A postdoctoral position is available immediately in the laboratory of Dr. Takao Yagi at The Scripps Research Institute. The successful candidate will participate in studies related to the proton-translocating NADH-quinone oxidoreductase (complex I). Projects include characterization of bacterial systems as models for mitochondrial complex I. In addition to experiments of native expression, we are conducting manipulation of chromosomal genes. Experience in molecular biology and familiality with DNA manipulation are required. More details about the project can be found at the laboratory's web site shown below. Candidates are expected to hold a Ph.D. or M.D. degree.

Interested candidates should send/e-mail curriculum vitae and names of three references to:

Dr. Takao Yagi
The Scripps Research Institute
Department of Molecular & Experimental Medicine
MEM256
10550 N Torrey Pines Rd.
La Jolla, CA 92037
U.S.A.

E-mail: yagi@scripps.edu
Web: http://www.scripps.edu/mem/biochem/yagi/

Representative publications:

Kao, M.-C., Di Bernardo, S., Nakamaru-Ogiso, E., Miyoshi, H., Matsuno-Yagi, A., and Yagi, T. (2005) Characterization of the Membrane Domain Subunit NuoJ (ND6) of the NADH-Quinone Oxidoreductase from Escherichia coli by Chromosomal DNA Manipulation. Biochemistry 44:3562-3571. [PM:15736965].

Nakamaru-Ogiso, E., Yano, T., Yagi, T., and Ohnishi, T. (2005) Characterization of the iron-sulfur cluster N7(N1c) in the subunit NuoG of the proton-translocating NADH-quinone oxidoreductase from Escherichia coli. J. Biol. Chem. 280:301-307. [PM:15520003].

Kao, M.-C., Di Bernardo, S., Perego, M., Nakamaru-Ogiso, E., Matsuno-Yagi, A., and Yagi, T. (2004) Functional roles of four conserved charged residues in the membrane domain subunit NuoA of the proton-translocating NADH-quinone oxidoreductase from Escherichia coli. J. Biol. Chem. 279:32360-32366. [PM:15175326].