Katherine T. Barglow

Enzyme Discovery and Characterization by Proteome Reactivity Profiling

Advisor: Benjamin F. Cravatt, Ph.D., Professor and Chair, Department of Chemical Physiology

Diana Renee Bowley

Yeast and Phage Display of Antibodies: Comparisons and New Developments

Advisor: Dennis R. Burton, Ph.D., Professor, Department of Immunology

Amandeep K. Dhillon

Characterizing the Neutralizing Antibody Repertoires of Asymptomatic HIV-1 Infected Individuals with Broadly Neutralizing Sera

Advisor: Dennis R. Burton, Ph.D., Professor, Department of Immunology

Anna V. Galkin

Targeting Tyrosine Kinases in Solid Tumors and Hematopoietic Malignancies

Advisor: Peter K. Vogt, Ph.D., Professor, Department of Molecular and Experimental Medicine

Sarah Richardson Hanson

Exploring Glycan Function:
I. Intrinsic Effects of N-glycans on b-Sheet Protein Folding
II. Development of Glycoproteomic Tools for Monitoring Glycan Transformations

Advisor: Chi-Huey Wong, Ph.D., Professor, Department of Chemistry

Nadia Haq

Progress Toward the Total Synthesis of Sultriecin

Advisor: Dale L. Boger, Ph.D. Professor, Department of Chemistry

Chan Woo Huh

Stereodivergent Synthesis of Bistetrahydrofuran-containing Acetogenins through [3+2] Annulation Strategy, and Progress Toward a Complete Diastereomer Library

Advisor: William R. Roush, Ph.D., Professor, Department of Chemistry

Reshma Jagasia

Part 1. Scope and Mechanism of Peptide Cyclodimerization by the CuI-Mediated Azide- Alkyne Cycloaddition Reaction
Part 2. Controlling Staphylococcus aureus Infection by Disrupting Bacterial Communication with a Monoclonal Antibody

Advisor: M. G. Finn, Ph.D., Associate Professor, Department of Chemistry

Jeffrey R. Johnson

Proteomic and Bioinformatic Analyses of Parasitic Pathogens

Co-Advisors:
Elizabeth A. Winzeler, Ph.D., Associate Professor, The Institute for Childhood and Neglected Diseases
John R. Yates, III, Ph.D., Professor, Department of Chemical Physiology

Eiton Kaltgrad

Applications of Polyvalent Carbohydrate Display on Cowpea Mosaic Virus and Bacteriophage Qβ

Advisor: M. G. Finn, Ph.D., Associate Professor, Department of Chemistry

Ricardo Lira Medina

I. Studies Towards the Total Synthesis of Tetrafibricin
II. Development of a Synthetic Sequence to Access Structurally Constrained Cysteine
Protease Inhibitors
III. Development of a Method for the Synthesis of N-aryl-2-benzylindolines via the
Tandem Arylation of 2-allylanilines

Advisor: William R. Roush, Ph.D., Professor, Department of Chemistry

Ewa Teresa Lis

Molecular Mechanisms of Mutation in S. cerevisiae

Advisor: Floyd E. Romesberg, Ph.D., Associate Professor, Department of Chemistry

Katherine Theresa Marcucci

A Molecular Approach to Understanding Structure-function Relationships in Porcine Endogenous Retrovirus (PERV) Late Domain-associated Assembly and Release and Receptor-mediated Entry

Advisor: Daniel R. Salomon, M.D., Associate Professor, Department of Molecular and Experimental Medicine

Casey Jacob Nelson Mathison

Part I. Acyl Cyanide Coupling Reactions and the Synthesis of b-Tricarbonyl Natural
Products
Part II. Oxidation of Heteroatom-Containing Substrates with Hypervalent Iodine(V) Reagents

Advisor: Phil S. Baran, Ph.D., Associate Professor, Department of Chemistry

Valentin O. Rodionov

Mechanistic Investigation of Copper (I) Catalyzed Azide-Alkyne [3+2] Cycloaddition

Advisor: M. G. Finn, Ph.D. Associate Professor, Department of Chemistry

Christopher B. Roth

Β-Adrenergic Receptor Stability Engineering for the Advancement of GPCR Structural Biology

Advisor: Raymond C. Stevens, Ph.D., Professor, Department of Molecular Biology

Houchao Tao

Part I: Extension of 1,3,4,-Oxadiazole Chemistry: Studies Toward the Total Synthesis of Aspidospermidine Part II: Progress Toward the Total Synthesis of Rebeccamycin

Advisor: Dale L. Boger, Ph.D., Professor, Department of Chemistry

Mark Shannon Tichenor

Total Synthesis of Yatakemycin: Structure Revision, Analogue Studies and Biological Properties

Advisor: Dale L. Boger, Ph.D., Professor, Department of Chemistry

José Luis Vela

The Role of the Recombining Sequence/Kappa Deleting Element (RS/kde) in B Lymphocyte Tolerance and Receptor Editing

Advisor: David A. Nemazee, Ph.D., Professor, Department of Immunology

Sheng-Kai Wang

Part I: Discovery of Sphingosine 1-Phosphate Receptor Type-1 Antagonists
Part II: Development of Carbohydrate Based HIV-1 Vaccine and Antiviral Agents

Chi-Huey Wong, Ph.D., Professor, Department of Chemistry

Andrew B. Ward

The Ins and Outs of the ABC Transporter MsbA

Co-Advisors:
Ronald A. Milligan, Ph.D., Professor, Department of Cell Biology
Geoffrey Chang, Ph.D., Associate Professor, Department of Molecular Biology

Craig K. Yoshioka

Electron Microscopy: Past to Present to Future - Automation and Case Studies

Co-Advisors:
Ronald A. Milligan, Ph.D., Professor, Department of Cell Biology
Bridget O. Carragher, Ph.D., Associate Professor, Department of Cell Biology

Jason Andrew Young

Plasmodium falciparum Functional Genomics: Elucidation of Gene Function and Transcriptional Control Mechanisms

Advisor: Elizabeth A. Winzeler, Ph.D., Associate Professor, The Institute for Childhood and Neglected Diseases