Paulson Laboratory

Shengyang Wang, Ph.D.   The Scripps Research Institute 10550 North Torrey Pines Road, MB-214 La Jolla, CA 92037 858-784-7539(phone) shwang@scripps.edu

EDUCATION: January 2017 - Ph.D. Organic chemistry, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Shanghai (China) August 2011 - B.Sc. Chemistry, Zhengzhou University, Henan Province (China) PROFESSIONAL EXPERIENCES: January 2021 to Present: Postdoctoral Associate @ The Scripps Research Institute, La Jolla, CA, USA (Advisor: Prof. James C. Paulson) January 2019 to December 2020: Research Assistant @ Innovation Research Institute of Traditional Chinese Medicine, Shanghai University, China (Advisors: Professor Biao Yu, Professor Guoqiang Lin) January 2017 to December 2018: Research Assistant @ State Key Laboratory of Bioorganic and Natural Product Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China (Advisor: Professor Biao Yu) HONORS AND AWARDS: 2014 to 2016: Academic scholarship of University of Chinese Academy of Sciences 2010: Excellent Student Award of Zhengzhou University PUBLICATIONS: Lin TH, Zhu X, Wang S, Zhang D, McBride R, Yu W, Babarinde S, Paulson JC, Wilson IA. A single mutation in bovine influenza H5N1 hemagglutinin switches specificity to human receptors. Science. 2024;386(6726):1128-1134. Thompson AJ, Wu NC, Canales A, Kikuchi C, Zhu X, de Toro BF, Canada FJ, Worth C, Wang S, McBride R, Peng W, Nycholat CM, Jimenez-Barbero J, Wilson IA, Paulson JC. Cell Host Microbe. 2024;32(2):261-275.e4. Zhao Y, Wang S, Yu B. Dimerization of aldosuloses and aldonolactones into branched higher carbon sugars. Chem Commun (Camb). 2020;56(13):2020-2. Wang F, Zhang WH, Zhao J, Kang WJ, Wang S, Yu B, Pan HX, Tang GL. Characterization of Miharamycin Biosynthesis Reveals a Hybrid NRPS-PKS to Synthesize High-Carbon Sugar from a Complex Nucleoside. J Am Chem Soc. 2020;142(13):5996-6000. Wang S, Zhang Q, Zhao Y, Sun J, Kang W, Wang F, Pan H, Tang G, Yu B. The Miharamycins and Amipurimycin: their Structural Revision and the Total Synthesis of the Latter. Angew Chem Int Ed Engl. 2019;58(31):10558-62. Kang WJ, Pan HX, Wang S, Yu B, Hua H, Tang GL. Identification of the Amipurimycin Gene Cluster Yields Insight into the Biosynthesis of C9 Sugar Nucleoside Antibiotics. Org Lett. 2019;21(9):3148-52. Wang S, Sun J, Zhang Q, Cao X, Zhao Y, Tang G, Yu B. Amipurimycin: Total Synthesis of the Proposed Structures and Diastereoisomers. Angewandte Chemie International Edition. 2018;57(11):2884-8.

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