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Wenjie Peng, Ph.D. The Scripps Research Institute 10550 North Torrey Pines Road, MB-209 La Jolla, CA 92037 858-784-7541 (phone) 858-784-9690 (fax) wenjiep@scripps.edu |
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EDUCATION September 2001 - July 2006: Ph.D., Organic Chemistry September 1997 - July 2001: B.Sc., Chemistry at Nankai University, Tianjin, China PROFESSIONAL EXPERIENCES November 2015 to Present: Staff Scientist, The Scripps Research Institute, La Jolla, CA, USA (Advisor: Prof. James C. Paulson) January 2010 to October 2015: Postdoctoral Fellow, The Scripps Research Institute, La Jolla, CA, USA (Advisor: Prof. James C. Paulson) December 2006 - January 2010: Postdoctoral Fellow, Department of Chemistry, University of Alberta, Canada (Advisor: Prof. Todd L. Lowary) July 2006 - November 2006: Assistant Researcher, Shanghai Institute of Organic chemistry, CAS, Shanghai, China (Advisor: Dr. Biao Yu) September 2001 - July 2006: Doctoral Candidate HONORS AND AWARD 2012: USACICS travel grant to present scientific talk at the ICS-2012 Madrid, Spain PUBLICATIONS Peng W, Paulson JC. CD22 Ligands on a Natural N-Glycan Scaffold Efficiently Delivers Tox-ins to B-Lymphoma Cells. J Am Chem Soc. 2017;139(36):12450-12458. Li W, Hulswit RJG, Widjaja I, Raj VS, McBride R, Peng W, Widagdo W, Tortorici MA, van Dieren B, Lang Y, van Lent JWM, Paulson JC, de Haan CAM, de Groot RJ, van Kuppeveld FJM, Haagmans BL, Bosch BJ. Identification of sialic acid-binding function for the Middle East respiratory syndrome coronavirus spike glycoprotein. Proc Natl Acad Sci U S A. 2017;114(40):E8508-E8517 de Vries RP, Tzarum N, Peng W, Thompson AJ, Ambepitiya Wickramasinghe IN, de la Pena ATT, van Breemen MJ, Bouwman KM, Zhu X, McBride R, Yu W, Sanders RW, Verheije MH, Wilson IA, Paulson JC. A single mutation in Taiwanese H6N1 influenza hemagglutinin switches binding to human-type receptors. EMBO Mol Med. 2017;9(9):1314-1325. de Vries RP, Peng W, Grant OC, Thompson AJ, Zhu X, Bouwman KM, de la Pena ATT, van Breemen MJ, Ambepitiya Wickramasinghe IN, de Haan CAM, Yu W, McBride R, Sanders RW, Woods RJ, Verheije MH, Wilson IA, Paulson JC. Three mutations switch H7N9 influenza to human-type receptor specificity. PLoS Pathog. 2017;13(6):e1006390. Tzarum N, McBride R, Nycholat CM, Peng W, Paulson JC, Wilson IA. Unique structural features of influenza H15 HA. J Virol. 2017;91(2):e00046-17. Tzarum N, de Vries RP, Peng W, Thompson AJ, Bouwman KM, McBride R, Yu W, Zhu X, Verheije MH, Paulson JC, Wilson IA. The 150-Loop Restricts the Host Specificity of Human H10N8 Influenza Virus. Cell Rep. 2017;19(2):235-245. Dai M, McBride R, Dortmans JC, Peng W, Bakkers MJ, de Groot RJ, van Kuppeveld FJ, Paulson JC, de Vries E, de Haan CA. Mutation of the 2nd Sialic Acid-Binding Site Resulting in Reduced Neuraminidase Activity Preceded Emergence of H7N9 Influenza A Virus. J Virol. 2017;91(9):e00049-17. Guo H, de Vries E, McBride R, Dekkers J, Peng W, Bouwman KM, Nycholat C, Verheije MH, Paulson JC, van Kuppeveld FJ, de Haan CAM. Highly Pathogenic Influenza A(H5Nx) Viruses with Altered H5 Receptor-Binding Specificity. Emerg Infect Dis. 2017;23(2):220-231. Peng W, de Vries RP, Grant OC, Thompson AJ, McBride R, Tsogtbaatar B, Lee PS, Razi N, Wilson IA, Woods RJ, Paulson JC. Recent H3N2 Viruses Have Evolved Specificity for Extended, Branched Human-type Receptors, Conferring Potential for Increased Avidity. Cell Host Microbe. 2017;21(1):23-34. Hiono T, Okamatsu M, Igarashi M, McBride R, de Vries RP, Peng W, Paulson JC, Sakoda Y, Kida H. Amino acid residues at positions 222 and 227 of the hemagglutinin together with the neuraminidase determine binding of H5 avian influenza viruses to sialyl Lewis X. J Arch Virol. 2016;161(2):307-316. Macauley MS, Kawasaki N, Peng W, Wang SH, He Y, Arlian BM, McBride R, Kanagi R, Khoo KH, Paulson JC. Unmasking of CD22 on germinal center B-cells occurs by alternative mechanisms in mouse and man. J Biol Chem. 2015;290(50):30066-77. Wickramasinghe IN, de Vries RP, Weerts EA, van Beurden SJ, Peng W, McBride R, Ducatez M, Guy J, Brown P, Eterradossi N, Grone A, Paulson JC, Verheije MH. Novel receptor specificity of avian gammacoronaviruses causing enteritis. J Virol. 2015;89(17):8783-8792. Blattner C, Lee JH, Sliepen K, Derking R, Falkowska E, de la Pena AT, Cupo A, Julien JP, van Gils M, Lee PS, Peng W, Paulson JC, Poignard P, Burton DR, Moore JP, Sanders RW, Wilson IA, Ward AB. Structural Delineation of a Quaternary, Cleavage-Dependent Epitope at the gp41-gp120 Interface on Intact HIV-1 Env Trimers. Immunity. 2014;40(5):669-680. Nycholat CM, Peng W, McBride R, Antonopoulos A, de Vries RP, Polonskaya Z, Finn MG, Dell A, Haslam SM, Paulson JC. Synthesis of Biologically Active N- and O-Linked Glycans with Multisialylated Poly-N-acetyllactosamine Extensions Using P. damsela a2-6 Sialyltransferase. J Am Chem Soc. 2013;135(49):18280-18283. Wang Z, Chinoy ZS, Ambre SG, Peng W, McBride R, de Vries RP, Glushka J, Paulson JC, Boons GJ. A General Strategy for the Chemoenzymatic Synthesis of Asymmetrically Branched N-Glycans. Science. 2013;341(6144):379-383. Peng W, Pranskevich J, Nycholat C, Gilbert M, Wakarchuk W, Paulson J, Razi N. Helicobacter pylori b1,3-N-acetylglucosaminyltransferase for versatile synthesis of type 1 and type 2 poly LacNAcs on N-linked, O-linked and I-antigen glycans. Glycobiology. 2012;22(11):1453-1464. Peng W, Zou L, Bhamidi S, McNeil MR, Lowary TL. The Galactosamine Residue in Mycobacterial Arabinogalactan Is a-Linked. J Org Chem. 2012;77(21):9826-32. Nycholat CM, McBride R, Ekiert DC, Xu R, Rangarajan J, Peng W, Razi N, Gilbert M, Wakarchuk W, Wilson IA, Paulson JC. Recognition of Sialylated Poly-N-acetyllactosamine Chains on N- and O-Linked Glycans by Human and Avian Influenza A Virus Hemagglutinins. Angew Chem Int Ed Engl. 2012;51(20):4860-63. Peng W, Jayasuriya AB, Imamura A, Lowary TL. Synthesis of the 6-O-methyl-D-glycero-alpha-L-gluco-heptopyranose moiety present in the capsular polysaccharide from Campylobacter jejuni NCTC 11168. Org Lett. 2011; 13(19):5290-3. Peng W, Tang P, Hu X, Liu JO, Yu B. Synthesis of the A,B-ring-truncated OSW saponin analogs and their antitumor activities. Bioorg Med Chem Lett. 2007;17(20):5506-9. Zhu C, Peng W, Li Y, Han X, Yu B. Synthesis of 3-O-(beta-D-xylopyranosyl-(1-->2)-beta-D-glucopyranosyl)-3'-O-(beta-D-gluc opyranosyl)tamarixetin, the putative structure of aescuflavoside A from the seeds of Aesculus chinensis. Carbohydr Res. 2006;341(8):1047-51. Peng W, Han X, Yu B. Synthesis of C-Aryl-flavonoid Derivatives via Suzuki-Miyaura Coupling Reaction. Chinese J Chemistry. 2006;24(9):1154-62. Peng W, Li Y, Zhu C, Han X, Yu B. Synthesis of tamarixetin and isorhamnetin 3-O-neohesperidoside. Carbohydr Res. 2005;340(10):1682-8. Peng W, Sung J, Lin F, Han X, Yu B. Facile Synthesis of Ginsenoside Ro. Synlett. 2004;2:259-62. Peng W, Han X, Yu B. Synthesis of a Typical Glucuronide-Containing Saponin, 28-O--D-Glucopyranosyl Oleanate 3-O--D-Galactopyranosyl-(12)- [-D-glucopyranosyl-(13)]--D-glucuronopyranoside. Synthesis. 2004;10:1641-47. Lin F, Peng W, Xu W, Han X, Yu B. A facile preparation of uronates via selective oxidation with TEMPO/KBr/Ca(OCl)(2) under aqueous conditions. Carbohydr Res. 2004;339(6):1219-23. Li Y, Jiang Y, Yan XP, Peng WJ, Wu YY. A flow injection on-line multiplexed sorption preconcentration procedure coupled with flame atomic absorption spectrometry for determination of trace lead in water, tea, and herb medicines. Anal Chem. 2002;74(5):1075-80. PATENTS B. Yu, W. J. Peng, F. Lin, Synthesis of glucuronide oleanane-type triterpene saponin with bisdesmoside. (CN 200310108521) B. Yu, W. J. Peng, Synthesis and application of Ornithogalum saundersiae saponin OSW 1 two-ring analog without A and B rings. (CN 20071004) |
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