The Proposed Mechanism of Activation-induced Macrophage Cell Death
The Proposed Mechanism of Activation-induced Macrophage Cell Death |
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| LPS molecules activate theÊ "ERK pathway" in the macrophages. This induces downstream transcription factors, which cooperate withÊ zVAD-stabilized MEF2 transcription factors to induce Nur77 expression. The Nur77 induction leads to the cell death of activated macrophages. Image courtesy of Sung Ouk Kim. |