Two Schematic Views of Tolerance with a Generated B-Cell Repertoire of 20 Cells
Two Schematic Views of Tolerance with a Generated B-Cell Repertoire of 20 Cells |
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| Under clonal selection (top), cells in the generated B cell repertoire that are autoreactive are eliminated before they can pass into the periphery. Under receptor editing (bottom), autoreactive B cells have a chance to avoid selection by rearranging their receptors. Some rearrange, are no longer autoreactive, and survive (14', 16', 20'). Others, such as #11, are still autoreactive and are eliminated. |