Proposed model for LPS transport by MsbA
(From left to right) LPS initially binds to MsbA in the absence of nucleotide. During substrate binding and ATP hydrolysis, the transporter undergoes conformational changes causing the sugar head group of LPS to be 'flipped' within the internal chamber of MsbA while the LPS hydrocarbon chains are dragged through the lipid bilayer. Finally, LPS is presented to the outside of the membrane as observed in this structure.