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Fernando Spiller, Ph.D. The Scripps Research Institute 10550 North Torrey Pines Road, MB-209 La Jolla, CA 92037 858-784-7537 (phone) 858-784-9690 (fax) fspiller@scripps.edu |
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EDUCATION 2009: Ph.D., Pharmacology/Immunology, University of Sao Paulo and University of Torino 2006: MSc., Pharmacology/Immunology,University of Sao Paulo 2004: B.Sc., Pharmacy/Clinical Biochemistry, Pontifical Catholic University of Rio Grande do Sul (PUCRS) PROFESSIONAL EXPERIENCES: 2014 to Present - Research Associate, The Scripps Research Institute, La Jolla, CA, USA (Advisor: Prof. James C. Paulson) 2011 to Present - Assistant Professor, Dept. of Pharmacology, Federal University of Santa Catarina, Florianopolis, Brazil 2009 to 2010 - Research Fellow, Sao Paulo Research Foundation, Sao Paulo, Brazil (Advisor: Prof. Fernando Cunha) 2006 to 2009 - Doctoral Candidate, Sao Paulo Research Foundation, Sao Paulo, Brazil 2004 to 2006 - Master Fellow of National Council for Technological and Scientific Development (CNPq), Brazil PROFESSIONAL MEMBERSHIPS: 2012-present: Member of Executive Committee, Center for Biotechnology and Biosciences, Federal University of Santa Catarina, Brazil 2011-present: Member of Executive Committee, Center for Pharmacology, Federal University of Santa Catarina, Brazil 2011-present: Organizing Committee, South Meeting on Immunology, Brazil 2012-present: Ad-hoc reviewer of PLOS ONE 2009-present: Ad-hoc reviewer of Brazilian Journal of Medical and Biological Research 2010-present: Member, Brazilian Society of Immunology (SBI) 2007-present: Member, Brazilian Society of Pharmacology and Experimental Therapeutics (SBFTE) PUBLICATIONS: Sonego F, Castanheira FV, Czaikoski PG, Kanashiro A, Souto FO, Franca RO, Nascimento DC, Freitas A, Spiller F, Cunha LD, Zamboni DS, Alves-Filho JC, Cunha FQ. MyD88-, but not Nod1- and/or Nod2-deficient mice, show increased susceptibility to polymicrobial sepsis due to impaired local inflammatory response. PLoS One. 2014 Aug 1;9(8):e103734. Barroso-Sousa R, Lobo RR, Mendonca PR, Memoria RR, Spiller F, Cunha FQ, Pazin-Filho A. Decreased levels of alpha-1-acid glycoprotein are related to the mortality of septic patients in the emergency department. Clinics (Sao Paulo). 2013;68(8):1134-9. Neves FS, Spiller F. Possible mechanisms of neutrophil activation in Behcet's disease. Int Immunopharmacol. 2013;17(4):1206-10. Czaikoski PG, Nascimento DC, Sonego F, de Freitas A, Turato WM, de Carvalho MA, et al. Heme oxygenase inhibition enhances neutrophil migration into the bronchoalveolar spaces and improves the outcome of murine pneumonia-induced sepsis. Shock. 2013;39(4):389-96. Carlos D, Spiller F, Souto FO, Trevelin SC, Borges VF, de Freitas A, et al. Histamine h2 receptor signaling in the pathogenesis of sepsis: studies in a murine diabetes model. J Immunol. 2013;191(3):1373-82. Spiller F, Carlos D, Souto FO, de Freitas A, Soares FS, Vieira SM, et al. alpha1-Acid glycoprotein decreases neutrophil migration and increases susceptibility to sepsis in diabetic mice. Diabetes. 2012;61(6):1584-91. PMCID: 3357278. Spiller F, Costa C, Souto FO, Vinchi F, Mestriner FL, Laure HJ, et al. Inhibition of neutrophil migration by hemopexin leads to increased mortality due to sepsis in mice. Am J Respir Crit Care Med. 2011;183(7):922-31. Paula-Neto HA, Alves-Filho JC, Souto FO, Spiller F, Amendola RS, Freitas A, et al. Inhibition of guanylyl cyclase restores neutrophil migration and maintains bactericidal activity increasing survival in sepsis. Shock. 2011;35(1):17-27. Neto-Neves EM, Dias-Junior CA, Uzuelli JA, Pereira RP, Spiller F, Czaikoski PG, et al. Sildenafil improves the beneficial hemodynamic effects exerted by atorvastatin during acute pulmonary thromboembolism. Eur J Pharmacol. 2011;670(2-3):554-60. Freitas A, Alves-Filho JC, Trevelin SC, Spiller F, Suavinha MM, Nascimento DC, et al. Divergent role of heme oxygenase inhibition in the pathogenesis of sepsis. Shock. 2011;35(6):550-9. Spiller F, Orrico MI, Nascimento DC, Czaikoski PG, Souto FO, Alves-Filho JC, et al. Hydrogen sulfide improves neutrophil migration and survival in sepsis via K+ATP channel activation. Am J Respir Crit Care Med. 2010;182(3):360-8. Neto-Neves EM, Montenegro MF, Dias-Junior CA, Spiller F, Kanashiro A, Tanus-Santos JE. Chronic treatment with quercetin does not inhibit angiotensin-converting enzyme in vivo or in vitro. Basic Clin Pharmacol Toxicol. 2010;107(4):825-9. Alves-Filho JC, Spiller F, Cunha FQ. Neutrophil paralysis in sepsis. Shock. 2010;34 Suppl 1:15-21. Alves-Filho JC, Freitas A, Souto FO, Spiller F, Paula-Neto H, Silva JS, et al. Regulation of chemokine receptor by Toll-like receptor 2 is critical to neutrophil migration and resistance to polymicrobial sepsis. Proc Natl Acad Sci U S A. 2009;106(10):4018-23. PMCID: 2656197. Spiller F, Alves MK, Vieira SM, Carvalho TA, Leite CE, Lunardelli A, et al. Anti-inflammatory effects of red pepper (Capsicum baccatum) on carrageenan- and antigen-induced inflammation. J Pharm Pharmacol. 2008;60(4):473-8. Alves-Filho JC, de Freitas A, Spiller F, Souto FO, Cunha FQ. The role of neutrophils in severe sepsis. Shock. 2008;30 Suppl 1:3-9. Torres-Duenas D, Celes MR, Freitas A, Alves-Filho JC, Spiller F, Dal-Secco D, et al. Peroxynitrite mediates the failure of neutrophil migration in severe polymicrobial sepsis in mice. Br J Pharmacol. 2007;152(3):341-52. PMCID: 2042948. Rios-Santos F, Alves-Filho JC, Souto FO, Spiller F, Freitas A, Lotufo CM, et al. Down-regulation of CXCR2 on neutrophils in severe sepsis is mediated by inducible nitric oxide synthase-derived nitric oxide. Am J Respir Crit Care Med. 2007;175(5):490-7. Mestriner FL, Spiller F, Laure HJ, Souto FO, Tavares-Murta BM, Rosa JC, et al. Acute-phase protein alpha-1-acid glycoprotein mediates neutrophil migration failure in sepsis by a nitric oxide-dependent mechanism. Proc Natl Acad Sci U S A. 2007;104(49):19595-600. PMCID: 2148334. Morrone FB, Horn AP, Stella J, Spiller F, Sarkis JJ, Salbego CG, et al. Increased resistance of glioma cell lines to extracellular ATP cytotoxicity. J Neurooncol. 2005;71(2):135-40. |
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