Publications

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1. •2000-2009
   

Von Seggern DJ, Huang S, Fleck SK, Stevenson SC,  Nemerow GR.  2000.  Adenovirus vector rpseudotyping in fiber-expressing cell lines: Improved transduction of Epstein-Barr virus-transformed B cells.  J Virol. 74(1):354-362.     PMCID: PMC111546

Saphire ACS, Guan T, Schirmer EC,  Nemerow GR, Gerace L.  2000.  Nuclear import of adenovirus DNA in vitro involves the nuclear protein import pathway and hsc70.   J Biol Chem.  275(6):4298-4304.

Wang K, Guan T, Cheresh DA,  Nemerow GR.  2000.  Regulation of adenovirus membrane penetration by the cytoplasmic tail of integrin β5.  J Virol. 74(6):2731-2739.     PMCID: PMC111763

Huang S, New L, Pan Z, Han J,  Nemerow GR.  2000.  Urokinase plasminogen activator/urokinase-specific surface receptor expression and matrix invasion by breast cancer cells requires constitutive p38α mitogen-activated protein kinase activity.  J Biol Chem. 275(16):12266-12272.

Huang S, Stupack D, Liu A, Cheresh D,  Nemerow GR.  2000.  Cell growth and matrix invasion of EBV-immortalized human B lymphocytes is regulated by expression of alphav integrins.  Oncogene. 19(15):1915-1923.

Li E, Stupack DG, Brown SL, Klemke R, Schlaepfer DD,  Nemerow GR.  2000.  Association of p130CAS with phosphatidylinositol-3-OH kinase mediates adenovirus cell entry.  J Biol Chem. 275(19):14729-14735.

Xia Y, Makris C, Su B, Li E, Yang J,  Nemerow GR, Karin M.  2000.  MEK kinase 1 is critically required for c-Jun N-terminal kinase activation by proinflammatory stimuli and growth factor-induced cell migration.  Proc Natl Acad Sci U S A. 97(10):5243-5248.     PMCID: PMC25813

Nemerow GR.  2000.  Cell receptors involved in adenovirus entry.  Virology. 274:1-4. Review.

Nemerow GR. 2000.  Adenoviral vectors--new insights.  Trends Microbiol. 8(9):391-394. Comment.

Li E, Brown SL, Von Seggern DJ, Brown GB,  Nemerow GR.  2000.  Signaling antibodies complexed with adenovirus circumvent CAR and integrin interactions and improve gene delivery.  Gene Ther. 7:1593-1599.

Wu E, Fernandez J, Fleck SK, Von Seggern DJ, Huang S,  Nemerow GR.  2001.  A 50-kDa membrane protein mediates sialic acid-independent binding and infection of conjunctival cells by adenovirus type 37.  Virology. 279:78-89.

Li E, Brown SL, Dolman CS, Brown GB,  Nemerow GR.  2001.  Production of functional antibodies generated in a nonlytic insect cell expression system.  Protein Expr Purif. 21:121-128.

Jakubczak JL, Rollence ML, Stewart DA, Jafari JD, Von Seggern DJ, Nemerow GR, Stevenson SC, Hallenbeck PL.  2001.  Adenovirus type 5 viral particles pseudotyped with mutagenized fiber proteins show diminished infectivity of coxsackie B-adenovirus receptor-bearing cells.  J Virol.75(6):2972-2981.     PMCID: PMC115923

Li E, Brown SL, Stupack DG, Puente XS, Cheresh DA, Nemerow GR.  2001.  Integrin αvβ1 is an adenovirus coreceptor.  J Virol. 75(11):5405-5409.     PMCID: PMC114949

Chiu CY, Wu E, Brown SL, Von Seggern DJ,  Nemerow GR, Stewart PL.  2001.  Structural analysis of a fiber-pseudotyped adenovirus with ocular tropism suggests differential modes of cell receptor interactions.  J Virol. 75(11):5375-5380.     PMCID: PMC114944

Nemerow GR, Stewart PL.  2001.  Antibody neutralization epitopes and integrin binding sites on nonenveloped viruses. Virology. 288:189-191. Review.

Nicklin SA, Von Seggern DJ, Work LM, Pek DC, Dominiczak AF,  Nemerow GR, Baker AH.  2001.  Ablating adenovirus type 5 fiber-CAR binding and HI loop insertion of the SIGYPLP peptide generate an endothelial cell-selective adenovirus.  Mol Ther. 4(6):534-542.

Nemerow GR, Cheresh DA.  2002.  Herpesvirus hijacks an integrin.  Nat Cell Biol. 2002 4:E69-71. News & Views.

Nemerow GR.  2002.  Biology of adenovirus Cell Entry.  In: Curiel DT, Douglas JT, editors.  Adenoviral vectors for gene therapy.   Amsterdam; Boston: Elsevier Science; Academic Press. p. 19-38.

Von Seggern DJ, Aguilar E, Kinder K, Fleck SK, Gonzalez Armas JC, Stevenson SC, Ghazal P,  Nemerow GR, Friedlander M.  2003. In vivo transduction of photoreceptors or ciliary body by intravitreal injection of pseudotyped adenoviral vectors. Mol Ther. 7(1):27-34.

Nemerow G,  Bloomer, L.   Control of Communicable and Certain Noninfectious Diseases.  In: Salvato JA., Nemerow NL, Agardy FJ, editors.  Environmental Engineering.  5th ed.  Hoboken, N.J.: Wiley.  p 1-166.

Goosney DL,  Nemerow GR.  Adenovirus infection: taking the back roads to viral entry.  Curr Biol. 13:R99-R100.

Hsia DA, Mitra SK, Hauck CR, Streblow DN, Nelson JA, Ilic D, Huang S, Li E,  Nemerow GR, Leng J, Spencer KS, Cheresh DA, Schlaepfer DD.  2003.  Differential regulation of cell motility and invasion by FAK.  J Cell Biol.160(5):753-767.     PMCID: PMC2173366

Erratum: J Virol. 2004 Feb;78(4):2167.

Wu E, Pache L, Von Seggern DJ, Mullen TM, Mikyas Y, Stewart PL,  Nemerow GR.   2004.  Flexibility of the adenovirus fiber is required for efficient receptor interaction.  J Virol. 77(13):7225-35.      PMCID:  PMC164825    

Smith TA, Idamakanti N, Rollence ML, Marshall-Neff J, Kim J, Mulgrew K,  Nemerow GR, Kaleko M, Stevenson SC.  2003.  Adenovirus serotype 5 fiber shaft influences in vivo gene transfer in mice.  Hum Gene Ther. 14:777-787.

Stewart PL, Dermody TS,  Nemerow GR  2003.  Virus Structure:  Structural basis of nonenveloped virus cell entry.  In:  Chiu W, Johnson JE, editors.  Advances in Protein Chemistry.   Amsterdam; Boston: Elsevier; Academic Press.  64:455-491.

Nicklin SA, Dishart KL, Buening H, Reynolds PN, Hallek M,  Nemerow GR, Von Seggern DJ, Baker AH.  2003.  Transductional and transcriptional targeting of cancer cells using genetically engineered viral vectors.  Cancer Lett. 201:165-173.

Wodrich H, Guan T, Cingolani G, Von Seggern D, Nemerow G, Gerace L.  2003.  Switch from capsid protein import to adenovirus assembly by cleavage of nuclear transport signals.  EMBO J.22(23):6245-55.      PMCID: PMC291855

Wu E, Trauger SA, Pache L, Mullen TM, Von Seggern DJ, Siuzdak G,  Nemerow GR.  2004.  Membrane cofactor protein is a receptor for adenoviruses associated with epidemic keratoconjunctivitis.  J Virol. 78(8):3897-3905.     PMCID: PMC374279

Wu E,  Nemerow GR.  2004.  Virus yoga: the role of flexibility in virus host cell recognition.  Trends Microbiol. 12(4):162-169. Review.

Trauger SA, Wu E, Bark SJ,  Nemerow GR, Siuzdak G.  2004.  The identification of an adenovirus receptor by using affinity capture and mass spectrometry.  Chembiochem.5:1095-1099.

Hsu C, Boysen M, Gritton LD, Frosst PD,  Nemerow GR, Von Seggern DJ.  2005.  In vitro dendritic cell infection by pseudotyped adenoviral vectors does not correlate with their in vivo immunogenicity.  Virology. 332:1-7.

Wiethoff CM, Wodrich H, Gerace L,  Nemerow GR.  2005.  Adenovirus protein VI mediates membrane disruption following capsid disassembly.  J Virol. 79(4):1992-2000.     PMCID: PMC546575

Saban SD, Nepomuceno RR, Gritton LD,  Nemerow GR, Stewart PL.  2005.  CryoEM structure at 9Å resolution of an adenovirus vector targeted to hematopoietic cells.  J Mol Biol. 349:526-37.

Nicklin SA, Wu E,  Nemerow GR, Baker AH.  2005.  The influence of adenovirus fiber structure and function on vector development for gene therapy. Mol Ther. 12(3):384-393. Review.

Horne WS, Wiethoff CM, Cui C, Wilcoxen KM, Amorin M, Ghadiri MR, Nemerow GR.  2005.  Antiviral cyclic D,L-α-peptides: targeting a general biochemical pathway in virus infections.  Bioorg Med Chem. 13:5145-53.    
PMCID: PMC1829313

Iacobelli-Martinez M, Nepomuceno RR, Connolly J,  Nemerow GR.  2005.  CD46-utilizing adenoviruses inhibit C/EBPβ-dependent expression of proinflammatory cytokines.  J Virol. 79(17):11259-11268.     PMCID: PMC1193609

Maginnis MS, Forrest JC, Kopecky-Bromberg SA, Dickeson SK, Santoro SA, Zutter MM,  Nemerow GR, Bergelson JM, Dermody TS.  2006.  β1 integrin mediates internalization of mammalian reovirus  .J Virol. 2006 80(6):2760-2770.      PMCID: PMC1395463

Wodrich H, Cassany A, D'Angelo MA, Guan T, Nemerow G, Gerace L.  2006.  Adenovirus core protein pVII is translocated into the nucleus by multiple import receptor pathways.  J Virol. 80(19):9608-9618.     PMCID: PMC1617226

Saban SD, Silvestry M, Nemerow GR, Stewart PL.  2006.  Visualization of α-helices in a 6-Å resolution cryoelectron microscopy structure of adenovirus allows refinement of capsid protein assignments.  J Virol. 80(24):12049-12059.     PMCID: PMC1676273

Iacobelli-Martinez M, Nemerow GR.  2007.  Preferential activation of toll-like receptor nine by CD46-utilizing adenoviruses.  J Virol.81(3):1305-1312.      PMCID: PMC1797540

Nepomuceno RR, Pache L, Nemerow GR.  2007.  Enhancement of gene transfer to human myeloid cells by adenovirus-fiber complexes.  Mol Ther. 15(3):571-578.

Stewart PL, Nemerow GR.  2007.  Cell integrins: commonly used receptors for diverse viral pathogens.  Trends Microbiol. 15(11):500-507. Review.

Smith JG, Nemerow GR.  2008.  Mechanism of adenovirus neutralization by Human α-defensins.  Cell Host Microbe. 3:11-19.

Pache L, Venkataraman S,  Nemerow GR, Reddy VS.  2008.  Conservation of fiber structure and CD46 usage by subgroup B2 adenoviruses.Virology. 375:573-579.

Smith JG, Cassany A, Gerace L, Ralston R, Nemerow GR.  2008.  Neutralizing antibody blocks adenovirus infection by arresting microtubule-dependent cytoplasmic transport.  J Virol. 82(13):6492-6500.      PMCID: PMC2447115

Pache L, Venkataraman S, Reddy VS, Nemerow GR.S  2008.  Structural variations in species B adenovirus fibers impact CD46 association.  J Virol. 82(16):7923-7931.      PMCID: PMC2519554

Nemerow GR, Pache L, Reddy V, Stewart PL.  2009.  Insights into adenovirus host cell interactions from structural studies. Virology. 384:380-388.  Review.    PMCID: PMC2666334

Lai CY, Wiethoff CM, Kickhoefer VA, Rome LH, Nemerow GR.  2009.  Vault nanoparticles containing an adenovirus-derived membrane lytic protein facilitate toxin and gene transfer.  ACS Nano. 3(3):691-699.     PMCID: PMC2707358

Silvestry M, Lindert S, Smith JG, Maier O, Wiethoff CM, Nemerow GR, Stewart PL.  2009.  Cryo-electron microscopy structure of adenovirus type 2 temperature-sensitive mutant 1 reveals insight into the cell entry defect.  J Virol. 83(15):7375-7383.      PMCID: PMC2708647

Nemerow GR.  2009.  A new link between virus cell entry and inflammation: adenovirus interaction with integrins induces specific proinflammatory responses.  Mol Ther. 17(9):1490-1491. Review.      PMCID: PMC2829938

Lindert S, Silvestry M, Mullen TM, Nemerow GR, Stewart PL. 2009.  Cryo-electron microscopy structure of an adenovirus-integrin complex indicates conformational changes in both penton base and integrin.  J Virol. 83(22):11491-11501.     PMCID: PMC2772687

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