The Friedlander Laboratory Department of Cell Biology

Michael I. Dorrell, Edith Aguilar, Christoph Weber, Martin Friedlander. IOVS The Scripps Research Institute, La Jolla, CA Microarray Home      Statistical Analyses      Gene Search

Cluster 5

Genes whose expressions are lowest at middle timepoints

Cluster 5 represents genes whose expression is relatively high at birth. The expression then decreases, is lowest during the middle timepoints tested (post-natal days 8-12), and then increases once again. Although many developmental events are occurring simultaneously and caution should be taken when predicting gene functions from expression data alone, these genes are likely to have overlapping functions in neural development and neural maintenance. Thus, many of these genes may be involved in developing the neural retina and retinal synapses and then become required once again to maintain or restore neurons at the state required for continuous function.

Normalized chip to chip and per gene
"po-adult, triplicate"

Common Name	P0	P4	P8	P10	P12	P14	P21	Adult	Genbank	Affy ID#	Keywords	Product	Function
Enc1	3.781	1.009	1.58	1.124	1.681	2.506	1.301	4.096	AA822539	100920_at	EST
EST	2.761	1.091	1.287	1.083	1.932	2.11	1.263	3.384	AA407599	102091_f_at	EST
EST	2.84	1.313	1.159	1.026	1.53	1.735	0.921	2.477	M73818	92402_at
Incenp	3.187	1.477	1.447	1.233	2.225	1.897	1.593	2.406	AW045530	104468_at	EST
EST	2.849	2.157	2.147	1.362	2.459	2.261	1.95	4.858	U19315	101718_f_at		immunoglobulin kappa light chain variable region
Ptch	2.561	1.802	2.053	1.564	2.264	1.988	2.298	3.502	U46155	104031_at		patched	transmembrane protein
EST	2.701	1.798	1.409	1.116	2.382	2.454	2.341	4.648	X00651	96972_f_at	Ig kappa light chain; Ig light chain; immunoglobulin; joining region; variable region
12/B1 kappa	2.021	1.081	1.342	0.959	2.429	1.548	1.376	3.263	AB017349	102585_f_at	immunoglobulin light chain V region; 12/B1 kappa; immunoglobulin heavy chain V region	immunoglobulin light chain V region
V kappa	3.165	1.947	1.864	2.188	2.668	2.566	1.627	4.918	AF045024	97566_f_at		immunoglobulin kappa light chain variable region
EST	3.052	1.24	0.938	1.06	1.965	2.013	1.418	4.859	Y12713	98577_f_at
EST	4.213	1.629	1.115	1.106	1.781	1.719	1.425	6.184	M15593	101640_f_at	J-region; V-region; immunoglobulin light chain; immunoglobulin-kappa; processed gene
AL024016	2.452	1.788	1.614	1.467	1.634	1.592	1.78	3.006	AI838592	95637_at	EST
Xmr	3.767	0.691	0.275	0.805	0.689	1.498	0.215	2.156	X72697	102818_at	meiosis-specific protein; nuclear protein; XLR gene family; XMR gene; XY body	"Xlr-related, meiosis regulated"
Foxm1	6.016	2.288	0.209	1.41	1.299	1.29	1.342	1.847	Y11245	98306_g_at	transcription factor	winged-helix transcription factor
Gtse1	7.119	3.848	0.212	0.784	0.785	1.146	1.013	1.752	AJ222580	103270_at	B99 gene	B99 protein	p53 regulated microtubule localised protein
Ppnr-pending	3.155	1.667	0.181	1.35	2.37	1.324	1.73	1.978	X65588	101186_at	clock regulated gene; mp41 gene	per-pentamer repeat gene
Frk	4.605	0.824	0.248	1.301	1.424	2.333	1.68	3.236	Z48757	92959_at	intestinal tyrosine kinase	intestinal tyrosine kinase	protein tyrosine kinase
sst2	5.201	1.961	1.742	2.22	2.048	1.835	2.747	2.888	AF008914	98350_at		somatostatin receptor type 2
Dlx2	6.015	1.689	1.122	1.073	0.91	0.415	1.764	1.808	M80540	92332_at	Tes-1 homeobox protein; homeodomain	Tes-1 homeobox protein
Fgfr1	3.272	1.702	1.85	1.545	1.475	1.176	1.809	2.549	U22324	97509_f_at		"fibroblast growth factor receptor-1, long isoform precursor"
Fgf9	5.077	3.066	2.156	1.41	1.82	1.937	2.536	2.384	U33535	100346_at		fibroblast growth factor 9
EST	4.128	2.77	1.767	1.608	1.823	1.892	2.118	2.113	AI642677	97105_at	EST
AA409766	4.594	2.878	2.367	2.109	2.322	2.237	2.283	2.513	AA409766	94662_at	EST
Grb10	9.999	2.439	2.478	1.8	2.104	2.345	2.64	2.361	AF022072	93690_at		adapter protein
AA408648	3.643	2.325	2.289	1.769	1.788	2.011	2.194	2.65	AI840815	94363_at	EST
AI467657	4.03	1.633	0.808	0.907	0.701	1.286	1.731	2.416	AI553024	92202_g_at	EST
Ptprl	4.382	1.397	0.186	0.187	0.16	0.215	1.27	2.878	D88187	100454_at	Ftp-1	Ftp-1
Spag5	4.65	1.276	1.159	0.439	2.203	1.172	1.871	2.956	X81633	92412_s_at	s17 gene
Fbln1	3.212	1.951	1.36	0.999	1.814	1.527	1.628	2.319	X70853	94309_g_at	extracellular matrix protein; fibulin	BM-90/fibulin
edr	3.652	2.409	2.265	1.659	2.276	1.828	2.298	2.583	AJ007909	98525_f_at	edr gene; erythroid differentiation regulator	erythroid differentiation regulator
Cish3	4.714	2.505	1.695	0.506	1.186	1.344	1.326	1.606	U88328	92232_at		suppressor of cytokine signalling-3
AI593484	7.555	3.487	2.287	0.175	1.831	1.443	2.088	2.041	AI593484	94784_at	EST
EST	3.562	2.854	0.215	0.601	1.231	0.145	0.777	2.707	AA267568	96579_at	EST
Nrg1	2.694	2.609	1.232	1.303	1.378	0.676	1.152	2.264	AB025413	98313_at	Ten-m4	Ten-m4
p16	3.022	2.449	1.164	1.214	1.405	0.955	1.675	2.475	X52102	100138_f_at	16 kDa protein	16 kDA protein
Ahcy	2.696	2.51	1.242	1.439	1.414	1.307	1.701	1.981	L32836	96025_g_at	S-adenosyl-L-homocysteine hydrolase; adenosylhomocysteinase; copper-binding protein; homocysteine hydrolysis	S-adenosyl-L-homocysteine hydrolase	copper binding; hydrolysis of homocysteine
Csrp	3.33	2.34	1.225	1.126	1.111	1.087	1.46	1.908	D88793	92608_at	CRP-1; cystein rich protein-1	cystein rich protein-1
1810014L12Rik	4.292	2.562	1.703	1.39	1.354	1.358	1.768	2.307	AI852985	95137_at	EST
1700030K07Rik	3.073	2.406	1.552	1.791	1.544	1.54	1.694	2.421	AW045233	93046_at	EST
Pea3	4.005	1.919	1.229	1.19	1.726	1.133	1.627	2.452	X63190	92979_at	oncogene; PEA3 polypeptide	polyomavirus enhancer activator 3
Col5a2	4.529	2.861	1.807	1.611	2.076	1.306	2.236	2.481	L02918	92567_at	alpha-2 type V collagen	procollagen type V alpha 2
Borg4-pending	4.03	2.381	1.614	1.771	1.847	1.316	1.618	2.335	AI844806	94036_at	EST
Serping1	3.939	2.452	1.252	1.219	1.72	1.16	1.266	2.208	AF010254	99081_at		C1 inhibitor
Taf15	4.888	4.483	2.497	1.212	2.094	1.147	1.336	2.52	AW107462	96554_r_at	EST
1200009I24Rik	3.597	2.678	1.299	1.801	1.815	1.698	1	1.828	AA250299	101366_f_at	EST
EST	4.29	3.143	1.255	1.926	1.654	1.287	1.486	1.78	AI449034	103720_at	EST
Rad51	6.234	2.488	1.38	1.069	2.217	1.947	0.942	2.394	D13803	104527_at	ATPase; DNA repair; MmRad51; RecA-like protein; meiosis; recombination	MmRad51
Gfpt2	3.185	2.376	1.098	0.419	2.51	1.126	1.239	1.147	AB016780	103737_at	Glutamine:fructose-6-phosphate amidotransferase 2	Glutamine:fructose-6-phosphate amidotransferase 2
Racgap1	12.1	5.026	0.216	0.193	1.946	0.681	0.978	1.849	AW122347	94953_at	EST
Ntsr2	4.753	2.867	0.223	0.225	2.79	0.156	1.137	0.236	U51908	93137_at		neurotensin receptor
SLC6A5	1.941	8.059	0.208	0.196	0.251	0.228	1.534	3.241	U92654	99409_at		norepinephrine transporter	removes norepinephrine from synaptic cleft
Enc1	3.113	0.928	0.966	0.86	1.078	1.915	1.708	3.609	AI848479	98524_f_at	EST
Cd84	3.194	0.612	0.669	0.577	0.354	2.416	2.191	5.754	AA607237	104228_at	EST
1700029H17Rik	3.108	0.53	0.338	0.868	0.357	2.661	0.889	6.523	L04848	103847_at	pseudogene
Rdh7	3.253	0.234	0.225	1.067	0.194	3.937	1.985	3.898	AF056194	100634_at		short-chain dehydrogenase CRAD2
EST	3.127	2.106	1.21	1.581	1.806	2.54	2.811	4.211	X00652	96971_f_at	Ig kappa light chain; Ig light chain; immunoglobulin; joining region; variable region	Ig-kappa light chain V-J kappa 5 joining region
Ly6a	2.304	1.7	0.106	0.68	0.894	1.753	2.038	3.783	X04653	93078_at	Ly-6 alloantigen; signal peptide	"lymphocyte antigen 6 complex, locus A"
Cntnap1	1.635	1.146	0.167	0.347	0.249	2.572	2.664	3.179	AF039833	94626_at		neurexin IV
Hoxb13	2.921	1.982	0.177	0.128	0.725	3.633	2.971	3.821	U57051	99808_at		Hoxb-13
EST	1.104	1.565	0.609	1.33	0.211	2.062	2.346	3.445	AF109905	92307_at		Hsc70t; smRNP; G7A; NG23; MutS homolog; CLCP; NG24; NG25; NG26
EST	3.421	0.064	0.547	0.304	2.345	2.156	2.664	7.03	L33954	93927_f_at		Ig variable region heavy chain precursor
Cd84	2.002	0.97	1.181	1.154	1.956	2.14	2.315	3.569	AA624599	100914_at	EST
Penk1; ENK; PPA; AI326464	1.32	0.794	0.638	0.715	1.425	1.803	2.322	2.282	M55181	94516_f_at	proenkephalin; spermatogenic-specific proenkephalin	spermatogenic-specific proenkephalin
5T4	2.027	0.87	0.891	1.111	1.635	1.958	3.04	2.464	AJ012160	95345_at	5T4 gene; 5T4 oncofetal trophoblast glycoprotein	5T4 oncofetal trophoblast glycoprotein
Amy2	2.872	0.178	0.95	2.133	1.452	2.569	2.553	6.146	X02578	97524_f_at	amylase-alpha	"amylase 2, pancreatic"
Gtf3a	2.634	2.884	1.779	1.305	2.511	1.306	3.002	6.158	AI850893	94557_at	EST
Fxyd1; PLM; PML; 0610012C17Rik	2.022	2.157	1.224	1.148	1.436	1.407	2.302	3.251	AF091390	93040_at		phospholemman precursor
Krt1-12	3.154	2.979	1.389	0.486	1.523	1.451	1.713	8.51	U02880	97788_at		K12 keratin
C81363	3.095	1.945	1.701	0.768	1.249	0.664	1.828	3.87	C81361	102111_f_at	EST
Wnt5b	2.17	1.784	1.497	0.87	1.038	0.777	1.538	3.202	M89799	103513_at	Wnt-1 related protein; Wnt-5b protein; int-1 related protein	wingless-related MMTV integration site 5B
Hoxa6; Hox-1.2	1.677	1.236	1.386	0.633	1.039	1.184	1.788	2.647	M11988	102580_r_at	homeo box
Atf3	1.7	1.335	1.55	0.636	0.798	1.293	2.593	4.924	U19118	104156_r_at	leucine zipper; transcription factor	LRG-21	transcription factor
EST	1.783	1.078	1.093	0.727	0.679	1.381	2.43	2.591	AI606915	104231_at	EST
Prdx5-rs3; CP-2; Aop2-rs3	2.235	1.428	1.412	1.111	1.019	1.727	2.824	1.885	AF093853	100332_s_at		1-Cys peroxiredoxin protein 2
Kcnk1	2.241	1.153	1.242	1.217	1.471	1.213	2.444	2.731	AF033017	102335_at		TWIK-1 K+ channel
Fah	2.926	1.597	1.595	1.349	1.738	1.914	2.317	2.41	Z11774	98588_at	fumarylacetoacetase	fumarylacetoacetase
cell surface protein CD19	1.277	1.433	1.093	0.719	2.256	1.44	2.508	2.984	M28240	99945_at	cell surface protein	cell surface protein CD19
Edn2	0.164	2.468	1.082	0.58	0.256	0.234	10.041	33.2	X59556	100695_at	vasoactive intestinal contractor	"vasoactive intestinal contractor, prepropeptide"
Klra7	2.349	1.804	1.785	1.31	2.18	0.767	1.508	3.569	U10094	97761_f_at		Ly-49G.2 antigen
Rfx2	2.761	0.859	0.82	1.028	1.874	0.176	0.221	3.423	X76089	102219_at	DNA-binding protein RFX2	DNA binding protein RFX2
Hlx	4.87	2.499	2.471	2.164	2.376	0.205	1.843	3.208	X58250	102657_at	DNA-binding protein; embryogenesis; haematopoiesis; homeobox; transcription factor	H2.0-like homeo box gene
2810012G08Rik	1.065	1.791	0.548	1.343	1.234	0.168	1.377	4.158	AA683785	102942_at	EST
Myf6	2.381	0.946	1.377	1.507	0.224	0.088	2.736	3.65	X59060	102265_at	muscle specific protein; myf-6 gene; regulatory gene	myogenic factor 6