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Scripps Laboratories for tRNA Synthetase Research

Weiwei He

Photo of Weiwei He

M.S. (2004-2007) - Biochemistry and Molecular Biology
University of Science and Technology of China (USTC)
Hefei, Anhui, P.R. China

B.S. (1999-2003) - Biochemistry and Molecular Biology
Shantou University
Shantou, Guangdong, P.R. China

Current Research Focus

GlyRS and TyrRS are the only two of 20 aminoacyl tRNA synthetases associated with Charcot-Marie-Tooth (CMT) disease. Up to date, at least 10 different mutations in GlyRS gene were identified with CMT2D disease. 3 different mutations in TyrRS gene were identified with DI-CMTC disease. Despite many efforts, the connection between these two tRNA synthetases and CMT still remains not clear. My project mainly focuses on try to understand molecular mechanism of mutant GlyRS in CMT-2D disease from cellular and structural aspects.

Publications

Xiaopeng Zhou, Yali Han, and Weiwei He. RAPD in Thais clavigera Mechanism study of distortion--Application of RAPD on the study of imposex mechanism in Thais Clavigera. Marine Environmental Science, 2004 Vol.23 No.4: 31-34 (Chinese)

Weiwei He, Yi Wang, Wei Liu and Cong-Zhao Zhou. Crystal structure of Saccharomyces cerevisiae 6-phosphogluconate dehydrogenase Gnd1. BMC Structural Biology 2007, 7:38 (14 June 2007)

Conference presentations

Weiwei He and Cong-Zhao Zhou. Crystal Structure of Yeast 6-Phosphogluconate Dehydrogenase 6PGDH/Gnd1. International Conference on Structural Genomics, Beijing, China. October, 2006.

Wei Zhang, Weiwei He, Mir Hussain Nawaz, Paul Schimmel and Xiang-Lei Yang. Charcot-Marie-Tooth disease-causing mutations in human-tRNA synthetase induce Daxx-mediated neuronal cell apoptosis. International conference on aminoacyl-tRNA synthetases: From basic mechanisms to systems biology. (aaRS2008) Veyrier du Lac, France. September, 2008.

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