Yagi Lab Home Page

2011 - present

Sato, M., Sinha, P. K., Torres-Bacete, J., Matsuno-Yagi, A., and Yagi, T. (2013) Energy transducing roles of antiporter-like subunits in E. coli NDH-1 with main focus on subunit NuoN (ND2) J. Biol. Chem. 288:24705-24716. [PM:23864658]
Marella, M., Patki, G., Matsuno-Yagi, A., and Yagi, T. (2013) Complex I inhibition in the visual pathway induces disorganization of the node of Ranvier Neurobiol.Dis. 58:281-288. [PM:23816754]
Ferris, C. F., Marella, M., Smerkers, B., Barchet, T. M., Gershman, B., Matsuno-Yagi, A., and Yagi, T. (2013) A phenotypic model recapitulating the neuropathology of Parkinson's disease Brain Behavior 3:351-366. [ Open access]
Santidrian, A. F., Matsuno-Yagi, A., Ritland, M., Seo, B. B., Leboeuf, S. E., Gay, L. J., Yagi, T., and Felding-Habermann, B. (2013) Mitochondrial complex I activity and NAD⁺/NADH balance regulate breast cancer progression. J. Clin. Invest 123:1068-1081. [PM:23426180]
Torres-Bacete, J., Sinha, P. K., Sato, M., Patki, G., Kao, M. C., Matsuno-Yagi, A., and Yagi, T. (2012) Roles of Subunit NuoK (ND4L) in the Energy Transducing Mechanism of E. coli NDH-1 (NADH:quinone oxidoreductase). J. Biol. Chem. 287:42763-42772. [PM:23105119]
Iwata, M., Lee, Y., Yamashita, T., Yagi, T., Iwata, S., Cameron, A.D., and Maher, M.J. (2012) The structure of the yeast NADH dehydrogenase (Ndi1) reveals overlapping binding sites for water- and lipid-soluble substrates Proc Natl Acad Sci U S A. 109:15247-15252. [PM:22949654]
Sinha, P. K., Nakamaru-Ogiso, E., Torres-Bacete, J., Sato, M., Castro-Guerrero, N., Ohnishi, T., Matsuno-Yagi, A., and Yagi, T. (2012) Electron Transfer in subunit NuoI (TYKY) of Escherichia coli NDH-1 (NADH:quinone oxidoreductase) J. Biol.Chem. 287:17363-17373. 2012. [PM:22474289]
Marella, M., Seo, B. B., Flotte, T. R., Matsuno-Yagi, A., and Yagi, T. (2011) No immune response by the expression of the yeast Ndi1 protein in rats PloS One 6:e25910. [PM:21991386]
Torres-Bacete, J., Sinha, P. K., Matsuno-Yagi, A., Yagi, T. (2011) Structural contribution of the C-terminal segments of NuoL (ND5) and NuoM (ND4) subunits of complex I from E. coli J. Biol. Chem. 286:34007-34014. [PM:21835926]
Yang, Y., Yamashita, T., Nakamaru-Ogiso, E., Hashimoto, T., Murai, M., Igarashi, J., Miyoshi, H., Mori, N., Matsuno-Yagi, A., Yagi, T., Kosaka, H. (2011) Reaction mechanism of single subunit NADH-ubiquinone oxidoreductase (Ndi1) from Saccharomyces cerevisiae: evidence for a ternary complex mechanism J. Biol. Chem. 286:9287-9297. [PM:21220430]

2006 - 2010

Barber-Singh, J., Seo, B. B., Matsuno-Yagi, A., and Yagi, T. (2010) Protective Role of rAAV-NDI1, serotype 5, in an Acute MPTP Mouse Parkinson's Model Parkinson's Disease 2011:438370. [PM:21188192] Online article
Castro-Guerrero, N., Sinha, P. K., Torres-Bacete, J., Matsuno-Yagi, A., and Yagi, T. (2010) Pivotal Roles of Three Conserved Carboxyl Residues of NuoC (30k) Segment in the Structural Integrity of Proton-translocating NADH-Quinone Oxidoreductase (NDH-1) from Escherichia coli Biochemistry 49:10072-10080. [PM:20979355]
Nakamaru-Ogiso., E, Kao, M. C., Chen, H., Sinha, S. C., Yagi, T., and Ohnishi, T. (2010) The membrane subunit NuoL(ND5) is involved in the indirect proton pumping mechanism of E. coli complex I J. Biol. Chem. 285:39070-39078. [PM:20826797]
Marella, M., Seo, B. B., Thomas, B. B., Matsuno-Yagi, A., and Yagi, T. (2010) Successful amelioration of mitochondrial optic neuropathy using the yeast NDI1 gene in a rat animal model PLoS One 5: e11472. [PM:20628600] Online article
Sanz, A., Soikkeli, M., Portero-Otín, M., Wilson, A., Kemppainen, E., McIlroy, G., Ellilä, S., Kemppainen, K. K., Tuomela, T., Lakanmaa, M., Kiviranta, E., Stefanatos, R., Dufour, E., Hutz, B., Naudí, A., Jové, M., Zeb, A., Vartiainen, S., Matsuno-Yagi, A., Yagi, T., Rustin, P., Pamplon, R., Jacobs, H. T. (2010) Expression of the yeast NADH dehydrogenase Ndi1 in Drosophila confers increased lifespan independently of dietary restriction Proc Natl Acad Sci U S A. 107:9105-9110. [PM:20435911]
Murai, M., Yamashita, T., Senoh, M., Mashimo, Y., Kataoka, M., Kosaka, H., Matsuno-Yagi, A., Yagi, T., and Miyoshi, H. (2010) Characterization of the Ubiquinone Binding Site in Alternative NADH-Quinone Oxidoreductase of Saccharomyces cerevisiae by Photoaffinity Labeling Biochemistry 49:2973-2980. [PM:20192260]
Nakamaru-Ogiso, E., Han, H., Matsuno-Yagi, A., Keinan, E., Sinha, S. C., Yagi, T., and Ohnishi, T. (2010) The ND2 subunit was labeled by a photoaffinity analogue of asimicin, a potent complex I inhibitor FEBS Lett. 584:883-888. [PM:20074573]
Sinha, P. K., Castro-Guerrero, N., Matsuno-Yagi, A., Yagi, T., and Torres-Bacete, J. (2009) Bacterial complex I (NDH-1): Functional roles of the hydrophobic domain Current Topics in Biochemical Research 11:79-90. [Abstract]
Marella, M., Seo, B. B., Yagi, T., and Matsuno-Yagi, A. (2009) Parkinson's disease and mitochondrial complex I: A perspective on the Ndi1 therapy J. Bioenerg. Biomembr. 41:493-497. [PM:19904590]
Torres-Bacete, J., Sinha, P. K., Castro-Guerrero, N., Matsuno-Yagi, A., and Yagi, T. (2009) Features of Subunit NuoM (ND4) in Escherichia coli NDH-1: Topology and implications of conserved Glu144 for coupling site 1 J. Biol. Chem. 284:33062-33069. [PM:19815558]
Barber-Singh, J., Seo, B. B., Nakamaru-Ogiso, E., Lau, Y. S., Matsuno-Yagi, A., and Yagi, T. (2009) Neuroprotective effect of long-term NDI1 gene expression in a chronic mouse model of Parkinson's disorder, Rejuvenation Res. 12:259-267. [PM:19653878]
Sinha, P. K., Torres-Bacete, J., Nakamaru-Ogiso, E., Castro-Guerrero, N., Matsuno-Yagi, A., and Yagi, T. (2009) Critical roles of subunit NuoH (ND1) in the assembly of peripheral subunits with the membrane domain of Escherichia coli NDH-1 J. Biol. Chem. 284:9814-9823. [PM:19189973]
Ichimaru, N., Murai, M., Kakutani, N., Kako, J., Ishihara, A., Nakagawa, Y., Nishioka, T., Yagi, T., and Miyoshi, H. (2008) Synthesis and Characterization of New Piperazine-Type Inhibitors for Mitochondrial NADH-Ubiquinone Oxidoreductase (Complex I) Biochemistry 47:10816-10826. [PM:18781777]
Nakamaru-Ogiso, E., Matsuno-Yagi, A., Yoshikawa, S., Yagi, T., and Ohnishi, T. (2008) Iron-sulfur cluster N5 is coordinated by a HXXXCXXCXXXXXC motif in the nuog subunit of E. coli NADH:Quinone oxidoreductase (complex I) J. Biol. Chem. 283:25979-25987. [PM:18603533]
Marella, M., Seo, B. B., Nakamaru-Ogiso, E., Greenamyre, J. T., Matsuno-Yagi, A., and Yagi, T. (2008) Protection by the NDI1 Gene against Neurodegeneration in a Rotenone Rat Model of Parkinson's Disease PLoS ONE 3:e1433. [PM:18197244] Online article
Torres-Bacete, J., Nakamaru-Ogiso, E., Matsuno-Yagi, A., and Yagi, T. (2007) Characterization of the NuoM (ND4) subunit in Escherichia coli NDH-1: Conserved charged residues essential for energy-coupled activities J. Biol. Chem. 282:36914-36922. [PM:17977822]
Marella, M., Seo, B. B., Matsuno-Yagi, A., and Yagi, T. (2007) Mechanism of cell death caused by complex I defects in a rat dopaminergic cell line J. Biol. Chem. 282:24146-24156. [PM:17581813]
Escobar-Khondiker, M., Höllerhage, M., Muriel, M.-P., Champy, P., Bach, A., Depienne, C., Respondek, G., Yamada, E. S., Lannuzel, A., Yagi, T., Hirsch, E. C., Oertel, W. H., Jacob, R., Michel, P. P., Ruberg, M., and Höglinger, G. U. (2007) Annonacin, a natural mitochondrial complex I inhibitor, causes tau pathology in cultured neurons. J. Neurosci. 27:7827-7837. [PM:17634376]
Murai, M., Ishihara, A., Nishioka, T., Yagi, T., and Miyoshi, H. (2007) The ND1 Subunit Constructs Inhibitor Binding Domain in Bovine Heart Mitochondrial Complex I. Biochemistry 46:6409-6416. [PM:17474759]
Yamashita, T., Nakamaru-Ogiso, E., Miyoshi, H., Matsuno-Yagi, A., and Yagi, T. (2007) Roles of bound quinone in the single subunit NADH-quinone oxidoreductase (Ndi1) from Saccharomyces cerevisiae. J. Biol. Chem. 282:6012-6020. [PM:17200125]
Richardson, J. R., Caudle, W. M., Guillot, T. S., Watson, J. L., Nakamaru-Ogiso, E., Seo, B. B., Sherer, T. B., Greenamyre, J. T., Yagi, T., Matsuno-Yagi, A., and Miller, G. W. (2007) Obligatory Role For Complex I Inhibition in the Dopaminergic Neurotoxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Toxicol. Sci. 95:196-204. [PM:17038483]
Sherer, T. B., Richardson, J. R., Testa, C. M., Seo, B. B., Panov, A. V., Yagi, T., Matsuno-Yagi, A., Miller, G. W., and Greenamyre, J. T. (2007) Mechanism of Toxicity of Pesticides Acting at Complex I: Relevance to Environmental Etiologies of Parkinson's Disease. J. Neurochem. 100:1469-1479. [PM:17241123]
Seo, B. B., Marella, M., Yagi, T., and Matsuno-Yagi, A. (2006) The single subunit NADH dehydrogenase reduces generation of reactive oxygen species from complex I. FEBS Lett. 580:6105-6108. [PM:17055488]
Schnermann, M. J., Romero, A., Hwang, I., Nakamaru-Ogiso, E., Yagi, T., and Boger, D. L. (2006) Total synthesis of piericidin A1 and B1 and key analogues. J. Am. Chem. Soc. 128:11799-11807. [PM:16953619]
Seo, B. B., Nakamaru-Ogiso, E., Flotte, T. R., Matsuno-Yagi, A., and Yagi, T. (2006) In vivo complementation of complex I by the yeast Ndi1 enzyme: possible application for treatment of Parkinson's disease. J. Biol. Chem. 281:14250-14255. [PM:16543240]
Yagi, T., Seo, B. B., Nakamaru-Ogiso, E., Marella, M., Barber-Singh, J., Yamashita, T., Kao, M.-C., and Matsuno-Yagi, A. (2006) Can a Single Subunit Yeast NADH Dehydrogenase (Ndi1) Remedy Diseases Caused by Respiratory Complex I Defects? Rejuvenation Res. 9:191-197. [PM:16706641]
Yagi, T., Seo, B. B., Nakamaru-Ogiso, E., Marella, M., Barber-Singh, J., Yamashita, T., and Matsuno-Yagi, A. (2006) Possibility of Transkingdom Gene Therapy for Complex I Diseases. Biochim. Biophys. Acta 1757:708-714. [PM:16581014]
Betarbet, R., Canet-Aviles, R. M., Sherer, T. B., Mastroberardino, P. G., McLendon, C., Kim, J. H., Lund, S., Na, H. M., Taylor, G., Bence, N. F., Kopito, R., Seo, B. B., Yagi, T., Yagi, A., Klinefelter, G., Cookson, M. R., and Greenamyre, J. T. (2006) Intersecting pathways to neurodegeneration in Parkinson's disease: Effects of the pesticide rotenone on DJ-1, α-synuclein, and the ubiquitin-proteasome system. Neurobiol. Dis. 22:404-420. [PM:16439141]

2001 - 2005

Kao, M.-C., S., Nakamaru-Ogiso, E., Matsuno-Yagi, A., and Yagi, T. (2005) Characterization of the Membrane Domain Subunit NuoK (ND4L) of the NADH-Quinone Oxidoreductase from Escherichia coli . Biochemistry 44:9545-9554. [PM:15996109]
Velazquez, I., Nakamaru-Ogiso, E., Yano, T., Ohnishi, T., and Yagi, T. (2005) Amino acid residues associated with cluster N3 in the NuoF subunit of the proton-translocating NADH-quinone oxidoreductase from Escherichia coli. FEBS Lett. 579:3164-3168. [PM:15922336].
Kao, M.-C., Di Bernardo, S., Nakamaru-Ogiso, E., Miyoshi, H., Matsuno-Yagi, A., and Yagi, T. (2005) Characterization of the Membrane Domain Subunit NuoJ (ND6) of the NADH-Quinone Oxidoreductase from Escherichia coli by Chromosomal DNA Manipulation. Biochemistry 44:3562-3571. [PM:15736965].
Nakamaru-Ogiso, E., Yano, T., Yagi, T., and Ohnishi, T. (2005) Characterization of the iron-sulfur cluster N7(N1c) in the subunit NuoG of the proton-translocating NADH-quinone oxidoreductase from Escherichia coli. J. Biol. Chem. 280:301-307. [PM:15520003].
Seo, B. B., Nakamaru-Ogiso, E., Cruz, P., Flotte, T. R., Yagi, T., and Matsuno-Yagi, A. (2004) Functional Expression of the Single Subunit NADH Dehydrogenase in Mitochondria In Vivo: A Potential Therapy for Complex I Deficiencies. Hum. Gene Ther. 15:887-895. [PM:15353043].
Kao, M.-C., Di Bernardo, S., Perego, M., Nakamaru-Ogiso, E., Matsuno-Yagi, A., and Yagi, T. (2004) Functional roles of four conserved charged residues in the membrane domain subunit NuoA of the proton-translocating NADH-quinone oxidoreductase from Escherichia coli. J. Biol. Chem. 279:32360-32366. [PM:15175326].
Bai, Y., Hu, P., Park, J. S., Deng, J. H., Song, X., Chomyn, A., Yagi, T., and Attardi, G. (2004) Genetic and Functional Analysis of Mitochondrial DNA-Encoded Complex I Genes. Ann. N. Y. Acad. Sci. 1011:272-283. [PM:15126303].
Kao, M.-C., Matsuno-Yagi, A., and Yagi, T. (2004) Subunit Proximity in the H⁺-Translocating NADH-Quinone Oxidoreductase Probed by Zero-Length Cross-Linking. Biochemistry 43:3750-3755. [PM:15035646].
Stroh, A., Anderka, O., Pfeiffer, K., Yagi, T., Finel, M., Ludwig, B., and Schagger, H. (2004) Assembly of respiratory complexes I, III, and IV into NADH oxidase supercomplex stabilizes complex I in Paracoccus denitrificans. J. Biol. Chem. 279:5000-5007. [PM:14610094].
Yagi, T., Di Bernaldo, S., Nakamaru-Ogiso, E., Kao, M.-C., Seo, B.B., and Matsuno-Yagi, A. (2004) NADH Dehydrogenease (NADH-Quinone Oxidoreductase). in Respiration in Archaea and Bacteria. (ed: Zannoni, D.) pp15-40, Kluwer Publishings, Dordrecht.
Kao, M.-C., Di Bernardo, S., Matsuno-Yagi, A., and Yagi, T. (2003) Characterization and topology of the membrane domain Nqo10 subunit of the proton-translocating NADH-quinone oxidoreductase of Paracoccus denitrificans. Biochemistry 42:4534-4543. [PM:12693950].
Nakamaru-Ogiso, E., Sakamoto, K., Matsuno-Yagi, A., Miyoshi, H., and Yagi, T. (2003) The ND5 subunit was labeled by a photoaffinity analogue of fenpyroximate in bovine mitochondrial complex I. Biochemistry 42:746-754. [PM:12534287].
Nakamaru-Ogiso, E., Seo, B. B., Yagi, T., and Matsuno-Yagi, A. (2003) Amiloride inhibition of the proton-translocating NADH-quinone oxidoreductase of mammals and bacteria. FEBS Lett. 549:43-46. [PM:12914922].
Sherer, T. B., Betarbet, R., Testa, C. M., Seo, B. B., Richardson, J. R., Kim, J. H., Miller, G. W., Yagi, T., Matsuno-Yagi, A., and Greenamyre, J. T. (2003) Mechanism of toxicity in rotenone models of Parkinson's disease. J. Neurosci. 23:10756-10764. [PM:14645467].
Yagi, T. and Matsuno-Yagi, A. (2003) The proton-translocating NADH-quinone oxidoreductase in the respiratory chain: The secret unlocked. Biochemistry 42:2266-2274. [PM:12600193].
Yano, T., Sklar, J., Nakamaru-Ogiso, E., Takahashi, Y., Yagi, T., and Ohnishi, T. (2003) Characterization of cluster N5 as a fast-relaxing [4Fe-4S] cluster in the Nqo3 subunit of the proton-translocating NADH-ubiquinone oxidoreductase from Paracoccus denitrificans. J. Biol. Chem. 278:15514-15522. [PM:12600982].
Kao, M.-C., Di Bernardo, S., Matsuno-Yagi, A., and Yagi, T. (2002) Characterization of the membrane domain Nqo11 subunit of the proton-translocating NADH-quinone oxidoreductase of Paracoccus denitrificans. Biochemistry 41:4377-4384. [PM:11914084].
Nakamaru-Ogiso, E., Yano, T., Ohnishi, T., and Yagi, T. (2002) Characterization of the iron-sulfur cluster coordinated by a cysteine cluster motif (CxxCxxxCx₂₇C) in Nqo3 subunit in the proton-translocating NADH-quinone oxidoreductase (NDH-1) of Thermus thermophilus HB-8. J. Biol. Chem. 277:1680-1688. [PM:11704668].
Seo, B. B., Nakamaru-Ogiso, E., Flotte, T. R., Yagi, T., and Matsuno-Yagi, A. (2002) A single-subunit NADH-quinone oxidoreductase renders resistance to mammalian nerve cells against complex I inhibition. Mol. Ther. 6:336-341. [PM:12231169].
Zu, Y., Di Bernardo, S., Yagi, T., and Hirst, J. (2002) Redox properties of the [2Fe-2S] center in the 24 kDa (NQO2) subunit of NADH:ubiquinone oxidoreductase (complex I). Biochemistry 41:10056-10069. [PM:12146970].
Bai, Y., Hajek, P., Chomyn, A., Chan, E., Seo, B. B., Matsuno-Yagi, A., Yagi, T., and Attardi, G. (2001) Lack of complex I activity in human cells carrying a mutation in mtDNA-encoded ND4 subunit is corrected by the Saccharomyces cerevisiae NADH-quinone oxidoreductase (NDI1) gene. J. Biol. Chem. 276:38808-38813. [PM:11479321].
Di Bernardo, S. and Yagi, T. (2001) Direct interaction between a membrane domain subunit and a connector subunit in the H⁺-translocating NADH-quinone oxidoreductase. FEBS Lett. 508:385-388. [PM:11728457].
Matsuno-Yagi, A. and Yagi, T. (2001) Introduction: complex I -- an L-shaped black box. J. Bioenerg. Biomembr. 33:155-157. [PM:11695824].
Yagi, T., Seo, B. B., Di Bernardo, S., Nakamaru-Ogiso, E., Kao, M.-C., and Matsuno-Yagi, A. (2001) NADH dehydrogenases: From basic science to biomedicine. J. Bioenerg. Biomembr. 33:233-242. [PM:11695833].

1996 - 2000

Di Bernardo, S., Yano, T., and Yagi, T. (2000) Exploring the membrane domain of the reduced nicotinamide adenine dinucleotide-quinone oxidoreductase of Paracoccus denitrificans: Characterization of the NQO7 subunit. Biochemistry 39:9411-9418. [PM:10924136].
Seo, B. B., Wang, J., Flotte, T. R., Yagi, T., and Matsuno-Yagi, A. (2000) Use of the NADH-Quinone oxidoreductase (NDI1) gene of Saccharomyces cerevisiae as a possible cure for complex I defects in human cells. J. Biol. Chem. 275:37774-37778. [PM:10982813].
Au, H. C., Seo, B. B., Matsuno-Yagi, A., Yagi, T., and Scheffler, I. E. (1999) The NDUFA1 gene product (MWFE protein) is essential for activity of complex I in mammalian mitochondria. Proc. Natl. Acad. Sci. U. S. A. 96:4354-4359. [PM:10200266].
Ohnishi, T., Magnitsky, S., Toulokhonova, L., Yano, T., Yagi, T., Burbaev, D. S., and Vinogradov, A. D. (1999) EPR studies of the possible binding sites of the cluster N2, semiquinones, and specific inhibitors of the NADH:quinone oxidoreductase (complex I). Biochem. Soc. Trans. 27:586-591. [PM:10917647].
Schuler, F., Yano, T., Di Bernardo, S., Yagi, T., Yankovskaya, V., Singer, T. P., and Casida, J. E. (1999) NADH-quinone oxidoreductase: PSST subunit couples electron transfer from iron-sulfur cluster N2 to quinone. Proc. Natl. Acad. Sci. U. S. A 96:4149-4153. [PM:10097178].
Seo, B. B., Matsuno-Yagi, A., and Yagi, T. (1999) Modulation of oxidative phosphorylation of human kidney 293 cells by transfection with the internal rotenone-insensitive NADH-quinone oxidoreductase (NDI1) gene of Saccharomyces cerevisiae. Biochim. Biophys. Acta 1412:56-65. [PM:10354494].
Yano, T., Magnitsky, S., Sled', V. D., Ohnishi, T., and Yagi, T. (1999) Characterization of the putative 2x[4Fe-4S] binding NQO9 subunit of the proton-translocating NADH-quinone oxidoreductase (NDH-1) of Paracoccus denitrificans: Expression, reconstitution, and EPR characterization. J. Biol. Chem. 274:28598-28605. [PM:10497226].
Yano, T. and Yagi, T. (1999) H⁺-translocating NADH-quinone oxidoreductase (NDH-1) of Paracoccus denitrificans: Studies on topology and stoichiometry of the peripheral subunits. J. Biol. Chem. 274:28606-28611. [PM:10497227].
Kitajima-Ihara, T. and Yagi, T. (1998) Rotenone-insensitive internal NADH-quinone oxidoreductase of Saccharomyces cerevisiae mitochondria: the enzyme expressed in Escherichia coli acts as a member of the respiratory chain in the host cells. FEBS Lett. 421:37-40. [PM:9462835].
Ohnishi, T., Sled, V. D., Yano, T., Yagi, T., Burbaev, D. S., and Vinogradov, A. D. (1998) Structure-function studies of iron-sulfur clusters and semiquinones in the NADH-Q oxidoreductase segment of the respiratory chain. Biochim. Biophys. Acta 1365:301-308. [PM:9693742].
Ohshima, M., Miyoshi, H., Sakamoto, K., Takegami, K., Iwata, J., Kuwabara, K., Iwamura, H., and Yagi, T. (1998) Characterization of the ubiquinone reduction site of mitochondrial complex I using bulky synthetic ubiquinones. Biochemistry 37:6436-6445. [PM:9572861].
Seo, B. B., Kitajima-Ihara, T., Chan, E. K., Scheffler, I. E., Matsuno-Yagi, A., and Yagi, T. (1998) Molecular remedy of complex I defects: Rotenone-insensitive internal NADH-quinone oxidoreductase of Saccharomyces cerevisiae mitochondria restores the NADH oxidase activity of complex I-deficient mammalian cells. Proc. Natl. Acad. Sci. U. S. A 95:9167-9171. [PM:9689052].
Yagi, T., Yano, T., Di Bernardo, S., and Matsuno-Yagi, A. (1998) Procaryotic complex I (NDH-1), an overview. Biochim. Biophys. Acta 1364:125-133. [PM:9593856].
Yano, T., Chu, S. S., Sled', V. D., Ohnishi, T., and Yagi, T. (1997) The proton-translocating NADH-quinone oxidoreductase (NDH-1) of thermophilic bacterium Thermus thermophilus HB-8: Complete DNA sequence of the gene cluster and thermostable properties of the expressed NQO2 subunit. J. Biol. Chem. 272:4201-4211. [PM:9020134].
Takano, S., Yano, T., and Yagi, T. (1996) Structural studies of the proton-translocating NADH-quinone oxidoreductase (NDH-1) of Paracoccus denitrificans: Identity, property, and stoichiometry of the peripheral subunits. Biochemistry 35:9120-9127. [PM:8703916].
Yano, T., Sled, V. D., Ohnishi, T., and Yagi, T. (1996) Expression and characterization of the flavoprotein subcomplex composed of 50-kDa (NQO1) and 25-kDa (NQO2) subunits of the proton-translocating NADH-quinone oxidoreductase of Paracoccus denitrificans. J. Biol. Chem. 271:5907-5913. [PM:8621464].

1991 - 1995

Yano, T., Yagi, T., Sled', V. D., and Ohnishi, T. (1995) Expression and characterization of the 66-kilodalton (NQO3) iron-sulfur subunit of the proton-translocating NADH-quinone oxidoreductase of Paracoccus denitrificans. J. Biol. Chem. 270:18264-18270. [PM:7629145].
Crouse, B. R., Yano, T., Finnegan, M. G., Yagi, T., and Johnson, M. K. (1994) Properties of the iron-sulfur center in the 25-kilodalton subunit of the proton-translocating NADH-quinone oxidoreductase of Paracoccus denitrificans. J. Biol. Chem. 269:21030-21036. [PM:8063721].
Ohnishi, T., Meinhardt, S. W., Von Jagow, G., Yagi, T., and Hatefi, Y. (1994) Effect of ethoxyformic anhydride on the Rieske iron-sulfur protein of bovine heart ubiquinol: Cytochrome c oxidoreductase. FEBS Lett. 353:103-107.
Ohnishi, T., Sled, V. D., Rudnitzky, N. I., Meinhardt, S. W., Yagi, T., Hatefi, Y., Link, T., Von Jagow, G., Saribas, A. S., and Daldal, F. (1994) Topographical distribution of redox centres and the Q_o site in ubiquinol-cytochrome-c oxidoreductase (complex III) and ligand structure of the Rieske iron-sulphur cluster. Biochem. Soc. Trans. 22:191-197.
Yano, T., Sled, V. D., Ohnishi, T., and Yagi, T. (1994) Identification of amino acid residues associated with the [2Fe-2S] cluster of the 25 kDa (NQO2) subunit of the proton- translocating NADH-quinone oxidoreductase of Paracoccus denitrificans. FEBS Lett. 354:160-164. [PM:7957917].
Yano, T., Sled', V. D., Ohnishi, T., and Yagi, T. (1994) Expression of the 25 kilodalton iron-sulfur subunit of the energy-transducing NADH-ubiquinone oxidoreductase of Paraccocus denitrificans. Biochemistry 33:494-499. [PM:8286379].
Xu, X., Matsuno-Yagi, A., and Yagi, T. (1993) DNA sequencing of the seven remaining structural genes of the gene cluster encoding the energy-transducing NADH-quinone oxidoreductase of Paracoccus denitrificans. Biochemistry 32:968-981. [PM:8422400].
Yagi, T., Yano, T., and Matsuno-Yagi, A. (1993) Characteristics of the energy-transducing NADH-quinone oxidoreductase of Paracoccus denitrificans as revealed by biochemical, biophysical, and molecular biological approaches. J. Bioenerg. Biomembr. 25:339-345. [PM:8226715].
Yagi, T. (1993) Isolation and characterization of the ND2 polypeptide of the bovine energy-transducing NADH-ubiquinone oxidoreductase (complex I). Biochem. Int. 30:253-260. [PM:8364407].
Yagi, T. (1993) The bacterial energy-transducing NADH-quinone oxidoreductases. Biochim. Biophys. Acta 1141:1-17. [PM:8435434].
Yano, T., Sled, V., Ohnishi, T., and Yagi, T. (1993) Expression of the iron-sulfur cluster binding subunits of the energy-transducing NADH-ubiquinone oxidoreductase (NDH-1) of Paracoccus denitrificans. Biol. Chem. Hoppe Seyler 374:820-
Xu, X., Matsuno-Yagi, A., and Yagi, T. (1992) Structural features of the 66-kDa subunit of the energy-transducing NADH-ubiquinone oxidoreductase (NDH-1) of Paracoccus denitrificans. Arch. Biochem. Biophys. 296:40-48. [PM:1605643].
Xu, X., Matsuno-Yagi, A., and Yagi, T. (1992) Gene cluster of the energy-transducing NADH-quinone oxidoreductase of Paracoccus denitrificans: characterization of four structural gene products. Biochemistry 31:6925-6932. [PM:1637825].
Yagi, T., Xu, X., and Matsuno-Yagi, A. (1992) The energy-transducing NADH-quinone oxidoreductase (NDH-1) of Paracoccus denitrificans. Biochim. Biophys. Acta 1101:181-183. [PM:1633184].
Xu, X. M., Matsuno-Yagi, A., and Yagi, T. (1991) The NADH-binding subunit of the energy-transducing NADH-ubiquinone oxidoreductase of Paracoccus denitrificans: gene cloning and deduced primary structure. Biochemistry 30:6422-6428. [PM:1905152].
Xu, X. M. and Yagi, T. (1991) Identification of the NADH-binding subunit of energy-transducing NADH-quinone oxidoreductase (NDH-1) of Thermus thermophilus HB-8. Biochem. Biophys. Res. Commun. 174:667-672. [PM:1899572].
Xu, X. M., Matsuno-Yagi, A., and Yagi, T. (1991) Characterization of the 25-kilodalton subunit of the energy-transducing NADH-ubiquinone oxidoreductase of Paracoccus denitrificans: sequence similarity to the 24-kilodalton subunit of the flavoprotein fraction of mammalian complex I. Biochemistry 30:8678-8684. [PM:1909571].
Yagi, T., Xu, X., and Matsuno-Yagi, A. (1991) Gene cluster of the energy-transducing NADH-ubiquinone oxidoreductase (NDH-1) of Paracoccus denitrificans. Biol. Chem. Hoppe Seyler 372:555-555.
Yagi, T. (1991) Bacterial NADH-quinone oxidoreductases. J. Bioenerg. Biomembr. 23:211-225. [PM:2050655].

1986 - 1990

Meinhardt, S. W., Wang, D.-C., Hon-nami, K., Yagi, T., Oshima, T., and Ohnishi, T. (1990) Studies on the NADH-menaquinone oxidoreductase segment of the respiratory chain in Thermus thermophilus HB-8. J. Biol. Chem. 265:1360-1368. [PM:2153129].
Yagi, T. (1990) Inhibition by capsaicin of NADH-quinone oxidoreductases is correlated with the presence of energy-coupling site 1 in various organisms. Arch. Biochem. Biophys. 281:305-311. [PM:2118334].
Yagi, T. and Dinh, T. M. (1990) Identification of the NADH-binding subunit of NADH-ubiquinone oxidoreductase of Paracoccus denitrificans. Biochemistry 29:5515-5520. [PM:2117469].
Han, A.-L., Yagi, T., and Hatefi, Y. (1989) Studies on the Structure of NADH:Ubiquinone Oxidoreductase Complex: Topography of the Subunits of the Iron-Sulfur Protein Component. Arch. Biochem. Biophys. 275:166-173. [PM:2510601].
Yagi, T. (1989) Structure and function of NADH-quinone oxidoreductase in respiratory chain. Protein Nucleic Acid Enzyme 34:351-363. [PM:2664898].
Han, A.-L., Yagi, T., and Hatefi, Y. (1988) Studies on the Structure of NADH:Ubiquinone Oxidoreductase Complex: Topography of the Subunits of the Iron-Sulfur Flavoprotein Component. Arch. Biochem. Biophys. 267:490-496. [PM:2463782].
Ohnishi, T., Meinhardt, S. W., Yagi, T., and Oshima, T. (1988) Comparative studies on the NADH-Q oxidoreductase segment of the bacterial respiratory chain. in Advances in Membrane Biochemistry and Bioenergetics (Kim et al. eds.), pp. 237-248, Plenum Press.
Yagi, T. (1988) NADH-ubiquinone oxidoreductase. Biophysics 28:27-30.
Yagi, T. and Hatefi, Y. (1988) Identification of the DCCD-binding subunit of NADH-ubiquinone oxidoreductase (complex I). J. Biol. Chem. 263:16150-16155. [PM:3141400].
Yagi, T., Hon-nami, K., and Ohnishi, T. (1988) Purification and characterization of two types of NADH-quinone reductase from Thermus thermophilus HB-8. Biochemistry 27:2008-2013. [PM:3378042].
Meinhardt, S. W., Kula, T., Yagi, T., Lillich, T., and Ohnishi, T. (1987) EPR characterization of iron-sulfer clusters in the NADH:ubiquinone oxidoreductase segment of the respiratory chain in Paracoccus denitrificans. J. Biol. Chem. 262:9147-9153. [PM:3036849].
Yagi, T. (1987) Inhibition of NADH-ubiquinone reductase activity by N',N'-dicyclohexylcabodiimide and correlation of this inhibition with the occurrence of energy coupling site 1 in various organisms. Biochemistry 26:2822-2828. [PM:3111526].
Yagi, T. (1986) Purification and characterization of NADH dehydrogenase complex from Paracoccus denitrificans. Arch. Biochem. Biophys. 250:302-311. [PM:3096211].