Lymphoid cells from a patient with Friedreich's Ataxia. Upper Left: Cells are stained green with a fluorescent (Bodipy) derivative of one of the Gottesfeld lab's active histone deacetylase inhibitors. Upper Right: Nuclei are stained with a substance called DAPI to show total DNA content. Lower Left: The merged image shows nuclear localization of the histone deacetylase inhibitor. Lower Right: This panel shows a bright field image of the cells. |