Virus infection of dendritic cells results in immune suppression |
Viruses, including measles and LCMV, have evolved strategies to evade host immune responses by infecting dendritic cells within the bone marrow, resulting in increased local production of type I IFN. Signaling through STAT2, but not STAT1, virus-induced type I IFN inhibits the development of precursor DC (pDC) into DC. The significant reduction in DC frequency and number that occurs dramatically impacts T cell development and hinders the adaptive immune responses to viral infection. |