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Fabian Pfrengle, Ph.D. The Scripps Research Institute 10550 North Torrey Pines Road, MEM-L71 La Jolla, CA 92037 858-784-9636(phone) 858-784-9690 (FAX) pfrengle@scripps.edu |
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EDUCATION: July 2010 - Ph.D. Chemistry, Freie Universitaet Berlin (Germany) February 2006 - M.S. Chemistry, Freie Universitaet Berlin (Germany) PROFESSIONAL EXPERIENCES: October 2010 to Present - Postdoctoral Fellow, The Scripps Research Institute, La Jolla, CA, USA (Advisor: Prof. James C. Paulson) February 2006 to September 2010 - Doctoral Candidate, Department of Chemistry @ Freie Universitaet Berlin, Germany (Advisor: Prof. Hans-Ulrich Reissig) February 2006 to September 2010 - Supervisor / Teacher, Chemistry lab courses for students in medicine and biology - supervision of advanced lab courses in organic chemistry - assistance in basic and advanced organic chemistry lectures @ Freie Universitaet Berlin, Germany ACADEMIC AND PROFESSIONAL HONORS: 2010-2012: Doctoral Fellowship - Deutscher Akademischer Austausch Dienst (DAAD) 2006 to present: Member of German Chemical Society 2007-2009: PhD Scholarship - The Fonds der Chemischen Industie (VCI) 2006: Best diploma in chemistry - Freie Universitaet Berlin PUBLICATIONS: Pfrengle F, Macauley MS, Kawasaki N, Paulson JC. Copresentation of Antigen and Ligands of Siglec-G Induces B Cell Tolerance Independent of CD22. J Immunol. 2013;191(4):1724-1731. Macauley MS, Pfrengle F, Rademacher C, Nycholat CM, Gale AJ, von Drygalski A, Paulson JC. Antigenic liposomes displaying CD22 ligands induce antigen-specific B cell apoptosis. J Clin Invest. 2013;123(7):3074-3083. Roskamp M, Enders S, Pfrengle F, Yekta S, Dekaris V, Dernedde J, Reissig HU, Schlecht S. Multivalent interaction and selectivities in selectin binding of functionalized gold colloids decorated with carbohydrate mimetics. Org Biomol Chem. 2011;9(21):7448-56. Pfrengle F, Reissig HU. Amino sugars and their mimetics via 1,2-oxazines. Chem Soc Rev. 2010;39(2):549-57. Pfrengle F, Reissig HU. Internally protected amino sugar equivalents from enantiopure 1,2-oxazines: synthesis of variably configured carbohydrates with C-branched amino sugar units. Chemistry. 2010;16(39):11915-25. Pfrengle F, Reissig HU. Addition of lithiated enol ethers to nitrones and subsequent Lewis acid induced cyclizations to enantiopure 3,6-dihydro-2H-pyrans - an approach to carbohydrate mimetics. Beilstein J Org Chem. 2010;6. Al-Harrasi A, Pfrengle F, Prisyazhnyuk V, Yekta S, Koos P, Reissig HU. Enantiopure aminopyrans by a Lewis acid promoted rearrangement of 1,2-oxazines: versatile building blocks for oligosaccharide and sugar amino acid mimetics. Chemistry. 2009;15(43):11632-41. Pfrengle F, Al-Harrasi A, Brudgam I, Reissig HU. Unusual Enantiopure Heterocyclic Skeletons via Lewis Acid Promoted Rearrangements of 1,3-Dioxolanyl-Substituted 1,2-Oxazines. Eur J Org Chem. 2009;2:282-91. Pfrengle F, Lentz D, Reissig HU. A new ring closure approach to enantiopure 3,6-dihydro-2H-pyrans: stereodivergent access to carbohydrate mimetics. Org Lett. 2009;11(23):5534-7. Pfrengle F, Lentz D, Reissig HU. Stereodivergent de novo synthesis of branched amino sugars by lewis Acid promoted rearrangement of 1,2-oxazines. Angew Chem Int Ed Engl. 2009;48(17):3165-9. Pfrengle F, Dekaris V, Schefzig L, Zimmer R, Reissig HU. Indium Trichloride Mediated Cleavage of Acetonides in the Presence of Acid-Labile Functional Groups Enhancing the Synthetic Utility of 1,3-Dioxolanyl-Substituted 1,2-Oxazines. Synlett. 2008:2965-68. Pfrengle F, Al-Harrasi A, Reissig HU. Lewis Acid Promoted Rearrangements of 1,3-Dioxolanyl-Substituted 1,2-Oxazines into Novel Products with 1,3,6-Trioxa-7-azacyclopenta[cd]indene Skeletons. Synlett. 2006:3498-500. |
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