Vol
7. Issue 25 / September 10, 2007 |
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Etcetera
In announcing the award, the International Balzan Prize Foundation of Italy and Switzerland cited Beutler and Hoffmann "for their discovery of the genetic mechanisms responsible for innate immunity. They have worked in close cooperation to develop a new vision of the molecular defense strategy deployed by animals across a wide evolutionary spectrum against infectious agents. Their work has led to very promising medical applications." Beutler, who holds a B.A. from the University of California, San Diego, and an M.D. from the University of Chicago, has spearheaded the use of a technique called "forward genetics" to study genes used by the mammalian innate immune system to clear pathogens from the body. Beutler is credited with the identification of the key receptors that inform the body when an infection is present. The same receptors also initiate inflammation and shock when an infection becomes widespread. Together with his colleagues at Scripps Research, including Kasper Hoebe (an assistant professor in the Department of Genetics), Beutler has continued to analyze these receptors, and has pursued an ambitious search for all proteins that protect mammals against defined infections. The International Balzan Prize Foundation, established in 1957, promotes culture, science, and the most meritorious initiatives in the cause of humanity, peace, and brotherhood among peoples. It achieves its aim through the annual award of four prizes in two general fields. The first encompasses literature, the moral sciences, and the arts, while the second encompasses medicine and the physical, mathematical, and natural sciences. Each prize has a monetary value of 1 million Swiss francs (currently equivalent to approximately $830,000). Just over 100 people have received the Balzan Prize since it was first presented, including such diverse and influential figures as Mother Teresa of Calcutta, Pope John XIII, composer Paul Hindemith, cognitive development pioneer Jean Piaget, astrophysicists Fred Hoyle and Martin Schwarzschild, climatologist Roger Revelle, and biologist Karl von Frisch. For more information and a complete list of prizewinners, see the foundation's web site at
Send comments to: mikaono[at]scripps.edu
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