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Scripps Laboratories for tRNA Synthetase Research

Nahia Ezcurdia, Ph.D.

Photo of Nahia Ezcurdia, Ph.D.

Education:

B.S., Cellular Biology and Physiology, Universite Victor Segalen Bordeaux II (France)

M.S., Molecular and Cellular Biology, Universite Victor Segalen Bordeaux II (France) and University of Catania (Italy)

Ph.D., Internal Medicine, Hospital Universitari Vall Hebron Research Institute, Barcelona (Spain)

Current Research Focus:

My project is focused on understanding the molecular mechanisms in Charcot-Marie-Tooth neurodegenerative disease caused by mutations in Glycine-tRNA synthetase.

Publications:

Rodríguez S, Raurell I, Ezkurdia N, Augustin S, Esteban R, Genescà J, Martell M. The renal effects of droxidopa are maintained in propranolol treated cirrhotic rats. Liver Int. 2014 Jan 19

Ezkurdia N, Raurell I, Rodríguez S, González A, Esteban R, Genescà J, Martell M. Inhibition of neuronal apoptosis and axonal regression ameliorates sympathetic atrophy and hemodynamic alterations in portal hypertensive rats. PLoS One. 2014 Jan 6;9(1):e84374.

Kucharczyk R, Giraud MF, Brèthes D, Wysocka-Kapcinska M, Ezkurdia N, Salin B, Velours J, Camougrand N, Haraux F, di Rago JP. Defining the pathogenesis of human mtDNA mutations using a yeast model: the case of T8851C. Int J Biochem Cell Biol. 2013 Jan;45(1):130-40.

Coll M, Rodriguez S, Raurell I, Ezkurdia N, Brull A, Augustin S, Guardia J, Esteban R, Martell M, Genescà J. Droxidopa, an oral norepinephrine precursor, improves hemodynamic and renal alterations of portal hypertensive rats. Hepatology. 2012 Nov;56(5):1849-60.

Ezkurdia N, Coll M, Raurell I, Rodriguez S, Cuenca S, González A, Guardia J, Esteban R, Genescà J, Martell M. Blockage of the afferent sensitive pathway prevents sympathetic atrophy and hemodynamic alterations in rat portal hypertension. Liver Int. 2012 Sep;32(8):1295-305.

Couplan E, Aiyar RS, Kucharczyk R, Kabala A, Ezkurdia N, Gagneur J, St Onge RP, Salin B, Soubigou F, Le Cann M, Steinmetz LM, di Rago JP, Blondel M. A yeast-based assay identifies drugs active against human mitochondrial disorders. Proc Natl Acad Sci U S A. 2011 Jul 19;108(29):11989-94.

Martell M, Coll M, Ezkurdia N, Raurell I, Genescà J. Physiopathology of splanchnic vasodilation in portal hypertension. World J Hepatol. 2010 Jun 27;2(6):208-20.

Kucharczyk R, Ezkurdia N, Couplan E, Procaccio V, Ackerman SH, Blondel M, di Rago JP. Consequences of the pathogenic T9176C mutation of human mitochondrial DNA on yeast mitochondrial ATP synthase. Biochim Biophys Acta. 2010 Jun-Jul;1797(6-7):1105-12.

Coll M, Martell M, Raurell I, Ezkurdia N, Cuenca S, Hernández-Losa J, Esteban R, Guardia J, Bosch J, Genescà J. Atrophy of mesenteric sympathetic innervation may contribute to splanchnic vasodilation in rat portal hypertension. Liver Int. 2010 Apr;30(4):593-602.

Rak M, Tetaud E, Duvezin-Caubet S, Ezkurdia N, Bietenhader M, Rytka J, di Rago JP. A yeast model of the neurogenic ataxia retinitis pigmentosa (NARP) T8993G mutation in the mitochondrial ATP synthase-6 gene. J Biol Chem. 2007 Nov 23;282(47):34039-47.

 

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