Shown here is an early precursor antibody of the highly potent PGT121 family in complex with the HIV-1 SOSIP Env trimer structure at 3.0 Å resolution. The three gp120 subunits of the HIV Env trimer are shown in a surface representation while the three gp41 subunits are shown as ribbons. The glycans that decorate the HIV-1 trimer are represented in yellow spheres and the Fab regions of the precursor antibody (3H+109L) are shown as colored ribbons bound to the HIV-1 Env trimer. (Image courtesy of the TSRI Wilson lab.)