Publications


The metabolite α-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR

     Chin RM, et al.
     Nature  2014 Jun 19;509(7505):397-401

     Pub5  DOI5
  • Fig. 1Compound Screening Libraries.
  • Fig. 2Examples of C. elegans phenotypes that can be imaged in 96-well plates.
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The metabolite α-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR

     Chin RM, et al.
     Nature  2014 Jun 19;509(7505):397-401

     Pub5  DOI5
  • Fig. 1a-KG extends the adult lifespan of C. elegans.
  • Fig. 2a-KG binds and inhibits ATP synthase.
  • Fig. 3a-KG longevity is mediated through ATP synthase and the dietary restriction/TOR axis.
  • Fig. 4Inhibition of ATP synthase by a-KG causes a conserved decrease in TOR pathway activity.
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A pharmacological network for lifespan extension in Caenorhabditis elegans

     Ye X, Linton JM, Schork NJ, Buck LB, Petrascheck M
     Aging Cell  2014 Apr;13(2):206-15

     Pub4  DOI4
  • Fig. 1Overview of screening strategy and results.
  • Fig. 2Numerous compounds increase Caenorhabditis elegans lifespan.
  • Fig. 3Many compounds protect Caenorhabditis elegans from oxidative stress.
  • Fig. 4Correlation between effects of compounds on lifespan and stress resistance.
  • Fig. 5Pharmacological network for lifespan extension.
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Measuring Caenorhabditis elegans life span in 96 well microtiter plates

     Solis GM, Petrascheck M.
     J Vis Exp.  2011 Mar 18;(49). pii: 2496

     Pub3  DOI3
  • The microtiter plate based lifespan assay accurately reproduces changes in lifespan reported in the literature.
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A high-throughput screen for chemicals that increase the lifespan of Caenorhabditis elegans

     Petrascheck M, Ye X, Buck LB.
     Ann N Y Acad Sci.  2009 Jul;1170:698-701

     Pub2  DOI2
  • Extension of C. eleganslifespan by mianserin.
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An antidepressant that extends lifespan in adult Caenorhabditis elegans

     Petrascheck M, Ye X, Buck LB.
     Nature 2007 Nov 22;450(7169):553-6

     Pub  DOI1
  • Fig. 1Increases in C. elegans lifespan by human serotonin receptor antagonists require serotonin and octopamine signalling.
  • Fig. 2Mianserin and methiothepin are antagonists of SER-3 octopamine and SER-4 serotonin receptors.
  • Fig. 3Lifespan extension by mianserin and dietary restriction are related.
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