Source: Interfolio F180
Christopher Parker, PhD
Research Focus
Broadly speaking, the Parker Lab seeks to develop chemistry-enabled strategies to investigate human biology and disease pathology. Our research integrates organic synthesis with chemical proteomics and cell/molecular biology to (1) to study how small molecules might regulate, or be designed to regulate, complex biological processes such as immune responses and, (2) illuminate molecular mechanisms that contribute to disease. Our primary objectives are not only to better understand protein function and corresponding disease roles, but also to create chemical tools and technologies that might facilitate the development of new therapeutics. Check out our lab website for additional information on our research.
Education
Ph.D. (Chemistry), Yale University, 2013B.S. (Chemistry), Case Western Reserve University, 2007
Professional Experience
2013-2018 American Cancer Society Postdoctoral Research Fellow, The Scripps Research Institute2018-2022 Assistant Professor, Department of Chemistry, The Scripps Research Institute
2022-2024 Associate Professor, Department of Chemistry, The Scripps Research Institute
2024-present Professor, Department of Chemistry, The Scripps Research Institute
Awards & Professional Activities
2023 Chan Zuckerberg Initiative, Exploratory Cell Network Award
2020 CDMRP New Investigator Idea Development Award (DoD)
2017 Aspen Cancer Conference Fellow
2014-2017 American Cancer Society Postdoctoral Fellowship
2009 Dox Fellowship in Recognition of Excellence in Academics and Research in Organic Chemistry
2008 T.F. Cooke Award for Teaching Assistant Excellence
2006 GlaxoSmithKline (GSK) Undergraduate Research Fellowship
2005 Howard Hughes Medical Institute (HHMI) Undergraduate Research Fellowship
2005 Merck Index Award
2005-2007 Case Western Reserve Alumni Scholarship
2003-2007 Case Western Reserve Full Tuition Scholarship
Selected Publications
Chiu, T-Y.; Lazar, D. C.; Wang, W. W.; Wozniak, J. M.; Jadhav, A. M.; Li, W.; Gazaniga, N.; Theofilopoulos, A. N.; Teijaro, J. R.; Parker, C. G. Chemoproteomic Development of SLC15A4 Inhibitors with Anti-Inflammatory Activity. Nature Chemical Biology 2024, 20, 1000-1011.
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Wozniak, J. M.; Li, W.; Governa, P.; Chen, L-Y.; Jadhav, A. M.; Dongre, A.; Forli, S.; Parker, C. G. Enhanced Mapping of Small-Molecule Binding Sites in Cells. Nature Chemical Biology 2024, 20, 823-834.
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Tang, J.; Li, W.; Chiu, T-Y.; Martínez‐Peña, F.; Luo, Z.; Chong, C. K.; Wei, Q.; Gazaniga, N.; West, T. J.; See, Y. Y.; Lairson, L. L.; Parker, C. G.; Baran, P. S. Synthesis of Portimines Reveals the Basis of their Anti-cancer Activity. Nature 2023, 622, 507.
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Parker, Christopher G.; Homan, Rick A.; Jadhav, Appaso M.; Conway, Louis P. A Chemical Proteomic Map of Heme–Protein Interactions. Journal of the American Chemical Society 2022, 144, 15013-15019.
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Parker, Christopher G.; Wang, Wesley W.; Chen, Li-Yun; Wozniak, Jacob M.; Jadhav, Appaso M.; Anderson, Hayden; Malone, Taylor E. Targeted Protein Acetylation in Cells Using Heterobifunctional Molecules. Journal of the American Chemical Society 2021, 143, 16700-16708.
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Rubiano, Juanita S.; Parker, Christopher G.; Li, Weichao; Lawrence, R M.; Jadhav, Appaso M.; Homan, Rick A.; Hawkins, Richard; Conway, Louis P. Evaluation of fully-functionalized diazirine tags for chemical proteomic applications.. Chemical science 2021, 7839-7847.