Publications

 

Metlagel, Z.,* Otomo, C.,* Takaesu, G., and Otomo, T. (2013) Structural basis of ATG3 recognition by the autophagic ubiquitin-like protein ATG12. Proc. Natl. Acad. Sci. U.S.A.


Otomo, C., Metlagel, Z., Takaesu, G., and Otomo, T. (2012) Structure of the human ATG12~ATG5 conjugate required for LC3 lipidation in autophagy. Nat. Struct. Mol. Biol. 20:59-66, doi:10.1038/nsmb.2431


Otomo, T., Tomchick, D.R., Otomo, C., Machius, M., and Rosen, M.K. (2010) Crystal structure of the Formin mDia1 in autoinhibited conformation. PLoS One. 5:e12896


Shemesh, T., Otomo, T., Rosen, M.K., Bershadsky. A.D., and Kozlov, M.M. (2005) A novel mechanism of actin filament processive capping by formin: solution of the rotation paradox. J. Cell Biol. 170:889-93.


Otomo, T., Otomo, C., Tomchick, D.R., Machius, M., and Rosen, M.K. (2005) Structural basis of Rho GTPase-mediated activation of the formin mDia1. Mol. Cell 18:273-81.


Otomo, T., Tomchick, D.R., Otomo, C., Panchal, S.C., Machius, M., and Rosen, M.K. (2005) Structural basis of actin filament nucleation and processive capping by a formin homology 2 domain. Nature 433:488-94.


Seth, A., Otomo, T, Yin, H.L., and Rosen, M.K. (2003) Rational design of genetically encoded fluorescence resonance energy transfer-based sensors of cellular Cdc42 signaling. Biochemistry 42:3997-4008.


Otomo, T., Sakahira, H., Uegaki, K., Nagata, S., and Yamazaki, T. (2000) Structure of the heterodimeric complex between CAD domains of CAD and ICAD. Nat. Struct. Biol. 7:658-662.


Otomo, T., Yamazaki, T., Murakami, K., Ishihama, A., and Kyogoku, Y. (2000) Structural study of the N-terminal domain of alpha subunit of Eschericia coli RNA polymerase solubilized with non-denaturing detergents. J. Biochem. 128:337-344.


Uegaki, K.,* Otomo, T.,* Sakahira, H., Shimizu, M., Yumoto, N., Kyogoku, Y., Nagata, S., and Yamazaki, T. (2000) Structure of the CAD domain of caspase-activated DNase and interaction with the CAD domain of its inhibitor. J. Mol. Biol. 297:1121-1128. (*equal contribution)


Won, H.S., Yamazaki, T., Lee, T.W., Jee, J.G., Yoo, M.K., Park, S.H., Otomo, T., Aiba, H., Kyogoku, Y., and Lee, B.J. (2000) Backbone NMR assignments of a high molecular weight protein (47kDa), cyclic AMP receptor protein (apo-CRP). J. Biomol. NMR 16:79-80.


Otomo, T., Ito, N., Kyogoku, Y., and Yamazaki, T. (1999) NMR observation of selected segments in a larger protein: Central-segment isotope labeling through intein-mediated ligation Biochemistry 38:16040-16044.


Otomo, T., Teruya, K., Uegaki, K., Yamazaki, T., and Kyogoku, Y. (1999) Improved segmental isotope labeling of proteins and application to a larger protein. J. Biomol. NMR 14:105-114.


Yamazaki, T., Otomo, T., Oda, N., Kyogoku, Y., Uegaki, K., Ito, N., Ishino, Y., and Nakamura, H. (1998) Segmental isotope labeling for protein NMR using peptide splicing. J. Am. Chem. Soc.120:5591-5592.


Jeon, Y.H., Yamazaki, T., Otomo, T., Ishihama, A., and Kyogoku, Y. (1997) Flexible linker in the RNA polymerase alpha subunit facilitates the independent motion of the C-terminal activator contact domain. J. Mol. Biol. 267:953-962.