publications

Publications

2016

Global IP6K1 deletion enhances temperature modulated energy expenditure which reduces carbohydrate and fat induced weight gain., Zhu, Q., Ghoshal, S., Tyagi, R. and Chakraborty, A., Molebular Metabolism, 2016 November 28;6(1); 73-85 Pubmed PMIS:28123939; PMC5220553
Adipocyte-specific deletion of Ip6k1 reduces diet-induced obesity by enhancing AMPK-mediated thermogenesis. Zhu Q, Ghoshal S, Rodrigues A, Gao S, Asterian A, Kamenecka TM, Barrow JC, Chakraborty A., J Clinical Investigation 2016 Nov 1; 126 (11): 4273-4288. DOI: 10.1172/JCI85510. Epub 2016 Oct 4, PMID:27701146 PMC509689
Inositol hexakisphosphate kinase-1 interacts with perilipin1 to modulate lipolysis, Ghoshal, S., Tyagi, R., Zhu, Q., Chakraborty, A., J Biochem Cell Biology, 2016 Sept: 78: 149-55. DOI: 10.1016/j.biocell.2016.06018. Epub Jun 29. PMID 27373682, PMC 5003629
TNP [N2-(m-Trifluorobenzyl), N6-(p-nitrobenzyl) purine] ameliorates diet induced obesity and insulin resistance via inhibition of the IP6K1 pathway. Ghoshal, S, Zhu, Q., Asteian, A., Lin, H., Xu, H, Ernst, G., Barrow, J.C., Xu, B., Cameron, M.D., Kamenecka, T.M. and Chakraborty, A. Molecular Metabolism 2016 Aug 21; 5(10):903-17. DOI: 10.1016/j.molmet.2016.08.008. eCollection 2016 PMID 27689003 PMC5034689

2013

Inositol hexakisphosphate kinase-1 regulates behavioral responses via GSK3 signaling pathways. Chakraborty A, Latapy C, Xu J, Snyder SH, Beaulieu JM. Mol Psychiatry 2013. doi: 10.1038/mp.2013.21. PMID: 23439485

2011

Inositol pyrophosphates as mammalian cell signals. Chakraborty A, Kim S, Snyder SH. Sci Signal. 2011, 4, re1. PMID: 21878680 PMCID: PMC3667551
Inositol hexakisphosphate kinase 1 regulates neutrophil function in innate immunity by inhibiting phosphatidylinositol-(3,4,5)-trisphosphate signaling. Prasad A, Jia Y, Chakraborty A, Li Y, Jain SK, Zhong J, Roy SG, Loison F, Mondal S, Sakai J, Blanchard C, Snyder SH, Luo HR. Nat Immunol. 2011, 12, 752-60. PMID: 21685907 PMCID: PMC3140608 DOI: 10.1038/ni.2052
Casein kinase-2 mediates cell survival through phosphorylation and degradation of inositol hexakisphosphate kinase-2. Chakraborty A, Werner JK Jr, Koldobskiy MA, Mustafa AK, Juluri KR, Pietropaoli J, Snowman AM,Snyder SH. Proc Natl Acad Sci U S A. 2011, 108, 2205-9.
Amino acid signaling to mTOR mediated by inositol polyphosphate multikinase. Kim S, Kim SF, Maag D, Maxwell MJ, Resnick AC, Juluri KR, Chakraborty A, Koldobskiy MA, Cha SH, Barrow R, Snowman AM, Snyder SH. Cell Metab. 2011, 13, 215-21.

2010

Inositol pyrophosphates inhibit Akt signaling, thereby regulating insulin sensitivity and weight gain. Chakraborty A, Koldobskiy MA, Bello NT, Maxwell M, Potter JJ, Juluri KR, Maag D, Kim S, Huang AS, Dailey MJ, Saleh M, Snowman AM, Moran TH, Mezey E, Snyder SH. Cell 2010, 143, 897-910.
p53-mediated apoptosis requires inositol hexakisphosphate kinase-2. Koldobskiy MA, Chakraborty A, Werner JK Jr, Snowman AM, Juluri KR, Vandiver MS, Kim S, Heletz S, Snyder SH. Proc Natl Acad Sci U S A. 2010, 107, 20947-51.

2009

Glutamatergic regulation of serine racemase via reversal of PIP2 inhibition. Mustafa AK, van Rossum DB, Patterson RL, Maag D, Ehmsen JT, Gazi SK, Chakraborty A, Barrow RK, Amzel LM, Snyder SH. Proc Natl Acad Sci U S A. 2009, 106, 2921-6.

2008

HSP90 regulates cell survival via inositol hexakisphosphate kinase-2. Chakraborty A, Koldobskiy MA, Sixt KM, Juluri KR, Mustafa AK, Snowman AM, van Rossum DB, Patterson RL, Snyder SH. Proc Natl Acad Sci U S A. 2008, 105, 1134-9.

2007

Inositol pyrophosphate pyrotechnics. Bhandari R, Chakraborty A, Snyder SH. Cell Metab. 2007, 5, 321-3.
Amino acid residues of Leishmania donovani cyclophilin key to interaction with its adenosine kinase: biological implications. Sen B, Venugopal V, Chakraborty A, Datta R, Dolai S, Banerjee R, Datta AK. Biochemistry 2007, 46, 7832-43.

2006

Reversal of ADP-mediated aggregation of adenosine kinase by cyclophilin leads to its reactivation. Sen B, Chakraborty A, Datta R, Bhattacharyya D, Datta AK. Biochemistry 2006, 45, 263-71.
Homology-model-guided site-specific mutagenesis reveals the mechanisms of substrate binding and product-regulation of adenosine kinase from Leishmania donovani. Datta R, Das I, Sen B, Chakraborty A, Adak S, Mandal C, Datta AK. Biochem J. 2006, 394, 35-42.

2005

Mutational analysis of the active-site residues crucial for catalytic activity of adenosine kinase from Leishmania donovani. Datta R, Das I, Sen B, Chakraborty A, Adak S, Mandal C, Datta AK. Biochem J. 2005, 387, 591-600.

2004

Isomerase-independent chaperone function of cyclophilin ensures aggregation prevention of adenosine kinase both in vitro and under in vivo conditions. Chakraborty A, Sen B, Datta R, Datta AK. Biochemistry. 2004, 43, 11862-72.

2002

A single-domain cyclophilin from Leishmania donovani reactivates soluble aggregates of adenosine kinase by isomerase-independent chaperone function. Chakraborty A, Das I, Datta R, Sen B, Bhattacharyya D, Mandal C, Datta AK. J Biol Chem. 2002, 277, 47451-60.

Publications

2016

Global IP6K1 deletion enhances temperature modulated energy expenditure which reduces carbohydrate and fat induced weight gain., Zhu, Q., Ghoshal, S., Tyagi, R. and Chakraborty, A., Molebular Metabolism, 2016 November 28;6(1); 73-85 Pubmed PMIS:28123939; PMC5220553

Inositol hexakisphosphate kinase-1 interacts with perilipin1 to modulate lipolysis, Ghoshal, S., Tyagi, R., Zhu, Q., Chakraborty, A., J Biochem Cell Biology, 2016 Sept: 78: 149-55. DOI: 10.1016/j.biocell.2016.06018. Epub Jun 29. PMID 27373682, PMC 5003629

2013

Inositol hexakisphosphate kinase-1 regulates behavioral responses via GSK3 signaling pathways. Chakraborty A, Latapy C, Xu J, Snyder SH, Beaulieu JM. Mol Psychiatry 2013. doi: 10.1038/mp.2013.21. PMID: 23439485

2011

Inositol pyrophosphates as mammalian cell signals. Chakraborty A, Kim S, Snyder SH. Sci Signal. 2011, 4, re1. PMID: 21878680 PMCID: PMC3667551

Casein kinase-2 mediates cell survival through phosphorylation and degradation of inositol hexakisphosphate kinase-2. Chakraborty A, Werner JK Jr, Koldobskiy MA, Mustafa AK, Juluri KR, Pietropaoli J, Snowman AM,Snyder SH. Proc Natl Acad Sci U S A. 2011, 108, 2205-9.

Amino acid signaling to mTOR mediated by inositol polyphosphate multikinase. Kim S, Kim SF, Maag D, Maxwell MJ, Resnick AC, Juluri KR, Chakraborty A, Koldobskiy MA, Cha SH, Barrow R, Snowman AM, Snyder SH. Cell Metab. 2011, 13, 215-21.

2010

Inositol pyrophosphates inhibit Akt signaling, thereby regulating insulin sensitivity and weight gain. Chakraborty A, Koldobskiy MA, Bello NT, Maxwell M, Potter JJ, Juluri KR, Maag D, Kim S, Huang AS, Dailey MJ, Saleh M, Snowman AM, Moran TH, Mezey E, Snyder SH. Cell 2010, 143, 897-910.

p53-mediated apoptosis requires inositol hexakisphosphate kinase-2. Koldobskiy MA, Chakraborty A, Werner JK Jr, Snowman AM, Juluri KR, Vandiver MS, Kim S, Heletz S, Snyder SH. Proc Natl Acad Sci U S A. 2010, 107, 20947-51.

2009

Glutamatergic regulation of serine racemase via reversal of PIP2 inhibition. Mustafa AK, van Rossum DB, Patterson RL, Maag D, Ehmsen JT, Gazi SK, Chakraborty A, Barrow RK, Amzel LM, Snyder SH. Proc Natl Acad Sci U S A. 2009, 106, 2921-6.

2008

HSP90 regulates cell survival via inositol hexakisphosphate kinase-2. Chakraborty A, Koldobskiy MA, Sixt KM, Juluri KR, Mustafa AK, Snowman AM, van Rossum DB, Patterson RL, Snyder SH. Proc Natl Acad Sci U S A. 2008, 105, 1134-9.

2007

Inositol pyrophosphate pyrotechnics. Bhandari R, Chakraborty A, Snyder SH. Cell Metab. 2007, 5, 321-3.

Amino acid residues of Leishmania donovani cyclophilin key to interaction with its adenosine kinase: biological implications. Sen B, Venugopal V, Chakraborty A, Datta R, Dolai S, Banerjee R, Datta AK. Biochemistry 2007, 46, 7832-43.

2006

Reversal of ADP-mediated aggregation of adenosine kinase by cyclophilin leads to its reactivation. Sen B, Chakraborty A, Datta R, Bhattacharyya D, Datta AK. Biochemistry 2006, 45, 263-71.

Homology-model-guided site-specific mutagenesis reveals the mechanisms of substrate binding and product-regulation of adenosine kinase from Leishmania donovani. Datta R, Das I, Sen B, Chakraborty A, Adak S, Mandal C, Datta AK. Biochem J. 2006, 394, 35-42.

2005

Mutational analysis of the active-site residues crucial for catalytic activity of adenosine kinase from Leishmania donovani. Datta R, Das I, Sen B, Chakraborty A, Adak S, Mandal C, Datta AK. Biochem J. 2005, 387, 591-600.

2004

Isomerase-independent chaperone function of cyclophilin ensures aggregation prevention of adenosine kinase both in vitro and under in vivo conditions. Chakraborty A, Sen B, Datta R, Datta AK. Biochemistry. 2004, 43, 11862-72.

2002

A single-domain cyclophilin from Leishmania donovani reactivates soluble aggregates of adenosine kinase by isomerase-independent chaperone function. Chakraborty A, Das I, Datta R, Sen B, Bhattacharyya D, Mandal C, Datta AK. J Biol Chem. 2002, 277, 47451-60.