Two postdoctoral positions are available immediately in the laboratory of Dr. Takao Yagi at The Scripps Research Institute. The successful candidates will participate in studies related to mitochondrial diseases. Projects include molecular remedy of complex I (NADH-quinone oxidoreductase) deficiencies and Parkinson's disease using the yeast NADH dehydrogenase (Ndi1) as a therapeutic agent. In addition to experiments at the cellular level which produced promising results, in vivo experiments involving mouse and rat models are currently underway in the laboratory. More details about the project can be found at the laboratory's web site shown below. Candidates are expected to hold a Ph.D. or M.D. degree. Experience in cell culture, microscopy and small animal handling would be valuable.
Interested candidates should send/e-mail curriculum vitae and names of three references to:
Dr. Takao Yagi
The Scripps Research Institute
Department of Molecular & Experimental Medicine
MEM256
10550 N Torrey Pines Rd.
La Jolla, CA 92037
U.S.A.
E-mail: yagi@scripps.edu
Web: http://www.scripps.edu/mem/biochem/yagi/
Representative publications:
Seo, B. B., Nakamaru-Ogiso, E., Cruz, P., Flotte, T. R., Yagi,
T., and Matsuno-Yagi, A. (2004) Functional expression of the single
subunit NADH dehydrogenase in mitochondria in vivo: A potential therapy
for complex I deficiencies. Hum. Gene Ther. 15:887-895.[PM:15353043].
Seo, B. B., Nakamaru-Ogiso, E., Flotte, T. R., Yagi, T., and
Matsuno-Yagi, A. (2002) A single-subunit NADH-quinone
oxidoreductase renders resistance to mammalian nerve cells against
complex I inhibition. Mol. Ther. 6:336-341. [PM:12231169].
Seo, B. B., Wang, J., Flotte, T. R., Yagi, T., and Matsuno-Yagi,
A. (2000) Use of the NADH-Quinone oxidoreductase (NDI1) gene
of Saccharomyces cerevisiae as a possible cure for complex I
defects in human cells. J. Biol. Chem. 275:37774-37778.
[PM:10982813].