Source: Interfolio F180


Donghyun Raphael Park, PhD

Scripps Fellow
Department of Integrative Structural and Computational Biology


 Email

Scripps Research Joint Appointments

Immunology & Microbiology
Skaggs Graduate School of Chemical and Biological Sciences

Research Focus

To achieve infection and survival, various pathogens use complex multiprotein nanomachines to inject bacterial substrates into target cells and the extracellular environment. These nanomachines play critical roles in host-pathogen interactions by modulating eukaryotic host cell functions. The Park lab laboratory aims to utilize cutting-edge cryo-electron tomography (cryo-ET) technologies to define how bacterial nanomachines assemble to orchestrate substrate secretion and, thus, pathogenicity in the native environment.

Education

B.S. (Microbiology), University of Minnesota, 2013
Ph.D. (Microbial Pathogenesis), Yale School of Medicine, 2022

Professional Experience

2013- 2015 Post-baccalaureate research, Bing Chen Laboratory, Harvard Mediacal School

Selected Publications

Dev, Jyoti; Park, Donghyun; Fu, Qingshan; Chen, Jia; Ha, Heather J.; Ghantous, Fadi; Herrmann, Tobias; Chang, Weiting; Liu, Zhijun; Frey, Gary; Seaman, Michael S.; Chen, Bing; Chou, James J J. Structural basis for membrane anchoring of HIV-1 envelope spike. 2016, 353, 172-175.

Park, Donghyun; Lara-Tejero, Maria; Waxham, M N.; Li, Wenwei; Hu, Bo; Galán, Jorg E.; Liu, Jun Visualization of the type III secretion mediated -host cell interface using cryo-electron tomography. 2018, 7.

Park, Donghyun; Chetrit, David; Hu, Bo; Roy, C R.; Liu, Jun Analysis of Dot/Icm Type IVB Secretion System Subassemblies by Cryoelectron Tomography Reveals Conformational Changes Induced by DotB Binding. 2020, 11.

Park, Donghyun; Steiner, Samuel; Shao, Meng; Roy, C R.; Liu, Jun Developmental Transitions Coordinate Assembly of the Coxiella burnetii Dot/Icm Type IV Secretion System. 2022, e0041022.