosphate signaling and sphingosine 1-phosphate receptor modulators.  Neurol Suppl 2011;76(8 Suppl 3):S9-14.  

64.  Park Hopson K, Truelove J, Chun J, Wang Y, Waeber C.  S1P activates store-operated calcium entry via receptor- and non-receptor-mediated pathways in vascular smooth muscle cells.  Am J Physiol Cell Physiol 2011;300(4):C919-C926. PMC3074633  Download PDF

63.  Herzog C, Schmitz M, Levkau B, Herrgott I, Mersmann J, Larmann J, Kai J, Winterhalter M, Chun J, Ulrich Muller F, Echtermeyer F, Hildebrand R, Theilmeier G.  Intravenous sphingosylphosphorylcholine protects ischemic and post-ischemic myocardial tissue in a mouse model of myocardial ischemia/reperfusion injury.  Mediat Inflam 2011;425191. PMC3022218  Download PDF

62.  Choi JW, Gardell SE, Herr DR, Rivera R, Lee CW, Noguchi K, Teo ST, Yung YC, Lu M, Kennedy G, Chun J.  FTY720 (fingolimod) efficacy in an animal model of multiple sclerosis requires astrocyte sphingosine 1-phosphate receptor (S1P1) modulation. Proc Natl Acad Sci USA 2011;108(2):751-756. PMC3021041  Download PDF

61.  Cohen JA, Chun J.  Reply.  Ann Neurol 2011;70(4):674.

60.  Chun J, Brinkmann V.  A mechanistically novel, first oral therapy for multiple sclerosis:  the development of fingolimod (FTY720, Gilenya). Discov Med 2011;12(64):213-228. PMC3694567 Download PDF

59.  Cohen JA, Chun J.  Mechanisms of fingolimod’s efficacy and adverse effects in multiple sclerosis.  Ann Neurol 2011;69(5):759-777.  Download PDF

58.  Noguchi K, Chun J.  Roles for lysophospholipid S1P receptors in Multiple Sclerosis.  Crit Rev Biochem Mol Bio 2011;46(1):2-10.  Download PDF

57.  Shea BS, Brooks SF, Fontaine BA, Chun J, Luster AD, Tager AM.  Prolonged exposure to sphingosine 1-phosphate receptor 1 agonists exacerbates vascular leak, fibrosis, and mortality after lung injury.  Am J Respir Cell Mol Biol 2010;43(6):662-673.  PMC2993087  Download PDF

56.  Nagai J, Uchida H, Matsushita Y, Yano R, Ueda M, Niwa M, Aoki J, Chun J, Ueda H.  Autotaxin and lysophosphatidic acid1 receptor-mediated demyelination of dorsal root fibers by sciatic nerve injury and intrathecal lysophosphatidycholine.  Mol Pain 2010;6:78. PMC2989310  Download PDF

55.  Imasawa T, Koike K, Ishii I, Chun J, Yatomi Y.  Blockade of sphingosine 1-phosphate receptor 2 signaling attenuates streptozotocin-induced apoptosis of pancreatic beta-cells.  Biochem Biophys Res Comm 2010;392(2):207-211. PMC3649530 Download PDF

54.  Takuwa N, Ohkura SI, Takashima SI, Ohtani K, Okamoto Y, Tanaka T, Hirano K, Usui S, Wang F, Du W, Yoshioka K, Banno Y, Sasaki M, Ichi I, Okamura M, Sugimoto N, Mizugishi K, Nakanuma Y, Ishii I, Takamura M, Kaneko S, Kojo S, Satouchi K, Mitumori K, Chun J, Takuwa Y.  S1P3-mediated cardiac fibrosis in sphingosine kinase 1 transgenic mice involves reactive oxygen species.  Cardiovasc Res 2010;85(3):484-493.  PMC2802201  Download PDF

53.  Lee CW, Choi JW, Chun J.  Neurological S1P signaling as an emerging mechanism of action of oral FTY720 (Fingolimod) in multiple sclerosis.  Arch Pharm Res 2010;33(10):1567-1574.  Download PDF

52.  Chun J, Hla T, Lynch KR, Spiegel S, Moolenaar WH.  International Union of Basic and Clinical Pharmacology. LXXVIII.  Lysophospholipid Receptor Nomenclature. Pharmacol Rev 2010;62(4):579-587. PMC2993255  Download PDF

51.  Chun J.  Targeting the lysophospholipid S1P receptor for the treatment of Multiple Sclerosis. Drugs Future 2010;35(6):495-501.  

50.  Choi JW, Herr DR, Noguchi K, Yung YC, Lee CW, Mutoh T, Lin M-E, Teo ST, Park KE, Mosley AN, Chun J.  LPA receptors:  Subtypes and biological actions.  Ann Rev Pharmacol Toxicol 2010;50:157–186.  Download PDF

49.  Chun J, Hartung H-P.  Mechanism of action of oral Fingolimod (FTY720) in multiple sclerosis.  Clin Neuropharm 2010;33(2):91-101. PMC2859693  Download PDF

48.  Jenne CN, Enders A, Rivera R, Watson SR, Bankovich AJ, Pereira JP, Xu Y, Roots CM, Beilke NJ, Banerjee A, Reiner SL, Miller SA, Weinmann AS, Goodnow CC, Lanier LL, Cyster JG, Chun J.  T-bet dependent S1P5 expression in NK cells promotes egress from lymph nodes and bone marrow.  J Exper Med 2009;206(11):2469-2481.  PMC2768857  Download PDF

47.  Nieuwenhuis B, Lüth A, Chun J, Huwiler A, Pfeilschifter J, Schäfer-Korting M, Kleuser B.  Involvement of the ABC-transporter ABCC1 and the sphingosine 1-phosphate receptor subtype S1P3 in the cytoprotection of human fibroblasts by the glucocorticoid dexamethasone.  J Mol Med 2009;87(6):645-657.  Download PDF

46.  Ikeda H, Watanabe N, Ishii I, Shimosawa T, Kume Y, Yomiya T, Inoue Y, Nishikawa T, Ohtomo N, Tanoue Y, Iitsuka S, Fujita R, Omata M, Chun J, Yatomi Y.  Sphingosine 1-phosphate regulates regeneration and fibrosis after liver injury via sphingosine 1-phosphate receptor 2 (S1P2).  J Lipid Res 2009;50(3):556-564.  PMC2638109  Download PDF

45.  Mutoh T, Chun J.  Lysophosphatidic acid and sphingosine 1-phosphate activation of G Protein-Coupled Receptors.  In Bradshaw RA & Dennis EA (eds.) Handbook of Cell Signaling, second edition, Elsevier, 2009.

44.  Tölle M, Pawlak A, Schuchardt M, Kawamura A, Tietge UJ, Lorkowski S, Keul P, Assmann G, Chun J, Levkau B, van der Giet M, Nofer JR.  HDL-associated lysosphingolipids inhibit NAD(P)H oxidase-dependent monocyte chemoattractant protein-1 production.  Arterioscler Thromb Vasc Biol 2008;28(8):1542-1548.  PMC2723752  Download PDF

43.  Choi JW, Lee CW, Chun J.  Biological roles of lysophospholipid receptors revealed by genetic null mice:  an update.  Biochem Biophys Acta 2008;1781:531-539.  PMC2657083  Download PDF

42.  Means CK, Miyamoto S, Chun J, Brown JH.  S1P1 receptor localization confers selectivity for Gi mediated camp and contractile responses.  J Biol Chem 2008;283(18):11954-11963.  PMC2335351  Download PDF

41.  Niessen F, Schaffner F, Furlan-Freguia C, Pawlinski R, Bhattacharjee G, Chun J, Derian CK, Andrade-Gordon P, Rosen H, Ruf W.  Dendritic cell PAR1-S1P3 signalling couples coagulation and inflammation.  Nature 2008;452(7187):654-658.  Download PDF

40.  Salomone S, Potts EM, Tyndall S, Ip PC, Chun J, Brinkmann V, Waeber C.  Analysis of sphingosine 1-phosphate receptors involved in constriction of isolated cerebral arteries with receptor null mice and pharmacological tools.  Br J Pharm 2008;153(1):140-147.  Download PDF

39.  Mutoh T, Chun J.  Lysophospholipid activation of g protein-coupled receptors.  Subcell Biochem 2008;49:269-297.  Download PDF

38.  Chun J.  “Extracellular Lipid Signals.” In the Wiley Encyclopedia of Chemical Biology, Tadhg P. Begley (ed.), 2008.

37. Chun J.  The sources of a lipid conundrum.  Science 2007;316:208-210.  Download PDF

36.  Serriere-Lanneau V, Teixeira-Clerc F, Li L, Schippers M, de Wries W, Julien B, Tran-Van-Nhieu J, Manin S, Poelstra K, Chun J, Carpentie S, Levade T, Mallat A, Lotersztajn S.  The sphingosine 1-phosphate receptor S1P2 triggers hepatic wound healing.  FASEB J 2007;21(9):2005-2013.  Download PDF

35.  Means CK, Xiao CY, Li Z, Zhang T, Omens JH,  Ishii I, Chun J, Brown JH.  Sphingosine 1-phosphate S1P2 and S1P3 receptor-mediated Akt activation protects against in vivo myocardial ischemia-reperfusion injury.  Am J Physiol Heart Circ Physiol 2007;92(6):H2944-H2951.  Download PDF

34.  Walter DH, Rochwalsky U, Reinhold J, Seeger F, Aicher A, Urbich C, Spyridopoulos I, Chun J, Brinkmann V, Keul P, Levkau B, Zeiher AM, Dimmeler S, Haendeler J. Sphingosine-1-phosphate stimulates the functional capacity of progenitor cells by activation of the CXCR4-dependent signaling pathway via the S1P3 receptor.  Arterioscler Thromb Vasc Biol 2007;27:275-282.  Download PDF

33.  Herr D, Grillet N, Schwander M, Rivera R, Müller U, Chun J.  Sphingosine 1-phosphate signaling is required for maintenance of hair cells largely via activation of S1P2.  J Neurosci 2007;27(6):1474-1478.  Download PDF

32.  Keller CD, Gil PR, Tolle M, van der Giet M, Chun J, Radeke HH, Schafer-Korting M, Kleuser B.  Immunomodulator FTY720 induces myofibroblast differentiation via the lysophospholipid receptor S1P3 and Smad3 signaling.  Am J Path 2007;170(1):281-292.  PMC1762708  Download PDF

31.  Rivera R, Chun J.  Potential therapeutic roles of lysophospholipid signaling in autoimmune related disease.  Future Lipidology 2007;2(5):535-545.

30.  Theilmeier G, Schmidt C, Herrmann J, Keul P, Schäfers M, Herrgott I, Mersmann J, Larmann J, Hermann S, Stypmann J, Schober O, Hildebrand R, Schulz R, Heusch G, Haude M, von Wnuck Lipinski K, Herzog C, Schmitz M, Erbel R, Chun J, Levkau, B.  High-density lipoproteins and their constituent sphingosine-1-phosphate directly protect the heart against ischemia/reperfusion injury in vivo via the S1P3 lysophospholipid receptor.  Circulation 2006;114:1403-1409.  Download PDF

29.  Birgbauer E, Chun J.  New developments in the biological functions of lysophospholipids.  Cell Mol Life Sci 2006;63:2695-2701.  Download PDF

28.  Rivera R, Chun J.  Biological effects of lysophospholipids.  Rev Physiol Biochem Pharmacol 2008;160:25-46.  Download PDF

27.  Gardell SE, Dubin AE, Chun J.  Emerging medicinal roles for lysophospholipid receptors.  Trends in Mol Med 2006;12:65-75.  Download PDF

26.  Chun J, Rosen H.  Lysophospholipid receptors as potential drug targets in tissue transplantation and autoimmune diseases.  Cur Pharm Design 2006;12:161-171.  Download PDF

25.  Tölle M, Levkau B, Keul P, Brinkmann V, Giebing G, Schönfelder G, Schäfers M, von Wnuck Lipinski K, Jankowski J, Jankowski V, Chun J, Zidek W, van der Giet M.  The immunomodulator FTY720 induces eNOS-dependent arterial vasodilation via the lysophospholipid receptor S1P3.  Circ Res 2005;96:913-920.  Download PDF

24.  Goparaju SK, Jolly PS, Watterson KR, Bektas M, Alvarez S, Sarkar S, Mel L, Ishii I, Chun J, Milstien S, Spiegel S.  The S1P2 receptor negatively regulates PDGF-induced motility and proliferation.  Mol Cell Biol 2005;25:4237-4249.  PMC1087716  Download PDF

23.  Chun J.  Lysophospholipids in the nervous system.  J Prostagland Lipid Mediators 2005;77:46-51.  Download PDF

22.  Girkontaite I, SakkV, Wagner M, Borggrefe T, Tedford K, Chun J, Fischer K-D.  The sphingosine-1-phosphate lysophospholipid receptor S1P3 regulates MAdCAM-1+ endothelial cells in splenic marginal sinus organization.  J Exp Med 2004;200:1491-1501.  PMC2211946  Download PDF

21.  Levkau B, Hermann S, Theilmeier G, van der Giet M, Chun J, Schober O, Schäfers M.  HDL stimulates myocardial perfusion in vivo.  Circulation 2004;110:3355-3359.  Download PDF

20.  Webb M, Tham C-S, Lin F-F, Lariosa-Willingham K, Yu N, Hale J, Mandala S, Chun J, Rao TS.  Sphingosine 1-phosphate receptor agonists attenuate relapsing-remitting experimental autoimmune encephalitis in SJL mice.  J Neuroimmunol 2004;153:108-121. Download PDF

19.  Rao TS, Lariosa-Willingham KD, Lin F-F, Yu N, Tham C-S, Chun J, Webb M.  Growth factor pre-treatment differentially regulates phosphoinositide turnover downstream of  lysophospholipid receptor and metabotropic glutamate receptors in cultured rat cerebrocortical astrocytes.  Int J Devel Neurosci 2004;22:131-135.  Download PDF

18.  Sanna G, Alfonso A, Liao J, Ahn M-Y, Peterson MS, Jo E, Webb B, Lefebvre S, Chun J, Gray N, Rosen H. Sphingosine 1-phosphate (S1P) receptor subtypes S1P1 and S1P3, respectively, regulate lymphocyte recirculation and heart rate.  J Biol Chem 2004;279:13839-13848.  Download PDF

17.  Nofer J-R, van der Giet M, Tölle M, Wolinska I, Sokoll A, von Wnuck-Lipinski K, Baba HA, Gödecke A, Ishii I, Kleuser B, Volker W, Fobker M, Zidek W, Assmann G, Chun J, Levkau B.  HDL induces NO-dependent vasorelaxation via the lysophospholipid receptor S1P3:  role of HDL-associated lysophospholipids.  J Clin Invest 2004;113:569-581.  PMC338256  Download PDF

16.  Baudhuin LM, Ying J, Zaslavsky A, Ishii I, Chun J, Yan Xu Y.  S1P3-mediated Akt activation and crosstalk with platelet-derived growth factor receptor (PDGFR).  FASEB J 2004;18:341-343.  Download PDF

15.  Anliker B, Chun J. Lysophospholipid G protein-coupled receptors.  J Biol Chem 2004;279:20555-20558.  Download PDF

14.  Anliker B, Chun J.  Cell surface receptors in lysophospholipid signaling.  Sem Cell and Devel Biol 2004;15:457-465.  Download PDF

13.  Ishii I, Fukushima N, Ye X, Chun J.  Lysophospholipid receptors:  Signaling and biology.  Ann Rev Biochem 2004;73:321-354.  Download PDF

12.  Olivera A, Rosenfeldt H, Bektas M, Wang F, Ishii I, Chun J, Milstien S, Spiegel S.  Sphingosine kinase type 1 induces G12/13-mediated stress fiber formation yet promotes growth and survival independent of G protein coupled receptors.  J Biol Chem 2003;278:46452-46460.  Download PDF

11.  Rao TS, Lariosa-Willingham KD, Lin F-F, Palfreyman EL, Yu N, Chun J, Webb M.  Pharmacological characterization of lysophospholipid receptor signal transduction pathways in rat cerebrocortical astrocytes.  Brain Res 2003;990:182-194.  Download PDF

10.  Liu H, Toman RE, Goparaju S,  Maceyka M,  Nava VE, Sankala H, Payne SG, Bektas M, Ishii I, Chun J, Milstien S, Spiegel S.  Sphingosine kinase type 2 is a putative BH3-only protein that induces apoptosis.  J Biol Chem 2003;278:40330-40336.  Download PDF

9.  McGiffert C, Contos JJA, Friedman B, Chun J.  Embryonic brain expression analysis of lysophospholipid receptor genes suggests roles for s1p1 in neurogenesis and s1p1-3 in angiogenesis.  FEBS Lett 2002;531:103-108.  Download PDF

8.  Contos JJA, Ye X, Sah V, Chun J.  Tandem genomic arrangement of a G protein (Gna15) and G protein-coupled receptor (s1p4/lpC1/Edg6) gene.  FEBS Lett 2002;531:99-102.  Download PDF

7.  Ishii I, Ye X, Friedman B, Kawamura S, Contos JJA, Kingsbury MA, Yang AH, Zhang G, Brown JH, Chun J.  Marked perinatal lethality and cellular signaling deficits in mice null for the two sphingosine 1-phosphate receptors, S1P2/LPB2/EDG-5 and S1P3/LPB3/EDG-3.  J Biol Chem 2002;277:25152-25159.  Download PDF

6.  Ishii I, Chun J.  Anandamide-induced neuroblastoma cell rounding via the CB1 cannabinoid receptors.  Neuroreport 2002;13:593-596.  

5.  Yang AH, Ishii I, Chun J.  In vivo roles of lysophospholipid receptors revealed by gene targeting studies in mice.  Biochim Biophys Acta 2002;1582:197-203.  Download PDF

4.  Chun J, Goetzl EJ, Hla,TL, Igarashi Y, Lynch KR, Moolenaar WH, Pyne S, Tigyi G.  International Union of Pharmacology.  XXXIV.  Lysophospholipid receptor nomenclature.  Pharmacol Rev 2002;54:265-269. Download PDF

3.  Ishii I, Friedman B, Ye X-Q, Kawamura S, McGiffert C, Contos JJA, Kingsbury M, Zhang G, Brown JH, Chun J.  Selective loss of sphingosine 1-phosphate signaling with no obvious phenotypic abnormality in mice lacking its G protein-coupled receptor, LPB3/EDG-3.  J Biol Chem 2001;276:33697-33704.  Download PDF

2.  Chun J, Weiner JA, Fukushima N, Contos JJA, Zhang G, Kumura Y, Dubin A, Ishii I, Hecht JH, Akita C, Kaushal D.  Neurobiology of receptor-mediated lysophospholipid signaling:  From the first lysophospholipid (LP) receptor to roles in nervous system function and development.  Ann NY Acad Sci 2000;905:110-117.  Download PDF

1.  Zhang G, Contos JJA, Weiner JA, Fukushima N, Chun J.  Comparative analysis of three murine G-protein coupled receptors activated by sphingosine-1-phosphate. Gene 1999;227:89-99.  Download PDF

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