Class of '16

Doctorate of Philosophy

	Ariadna Amador The regulation of sleep and wakefulness by the Rev-Erbs Advisor: Thomas P. Burris, PhD, Professor and Chair, Saint Louis University, Department of Pharmacology and Physiology

	Danielle Barrios-Steed Part I. Origins of Y. pestis Sensitivity to the Arylomycin Antibiotics and the Inhibition of Type I Signal Peptidase Part II. Investigations into the Synergistic Effect of Signal Peptidase Inhibitor and β-lactam co-therapy in MRSA Advisor: Floyd E. Romesberg, PhD, Professor, Department of Chemistry

	Joel William Blanchard Deprogramming Reprogramming: Development and Application of Technology for Altering Cellular Identity Advisor: Kristin Baldwin, PhD, Associate Professor, Department of Molecular and Cellular Neuroscience

	Michael Bollong Chemical Modulation of Cell Fate Advisor: Peter G. Schultz, PhD, Chief Executive Officer; Vice Chair, Board of Trustees; Professor, Department of Chemistry

	Jessica Bruhn Insights into the structural assemblies governing RNA virus transcription and genomic replication Advisor: Erica Ollmann Saphire, PhD, Professor of Immunology, Department of Immunology and Microbial Science

	Melody Campbell High-Throughput and High-Resolution Electron Microscopy Advisor: Bridget Carragher, PhD, Co-Director, New York Structural Biology Center

	Sandip Chatterjee Development of Proteomic Methods for the Functional Characterization of the Human Gut Microbiota Advisor: Dennis W. Wolan, PhD, Assistant Professor, Department of Molecular and Experimental Medicine

	John Chen Modulating the Quality and Secretion of Secreted Proteins using the ER Proteostasis Network Advisor: R. Luke Wiseman, PhD, Assistant Professor, Department of Molecular and Experimental Medicine

	Wentao Chen Enhanced Aromatic Sequons and Sulfur (VI) Fluoride Functional Groups in Biological Systems Advisor: Jeffery W. Kelly, PhD, Professor and Chair, Department of Molecular and Experimental Medicine

	Hai Dao Steroid Synthesis Inspired Methodologies for Selective Olefin Functionalization Advisor: Phil Baran, PhD, Professor, Department of Chemistry

	Christina Dreyton Small Molecule Probes to Study Protein Folding in the Cell Advisor: Paul R. Thompson, PhD, Professor, University of Massachusetts, Department of Biochemistry and Molecular Pharmacology Introduction: William R. Roush, PhD, Associate Dean of Graduate Studies, Florida; Professor, Department of Chemistry

	Francisco Garcia Expanding the Chemical Tool Kit for the Detection of Redox Regulated Protein Tyrosine Phosphatases Advisor: Kate Carroll, PhD, Associate Professor, Department of Chemistry

	Ryan Gianatassio Enabling Tools for Medicinal Chemistry Through C-H Functionalization and Strain Release Amination Advisor: Phil Baran, PhD, Professor, Department of Chemistry

	Kimberly Hartfield Functional Insights from Structural Analyses of Light- or Redox-Active Flavo- and Metalloproteins Advisor: C. David Stout, PhD, Associate Professor, Department of Integrative Structural and Computational Biology Introduction: Elizabeth Getzoff, PhD, Professor, Department of Integrative Structural and Computational Biology

	Cody James Higginson Functional Materials Based on Oxanorbornadiene Cleavable Linkers Advisor: M.G. Finn, PhD, Professor and Chair, Department of Chemistry and Biochemistry, Georgia Institute of Technology

	Jonathan Hulce Chemical Probes of Lipid Binding and Metabolizing Proteins Advisor: Benjamin Cravatt, PhD, Professor and Chair, Department of Chemical Physiology

	Daniel Jansen Potent Cytotoxins and HAT Hydrogenation through the Exploration of Asmarine Alkaloids Advisor: Ryan A. Shenvi, PhD, Associate Professor, Department of Chemistry

	Hyun-Yong Jin Function and Mechanism of MicroRNA-17~92 in B cells Advisor: Changchun Xiao, PhD, Associate Professor, Department of Immunology and Microbial Science

	Jiun-I Lai Transcriptional Profiling in Isogenic iPSC-Derived Friedreich’s Ataxia Neurons Advisor: Joel Gottesfeld, PhD, Professor, Department of Cell and Molecular Biology

	Sarah E. Leboeuf Sirtuin 5 Regulates Glucose and Glutamine Metabolism and Tumor Progression in Breast Cancer Advisor: Brunhilde Felding, PhD, Associate Professor, Department of Chemical Physiology

	Jeong Hyun Lee Structural Characterization of Broadly Neutralizing Quaternary Epitopes on the HIV-1 Envelope Glycoprotein Advisors: Andrew Ward, PhD, Associate Professor, Department of Integrative Structural and Computational Biology; Ian Wilson, PhD, Professor and Chair, Department of Integrative Structural and Computational Biology

	Xiaotian Lin ‘Self’ vs. ‘Non-Self’ Discrimination by the Immune System in Type 1 Diabetes Advisor: Linda A. Sherman, PhD, Professor, Department of Immunology and Microbial Science Introduction: Bruce Torbett, PhD, Professor, Department of Molecular and Experimental Medicine

	Yu Liu Small Molecule Probes to Study Protein Folding in the Cell Advisor: Jeffery W. Kelly, PhD, Professor and Chair, Department of Molecular and Experimental Medicine

	Xiaozhou Luo Chemical Biology Approaches to Novel Antibiotics and Vaccines Advisor: Peter G. Schultz, PhD, Chief Executive Officer; Vice Chair, Board of Trustees; Professor, Department of Chemistry

	Charles Daniel Murin Of Mice and Men: Investigating Antibody-mediated Immune Responses to Filoviruses by Electron Microscopy Advisors: Andrew Ward, PhD, Associate Professor, Department of Integrative Structural and Computational Biology; Erica Ollmann Saphire, PhD, Professor of Immunology, Department of Immunology and Microbial Science

	Lee Pedzisa Interrogating the Molecular Importance of the Protein Arginine Deiminase Family Advisor: William R. Roush, PhD, Associate Dean of Graduate Studies, Florida; Professor, Department of Chemistry

	Thomas Kelly Rainbolt The Activity and Regulation of Proteolysis in Mitochondrial Quality Control Advisor: R. Luke Wiseman, PhD, Assistant Professor, Department of Molecular and Experimental Medicine

	Brandon R. Rosen I. C–H Functionalization Logic Enables a Synthesis of (+)-Hongoquercin A II. Total Synthesis of Dixiamycin B by Electrochemical Oxidation III. Electrochemical Allylic C–H Oxidation Advisor: Phil S. Baran, PhD, Professor, Department of Chemistry

	Igor Rupniewski The Evolution of an Intein Domain for the Ephemeral Expression of a Peptide Sequence Advisor: M.G. Finn, PhD, Professor and Chair, Department of Chemistry and Biochemistry, Georgia Institute of Technology

	Justin Edward Sears I. New Insights into the Mechanism of the Fe(III)-Promoted Vinblastine Coupling II. Next Generation Synthesis of Vindoline via the [4 + 2]/[3 + 2] Cycloaddition Reaction Cascade of an Allene Dienophile Advisor: Dale L. Boger, PhD, Professor and Chair, Department of Chemistry

	Joshua Max Silverman Economics of the Bacterial Proteome Advisor: James R. Williamson, PhD, Vice President of Academic Affairs; Dean of Graduate and Postdoctoral Studies; Professor, Department of Integrative Structural and Computational Biology

	Sadichha Sitaula Regulation of Cholesterol Biosynthesis, Inflammation and Atherosclerosis by Nuclear Receptor REV-ERB Advisor: Thomas P. Burris, PhD, Professor and Chair, Saint Louis University, Department of Pharmacology and Physiology

	Benjamin Stein Development and Application of Proteomic Platforms to Annotate Protein Interaction and Signaling Dynamics Advisor: John Yates III, PhD, Professor, Department of Integrative Structural and Computational Biology Introduction: Reuben Shaw, PhD, Professor, Salk Institute, Molecular and Cell Biology Laboratory

	Lukas Susac NMR Studies of GPCR Structure and Function Advisor: Kurt Wüthrich, PhD, Professor, Department of Integrative Structural and Computational Biology

	Martin Gregory Tabor Development of a Practical Hydroamination Transform for use in Complex Synthesis Advisor: Ryan A. Shenvi, PhD, Associate Professor, Department of Chemistry

	Kanny Ka Kei Wan Potent cytotoxins and HAT hydrogenation through the Exploration of Asmarine Alkaloids Advisor: Ryan A. Shenvi, PhD, Associate Professor, Department of Chemistry

	Nathan C. Wilde The Two-Phase Synthesis of Taxane Natural Products: Developing the Tools for the Oxidase Phase Advisor: Phil S. Baran, PhD, Professor, Department of Chemistry

	Maben Ying Pursuing Reidispongiolide A: Studies on the Total Synthesis and Design and Synthesis of Natural Product Mimics Advisor: William R. Roush, PhD, Associate Dean of Graduate Studies, Florida; Professor, Department of Chemistry