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Yuan He, Ph.D. The Scripps Research Institute 10550 North Torrey Pines Road, MEM-L71 La Jolla, CA 92037 858-784-9636(phone) 858-784-9690 (FAX) yuanhe@scripps.edu |
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EDUCATION: 2011 - Ph. D. Chemistry, University of York (United Kingdom) 2007 - MRes Functional Genomics, University of York (United Kingdom) 2006 - BSc. Life Sciences and Technology, Northwest University (China) PROFESSIONAL EXPERIENCES: November 2011 to Present - Postdoctoral Fellow, The Scripps Research Institute, La Jolla, CA, USA (Advisor: Prof. James C. Paulson) August 2011 to October 2011 - Visiting post-doc, Simon Fraser University, Burnaby, Canada (Advisor: Prof. David J. Vocadlo) October 2007 to July 2011 - Doctoral Candidate, University of York, UK (Advisor: Prof. Gideon Davies) April 2007 to August 2007 - Industrial Internship, GlaxoSmithKline, Stevenage, UK ACADEMIC AND PROFESSIONAL HONORS: 2007 to 2011: University of York Overseas Scholarship 2007 to 2011: Department of Chemistry (University of York) Wild Fund 2010: Department of Chemistry (University of York) Shell Poster competition winner 2010: the 25th international carbohydrate symposium Travel Grant Award PUBLICATIONS: He Y, Bubb AK, Stubbs KA, Gloster TM, Davies GJ. Inhibition of a bacterial O-GlcNAcase homologue by lactone and lactam derivatives: structural, kinetic and thermodynamic analyses. Amino Acids. 2011;40(3):829-39. Martinez-Fleites C, He Y, Davies GJ. Structural analyses of enzymes involved in the O-GlcNAc modification. Biochim Biophys Acta. 2010;1800(2):122-33. Macauley MS, He Y, Gloster TM, Stubbs KA, Davies GJ, Vocadlo DJ. Inhibition of O-GlcNAcase using a potent and cell-permeable inhibitor does not induce insulin resistance in 3T3-L1 adipocytes. Chem Biol. 2010;17(9):937-48. He Y, Macauley MS, Stubbs KA, Vocadlo DJ, Davies GJ. Visualizing the reaction coordinate of an O-GlcNAc hydrolase. J Am Chem Soc. 2010;132(6):1807-9. Marcelo F, He Y, Yuzwa SA, Nieto L, Jimenez-Barbero J, Sollogoub M, Vocadlo DJ, Davies GD, Bleriot Y. Molecular basis for inhibition of GH84 glycoside hydrolases by substituted azepanes: conformational flexibility enables probing of substrate distortion. J Am Chem Soc. 2009;131(15):5390-2. He Y, Martinez-Fleites C, Bubb A, Gloster TM, Davies GJ. Structural insight into the mechanism of streptozotocin inhibition of O-GlcNAcase. Carbohydr Res. 2009;344(5):627-31. Balcewich MD, Stubbs KA, He Y, James TW, Davies GJ, Vocadlo DJ, Mark BL. Insight into a strategy for attenuating AmpC-mediated beta-lactam resistance: structural basis for selective inhibition of the glycoside hydrolase NagZ. Protein Sci. 2009;18(7):1541-51. Yuzwa SA, Macauley MS, Heinonen JE, Shan X, Dennis RJ, He Y, Whitworth GE, Stubbs KA, McEachern EJ, Davies GJ, Vocadlo DJ. A potent mechanism-inspired O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo. Nat Chem Biol. 2008;4(8):483-90. Martinez-Fleites C, Macauley MS, He Y, Shen DL, Vocadlo DJ, Davies GJ. Structure of an O-GlcNAc transferase homolog provides insight into intracellular glycosylation. Nat Struct Mol Biol. 2008;15(7):764-5. Wang ZF, He Y, Huang LJ. An alternative method for the rapid synthesis of partially O-methylated alditol acetate standards for GC-MS analysis of carbohydrates. Carbohydr Res. 2007;342(14):2149-51. |
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